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ibuprofen (ibuprofen, Diffutab)

✓ Approved

Therabel · PTGS1 · 小分子

什么是 ibuprofen？

ibuprofen 是一种小分子，由Therabel研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名ibuprofen, Diffutab
公司Therabel
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Therabel

作用机制

分子靶点

ibuprofen 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ibuprofen 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersAbdominal pain✓ Approved

相关研究文献

PubMedThe Journal of arthroplasty2026-06-13

Risk and Benefit Profile with Concurrent Nonsteroidal Anti-Inflammatory Drugs and Direct Oral Anticoagulants Following Total Knee Arthroplasty.

Paul Benjamin R BR, Verhey Jens T JT, Haak Grace M GM, Braithwaite Collin L CL et al.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed after total knee arthroplasty (TKA) for analgesia and inflammation control in conjunction with direct oral anticoagulants (DOACs) for venous thromboembolism (VTE) prophylaxis in high-risk patients. In non-orthopaedic populations, concurrent NSAID-anticoagulant increases bleeding risk, but post-TKA safety data remain limited. Using a national claims database (2010 to 2023), we identified patients undergoing primary TKA who received DOAC-only VTE prophylaxis for ≥ three days. Patients co-prescribed NSAIDs were propensity score-matched 1:3 to DOAC-only patients based on demographics, comorbidities, and preoperative anticoagulant use. The matched cohort included 12,733 patients who received DOAC plus NSAID therapy and 37,127 who received DOAC alone. Outcomes included 90-day medical and surgical complications, two-year implant-related complications, and arthrofibrosis-associated outcomes. Subanalyses evaluated outcomes by NSAID type and prescription duration. Combination therapy was associated with increased wound dehiscence (odds ratio (OR) 1.49, 95% confidence interval (CI) 1.20 to 1.87), surgical site infection (OR 1.71 [1.25 to 2.34]), and periprosthetic joint infection (OR 1.24 [1.01 to 1.52]), without differences in 90-day bleeding events (P > 0.05). At two years, NSAID plus DOAC therapy was associated with higher revision risk (OR 1.52 [1.13 to 2.05]), but lower arthrofibrosis (OR 0.92 [0.86 to 0.98]) and manipulation under-anesthesia rates (OR 0.69 [0.62 to 0.77]). Subgroup analyses demonstrated that celecoxib was associated with higher rates of wound dehiscence, surgical site infection, and blood loss anemia, while ibuprofen was associated with an increased risk of surgical site infection. Patients who received concurrent NSAIDs with DOAC prophylaxis following TKA had higher rates of wound complications, infection, and all-cause revision, despite lower rates of arthrofibrosis-related outcomes. These findings demonstrate a clinically relevant trade-off and emphasize the importance of patient-specific risk stratification and cautious NSAID selection when used concurrently with DOAC therapy after TKA.

PMID 42285321
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PubMedJournal of clinical medicine2026-06-12

Ibuprofen vs. Acetaminophen After Delivery in Women with Hypertensive Disorders of Pregnancy: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Cumic Jelena J, Anicic Radomir R, Mirkovic Mladen M, Ristic Jovana J et al.

Background/Objectives: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for postpartum pain management. However, previous studies have indicated that NSAIDs may increase systolic blood pressure, particularly in patients receiving antihypertensive therapy. The aim of the present study was to assess whether postpartum ibuprofen administration is associated with a higher risk of severe postpartum hypertension and increased mean arterial pressure (MAP) compared with acetaminophen. Methods: A systematic literature search was conducted in PubMed, Scopus, and Web of Science to identify relevant studies. Only randomized controlled trials were considered eligible for inclusion. For dichotomous outcomes, effect sizes were expressed as risk ratios (RRs) with corresponding 95% confidence intervals (CIs). For continuous outcomes, mean differences (MDs) with 95% CIs were calculated. Statistical heterogeneity among studies was assessed using the I2 statistic. A fixed-effects model was applied in cases of low heterogeneity (I2 < 20%). Results: No significant difference was observed in the prevalence of severe postpartum hypertension between the ibuprofen and acetaminophen groups (RR 1.07, 95% CI 0.84 to 1.35; p = 0.59; I2 = 0%). Similarly, MAP did not differ significantly between groups (MD -0.05 mmHg, 95% CI -1.53 to 1.42; p = 0.94; I2 = 0%). Conclusions: No increased risk of postpartum hypertension or difference in mean arterial pressure was observed between the ibuprofen and acetaminophen groups, supporting the safety of ibuprofen for postpartum analgesia in women with hypertensive disorders of pregnancy.

PMID 42278905
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PubMedCureus2026-06-12

Concurrent Gastrointestinal Perforation and Cardiopulmonary Arrest in Toxic Epidermal Necrolysis: A Case of Profound Multi-organ Involvement.

Alketbi Sheikha S, AlFalasi Amani Abdulla AA, Galadari Alia A

Toxic epidermal necrolysis (TEN) is a serious, life-threatening cutaneous adverse reaction whose prevalence is widespread epidermal necrosis and detachment, mostly initiated by an adverse drug reaction. Muco-cutaneous manifestation is well-known, but severe systemic complications, specifically gastrointestinal complications and cardiac events, are extremely uncommon, with few cases reported in the literature. This case describes a 27-year-old man who was diagnosed with TEN after taking ibuprofen. He had colonic perforation and cardiopulmonary arrest despite systemic therapies and a multidisciplinary approach. The case study shows that even though TEN is associated with poor prognosis, there are rare serious complications, which are likely to be mediated in this case by the excessive systemic inflammatory response and coagulopathy due to sepsis, and have detrimental outcomes. These unusual complications must be detected early and dealt with aggressively to enhance patient survival in severe TEN.

PMID 42281711
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PubMedMolecules (Basel, Switzerland)2026-06-12

Photo-Ozonation of Multiclass Pharmaceuticals in Model Water: Kinetic Comparison of UV-C, O3 and UV/O3 Under Selected pH Conditions.

Całus-Makowska Klaudia K, Grosser Anna A, Białek Hanna H

The removal of four representative pharmaceuticals-sulfamethoxazole (SMX), carbamazepine (CBZ), diclofenac (DCF) and ibuprofen (IBU)-was investigated in a model aqueous solution using UV-C photolysis, ozonation and a hybrid UV/O3 process. UV-C and UV/O3 experiments were conducted at initial pH 3, ~6 and 8, whereas single ozonation was applied at pH ~6 as a near-neutral reference. The processes were compared in terms of removal efficiency, apparent pseudo-first-order kinetics and kinetic enhancement. UV-C photolysis showed pronounced compound selectivity, with efficient removal of DCF and SMX but limited transformation of CBZ and IBU. Ozonation markedly improved the removal of ozone-reactive compounds, particularly CBZ and DCF. Under near-neutral conditions, UV/O3 provided high removal efficiencies for all target compounds after 30 min. Kinetic analysis showed that UV/O3 enhancement was compound-specific: apparent synergy was observed for CBZ and IBU, with SF values of 1.43 and 1.24, respectively, whereas SMX showed a subadditive response. DCF was rapidly removed under UV/O3 but was excluded from the main SF comparison because its concentration approached the lowest calibrated concentration level. These results indicate that UV/O3 is especially useful for poorly UV-susceptible pharmaceuticals.

PMID 42280232
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PubMedInflammopharmacology2026-06-11

In vitro ibuprofen has gene regulatory and anti-inflammatory properties in peripheral blood mononuclear cells of individuals with infection-provoked neurodevelopmental disorders.

Han Velda X VX, Hayes Jessica P JP, Gloss Brian B, Dissanayake Ruwani R et al.

Gene-environment interactions, leading to immune-brain cross-talk and neuroinflammation are increasingly recognised in neurodevelopmental disorders (NDDs), such as autistic regression and paediatric acute onset neuropsychiatric syndrome (PANS). Nonsteroidal anti-inflammatory drugs, including ibuprofen, provides relief to some neuropsychiatric symptoms, however, the therapeutic mechanisms are unclear. We describe the benefit of ibuprofen in 18 children (11 males, ages 5-20 years) with infection-provoked deteriorations compatible with PANS (16/18) or autistic regression (7/18), five met criteria for both. Ibuprofen was well tolerated and led to improved emotional control, obsessive-compulsive symptoms, and aggression during infection-related exacerbations or the chronic phase. Single-cell RNA sequencing (scRNA-seq) was performed on peripheral blood mononuclear cells (PBMCs) in two children and their respective age-, sex- matched controls, before and after 24 h of in vitro ibuprofen and/or paracetamol incubation. A total of 45,134 cells were included. At baseline in both cases, there was dysregulation of immune pathways (response to virus, cell killing) and downregulation of ribosomal and translational pathways. Ibuprofen reversed the pro-inflammatory state in both children with reversal of cell killing pathways (granzyme genes) in Case 1, and reversal of viral pathways (interferon genes) in Case 2. Ibuprofen also reversed translation pathways (ribosomal protein genes), and regulation of translation (including EIF genes). In vitro paracetamol produced similar but weaker effects than ibuprofen. Children with infection-provoked neurodevelopmental episodes have baseline transcriptional and immune dysregulation in peripheral immune cells. We show that ibuprofen has transcriptional and anti-inflammatory effects, and that scRNA-seq in vitro-based studies can inform disease-modifying therapies for individuals with NDDs.

PMID 42274981
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PubMedScientific reports2026-06-11

Green and applicable chromatographic approaches for the estimation of a multi-component cold and flu relief formulation along with in-vitro dissolution profiling.

Nabil Mona M, Marzouk Hoda M HM, Abbas Samah S SS, Lotfy Hayam M HM et al.

The emergence of novel pharmaceutical formulations requires the establishment of a reliable analytical method that can accurately quantify active ingredients for use in diverse quality control applications. An over-the-counter pharmaceutical combination of phenylephrine hydrochloride (PHE), chlorpheniramine maleate (CPM), and ibuprofen (IBU) is formulated to treat allergy, lessen fever, and relieve congestion. Two efficient and applicable liquid chromatographic methodologies were established, with an emphasis on ecological sustainability while preserving analytical precision and accuracy, in addition system suitability parameters were successfully determined for each method. The first approach involved high-performance thin-layer chromatography (HPTLC) combined with densitometric quantification, employing silica gel HPTLC 60 F254 aluminum sheets as the stationary phase. The developing system comprised ethyl acetate-methanol-aqueous ammonium hydroxide (8.0:2.0:0.1, by volume), and scanning was carried out at 265.0 nm. The respective resolutions (Rs) were 8.44 and 4.57 for PHE, IBU, and CPM, respectively. The second one is high-performance liquid chromatographic methodology (HPLC), whereas, efficient separation was achieved on a Kromasil 60-5-CN column using isocratic elution of 10.0 mM ammonium acetate buffer and ethanol (50: 50, v/v), adjusted with acetic acid to pH 2.5 at a flow rate of 1.3 mL/min, with DAD quantification at 265.0 nm, with overall run time about 6 min to achieve sufficient separation among the target analytes. The resolutions (Rs) were determined to be 7.62 and 3.21 for PHE, CPM, and IBU, respectively. The investigated approaches' performance was validated in adherence to the guidelines established by the International Conference on Harmonization guidelines, confirming its reliability for analytical application. Limit of detection (LOD) values were determined to be 0.02, 0.01, and 0.22 µg/band for PHE, CPM, and IBU, respectively in HPTLC method, whilst in HPLC-DAD method, LOD values were 0.03, 0.01, and 0.24 µg/mL for PHE, CPM, and IBU, respectively. These approaches can concurrently estimate the cited drugs in their raw forms, as well as their pharmaceutical combination. In addition, HPLC can monitor their dissolution profiles. Moreover, the applicability profile and ecological sustainability of the studied approaches were verified via employing up-to-date evaluation tools, along with comparisons against official and reported methodologies.

PMID 42270807
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