若生智能
Drug Database
IS

isosorbide dinitrate + hydralazine (hydralazine + ISDN / BiDil / ISDN + hydralazine)

✓ Approved

Arbor Pharmaceuticals, LLC · CACNA1C · 小分子

什么是 isosorbide dinitrate + hydralazine？

isosorbide dinitrate + hydralazine 是一种小分子，由Arbor Pharmaceuticals, LLC研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名hydralazine + ISDN, BiDil, ISDN + hydralazine
公司Arbor Pharmaceuticals, LLC
药物类别小分子
分子靶点CACNA1C
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Arbor Pharmaceuticals, LLC

作用机制

分子靶点

isosorbide dinitrate + hydralazine 作用于 1 个分子靶点：

CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

isosorbide dinitrate + hydralazine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersCardiac failure✓ Approved

相关研究文献

PubMedChemical science2026-08-04

Borane-assisted hydride addition and dihydrogen reductive elimination at iridium: a gateway to Ir(-i)/Ir(i) redox catalysis.

Kameo Hajime H, Kawahara Younosuke Y, Shimoyama Yoshihiro Y, Kambayashi Takuto T et al.

The σ-electron accepting character of the Z-type borane ligand enables hydride addition to the neutral Ir(i) carbonyl hydride complex 1 upon reaction with potassium alkoxide, concomitantly affording a ketone and an anionic Ir(i) complex 2 bearing two terminal hydride ligands. Single-crystal X-ray diffraction, T 1 measurements, IR (ν CO), XPS (Ir 4f7/2), and DFT analyses support a d 8 Ir(i) assignment for 2. Thermolysis of 2 triggers H2 reductive elimination to give the structurally characterized tetrahedral Ir(-i) carbonyl complex 3 and exposure of 3 to H2 cleanly regenerates 2, substantiating a reversible Ir(-i)/Ir(i) oxidative addition/reductive elimination process. This process is amenable to catalysis, as illustrated by the dehydrogenation of a secondary alcohol, highlighting the potential of Lewis-acidic Z-type ligands to access unconventional low-valent redox chemistry at iridium.

PMID 42549106
阅读全文 →
PubMedEcotoxicology and environmental safety2026-08-04

Perfluorooctanoic acid-induced exacerbation of myocardial ischemia-reperfusion injury: Roles of peroxisome proliferation activated receptor alpha-related fatty acid metabolism.

Chen Chen C, Bu Fangfang F, Gao Ya Y, Wang Yilin Y et al.

Perfluorooctanoic acid (PFOA) exposure has been associated with various negative effects on the cardiovascular system, including myocardial infarction. During myocardial infarction, ischemia-reperfusion (IR) injury is an important event, significantly affecting prognosis, while the effects of PFOA exposure on IR injury were not previously investigated. In the current study, C57B6 mice were pre-exposed to 0.005, 0.05 or 0.5 mg/kg/day PFOA for four weeks, and then IR injury was achieved with left anterior descending coronary artery ligation. The severity of IR injury was assessed with echocardiography, 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin & eosin staining and Masson trichrome staining, along with serum biomarkers for myocardial injury and oxidative stress. To investigate the molecular mechanism, peroxisome proliferation activated receptor alpha (PPAR alpha) antagonist GW6471 was co-administered with PFOA, and animals were subjected to identical morphological, functional and biochemical evaluations. qRT-PCR and western blotting were utilized to assess PPAR alpha downstream genes: carnitine palmitoyl transferase 1b (CPT1b) and fatty acid binding protein 3 (FABP3) in heart tissue samples. The results indicated that pre-exposure to 0.05 or 0.5 mg/kg PFOA for 4 weeks significantly increased the severity of IR injury as indicated by morphological, functional and biochemical parameters, while co-administration of GW6471 alleviated such effects. Pre-exposure to PFOA significantly elevated the expression of CPT1b and FABP3 in myocardial tissues, whose extent corresponded to the severity of IR injury well. Meanwhile, co-exposure to GW6471 effectively alleviated such changes, suggesting that activation of PPAR alpha related fatty acid metabolism is likely involved in PFOA-mediated exacerbation of IR injury.

PMID 42546566
阅读全文 →
PubMedDalton transactions (Cambridge, England : 2003)2026-08-04

Simple FT-IR determination of electron richness in metal-supported faujasites.

Serrano-Maldonado Alejandro A, Lerma-Berlanga Belén B, Zheng Yongkun Y, Mon Marta M et al.

We show a simple way to compare the electronic properties of a zeolite framework by a standard FT-IR analysis, after following the shift of the peak at ∼600 cm-1, which corresponds to the Si-O-Si bond bending [double ring (DR6)] vibrations of the framework. The FT-IR peak can significantly redshift from one metal-supported zeolite to another depending on the reduction degree of the metal. These results bring an extremely fast, inexpensive and non-destructive method to assess the electron density in metal-supported zeolites.

PMID 42549508
阅读全文 →
PubMedJournal of chromatography. A2026-08-04

Complementary application of high-speed gas chromatography and Fourier transform infrared spectroscopy for enhanced partial least squares modeling and prediction of the physical properties of kerosene-based rocket and jet fuels.

Ma Wenjing W, Parker Valencia M VM, Synovec Robert E RE

It is well established that partial least squares (PLS) regression is a powerful chemometric tool for linking complex fuel composition data to physicochemical properties when coupled with either gas chromatography (GC) or Fourier transform infrared spectroscopy (FT-IR). In this report, we investigate combining the analysis of high-speed GC with flame ionization detection (GC-FID) data with FT-IR data via data augmentation strategies with PLS modeling to optimize the prediction of viscosity, hydrogen content, heat of combustion, and density across a diverse set of 50 kerosene-based fuels. High-speed GC-FID separations were performed at 2-min and 5-fold slower at 10-min separation times, while comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC × GC-TOFMS) served as a high-resolution method to benchmark the PLS modeling performance. PLS models constructed from GC × GC-TOFMS achieved normalized root mean square error of prediction (NRMSEP) values of 2.9% (viscosity), 6.7% (hydrogen content), 10.6% (heat of combustion), and 3.4% (density). GC-FID models with 10-min separations produced similar performance with NRMSEPs of 3.1%, 7.0%, 9.8%, and 3.2%, respectively, while the high-speed 2-min separations yielded 2.7%, 7.4%, 8.1%, and 5.7%. FT-IR models provided competitive performance, achieving NRMSEPs of 5.1% (viscosity), 3.4% (hydrogen content), 9.9% (heat of combustion), and 2.0% (density). Data augmentation of 2-min GC-FID separations and FT-IR spectra further improved the PLS models, yielding NRMSEPs of 2.7% (viscosity), 4.5% (hydrogen content), 6.9% (heat of combustion), and 3.6% (density). Overall, the results demonstrate that high-speed GC-FID and FT-IR spectroscopy provide synergistic analytical modalities with data augmentation for rapid and robust fuel property prediction.

PMID 42546509
阅读全文 →
PubMedAnalytical and bioanalytical chemistry2026-08-04

In-source freezing of Trifolium repens leaf tissue to increase spatial resolution and quench stress responses during IR-MALDESI mass spectrometry imaging.

Mills Quinn Q, Muddiman David C DC

Mass spectrometry imaging (MSI) is a robust analytical tool for resolving the spatial localization of diverse metabolites in a tissue sample simultaneously. Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) is particularly advantageous for analyzing leaf tissue, since it bypasses the cuticle and uses endogenous water in the sample as a matrix, avoiding delocalization and reducing costs associated with sample preparation. While direct analysis of fresh tissue offers substantial benefits, it also presents a less-discussed challenge: plants initiate a cascade of metabolic responses to various forms of stress (e.g., mechanical wounding, heat stress), so freshly-harvested tissue can undergo major metabolic changes before and during analysis. Herein, a method is introduced which retains the benefits of IR-MALDESI MSI but increases spatial resolution and quenches metabolic processes by quickly freezing leaf tissue within the source enclosure immediately after harvest. Leaf samples were mounted on a glass slide with carboxymethylcellulose gel immediately after harvest and moved into the source enclosure, humidity was purged, and the sample was frozen using the Peltier-cooled stage. Camera images demonstrated minimal ice deposition on the sample surface, and evaluation of the phenylpropanoid pathway suggested that freezing the sample inhibited post-harvest stress responses during and prior to analysis. Frozen tissue analysis significantly decreased ablation spot diameter from 65.4 to 43.9 µm, enabling approximately a 1.5-fold increase in spatial resolution with a conventional 2.97-µm IR laser.

PMID 42547592
阅读全文 →
PubMedRadiologic clinics of North America2026-08-04

Interventional Procedures in Pediatric Musculoskeletal Diseases.

Gazzotti Silvia S, Aparisi Gómez Maria Pilar MP, Guglielmi Riccardo R, Guglielmi Giuseppe G et al.

Interventional radiology (IR) procedures are becoming increasingly relevant in the management of musculoskeletal disorders due to their high precision and low invasiveness. However, specific considerations need to be made when applied to children and adolescents, especially in terms of anesthetic care and radioprotection. The aim of this article is to provide a description of the main IR procedures available for the treatment of benign and malignant bone tumors, septic arthritis, and rheumatic diseases in the pediatric population (including radiofrequency ablation, high-intensity focused ultrasound, intralesional injection of sclerosing agents or steroids, biopsies, and embolization), summarizing available evidence and outlining distinctive aspects.

PMID 42547156
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多isosorbide dinitrate + hydralazine