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Drug Database
IB

ibuprofen (Ibuprof von CT 2% / Ibuprof von CT / Ibupan)

✓ Approved

Adare Pharma Solutions · PTGS1 · 小分子

什么是 ibuprofen？

ibuprofen 是一种小分子，由Adare Pharma Solutions研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Ibuprof von CT 2%, Ibuprof von CT, Ibupan
公司Adare Pharma Solutions
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Adare Pharma Solutions

作用机制

分子靶点

ibuprofen 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ibuprofen 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersAbdominal pain✓ Approved
Hepatobiliary disordersHepatitis✓ Approved

相关研究文献

PubMedPlastic and reconstructive surgery. Global open2026-08-06

Correction of Cicatricial Ectropion Using Sub-Orbicularis Oculi Fat Lift With Full-thickness Skin Graft.

Khorsandi Joshua J, Mansoury Brian B, Coleman Kendra K, Cataldo Kathryn K et al.

Cicatricial ectropion following facial thermal injury arises from anterior lamellar deficiency and persistent downward traction across the lid-cheek interface. Even with complete scar release and resurfacing, unresolved midface contracture can compromise corneal coverage and graft survival. This report describes a 45-year-old man with 47% total body surface area flame burns, including full-thickness facial involvement, who developed left lower eyelid cicatricial ectropion and exposure keratitis. After excision of the lid cicatrix and extensive facial scar release, residual inferior tension precluded lid apposition to the globe. A subperiosteal sub-orbicularis oculi fat-based midface suspension was therefore performed using drill-hole fixation to the infraorbital rim, reestablishing vertical support and reconstituting the lid-cheek junction. The lower lid was resurfaced with a supraclavicular full-thickness skin graft and stabilized with lateral canthopexy and protective tarsorrhaphy, whereas the adjacent facial defect received a sheet split-thickness graft. Postoperatively, the patient achieved complete graft take, stable eyelid closure, and excellent contour restoration at 3 months. This case highlights the biomechanical benefit of combining sub-orbicularis oculi fat-based midface suspension with lamellar replacement in burn-related ectropion and, in review of the literature, supports this integrated approach as an effective, durable method for restoring lower lid position and corneal protection in complex burn reconstruction.

PMID 42559498
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PubMedFrontiers in cellular and infection microbiology2026-08-06

The cycle of infectious fever - how it affects bacterial infections.

Kramarczyk Kinga K, Schmidt Piotr P, Krasna Karina K, Jasińska Weronika W et al.

Fever is one of the human body's most effective strategies in fighting infections. However, its precise role in eliminating pathogens, specifically the influence of heat on the bacterial cells on the mechanistic level under febrile temperatures has never been fully delineated. The concept of fever, as the immune system's first line of defense against pathogens involves two main components: the inflammatory response and the heat, which stimulates the host's immune cells and affects pathogens. This article summarizes independent findings, grouping the development of fever into a circular model, starting with pathogen invasion and the release of bacteria's exogenous pyrogens, continuing through the host immune response, and debating on the impact of fever on numerous human pathogens. This model focuses broadly on processes occurring within bacteria, particularly pathogen adaptation and the detrimental effect of heat released during fever on pathogen death. We also discussed the impact of commonly used antipyretics, such as acetaminophen, ibuprofen, and aspirin, on the overall outcome of infection and provided a framework within which new concepts and findings in this field can be developed.

PMID 42558355
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PubMedNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026-08-06

Drug safety in patients with mitochondrial disease: an observational cohort study.

Järvinen Oskar O, Martikainen Mika H MH

Mitochondrial diseases are common inherited neurometabolic disorders and frequently involve the nervous system, yet their multisystem nature often necessitates complex pharmacological management. Many commonly prescribed medications have off-target effects on mitochondrial function, and patients with mitochondrial disease may be particularly vulnerable to such effects due to impaired energy metabolism. However, systematic data on medication safety in this patient group remain scarce. In this retrospective, single-centre, cohort-based study at Turku University Hospital (Turku, Finland), we reviewed the medication data from all hospital stays and outpatient prescriptions of 44 mostly adult (20 women; mean age 50 years, range 12-83 years) patients with genetically and clinically confirmed mitochondrial disease for years 2010-2022. We used the Anatomical Therapeutic Chemical system for drug classification. Potential drug-drug interactions and potential adverse drug reactions were investigated. Special focus was on potential mitochondrial toxicity of drugs and clinically relevant drug-drug interactions. Altogether ~ 1000 individual medication entries were reviewed. We identified several common drugs with potentially adverse effects on mitochondria, including metformin, beta-blockers, statins, ciprofloxacin, fluoxetine, ibuprofen, and certain anti-seizure drugs. Medications generally considered contraindicated in mitochondrial disease were not observed. No high-risk drug interactions were detected. Additional finding of clinical relevance was the frequent use of analgesics. Further research regarding mitochondrial safety of several drug classes is needed for more evidence-based safety evaluations. Pain in the context of mitochondrial disease merits increased attention.

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PubMedJournal of Ayurveda and integrative medicine2026-08-06

Deciphering the action mechanism of the sacred plant "Ashvattha" (Ficus religiosa L.) in the treatment of delayed-onset muscle soreness.

Kartika I Gusti Agung Ayu IGAA, Awidarta Kevin K, Alakbaree Maysaa M, Ucche Sisca S et al.

DOMS is a common post-exercise syndrome characterized by pain, stiffness, and decreased muscle function. Conventional therapies have limited efficacy and have potential side effects. This study explored the molecular mechanisms of Ficus religiosa's alleviation of DOMS using network pharmacology, molecular docking, and molecular dynamics simulation analyses. This study used a network pharmacology framework to identify and analyze the phytochemicals from F. religiosa. Databases like IMPPAT 2.0 were used to retrieve potential compounds, while SwissTargetPrediction predicted target proteins. Therapeutic targets were identified using Genecards and OMIM databases. Protein-protein interaction networks were analyzed using STRING and Cytoscape software, while pathway enrichment was conducted using Enrichr. Molecular docking was performed using AutoDockTools (v1.5.7), followed by molecular dynamics simulations using GROMACS to validate target-compound interactions. Of the 140 phytochemicals, 44 met the drug-likeness and bioavailability criteria and were associated with 39 potential therapeutic targets for DOMS. KEGG enrichment analysis revealed inflammation, oxidative stress, and immune regulation as the primary mechanisms of action. Prostaglandin-endoperoxide synthase 2 (PTGS2) was identified as a critical target. Molecular docking showed that compounds such as α-eudesmol, epi-γ-eudesmol, and α-cadinol exhibited superior binding affinities for PTGS2 compared to ibuprofen. Finally, molecular dynamics simulation demonstrated that α-cadinol exhibited the most stable binding owing to its robust hydrogen bonding, whereas epi-α-cadinol displayed progressive stabilization and efficient accommodation inside the active region of the protein. This study suggests that F. religiosa could be used as a therapeutic agent for the management of DOMS. The key compounds, α-cadinol and epi-α-cadinol, show potential anti-inflammatory and analgesic effects.

PMID 42556252
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PubMedNaunyn-Schmiedeberg's archives of pharmacology2026-08-06

Pseudoephedrine poisoning reported to German poison centers: analysis of documented patient cases and the particular vulnerability of infants and toddlers.

Gezgin Funda F, Eyer Florian F, Zorn Gabriel G, Schaper Andreas A et al.

Poison centers (PCs) in Germany are medical facilities that serve as points of contact for cases of poisoning or suspected poisoning and are available by phone 24 h a day. Consultations are provided by physicians who have completed specialized training in toxicology. Members of the public, healthcare professionals, and institutions with questions regarding toxicology can seek advice from the PCs. Over-the-counter medicines play an important role when contacting the PCs. These include pseudoephedrine (PSE), an indirect sympathomimetic, which is used in Germany as a combination preparation for the treatment of cold and flu symptoms and for the symptomatic treatment of allergic rhinitis. In Germany, PSE is combined with acetylsalicylic acid, acetaminophen, or ibuprofen, as well as with first- and second-generation H1 receptor antagonists. PSE has a decongestant effect on the mucous membranes of the nose and sinuses but also has stimulating effects and causes a feeling of alertness. This study includes an analysis of PSE poisoning cases reported to German PCs. They were asked to provide information on documented cases of PSE poisoning. Three of the seven centers surveyed provided their data (Erfurt 136 cases, Göttingen 175 cases, and Munich 210 cases, overall n = 521). The individual cases were then analyzed in terms of various aspects. The patient cases analyzed revealed age-related differences, with a higher incidence in childhood, particularly among children under 6 years of age. There were also indications of gender-specific differences. At the PC Erfurt, cardiovascular and neurological events predominate, with a male dominance. In Munich, neurological and gastrointestinal symptoms predominated. However, a high proportion of cases with unknown gender made gender-specific classification difficult. In Germany, young children up to the age of six are more severely affected despite contraindications and account for a significant proportion of inquiries to PCs. In recent years, PCs in Germany have reported an increase in cases of poisoning involving PSE combination preparations. A variety of symptoms have been observed in connection with PSE poisoning. As a preventive measure, it would be advisable for physicians-particularly pediatricians-and pharmacists to provide better patient education to raise awareness of the risks. Public platforms could also be used to conduct more educational outreach. Overall, the clinical relevance of PSE poisoning is evident from the present findings, which therefore require increased attention. PCs play an important role in this regard by providing acute consultation and systematically collecting data. However, the present findings should be interpreted in light of the limited data available to PCs.

PMID 42560552
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PubMedMilitary medicine2026-08-06

Changes in Bone Mineral Density and Body Composition in Burn and Hindlimb Unloaded Rats.

Song Juquan J, Törö Gábor G, El Ayadi Amina A, Wolf Steven E SE et al.

Prolonged immobilization worsens the patient's recovery following severe burn injury and results in a prolonged hospitalization. This study aims to assess the alterations in bone mineral density and body composition in a pre-clinical model of cutaneous burn combined with immobilization. Adult male rats (n = 24) received scald burn of ∼40% total body surface area (TBSA) (B). After burn, 16 rats had their hindlimbs suspended (H) for either 3 days (BH3) or 14 days (BH14), whereas 8 rats underwent the burn procedure without suspension (B). Additional 8 rats without burn and hindlimb suspended were paired-housed and served as baseline controls (S). All rats were euthanized 21 days after burn for assessment using a high-resolution DEXA. We found that ratios of rat whole body mass, normalized to pre-burn mass, were significantly decreased over time in all burned rats (B: 0.9072 ± 0.0517; BH3: 0.8997 ± 0.0145; BH14: 0.8618 ± 0.0666) when compared to the control (1.1542 ± 0.0206) (P < .05). The same significant reductions were observed in lean mass, bone mineral content (BMC), and fat content (P < .05). To determine whether the DEXA measurement of body parts correlates with whole-body measurement, we performed DEXA of the isolated left hindlimb dissected at the hip joint. We found the ratios of isolated hindlimb tissue mass significantly decreased in all burned rats (B: 0.0552 ± 0.0018; BH3: 0.499 ± 0.0050; BH14: 0.0459 ± 0.0033) when compared to the control (0.0738 ± 0.0046) (P < .05). In addition, there was a significant decrease in hindlimb tissue mass in burned animals suspended for 14 days compared to their burned nonsuspended counterparts (P < .05). The ratios of lean mass (0.0362 ± 0.0031) in the isolated hindlimb also significantly decreased in BH14 group compared to B group (0.0591 ± 0.0034) (P < .05). DEXA scanning of the whole body revealed a cachectic state in burned rats. The whole-body DEXA results were concordant with those obtained from the corresponding isolated hindlimbs. The isolated hindlimbs showed a further decrease in lean mass in burned rats following 14 days of immobilization. We conclude that 14-day immobilization exacerbates the cachectic state in severely burned rats. This preclinical model may be used to develop and test effective therapeutic countermeasures.

PMID 42560231
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