tamsulosin (tamsulosin WOWTAB / Harnal D)

Sustained-release local anesthetics: advances in drug delivery systems for prolonged postoperative analgesia.

Oh Seok Kyeong SK, Hong Sang Hyun SH, Shim Jung-Woo JW

Effective perioperative pain control is essential for patient comfort and for optimizing surgical outcomes and the quality of recovery. Multimodal analgesic strategies have become a cornerstone of modern perioperative pain management. Although regional analgesia is widely used within this framework, the clinical utility of conventional local anesthetics remains limited by their relatively short duration of action. Continuous infusion techniques can sustain local anesthetic delivery; however, catheter-based systems have several device- and technique-related limitations. In response, sustained-release local anesthetic formulations have been developed to extend analgesia after a single administration. These formulations include liposomal preparations, polymer-based delivery systems, and hydrogel-based carriers. Liposomal bupivacaine uses a multivesicular delivery system that acts as a local drug depot and gradually releases the anesthetic at the injection site. Polymer-based systems that combine local anesthetics with anti-inflammatory agents enhance analgesia by modulating the local tissue environment. Hydrogel-based carriers, including thermoresponsive and hyaluronic acid-based platforms, provide sustained drug release through three-dimensional polymer networks while minimizing systemic exposure. Recent advances in these delivery platforms have expanded the clinical potential of sustained-release local anesthetic technologies. Nevertheless, widespread clinical adoption remains constrained by several challenges, including burst release, variability in release kinetics, high costs, and limited clinical evidence. Sustained-release local anesthetic systems may provide catheter-free, prolonged postoperative analgesia in accordance with the principles of enhanced recovery after surgery. As drug delivery technologies continue to evolve, sustained-release local anesthetic formulations are likely to play an increasingly important role in perioperative pain management.

An Integrated Bio-Based Film With Dynamic Covalent Networks for Coupled pH-Responsive Release and Colorimetric Reporting.

Wang Tongtong T, Sun Hui H, Weng Yunxuan Y

A multifunctional smart film was fabricated via dynamic Schiff base cross-linking between quaternary ammonium chitosan (HACC) and dialdehyde cellulose (DAC), enabling the integrated encapsulation, controlled release, and visual indication of curcumin within a single matrix without external sensors. Structural analyses (FTIR, XPS) confirmed the formation of the pH-responsive dynamic network. Curcumin incorporation significantly enhanced the film's performance, increasing tensile strength (TS) by ∼60%, improving barrier properties, and providing potent antioxidant activity (DPPH scavenging efficiency approaching 90%). The swelling behavior and release kinetics of the films were highly pH-dependent. Rapid burst release dominated by nonFickian diffusion was observed under acidic conditions (pH 4.0), whereas slow, sustained Fickian diffusion-controlled release occurred in neutral and alkaline environments (pH 7.0 and 9.0). Owing to the intrinsic chromophoric properties of curcumin, the films displayed distinct and reversible pH-dependent color changes, transitioning from bright yellow in acidic media to reddish-brown in alkaline conditions, enabling intuitive visual monitoring of environmental changes. This work demonstrates an effective strategy for designing bio-based innovative packaging materials that integrate sensing, protection, and controlled release functions within a unified, dynamically responsive polysaccharide network.

Modified Yoong Ultrasound-Guided Rotator Interval Injection for Adhesive Capsulitis: A 2-Year Follow-Up.

Mohamad Azwan Aziz AA, Mohamad Norlelawati N, Ramlan Muhammad Karbela Reza MKR, Arif Nik Kamarul NK et al.

Adhesive capsulitis (AC) is characterized by progressive fibrosis of the glenohumeral capsule, with the rotator interval (RI) as a key pathological site. Ultrasound-guided hydrodilation of the RI (Yoong technique) is an established intervention, but traversal of a thickened coracohumeral ligament (CHL) can be technically challenging and painful. This study reports preliminary 2-year outcomes of a modified technique targeting the subacromial-subdeltoid (SASD) bursa at the RI, combined with immediate postinjection manipulation. A retrospective case series was conducted on 13 patients with AC in the frozen phase treated between January 2023 and September 2023 at a single sports medicine clinic. The modified technique involved ultrasound-guided SASD bursa injection (20 mL mixture: 4 mL 1% lidocaine, 15 mL 5% dextrose, 1 mL triamcinolone acetonide 40 mg) with mechanical fenestration of the CHL, followed by immediate shoulder manipulation. Outcomes included forward flexion, abduction, external rotation, Visual Analog Scale (VAS), and Quick DASH scores measured at baseline, 2, 12, 24, 52, and 104 weeks. Mean age was 51.9 years (SD 7.52); 92.3% were female; 53.8% had diabetes. Significant improvements were observed across all outcomes (p < 0.001). Forward flexion improved from 76.6° (SD 6.3°) at baseline to 178.6° (SD 3.7°) at 104 weeks; abduction from 60.6° (SD 6.3°) to 178.8° (SD 2.7°); external rotation from 31.3° (SD 9.1°) to 78.0° (SD 3.6°). VAS decreased from 5.6 (SD 0.9) to 0 at 52 and 104 weeks. Quick DASH improved from 86.7 (SD 5.8) to 0.2 (SD 0.7) at 104 weeks. No complications were reported. This modified SASD-targeted injection technique, combined with immediate manipulation, was associated with sustained pain relief and functional improvement over 2 years in a small cohort of AC patients.

TGFβ-1 induces the release of BAG3 protein by human fibroblasts.

Manzo Paola P, Cammarota Anna Lisa AL, Basile Anna A, Del Papa Nicoletta N et al.