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ethyl icosapentate (MND2119 / MND 2119 / icosapent, Mochida)

✓ Approved

Sumitomo Pharma Co., Ltd. · 小分子 · 小分子

什么是 ethyl icosapentate？

ethyl icosapentate 是一种小分子，由Sumitomo Pharma Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名MND2119, MND 2119, icosapent, Mochida
公司Sumitomo Pharma Co., Ltd.
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Sumitomo Pharma Co., Ltd.

治疗适应症

ethyl icosapentate 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersHyperlipidaemia✓ Approved
Metabolism and nutrition disordersHypertriglyceridaemiaPhase III

相关研究文献

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Nitro- and nitrooxy-organic inhibitors of methanogenesis: revealing knowledge gaps and alternate ways in bovine rumen microbiome metabolism.

Mukhopadhyay Biswarup B

In the rumen, methanogens consume H2, generating methane and thermodynamically facilitating the production of short-chain fatty acids (SCFAs), ruminants' main energy source. Yet in animal trials, inhibiting methanogenesis by 27%-90% with 3-nitrooxypropanol minimally perturbs ruminal SCFA levels, sparing disproportionately low amount of H2. An Applied and Environmental Microbiology article (A. Castaneda, N. Indugu, K. Challa, K. Narayan, et al., Appl Environ Microbiol e01033-25, 2025, https://journals.asm.org/doi/10.1128/aem.01033-25) reports similar outcomes in an in vitro rumen experiment where ethyl-nitroacetate and ethyl-2-nitropropionate inhibited methanogenesis 100%. Hence, the rumen has fallback ways, perhaps evolved through exposures to plant metabolites. The nitroorganics offer an opportunity to determine the consequences of 100% inhibition of ruminal methanogenesis in live animals.

PMID 42550502
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Cu(ii) complex of a furoic acid-derived amide-imine conjugate for fluorescence detection of Th4+ with anticancer and molecular docking studies.

Changdar Sutapa S, Mitra Pritish P, Chatterjee Sabyasachi S, Suryakanta Uday U et al.

A furoic acid derived amide based imine derivative has been employed to prepare a copper complex (C2) which is characterized by different analytical as well as spectroscopic techniques and, structurally authenticated by SC-XRD analysis. The C2 is explored for selective detection of Th4+ in ethyl acetate medium via 'turn-on' fluorescence, following the metal ion displacement protocol. The associated binding constant and detection limit for Th4+ are 3.03 × 105 M-1 and 7.58 nM respectively. ESI-MS spectrum and Job's plot confirm 1 : 1 (mole ratio) stoichiometric interaction. The C2 shows cytotoxicity against human colon cancer cell lines such as HCT 116 and a breast cancer cell line, MCF 7 having IC50 values of 2.07 µM and 1.72 µM, respectively. Moreover, molecular docking studies unveil drug-like behavior, along with the mode of action of C2 towards retrieved proteins.

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Use of household super glue to close wounds in remote environments.

Tremayne Vincent Paris VP

Ethyl-cyanoacrylate (household super glue) is similar to medical-grade adhesive and is easily found in supermarkets and hardware shops. It can be used to close wounds when medical care is not easy to access and no other form of wound closure is available, for example when travelling or living in remote environments. While it is inexpensive and can be effective, using super glue to close wounds is not without risk and it could cause tissue damage, infection and significant burns if used incorrectly. This article explains when it would be appropriate to use super glue to close a wound, its similarities to medical-grade adhesive and its antimicrobial properties. It includes a step-by-step guide to using super glue to close a wound. The article aims to prepare nurses to reduce harm when super glue is the only option to close wounds in remote areas.

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PubMedFood chemistry: X2026-08-04

Unraveling the unique flavor characteristics and bioactive properties of Pingshan multistep fermented vinegar: a comparative study with the four famous vinegars of China.

Yang Dixinxin D, Li Zegang Z, Song Jiajia J, Suo Huayi H et al.

China's Four Famous Vinegars are recognized as industrial benchmarks and have been broadly studied. In contrast, the systematic quality characterization of Pingshan multistep fermented vinegar, a regional traditional Chinese vinegar, remains largely unexplored. We herein established a systematic comparative quality evaluation strategy by integrating high-performance liquid chromatography, gas chromatography-mass spectrometry, in vitro antioxidant assays, and multivariate statistical analysis. The results demonstrated that Pingshan multistep fermented vinegar exhibits the highest total phenolic content, with chlorogenic acid and vanillic acid as the main differential phenolics among the nine targeted analytes, and showed comparable DPPH and ABTS radical scavenging activities to benchmark vinegars. Furfural was the top differentiating volatile with characteristic abundance in PMFV, and ethyl butyrate along with 18 other odor-active compounds (odor activity value >1) are the main contributors to its aroma profile. The coordinated composition of organic acids and free amino acids forms its relatively balanced taste-related chemical profile.

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Ion transport mediated pH-responsive MRI contrast in dual wrapped MSNs.

Smith James P JP, Duncan Anna M AM, Ellis Connor M CM, Kerckhoffs Aidan A et al.

Functionalised polymers act as environmentally-responsive coatings, capable of sterically gating water exchange between bulk and Gd(iii) centres within mesoporous silica nanoparticles (Gd-MSNs). Using poly(2-(dimethylamino)ethyl methacrylate) (pDMAEMA, pK a = 6.4) this water barrier is pH actuated (MRI 'on' at pH < pK a, MRI 'off' at pH > pK a). Such pH-responsive polymer coated Gd-MSNs can subsequently be enveloped within vesicular structures, further limiting water access, providing an improved MRI 'off' state for the so-generated dual-wrapped structure (r 1 = 2.4 ± 0.2 mM-1 s-1, pH 8.0, 1.41 T, 298 K) compared with the polymer alone. When ion carriers (here a chloride-transporting tripodal thiourea alongside a protonophore, carbonyl cyanide m-chlorophenyl hydrazone) are integrated, it is possible to couple this pH gating to specific symport ion transport such that, ultimately, ionic rcognition triggers a ∼500% magnitude enhancement in relaxivity (r 1 = 14.5 ± 0.8 mM-1 s-1 at pH 5.0).

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Evaluation of the pharmacological effects of extracts and newly isolated phenolic acid glycosides from Gymnosporia chevalieri stems.

Doan Nghia Ai Thi NAT, Le Thi Hong Van THV, Nguyen Hoai Thi HT, Nguyen Hien Minh HM et al.

The stem extracts of Gymnosporia chevalieri were systematically evaluated for their biological activities. The methanol (M), the n-hexane (H), ethyl acetate (E), and water (W) extracts showed dose-dependent cytotoxic effects against human lung cancer cell lines (A549 and H460). The E and W extracts had selective cytotoxicity toward cancer cells compared with normal cells (BEAS-2B). The extracts also effectively suppressed cancer cell proliferation, migration, and invasion at non-cytotoxic concentrations, indicating strong anti-metastatic potential. Antioxidant evaluations showed that the E extract possessed the highest total phenolic and flavonoid contents and demonstrated the strongest ferric reducing antioxidant power and reducing power values, as well as the most potent ABTS and DPPH radical-scavenging activities, indicating a strong correlation between phenolic-flavonoid composition and antioxidant capacity. All extracts also displayed tyrosinase inhibitory activity, with the E and W extracts being more active than the M and H extracts. In parallel, pronounced anti-inflammatory effects were observed with the E and H extracts, as evidenced by inhibition of NO production. Phytochemical investigation further led to the identification of a mixture of two new phenolic glycosides, gymnosporosides A and B (1a-b), together with seven known components, thereby expanding the structural diversity to the Gymnosporia genus.

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