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INJEX system

✓ Approved

Equidyne · 治疗药物

什么是 INJEX system？

INJEX system 是一种治疗药物，由Equidyne研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection、Subcutaneous Injection。

药物档案

公司Equidyne
给药途径Injectable (Others), Intramuscular (IM) Injection, Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Equidyne

治疗适应症

INJEX system 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresOral appliance application✓ Approved

相关研究文献

PubMedInternational journal of pharmaceutics2026-06-13

A dual-microneedle system for integrated continuous glucose monitoring and feedback insulin delivery.

Zhao Kangxun K, Niu Yangguang Y, Cao Xiaoping X, Ma Tianqi T et al.

Effective precision diabetes management requires seamless integration of continuous glucose monitoring and therapeutic intervention. In this study, we present a novel dual-microneedle regulatory system, which combines a biosensing microneedle for real-time interstitial glucose monitoring and a therapeutic microneedle for precise transdermal insulin delivery. The biosensing microneedle utilizes glucose oxidase-functionalized electrodes for continuous glucose sensing (demonstrating a broad linear range of 1-34 mM and a limit of detection of 0.4 mM), while the therapeutic microneedle employs electroosmotic flow to regulate insulin infusion through hollow channels under a constant 5 V voltage. This integrated system was demonstrated to provide accurate glycemic control in diabetic Wistar rat models (achieving a 55 % blood glucose reduction within 144 min and demonstrating high clinical accuracy with 88 % of points in Zone A of the Clarke Error Grid), successfully merging continuous glucose monitoring with on-demand insulin delivery. The proposed system demonstrates a solid proof-of-concept for physically segregated closed-loop regulation, paving the way for the development of miniaturized, wearable artificial pancreas platforms for more effective diabetes management.

PMID 42285381
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PubMedNature biomedical engineering2026-06-13

Oesophageal tissue screening system for assessing the retention and mucosal absorption of biologics.

Karavasili Christina C, Young Thomas T, Chan Alvin A, Lal Nikhil N et al.

Drug delivery to the oesophagus poses unique challenges, including rapid transit time due to gravity and the presence of a stratified squamous non-keratinized epithelium. Here, to rapidly identify formulations of excipients for enhanced drug delivery to the oesophagus, we developed an oesophageal tissue screening system consisting of specialized custom plates, to incorporate gravity effects, and excised oesophageal mucosa tissues. Using the screening system, we built an excipient library identifying the most effective non-toxic permeation enhancers and selected the formulation that could prolong the retention on the oesophageal mucosa. We identified an absorption enhancer that resulted in a 876-fold increase in the oesophageal transport of a model drug (4 kDa) in pig tissue. We validated this formulation in human oesophageal tissue and in vivo in pigs with the model drug and infliximab (149 kDa), demonstrating enhanced permeability. We characterized the mechanism of the approach, noting its capacity for enhanced delivery without causing cellular disruption of the oesophageal tissue. The oesophageal tissue screening system shows promise for high-throughput screening of effective oesophageal drug delivery systems.

PMID 42286250
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PubMedJournal of physics. Condensed matter : an Institute of Physics journal2026-06-13

Intrinsic electronic structure and nanoscale domains in the kagome superconductor KV3Sb5probed by space resolved photoemission spectroscopy.

Tomassucci Giovanni G, Minati F F, Barinov Alexei Victorovich AV, Wang Zhiwei Z et al.

We have investigated the intrinsic electronic structure of the KV3Sb5kagome superconductor, which exhibits charge-density-wave (CDW) order, by combining scanning photoelectron microscopy (SPEM) and angle-resolved photoemission spectroscopy using a sub-micron beam. Our findings suggest that in the CDW phase of the system at 30 K, percolative paths emerge, while at room temperature, the system exhibits homogeneity with suppressed CDW correlations. Despite its inhomogeneous nature, the CDW persists even on the Sb-terminated surface, as evidenced by the Dirac-cone gap associated with 2 × 2 CDW fluctuations. These results suggest that KV3Sb5 can serve as a model system for exploring emergent quantum phenomena arising from the interplay of topology, strong correlations, and lattice instabilities.

PMID 42285130
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PubMedPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]2026-06-13

Automated alert system and collaborative workflow improve treatment adherence and clinical outcomes in emergency care for acute pancreatitis: A quality improvement project.

Pan Yingyu Y, Gao Xiaomao X, Jiang Xiaodong X, Wu Zuoyan Z et al.

Early management of acute pancreatitis (AP) is vital for improving prognosis, yet a significant "know-do gap" persists in clinical practice due to suboptimal guideline adherence. This project aimed to enhance adherence to core early treatments for AP patients in the emergency department and to improve clinical outcomes. A multifaceted intervention was implemented, comprising: (1) an automated alert system for real-time case screening; (2) a emergency-gastroenterology collaborative workflow; (3) "Just-in-Time Coaching" to provide bedside decision support; and (4) a structured daily reporting system to ensure fidelity. Primary process measure was adherence to early goal-directed fluid resuscitation. Initiation of enteral nutrition within 72 h of admission was tracked as a secondary process measure. Clinical outcome measures included organ failure, intensive care unit admission and 6-month mortality. Fluid overload and alert fatigue were assessed as balancing measures. Fluid resuscitation compliance increased significantly from 63.5% to 88.1% (OR = 5.34, p < 0.001). Enteral nutrition compliance showed a numeric increase (30.6% vs 43.5%) but didn't reach statistical significance. Regarding clinical outcomes, the intervention was associated with significantly reduced renal failure (17.6% vs 8.9%, aOR = 0.48, p = 0.043). No fluid overload events occurred in either phase. The alert system achieved 99.67% sensitivity with acceptable cognitive load. The "automated alert system coupled with a collaborative workflow" model effectively bridged the "know-do gap" in a high-pressure emergency environment, standardizing care processes and improving clinical outcomes for AP patients.

PMID 42285884
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PubMedCarbohydrate polymers2026-06-13

Preparation of water-soluble sodium polyglucuronates from water-insoluble glucans by NaBr-free TEMPO-catalyzed oxidation with sodium dichloroisocyanurate in water.

Chitbanyong Korawit K, Arnandan Pavitra Thevi PT, Hou Runqing R, Shibata Izumi I et al.

NaBr-free TEMPO-catalyzed oxidation with sodium dichloroisocyanurate (NaDCC) used as the consumed co-oxidant in water and room temperature was applied to water-insoluble polyglucans, such as a commercial regenerated cellulose (Bemliese), curdlan, α-(1 → 3)-glucan, corn starch, and 20% NaOH-treated/never-dried ramie. Water-soluble oxidized products with degrees of oxidation (DO) of >0.8 were obtained from Bemliese, curdlan, α-(1 → 3)-glucan, and corn starch by the TEMPO/NaDCC system at pH 9. The mass-average degrees of polymerization (DPw) of the oxidized products were higher than those prepared by the conventional TEMPO/NaBr/NaClO system at pH 10. In the case of 20% NaOH-treated and never-dried ramie, DOs were only ~0.6 and water-soluble oxidized products could not be obtained quantitatively. Consequently, the TEMPO/NaDCC system in water at pH 9 is advantageous for preparation of water-soluble oxidized products with higher DPw values from water-insoluble glucans, such as Bemliese, curdlan, α-(1 → 3)-glucan, and corn starch, by suppression of depolymerization probably because of no NaBrO present in the system. The water-soluble oxidized products or sodium polyglucuronates are possible to be used as biodegradable and metabolizable polymeric builders in laundry detergents.

PMID 42285656
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PubMedISA transactions2026-06-13

Finite-time sliding mode speed control using an adaptive three-stage reaching law for PMSM.

Huang Yifan Y, Lu Shaowu S, Song Bao B, Zheng Shiqi S

To address the challenge of balancing finite-time convergence and chattering suppression in sliding mode control for permanent magnet synchronous motors, this paper proposes a composite control scheme based on an adaptive three-stage reaching law (ATSRL) and an enhanced super-twisting sliding mode observer (ESTSMO). First, according to the distinct characteristics of system state, the ATSRL incorporates a clamped exponential term, a state-dependent adaptive term, and a nonlinear power term. It adaptively adjusts the reaching speed by system state and reduces the switching gain near the sliding surface, enabling fast finite-time convergence while effectively suppressing chattering. Second, to mitigate the deterioration of control performance caused by inertia mismatch, an extended sliding mode observer is employed for offline identification of system inertia, and then the ESTSMO is devised to estimate lumped disturbance online as a feedforward compensation term, which is directly embedded into the ATSRL-based control law. Interestingly, the offline-then-online framework provides accurate offline inertia identification via the ESMO, which is incorporated into the ESTSMO to significantly reduce disturbance estimation bias caused by inertia mismatch. Finally, simulation and experimental results validate the advantages of the proposed scheme.

PMID 42285857
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