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Factor VIII

✓ Approved

Quimbiotec · F8 · 细胞治疗

什么是 Factor VIII？

Factor VIII 是一种细胞治疗，由Quimbiotec研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

公司Quimbiotec
药物类别细胞治疗
分子靶点F8
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Quimbiotec

作用机制

分子靶点

Factor VIII 作用于 1 个分子靶点：

F8coagulation factor VIII (AHF, FVIII)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

Factor VIII 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersFactor VIII deficiency✓ Approved

相关研究文献

PubMedZentralblatt fur Chirurgie2026-06-13

[Robotic Management of a Bile Leak After Cholecystectomy Caused by an Aberrant Bile Duct of the Hepatic Segments, Using a Combined Biliodigestive Anastomosis Incorporating the Cystic Duct Stump].

Hochstein Jan Niklas JN, Umstadt Julia J, Neesse Albrecht A, Egberts Jan Hendrik JH

Bile leaks are serious complications after cholecystectomy. Their management is usually individualised and requires interdisciplinary surgical and endoscopic expertise. In cases of leaks caused by aberrant bile ducts, closure of the leak may be impossible-depending on the size of the drained liver area; therefore, drainage-e.g., by means of a biliodigestive anastomosis-is required. We report the case of a 66-year-old female patient referred from an external hospital with a bile duct leak caused by an aberrant bile duct of segments V and VIII and concomitant cystic duct stump insufficiency following laparoscopic cholecystectomy. Due to the extent of the drained liver area, surgical management with drainage of the bile duct was pursued. Preservation of the option for ERCP in the event of potential secondary complications, such as bile duct strictures, was considered important. Given the prior laparoscopic surgery, a minimally invasive approach was favoured. A robot-assisted exploration of the hepatic hilum and bile ducts was performed. Primary anastomosis was not feasible, due to the distance between the structures. For drainage of the bile duct, a combined anastomosis was created: the cystic duct stump was anastomosed to the aberrant bile duct on the posterior wall, and a biliodigestive anastomosis using a Roux-en-Y reconstruction was performed on the anterior wall. Intraoperatively, a biliary stent was placed via the cystic duct stump into the aberrant bile duct. The postoperative course was uneventful, with no recurrence of the bile leak. The patient was discharged after 11 days. The biliary stents were removed after 7 weeks, demonstrating good contrast drainage from the aberrant bile duct into the biliodigestive anastomosis. Robot-assisted management of bile duct injuries should be considered in patients with prior laparoscopic surgery. Roux-en-Y reconstruction incorporating the cystic duct stump to preserve the option of ERCP is a viable treatment strategy for leaks originating from larger aberrant bile ducts.

PMID 42285167
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PubMedBMC psychology2026-06-13

Validation and psychometric properties of the Arabic version of the Quality-of-Life Scale (QOLS) with a sample of general and special education teachers.

Almohayya Bander M BM, Alasim Khalid N KN

This study was performed to validate the Arabic version of the 15-item Quality-of-Life Scale (QOLS) using a sample of 401 teachers, including 235 general education teachers and 166 special education teachers. The psychometric properties of the QOLS were evaluated through exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). EFA supported a two factor solution, explaining 55.6% of the total variance, with Factor 1 reflecting personal and social well-being and Factor 2 reflecting leisure and autonomy. Internal consistency was excellent, with Cronbach's alpha and McDonald's omega coefficients of .91 and .92 for the total scale, respectively. Convergent validity was established via a strong positive correlation with the WHOQOL-Bref (r = .78), while discriminant validity was confirmed through a moderate negative correlation with the Health and Suffering Scale (r = -.57). CFA demonstrated acceptable model fit indices (CFI = 0.92, TLI = 0.90, RMSEA = 0.085, SRMR = 0.05), supporting the stability of the two-factor structure. Multi-CFA further indicated that measurement invariance was achieved across gender at configural, metric, and scalar levels, whereas full invariance was not supported across educational levels. The findings indicate that the Arabic QOLS is a reliable and valid instrument for assessing quality of life among physically active adult populations such as teachers. Implications for its application in educational and research contexts, as well as limitations regarding factor structure differences from the original QOLS, are discussed.

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PubMedBulletin of mathematical biology2026-06-13

Refining Niche Metric Calculations: A Modified Weighting Approach to Colwell and Futuyma's Method.

Özkan Kürşad K, Özdemir Serkan S, Muys Bart B, Doğan Salih S

The niche concept is central to ecology, evolution, and conservation biology. To assess resource dynamics in biological communities, the most widely used niche metrics are niche breadth and niche overlap. Colwell and Futuyma (1971) were the first to propose niche metrics that incorporated resource distinctness. In their framework, niche breadth and overlap are calculated using either a relative weighting factor d j or an absolute weighting factor δ j . Hanski (1978) later introduced an alternative weighting factor δ j ∗ , which accounts for both the quality and quantity of resource states in niche calculations. However, metrics based on d j , δ j and δ j ∗ have inherent mathematical and conceptual limitations. To overcome these issues, the present study introduces modified forms of these factors ( e d j , e δ j and e δ j ∗ ) and evaluates their performance using eight hypothetical and one empirical (ecological) resource matrix. The findings indicate that niche metrics incorporating the e d j factor represent the most coherent and biologically meaningful option.

PMID 42286335
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PubMedBioinformatics (Oxford, England)2026-06-13

SEMPLR: an R package for transcription factor binding prediction.

Kenney Grace E GE, Sherpa Rintsen N RN, Burgess Jeremy D JD, Boyle Alan P AP et al.

SEMPLR is an R package that predicts transcription factor binding and variant effects using SNP Effect Matrices (SEMs), providing efficient, genome-wide scoring, enrichment testing, and visualization tools for comprehensive analysis of regulatory sequences. Available on GitHub at https://github.com/grkenney/SEMPLR and on Bioconductor at https://bioconductor.org/packages/release/bioc/html/SEMPLR.html. Supplementary data are available at Bioinformatics online.

PMID 42286344
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PubMedScientific reports2026-06-13

PERMA-Profiler as a multidimensional measure of well-being in a French context.

Julie Jourdan J, Chris Serrand S, Thierry Chevallier C, Aurélie Schandrin S et al.

Subjective well-being is a central component of physical and mental health and is increasingly recognized as a key indicator of quality of life. Despite the widespread use of the PERMA framework, no validated French version of the PERMA-Profiler is currently available. The aim of this study was to translate and culturally adapt the PERMA-Profiler into French and to examine its psychometric properties in a large sample of adults. A total of 612 French-speaking adults completed the French version of the PERMA-Profiler as well as measures of flourishing, anxiety and depression. The sample was randomly divided into two independent subsamples to conduct exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). The EFA suggested a parsimonious three-factor solution, while comparative model tests confirmed the theoretical five-factor structure of the PERMA model. The CFA conducted on an independent subsample strongly confirmed a correlated five-factor model, as well as a second-order hierarchical model reflecting a general well-being factor. The PERMA-Profiler demonstrated good to excellent internal consistency for most dimensions and for the total score, although the "engagement" dimension showed lower reliability, which is consistent with previous validation studies. Test-retest analyses indicated good temporal stability for the total score and most subscales. Convergent validity was confirmed by strong positive associations with flourishing and perceived happiness. Discriminant validity was evidenced by weaker associations with anxiety, depression, loneliness and negative emotions than with flourishing, although some correlations with HADS anxiety and depression scores reached moderate to strong magnitude. Overall, the French version of the PERMA-Profiler has robust psychometric properties and supports the multidimensional structure of psychological well-being proposed by the PERMA framework. This instrument is a reliable and theoretically grounded tool for assessing the well-being of French-speaking adult population, while highlighting the distinct psychometric behavior of the Engagement dimension.

PMID 42286092
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PubMedExperimental physiology2026-06-13

(Poly)phenols: Mechanisms of action and efficacy of contemporary supplements for exercise recovery and performance.

Howatson Glyn G, Clifford Tom T

(Poly)phenols are a diverse group of bioactive chemical compounds present in a wide range of plant- and animal-based foods. Several thousands of (poly)phenols exist; many have potent biological effects, most notably antioxidant, anti-inflammatory and vasodilatory. As such, they are of growing interest as nutritional interventions for health maintenance and disease prevention, but also for athletes aiming to enhance recovery and performance. Although most of their recovery and performance benefits are ascribed to their antioxidant actions, they are unlikely to function as antioxidants in vivo. Rather, they might upregulate the transcription factor nuclear factor-erythroid-2-related factor (Nrf2), which, by upregulating various endogenous antioxidants, could modulate cellular redox balance. Likewise, their anti-inflammatory functions are likely to be driven by their effects on the transcription factor nuclear factor kappa B, which regulates numerous pro-inflammatory genes. Although receiving far less attention, (poly)phenols might also increase mitochondrial biogenesis and fat oxidation, both of which could enhance endurance exercise performance. These biological effects have consistently been demonstrated in vitro, but there is less mechanistic support for them in human studies, despite several clinical trials reporting, albeit inconsistently, improved recovery and exercise performance. Translating the findings from in vitro and animal models to humans is challenging, in large part owing to the poor bioavailability of most (poly)phenols and thus the limited amount of the intact metabolites available for biological effects. This brief review outlines the primary mechanisms through which (poly)phenols might influence exercise recovery and performance and highlights some of the evidence from research that investigates popular (poly)phenol supplements on key performance and recovery outcomes.

PMID 42285757
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