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streptokinase (Heberkinase)

✓ Approved

YM BioSciences Inc. · PLG · 重组蛋白

什么是 streptokinase？

streptokinase 是一种重组蛋白，由YM BioSciences Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Heberkinase
公司YM BioSciences Inc.
药物类别重组蛋白
分子靶点PLG
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, YM BioSciences Inc.

作用机制

分子靶点

streptokinase 作用于 1 个分子靶点：

PLGplasminogen (HAE4)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

streptokinase 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersMyocardial infarction✓ Approved

相关研究文献

PubMedChemistry & biodiversity2026-07-30

The Phytochemical Investigation, Thrombolytic, and Antioxidant Activity of Clerodendrum thomsoniae Balf.

Surana Ajaykumar Rikhabchand AR, Patil Prathamesh Shyam PS, Jadhav Ankita Mulchand AM, Narkhede Harsha Iccharm HI et al.

Clerodendrum thomsoniae Balf. f. (Lamiaceae) is commonly known as the bleeding-heart vine or glory tree and traditionally used for treating blood-related disorders. This research investigated the phytochemical constituents, antioxidant capacity, and thrombolytic potential of leaf extracts. Among the extracts, the ethanol extract exhibited the highest total phenolic content, which correlated with its strong antioxidant activity demonstrated through multiple assays including DPPH, hydrogen peroxide, nitric oxide (NO) scavenging, and ferrous ion chelation. The petroleum ether extract showed notable thrombolytic activity by effectively lysing blood clots, achieving 34.52% clot lysis, which was significantly higher than the negative control (7.89%) but lower than the standard drug streptokinase (60.23%). Through GC-MS analysis, identified several bioactive compounds including sterols and fatty acids, which likely contribute these health benefits. These results suggest that C. thomsoniae leaves are a promising natural alternative for managing cardiovascular disorder and oxidative stress. Further in vivo studies and isolation of active compounds are essential.

PMID 42531223
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PubMedBasic research in cardiology2026-07-18

Historical account of reperfusion therapy and the development of cardioprotection beyond reperfusion.

Heusch Gerd G, Kleinbongard Petra P, Gersh Bernard J BJ

The only way to salvage myocardium from infarction is timely reperfusion of the occluded coronary artery. Timely reperfusion reduces infarct size and mortality. The history of reperfusion therapy from the first clinical use of intravenous streptokinase in patients with acute myocardial infarction by Sherry et al. in the late 1950s, over seminal experimental dog studies by Ross Jr. et al., demonstrating infarct size reduction by timely reperfusion in the early 1970s, to a more systematic use of initially streptokinase and a later tissue plasminogen activator in clinical trials (GISSI, TIMI), the addition of platelet inhibition (ISIS) and ultimately mechanical recanalization by percutaneous coronary intervention with stenting, is reviewed in detail. Cardioprotection beyond timely reperfusion was first demonstrated in the seminal experimental dog studies of ischemic conditioning by Murry, Reimer, and Jennings in the 1980s and initiated a tsunami of experimental studies in various experimental models to identify the underlying signal transduction, but has not yet been established in clinical practice. Clinical trials on various forms of ischemic conditioning, potentially cardioprotective drugs and transcutaneous vagal nerve stimulation, are still underway.

PMID 42469452
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PubMedBMC cardiovascular disorders2026-07-15

Recurrent bilateral lower limb arterial embolism secondary to left ventricular thrombus in peripartum cardiomyopathy successfully treated with systemic streptokinase thrombolysis: a rare case report.

Ibrahim Raghad R, Alharbi Mohamad M, Hossin Huda H, Ibrahim Rahaf R et al.

Peripartum cardiomyopathy (PPCM) is an uncommon but potentially life-threatening form of heart failure occurring toward the end of pregnancy or during the months following delivery in women without pre-existing heart disease. Left ventricular systolic dysfunction predisposes patients to intracardiac thrombus formation and systemic thromboembolic complications, which are associated with significant morbidity and mortality. A 35-year-old multiparous woman presented shortly after spontaneous vaginal delivery of an intrauterine fetal demise with acute right lower-limb ischemia and heart failure. Transthoracic echocardiography demonstrated severe left ventricular systolic dysfunction (LVEF approximately 35%), severe functional mitral regurgitation, pulmonary hypertension, and a large left ventricular thrombus. She underwent urgent Fogarty embolectomy followed by therapeutic anticoagulation with unfractionated heparin and warfarin. Despite therapeutic anticoagulation (INR 2.0 and activated partial thromboplastin time approximately 90 seconds), she developed recurrent bilateral acute lower-limb ischemia five days later. Because of profound hemodynamic instability and prohibitive surgical risk, systemic streptokinase thrombolysis was administered. Repeat echocardiography performed immediately after thrombolysis demonstrated complete resolution of the left ventricular thrombus. Follow-up echocardiography one week later showed significant recovery of left ventricular systolic function (LVEF 45-50%), improvement of mitral regurgitation to mild-to-moderate, and reduction in pulmonary artery systolic pressure. This case highlights the importance of early recognition of thromboembolic complications in PPCM and demonstrates that systemic streptokinase thrombolysis may represent an effective life- and limb-saving therapeutic option in carefully selected patients when surgical or catheter-based interventions are not feasible.

PMID 42449265
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PubMedInternational journal of emergency medicine2026-07-12

Extensive coronary thrombosis following cannabis use in a young adult: a case report.

Saha Rupendra Nath RN, Duggal Bhanu B, Chawla Raghuraj R, Swain Akash A et al.

Cannabis use has been increasingly associated with acute coronary syndromes in young adults without conventional cardiovascular risk factors. The psychoactive compound Δ⁹-tetrahydrocannabinol (THC) exerts sympathomimetic, endothelial, and prothrombotic effects that may precipitate myocardial infarction through platelet activation and vasospasm. A 34-year-old man, a chronic cannabis user, presented with acute anterior ST-segment elevation myocardial infarction. Coronary angiography demonstrated a large thrombus involving the left main and proximal left anterior descending arteries, with complete mid-LAD occlusion (TIMI 0). In view of the extensive thrombus burden, 300,000 International units of intracoronary streptokinase followed by 1,200,000 IU intravenously was administered, resulting in significant thrombus resolution and restoration of TIMI II flow. The patient recovered uneventfully on dual antiplatelet therapy, statin, and anticoagulation. Cannabis associated thrombosis may involve multiple interrelated mechanisms: (i) catecholamine surge with tachycardia and vasospasm, (ii) endothelial dysfunction, and (iii) direct platelet activation via CB₁ and CB₂ receptors leading to increased thromboxane A₂ and P-selectin expression. This case illustrates a possible association between chronic cannabis exposure and large-vessel thrombosis in the absence of significant angiographic atherosclerosis. Intracoronary fibrinolysis may be considered in selected cases with prohibitive thrombus load where primary PCI is unsafe. This case underscores the prothrombotic potential of cannabis and highlights the need to recognize its cardiovascular risks. Understanding the cannabinoid-platelet-vascular axis may help prevent and manage cannabis-related coronary events. Not applicable as not a clinical trial.

PMID 42436387
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PubMedEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026-07-08

Streptococcal toxic shock syndrome caused by ST525 Streptococcus dysgalactiae subsp. equisimilis with genomic characterization of virulence and antimicrobial resistance.

Tsuji Shuma S, Fukushima Shinnosuke S, Gotoh Kazuyoshi K, Iio Koji K et al.

Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of severe invasive infections. We describe the clinical course of an immunocompromised patient with advanced breast cancer who developed streptococcal toxic shock syndrome, necrotizing fasciitis, and disseminated intramuscular abscesses caused by a multidrug-resistant Lancefield group G SDSE isolate, alongside a comprehensive genomic characterization of its virulence and antimicrobial resistance profiles. Genomic analysis identified the isolate as emm subtype stG840.0 and sequence type 525 (ST525), harboring genes encoding several virulence-associated factors, including an emm-like gene encoding an M-like surface protein, streptokinase, streptolysin O, streptolysin S, and SpeG. Through comprehensive genomic analysis of the highly virulent SDSE isolate, we provided insights into its underlying genetic background. Further accumulation of genomic data is expected to fully elucidate the mechanisms of virulence and antimicrobial resistance in SDSE.

PMID 42418061
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PubMedJACC. Case reports2026-06-18

Kounis Syndrome Triggered by Hymenoptera Stings and Exacerbated by Streptokinase.

Chai Siew Yap SY, Liew Kai Soon KS, Soh Kok Ming KM, Subramanian Seetha Devi SD et al.

Kounis syndrome (KS) is an allergy-mediated acute coronary syndrome that is frequently under-recognized and potentially life threatening. A 52-year-old man developed an inferior ST-segment elevation myocardial infarction following a bee swarm attack. Standard thrombolysis with streptokinase triggered severe hemodynamic collapse and systemic hemorrhage. Upon recognizing KS, management was shifted to steroids and antihistamines, leading to complete recovery. Recurrence was documented 8 years later following an ant bite. This case illustrates how standard acute coronary syndromes treatments, such as antigenic thrombolytics, can inadvertently exacerbate the allergic cascade in KS. It highlights the need to maintain a high index of suspicion when cardiac symptoms follow an allergic trigger. Avoid antigenic thrombolytics when KS is suspected to prevent iatrogenic clinical deterioration. Primary percutaneous coronary intervention and early allergy management are the preferred clinical strategies.

PMID 42313027
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