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insulin (Rinsulin R)

✓ Approved

GeroPharm · INSR · 重组蛋白

什么是 insulin？

insulin 是一种重组蛋白，由GeroPharm研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection、Intravenous (IV)、Subcutaneous Injection。

药物档案

商品名Rinsulin R
公司GeroPharm
药物类别重组蛋白
分子靶点INSR
给药途径Injectable (Others), Intramuscular (IM) Injection, Intravenous (IV), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, GeroPharm

作用机制

分子靶点

insulin 作用于 1 个分子靶点：

INSRinsulin receptor (CD220, HHF5)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

insulin 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersType 1 diabetes mellitus✓ Approved
Metabolism and nutrition disordersType 2 diabetes mellitus✓ Approved

相关研究文献

PubMedJournal of diabetes science and technology2026-08-05

Real-World Outcomes of Automated Insulin Delivery Use in Hospitalized Adults With Diabetes.

Ruddiman Kathleen R KR, Evans Joni K JK, Aloi Joseph A JA, Usoh Chinenye C et al.

Automated insulin delivery (AID) systems are increasingly used by individuals living with diabetes in the outpatient setting, but data on their safety and effectiveness during hospitalizations remains limited. The objective is to evaluate the use and efficiency of AID systems in hospitalized adults with diabetes. We performed a retrospective cohort study based on electronic health record data from hospital admissions of 316 patients with diabetes using insulin pumps. Automated insulin delivery and continuous glucose monitor use, insulin pump continuation, length of stay (LOS), and glycemic outcomes among the cohort were analyzed. The primary aims of the study were to describe rates of insulin pump continuation and reasons associated with removal, and rates of pump reinitiation. Secondary outcomes included effects of insulin pump removal and prompt endocrinology consultation on inpatient glycemic outcomes and LOS. Insulin pumps were continued in 64.2% of all admissions. The most common reason for pump discontinuation was surgery (30.1%). Length of stay was longer when pumps were removed (8.3 vs 4.7 days, P < .001) and when endocrinology consultation occurred more than 24 hours after admission (P < .001). Insulin pump continuation was associated with lower hyperglycemia (glucose >180 mg/dL) rates without an increase in hypoglycemia (glucose <70 mg/dL) in both critical and noncritical care settings. Continuation of insulin pumps was associated with improvement in hyperglycemia without increased hypoglycemia risk and with shorter LOS in the hospital. Standardized institutional policies including prompt glycemic management team consultation may help expand safe continuation of AID during hospitalizations.

PMID 42554596
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PubMedChemical science2026-08-05

Efficient lasing in size-tunable self-assembled organic microcavities.

Xue Lulu L, Shi Hongyan H, Qu Jiafan J, Deng Huachun H et al.

Blue-emitting organic semiconductor microcavities are attractive candidates for low-threshold, narrow-linewidth microlasers, but the controllable fabrication of high-quality cavities remains challenging. As a readily accessible organic gain material, 1,4-bis(4-methylstyryl)benzene (p-MSB) can spontaneously form single-crystalline microcavities through solution self-assembly and exhibits favorable amplified spontaneous emission (ASE) characteristics. However, self-assembled p-MSB microcavities typically adopt elongated hexagonal geometries with unequal side lengths, leading to increased optical mode leakage, weakened optical confinement, and limited lasing performance. Here, by regulating the solution atmosphere during self-assembled crystal growth, we obtained high-quality p-MSB hexagonal microcavities. The regular p-MSB hexagonal microcavities (regular-PHMs) with nearly identical side lengths were obtained by further adjusting the p-MSB concentration. As the cavity geometry approaches an ideal regular hexagon, optical mode leakage is effectively suppressed, leading to efficient lasing with a low optical pumping threshold of ∼4.12 µJ cm-2, a narrow linewidth of 0.2 nm, and a high-quality factor of ∼2283. In addition, single-mode lasing was realized by reducing the size of the regular-PHMs. These excellent lasing properties are closely associated with the cavity geometry and size, both of which can be precisely controlled through the crystal preparation process. This work demonstrates that size-tunable organic microcavities provide a promising platform for optical circuits and next-generation miniaturized optoelectronic devices.

PMID 42553453
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PubMedPloS one2026-08-05

In vitro evaluation of microfluidic WS6-loaded Eudragit nanoparticles for improving insulin-producing cell differentiation.

Abuarqoub Duaa D, Mohammad Marwa M, Albarghouthi Rand R, Abuoun Mohammad M et al.

This study explores a stem-cell-based approach for diabetes treatment by enhancing the viability and functionality of insulin-producing cells (IPCs) derived from stem cells of the apical papilla (SCAP). Although SCAP can differentiate into IPCs, limited cell survival remains a challenge. To address this, the proliferation enhancer WS6 was incorporated into Eudragit RS100 nanoparticles (NPs) using microfluidics. The WS6-loaded NPs were characterized for size, charge, PDI, morphology, stability, and drug loading. An MTT assay was performed as a preliminary screening method to evaluate the cytocompatibility of blank-NPs and to optimize treatment concentration. SCAP cells were treated with free WS6 or WS6-loaded NPs, and cellular uptake of NPs was evaluated using flow cytometry and fluorescence imaging. Additionally, the viability of treated cells was determined by propidium iodide (PI) and trypan blue. Prior to differentiation, definitive endoderm formation was assessed through SOX17 and FOXA2 expressions. After differentiation into IPCs, maturation markers such as insulin, C-peptide, PDX-1, NKX2.2, and NKX6.1 were examined, and apoptosis assays measured cell viability. Functional insulin secretion was tested using an in vitro glucose-stimulated insulin secretion (GSIS) assay. Results showed that WS6-loaded NPs significantly improved SCAP viability, increased healthy cell percentages, and enhanced IPC maturation. Treated IPCs demonstrated functional insulin secretion and improved glucose regulation. Overall, WS6-loaded NPs represent a promising approach to enhance IPC proliferation and generation for diabetes therapy.

PMID 42550869
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PubMedClinical cardiology2026-08-05

Associations of Healthy Lifestyle With All-Cause and Cardiovascular Disease Mortality in Individuals With Cardiovascular-Kidney-Metabolic Syndrome: Two Prospective Cohort Studies.

You Qiqi Q, Fu Wan W, Xu Mi M, Wu Yucen Y et al.

Cardiovascular-kidney-metabolic (CKM) syndrome poses a major health risk. This study assessed the impact of a healthy lifestyle on all-cause and cardiovascular disease (CVD) mortality in CKM individuals. We analyzed 306 831 and 9823 CKM individuals from UK Biobank and NHANES (2007-2018). A healthy lifestyle score was created based on seven factors: no current smoking, moderate drinking, healthy diet, regular physical activity, adequate sleep, low sedentary behavior and appropriate social connection. Primary outcomes were all-cause and CVD mortality from linked health records and death registries. Cox regression models showed that higher lifestyle scores were associated with reduced risks of all-cause (hazard ratio [HR]: 0.81, 95% confidence interval [CI]: 0.80-0.82) and CVD mortality (HR: 0.82, 95% CI: 0.80-0.84) in UK Biobank. In NHANES, higher scores were associated with 15% (95% CI: 0.80-0.90) and 11% (95% CI: 0.81-0.99) lower mortality risks. Both regular physical activity (HRs: 0.85 and 0.89 for UK Biobank, 0.76 and 0.73 for NHANES) and low sedentary behavior (HRs: 0.85 and 0.91 for UK Biobank, 0.79 and 0.67 for NHANES) were related to reduced mortality risks (p < 0.05). Participants with non-advanced CKM syndrome and a favorable lifestyle had the lowest mortality risks compared to those with advanced CKM syndrome and an unfavorable lifestyle. A healthy lifestyle, particularly regular physical activity and low sedentary behavior, was significantly associated with lower all-cause and CVD mortality in individuals with CKM syndrome. These associations were stronger in the early stages, highlighting the importance of timely and targeted lifestyle interventions.

PMID 42554187
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PubMedFrontiers in dental medicine2026-08-05

Bond strength of different viscosities Giomer-based composites to dentin under erosive conditions.

Pereira Maria Laura Diniz MLD, Baroudi Kusai K, Mishra Apurva A, González José Alejandro Castro JAC et al.

The present study aimed to evaluate the bond strength of Giomer-based restorative composites with different viscosities bonded to dentin under various erosive conditions. One hundred and twenty dentin specimens from human sound molars were selected and divided into three groups according to the erosive challenge: ERO (initial erosion with citric acid 0.3%, pH 2.6, 5 min, 5x/day, 1 day), CYC (ERO protocol, followed by an additional 5-day erosive cycling challenge after restoration), and CON (sound dentin, without erosion, control). Specimens were further subdivided into four groups (n = 10) according to the Giomer-based restorative material used: flowable composite (FC), flowable bulk-fill composite (FBF), regular-viscosity composite (CC), and regular-viscosity bulk-fill composite (CBF). Two cylinders (1.5 mm diameter) with the resins from each group were made in each sample, after applying the two-step self-etching adhesive system. In the CYC group, the erosive cycle was carried out before and after placement of the adhesive system and composite cylinders. Bond strength was assessed by the micro shear test, and failure was quantified in a stereomicroscope. The data were submitted to two-way ANOVA, followed by the Tukey test (p < 0.05). Significant differences were observed for the eroded substrate (p = 0.010) and the composite resins (p = 0.037), but not for their interaction (p = 0.677). The CYC groups showed lower bond strength values than control group, and only the FC composite presented lower values than FBF, while CC and CBF showed similar values. Erosive cycling decreased the bond strength for all composites tested, irrespective of their viscosity. Regarding the flowable composites, the bulk fill one presented a higher value than the conventional non-bulk fill, while this difference was not observed for the regular-viscosity composites.

PMID 42553394
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PubMedAnnals of gastroenterology2026-08-05

A guide to healthcare maintenance for the patient with inflammatory bowel disease.

Jaoude Celina R Bou CRB, Bitar Elio R ER, Mourad Fadi H FH, Gnanapandithan Karthik K et al.

Healthcare maintenance plays a vital role in the long-term management of patients with inflammatory bowel disease (IBD), particularly those receiving immunosuppressive therapies. This review emphasizes the importance of maintaining up-to-date vaccinations, regular bone and mental health assessments, and appropriate cancer screening in this population. It also highlights the added complexity of preventive care in immunosuppressed patients, outlining specific modifications to vaccination and screening strategies required to ensure safe and effective disease management. Gastroenterologists and other clinicians involved in IBD care should remain familiar with current guidelines and consistently integrate preventive health measures into routine clinical practice.

PMID 42553359
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