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COVID-19 vaccine (ZF2001 / Zifivax / ZF 2001)

✓ Approved

Anhui Zhifei Longcom Biopharma · 重组蛋白 · 重组蛋白

什么是 COVID-19 vaccine？

COVID-19 vaccine 是一种重组蛋白，由Anhui Zhifei Longcom Biopharma研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名ZF2001, Zifivax, ZF 2001
公司Anhui Zhifei Longcom Biopharma
药物类别重组蛋白, 疫苗
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, Anhui Zhifei Longcom Biopharma

治疗适应症

COVID-19 vaccine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsCOVID-19✓ Approved

相关研究文献

PubMedVaccine2026-06-13

Vaccine uptake in the context of mandate announcement and removal: Evidence from Europe and North America.

Gebremariam Aregawi G AG, Genie Mesfin M, Le Huong H, Regan Annette A et al.

The COVID-19 pandemic drove the implementation of vaccine mandates to protect spaces and/or increase vaccine uptake, though their design, timing, and scope varied across jurisdictions. This study examines the associations of vaccine mandate announcements and removals with COVID-19 vaccine uptake in France, Italy, and California (USA). We employed interrupted time series (ITS) analysis using aggregated data from Our World in Data and the Oxford COVID-19 Government Response Tracker. The primary outcomes were the weekly number of first and booster doses per 100,000 people. We estimated changes in the rate and trend of vaccine uptake following policy announcements and removals, adjusting for COVID-19 cases, deaths, and temporal autocorrelation to account for other influencing factors. Initial mandate announcements were associated with immediate increases in vaccine uptake: 113% (95% CI: 63 to 178%) in Italy, 195% (95% CI: 113 to 308%) in France, and 32% (95% CI: 16 to 51%) in California. However, these associations attenuated in more fully adjusted models, especially in France, where the initial association was no longer statistically significant after controlling for epidemiological conditions and temporal autocorrelation. Mandate removals were more consistently associated with declines in booster uptake in Italy and France, including declines of 62% (95% CI: -74 to -45%) and 70% (95% CI: -79 to -57%), respectively, while partial removal in California coincided with increased booster uptake. Vaccine mandate announcements were associated with short-term increases in vaccine uptake during key periods of the pandemic. Their removal was often associated with a slowing in uptake, highlighting the need for coordinated communication strategies to sustain coverage. Future policy responses should consider timing, mandate design, and transition planning in contexts where such policies are used.

PMID 42284807
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PubMedVaccine2026-06-13

Maternal and infant immunizations for respiratory diseases, United States, may 2025.

Razzaghi Hilda H, Garacci Emma E, Kahn Katherine E KE, Meghani Mehreen M et al.

To assess end-of-season coverage with influenza, tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap), and COVID-19 vaccines among pregnant women, and respiratory syncytial virus (RSV) immunization among pregnant women and their infants, during the 2024-25 respiratory illness season. Data from an Internet panel survey conducted during March 26-May 8, 2025, were analyzed. The study included 2738 currently and recently pregnant women; analysis of each immunization product was restricted to a subsample of participants eligible for the specific product (influenza: 1788; Tdap: 885; COVID-19: 2125; maternal RSV: 721; nirsevimab: 1416). Coverage was assessed for individual vaccines, along with demographic characteristics, provider recommendation for immunization, and attitudes, including perceptions on safety and effectiveness of vaccines. Differences in vaccination coverage between groups were assessed using t-tests. Among eligible participants, 51.0% reported receiving influenza vaccine before or during pregnancy, 52.6% reported receiving Tdap vaccine during pregnancy, 32.3% reported receiving the 2024-25 COVID-19 vaccine before or during pregnancy, and 49.3% reported receiving an RSV vaccine during pregnancy. Among 1416 women with eligible infants, 62.2% reported their infant received nirsevimab; overall, 70.4% of infants were protected by maternal RSV vaccine, nirsevimab, or both. Vaccination coverage was higher among women with a provider recommendation compared to those without for influenza (65.6% vs. 12.2%), Tdap (69.5% vs. 2.9%), and COVID-19 (56.4% vs. 4.4%) vaccines. Prevalence of provider recommendation for Tdap vaccination was lower among non-Hispanic Black (66.4%) and Hispanic women (60.1%) compared with non-Hispanic White women (83.2%). Women reporting being very/somewhat hesitant about a given vaccine were less likely than non-hesitant women to have received that vaccine. Provider recommendation and vaccine hesitancy were associated with maternal vaccine uptake. Because providers have been found to be trusted information sources for patients, efforts supporting informative vaccine conversations between providers and pregnant women could help increase the proportion of pregnant women and infants protected against severe respiratory illnesses.

PMID 42284808
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PubMedBMC primary care2026-06-13

Parental hesitancy and refusal toward routine childhood vaccination after the COVID-19 vaccination period: a cross-sectional study.

Eliaçık Ozan Emre OE, Çöme Oğulcan O, Günvar Tolga T

The COVID-19 pandemic intensified public debates on vaccines, amplifying concerns about safety, side effects, rapid development, and institutional trust. These concerns may be associated with current attitudes toward routine childhood immunization. This study assessed parental intentions regarding routine childhood vaccination among parents whose children had previously completed routine immunizations. This cross-sectional analytical study included 320 parents of children aged 4-8 years who had completed routine childhood vaccinations and registered at Dokuz Eylul University Training Family Health Centers. Participants were selected by simple random sampling. Data were collected using a sociodemographic questionnaire, literature-based items on vaccine attitudes, and the Vaccine Hesitancy Scale. Analyses employed descriptive statistics, chi-square, t-tests, ANOVA and multinomial logistic regression. Among parents whose children had completed routine immunizations before the pandemic, 9.7% reported refusal and 23.4% reported hesitancy if deciding today. In the multivariable model, lower educational status was independently associated with hesitancy, whereas lower income was associated with outright refusal. Previous acceptance of non-reimbursed childhood vaccines was inversely associated with both hesitancy and refusal. Side-effect perception, concerns about vaccine production and distrust in healthcare providers were independently associated with hesitancy, while vaccine effectiveness concerns and distrust in healthcare providers were independently associated with refusal. Hesitancy and refusal were observed among parents whose children had previously completed routine immunizations. Educational and socioeconomic factors, prior optional vaccine acceptance, vaccine-related concerns and healthcare provider trust were associated with current vaccination intention. Primary care-based, individualized vaccine communication is needed, while causal attitude changes cannot be inferred from this cross-sectional design.

PMID 42286487
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PubMedAmerican journal of human biology : the official journal of the Human Biology Council2026-06-13

Relationships Among Maternal Epstein-Barr Virus Antibodies, COVID-19, and Stress in Mothers up to 1-Year Postpartum.

Anastasi Emma E, Glass Delaney J DJ, Pan Tiffany D TD, Brindle Eleanor E et al.

Both psychosocial stress and current infection can increase the likelihood of reactivation of latent Epstein-Barr virus (EBV). Pregnancy and infection with SARS-CoV-2 can be stressful and modulate immune function. However, it is unknown how SARS-CoV-2 infection and stress further interact among postpartum women to affect EBV antigen and antibody expression. We examined associations among COVID-19 diagnosis, self-reported stress, and EBV immunoglobulin G (IgG) in previously collected data from 45 breastfeeding US women (1-18 months postpartum) during the height of the COVID-19 pandemic. Between June 2020 and March 2021, stress survey data and capillary dried blood HemaSpot samples were collected from 25 SARS-CoV-2 infected and 20 non-infected participants at multiple time points over the course of 60 days. Samples (N = 104) were later assayed for EBV IgG. Statistical methods were pre-registered, and relationships among SARS-CoV-2 infection, stress, and EBV IgG were analyzed via mixed-effects regression models, adjusting for time postpartum and time elapsed since enrollment. There was a statistically significant association between self-reported stress and EBV IgG levels, with higher average stress associated with higher average EBV IgG. EBV IgG relative concentration did not vary independently with COVID-19 positivity status or the number of COVID-19 symptoms. Results suggest that EBV IgG relative concentrations were elevated across sample participants by stress, but not by the relatively mild cases of COVID-19 the mothers experienced.

PMID 42286962
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PubMedSpatial and spatio-temporal epidemiology2026-06-13

A retrospective analysis of COVID-19 clusters in the Québec population from 2020 to 2022.

Saucier Adrien A, Charland Katia K, Fortin Élise É, Lacroix Christine C et al.

Throughout the pandemic, COVID-19 cases tended to organize into spatial clusters. In the absence of individual and/or network information on cases, however, surveillance systems face challenges in identifying the pathways through which these clusters emerge. Using Québec COVID-19 surveillance data from 2020 to 2022, this study identified characteristics associated with the likelihood of being among the first cases in a cluster. Our results show that young adults were consistently at higher risk of constituting the first cases of large community clusters across all waves, suggesting that closer monitoring of COVID-19 incidence in this age group could be pivotal for early detection of emerging clusters or new waves. Overall, our study provides valuable insights for public health authorities by helping to identify priority groups at the forefront of cluster emergence and by supporting the development of tailored and adaptive interventions.

PMID 42285631
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PubMedScientific reports2026-06-13

COVID-19 awareness and preparedness in secondary schools, Egypt.

Abdel Ghani Nahed M NM, Abd El-Wahab Ekram W EW, Mehanna Azza A, Osman Sherif Omar SO

The COVID-19 pandemic emphasized the need for health literacy and preparedness in schools. Evaluating students' awareness and school readiness is crucial to identify gaps and guide effective interventions for safer educational environments. This study aimed to assess knowledge, attitude, practice (KAP), and school environmental preparedness regarding COVID-19 among secondary school students in Desouk City, Egypt. A cross-sectional study was conducted from January to May 2022 involving 800 students from five randomly selected schools using proportional and systematic random sampling. Data was collected through a self-administered questionnaire and an adapted school environment inspection checklist. Participants had a mean age of 15.95 ± 1.11 years, and most were female (54.5%). The internet (58.8%) and social media (40.4%) were their main sources of COVID-19 information. While 60.6% had good knowledge about the disease, the majority demonstrated poor attitudes (52.9%) and practices (56.1%). Recognition of key symptoms like anosmia and dyspnea was relatively high. Female students and those attending a specific private school were more likely to have good knowledge. Despite satisfactory knowledge levels, gaps remain in students' attitudes and practices. Interventions tailored to their primary information sources are recommended, alongside school-level efforts to foster a health-supportive environment.

PMID 42286016
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