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insulin Aspart (NovoMix 30 Penfill / NovoMix 30 FlexPen / NovoRapid 30 Mix)

✓ Approved

Novo Nordisk A/S · INSR · 重组蛋白

什么是 insulin Aspart?

insulin Aspart 是一种重组蛋白,由Novo Nordisk A/S研发。该药已获批,用于治疗相关适应症,给药途径:Injectable (Others)、Subcutaneous Injection。

药物档案

商品名NovoMix 30 Penfill, NovoMix 30 FlexPen, NovoRapid 30 Mix
公司Novo Nordisk A/S
药物类别重组蛋白
分子靶点INSR
给药途径Injectable (Others), Subcutaneous Injection
状态Approved

作用机制

分子靶点

insulin Aspart 作用于 1 个分子靶点:

INSRinsulin receptor (CD220, HHF5)
需要更深入的分析?Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

insulin Aspart 针对 2 个适应症,涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersType 2 diabetes mellitus✓ Approved
Metabolism and nutrition disordersType 1 diabetes mellitusPhase I

相关研究文献

PubMedAdvanced materials (Deerfield Beach, Fla.)2026-08-05

A Hydro-Organo Biphasic Gel Electrolyte for Decoupled Interfacial Stability and Fast Ion Transport in Zinc Metal Batteries.

Zheng Tianrui T, Ju Zhengyu Z, Jung Sung Hoon SH, Huang Juanjuan J et al.

Organic and aqueous electrolytes offer complementary advantages in electrochemical stability and ion transport, but integrating both within a single electrolyte remains challenging. In this study, it is discovered that a distinct interphase can be spontaneously formed between the aqueous and organic phases through the synergy of amphiphilic monomers, Hofmeister effects, and phase partitioning. This aqueous-organic, mixed-solvent region boosts ion transfer by smoothing solvation change across phases, resulting in an order-of-magnitude increase in overall conductivity over biphasic counterparts without such an interphase. Meanwhile, compartmentalized organo- and hydrogel domains decouple anodic and cathodic interfacial chemistries. Demonstrated in zinc metal batteries, this biphasic gel electrolyte thermodynamically stabilizes zinc metal anodes and inhibits parasitic ion crossover, while also enabling high-rate operation comparable to aqueous systems. Accordingly, Zn||Zn symmetric cells demonstrate >3,600 h stable cycling at 5 mA cm-2 and 5 mAh cm-2, and MnO2||Zn full cells show high capacity retention after >3,000 cycles at 10 A g-1. Overall, the findings establish organizing phase and solvation chemistry as a general materials design principle toward advanced electrolyte systems for high-power, long-duration electrochemical energy storage.

PMID 42554350
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PubMedJournal of diabetes science and technology2026-08-05

Real-World Outcomes of Automated Insulin Delivery Use in Hospitalized Adults With Diabetes.

Ruddiman Kathleen R KR, Evans Joni K JK, Aloi Joseph A JA, Usoh Chinenye C et al.

Automated insulin delivery (AID) systems are increasingly used by individuals living with diabetes in the outpatient setting, but data on their safety and effectiveness during hospitalizations remains limited. The objective is to evaluate the use and efficiency of AID systems in hospitalized adults with diabetes. We performed a retrospective cohort study based on electronic health record data from hospital admissions of 316 patients with diabetes using insulin pumps. Automated insulin delivery and continuous glucose monitor use, insulin pump continuation, length of stay (LOS), and glycemic outcomes among the cohort were analyzed. The primary aims of the study were to describe rates of insulin pump continuation and reasons associated with removal, and rates of pump reinitiation. Secondary outcomes included effects of insulin pump removal and prompt endocrinology consultation on inpatient glycemic outcomes and LOS. Insulin pumps were continued in 64.2% of all admissions. The most common reason for pump discontinuation was surgery (30.1%). Length of stay was longer when pumps were removed (8.3 vs 4.7 days, P < .001) and when endocrinology consultation occurred more than 24 hours after admission (P < .001). Insulin pump continuation was associated with lower hyperglycemia (glucose >180 mg/dL) rates without an increase in hypoglycemia (glucose <70 mg/dL) in both critical and noncritical care settings. Continuation of insulin pumps was associated with improvement in hyperglycemia without increased hypoglycemia risk and with shorter LOS in the hospital. Standardized institutional policies including prompt glycemic management team consultation may help expand safe continuation of AID during hospitalizations.

PMID 42554596
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PubMedArchive of clinical cases2026-08-05

A rare de novo prenatal case of Down syndrome due to der(21;21)(q10;q10).

Manea-Sabau Ileana-Delia ID, Curici Antoanela A, Lucuta Lavinia L, Ciurea Tudor T et al.

Down syndrome (DS) is the most common chromosomal abnormality in the human population, most frequently caused by trisomy 21 due to meiotic nondisjunction. Rarely, DS may result from an isochromosome or a Robertsonian translocation, this being the least common variant. We present a rare prenatal case of Down syndrome caused by a derivative chromosome 21, together with a case-based review of previously reported prenatal der(21;21)/i(21q) rearrangements. We report a case of prenatal diagnosis of DS in a 13-week female fetus, characterized by a derivative chromosome 21, der(21;21)(q10;q10), identified by conventional karyotyping and subsequently confirmed by fluorescence in situ hybridization (FISH). First-trimester ultrasonography showed bilateral jugular lymphatic sacs, marked tricuspid regurgitation, and a single umbilical artery. Quantitative fluorescence polymerase chain reaction (QF-PCR) failed to detect the structural chromosomal abnormality. The rearrangement was considered likely de novo based on normal parental karyotypes. Consequently, the empirical recurrence risk is 1% for de novo cases, whereas in families with a parental 21q;21q rearrangement the recurrence risk may approach 100%. This case highlights the importance of integrating detailed ultrasound screening with molecular and cytogenetic techniques, including QF-PCR, conventional karyotyping, and FISH, for accurate prenatal diagnosis of DS. Precise determination of the underlying chromosomal abnormality is essential for providing accurate genetic counseling, estimating recurrence risk, and facilitating informed reproductive planning for the parents.

PMID 42553666
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PubMedPloS one2026-08-05

In vitro evaluation of microfluidic WS6-loaded Eudragit nanoparticles for improving insulin-producing cell differentiation.

Abuarqoub Duaa D, Mohammad Marwa M, Albarghouthi Rand R, Abuoun Mohammad M et al.

This study explores a stem-cell-based approach for diabetes treatment by enhancing the viability and functionality of insulin-producing cells (IPCs) derived from stem cells of the apical papilla (SCAP). Although SCAP can differentiate into IPCs, limited cell survival remains a challenge. To address this, the proliferation enhancer WS6 was incorporated into Eudragit RS100 nanoparticles (NPs) using microfluidics. The WS6-loaded NPs were characterized for size, charge, PDI, morphology, stability, and drug loading. An MTT assay was performed as a preliminary screening method to evaluate the cytocompatibility of blank-NPs and to optimize treatment concentration. SCAP cells were treated with free WS6 or WS6-loaded NPs, and cellular uptake of NPs was evaluated using flow cytometry and fluorescence imaging. Additionally, the viability of treated cells was determined by propidium iodide (PI) and trypan blue. Prior to differentiation, definitive endoderm formation was assessed through SOX17 and FOXA2 expressions. After differentiation into IPCs, maturation markers such as insulin, C-peptide, PDX-1, NKX2.2, and NKX6.1 were examined, and apoptosis assays measured cell viability. Functional insulin secretion was tested using an in vitro glucose-stimulated insulin secretion (GSIS) assay. Results showed that WS6-loaded NPs significantly improved SCAP viability, increased healthy cell percentages, and enhanced IPC maturation. Treated IPCs demonstrated functional insulin secretion and improved glucose regulation. Overall, WS6-loaded NPs represent a promising approach to enhance IPC proliferation and generation for diabetes therapy.

PMID 42550869
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PubMedAmerican journal of medical genetics. Part A2026-08-05

An Adult Presentation of KIF11-Related MCLID Syndrome: Case Report and 40-Year Follow-Up.

Chathurvedula Thrishna T, Rabelas Juvy J, Touleimat Kareem K, Marchi Elaine E et al.

Pathogenic variants in KIF11 are linked to autosomal dominant syndromes with microcephaly, chorioretinopathy, lymphedema, and intellectual disability (MCLID), though adult presentations remain underreported. We report a 42-year-old female presenting with a de novo single-amino acid in-frame deletion in the KIF11 gene (c.1294_1296del; p.Glu432del), who exhibited severe intellectual disability, microcephaly, hypotonia, seizures, and self-injurious behavior. There was evidence of developmental delays, ophthalmologic findings, and impairments in speech and adaptive functioning in her clinical history. Trio whole exome sequencing identified a diagnostic pathogenic variant in KIF11 and a maternally inherited SCN3A variant of uncertain significance. The presentation of the case offers an unusual longitudinal perspective of over four decades, illustrating the variable expressivity and long-term outcome of KIF11 disorders. This report calls for the consideration of KIF11 variants in the differential diagnosis of syndromic developmental delay and microcephaly in adults and underlines the diagnostic as well as the prognostic importance of detailed genetic and phenotypic analysis, particularly in cases with de novo variants.

PMID 42552906
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PubMedAnimal cells and systems2026-08-05

De novo whole transcriptome sequencing reveals differentially expressed messenger RNA and MicroRNA in hepatopancreas of Pandalus hypsinotus.

Lee Du Hyeong DH, Kim Woo Ryung WR, Shin Hae Jin HJ, Kim Jung-Min JM et al.

Pandalus hypsinotus (P. hypsinotus), also known as coonstripe shrimp, has high economic value and is widely distributed in Alaska, the Bering Sea and the East Sea of Korea. However, owing to the low catch rates and patchy spatial distribution, transcriptome-based studies on this species remain limited. Transcriptome analyses using PacBio Iso-Seq and Illumina RNA sequencing techniques were performed to establish a de novo unigene set of P. hypsinotus and identify differentially expressed genes (DEGs) in the hepatopancreas compared to the tail muscle. A search of all the unigenes against Gene Ontology (GO), KEGG, Pfam, BLASTN, and UniProt resulted in 46,703 annotated unigenes. A comparison of the sequences in the two tissue-derived libraries revealed 9,429 DEGs in the hepatopancreas. We also investigated the small RNAomes of P. hypsinotus using the Illumina small RNA sequencing technology. Because miRNAs are highly sensitive to stress responses and pathogen infections, they serve as effective indicators of the immune status, thereby acting as crucial tools for enhancing productivity and disease control in the aquaculture industry. The 130 identified microRNA (miRNA) candidates were classified into 32 orthologous and 98 novel miRNAs using BLASTN and miRBase. Through GO analysis and direct interactions between miRNAs and genes, the differentially expressed miRNAs (DEMs) and DEGs related to immune responses showed regulatory relationships based on their sequences. These findings provide a valuable resource for future studies on novel gene detection, gene mapping and biological pathways that may be regulated by miRNAs unique to P. hypsinotus.

PMID 42553694
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