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ibuprofen (Ibuprof von CT 2% / Ibuprof von CT / Ibupan)

✓ Approved

Adare Pharma Solutions · PTGS1 · 小分子

什么是 ibuprofen？

ibuprofen 是一种小分子，由Adare Pharma Solutions研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Ibuprof von CT 2%, Ibuprof von CT, Ibupan
公司Adare Pharma Solutions
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Adare Pharma Solutions

作用机制

分子靶点

ibuprofen 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ibuprofen 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersAbdominal pain✓ Approved
Hepatobiliary disordersHepatitis✓ Approved

相关研究文献

PubMedAuris, nasus, larynx2026-06-13

Stepwise surgical management of severe dysphagia in multiple system atrophy.

Ogawa Yumiko Y, Ueha Rumi R, Goto Takao T, Ramos Miguel Limbert ML et al.

Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder in which dysphagia progressively worsens over time. We report a 70-year-old man with MSA who had previously undergone laryngeal suspension and tracheostomy, allowing continued oral intake while preserving phonation. However, disease progression led to recurrent aspiration pneumonia, severe secretion retention, and transient ventilatory dependence. Reassessment revealed severe saliva pooling, silent aspiration, impaired laryngeal sensation, and upper esophageal sphincter (UES) dysfunction on high-resolution manometry. Given the patient's frailty, colonization with extended-spectrum beta-lactamase-producing organisms, and strong desire to resume oral intake, subglottic laryngeal closure combined with bilateral cricopharyngeal myotomy was performed through a minimally invasive surgical field. Postoperatively, aspiration was successfully prevented, UES opening improved, and partial oral intake was resumed without recurrent aspiration pneumonia. This case highlights the importance of individualized and stage-specific surgical decision-making for severe dysphagia in progressive neurodegenerative disease.

PMID 42284998
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PubMedTalanta2026-06-13

Dual-emission FS@Eu-TDA for fluorescence detection of PO43- in tap water and serum.

Wang Runnan R, Yu Xinhui X, Zhang Hao H, Lv Yang Y et al.

A novel dual-emission metal-organic framework composite, FS@Eu-TDA, was fabricated for the ratiometric fluorescence detection of phosphate (PO43-). This composite was prepared via an in-situ encapsulation strategy, in which fluorescein sodium molecules were incorporated as guest chromophores into Eu-MOF. The FS@Eu-TDA composite achieves a low limit of detection of 0.12 μM for PO43-. Benefiting from its dual-emission response, the composite enables visual PO43- detection. Specifically, its fluorescence color distinctly changes from red to green under UV light as the PO43- concentration increases. The practical applicability of FS@Eu-TDA was successfully validated in real samples, including tap water and fetal bovine serum. To address the limitations of powder suspension systems and achieve convenient detection, a flexible FS@Eu-TDA@PVP/PES composite hydrogel film was further fabricated, which exhibits a visual detection limit of 0.21 μM for PO43-. This work demonstrates that FS@Eu-TDA serves as a highly sensitive, accurate, and practical sensing platform for PO43- detection in environmental and biological samples.

PMID 42284750
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PubMedThe Journal of arthroplasty2026-06-13

Risk and Benefit Profile with Concurrent Nonsteroidal Anti-Inflammatory Drugs and Direct Oral Anticoagulants Following Total Knee Arthroplasty.

Paul Benjamin R BR, Verhey Jens T JT, Haak Grace M GM, Braithwaite Collin L CL et al.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed after total knee arthroplasty (TKA) for analgesia and inflammation control in conjunction with direct oral anticoagulants (DOACs) for venous thromboembolism (VTE) prophylaxis in high-risk patients. In non-orthopaedic populations, concurrent NSAID-anticoagulant increases bleeding risk, but post-TKA safety data remain limited. Using a national claims database (2010 to 2023), we identified patients undergoing primary TKA who received DOAC-only VTE prophylaxis for ≥ three days. Patients co-prescribed NSAIDs were propensity score-matched 1:3 to DOAC-only patients based on demographics, comorbidities, and preoperative anticoagulant use. The matched cohort included 12,733 patients who received DOAC plus NSAID therapy and 37,127 who received DOAC alone. Outcomes included 90-day medical and surgical complications, two-year implant-related complications, and arthrofibrosis-associated outcomes. Subanalyses evaluated outcomes by NSAID type and prescription duration. Combination therapy was associated with increased wound dehiscence (odds ratio (OR) 1.49, 95% confidence interval (CI) 1.20 to 1.87), surgical site infection (OR 1.71 [1.25 to 2.34]), and periprosthetic joint infection (OR 1.24 [1.01 to 1.52]), without differences in 90-day bleeding events (P > 0.05). At two years, NSAID plus DOAC therapy was associated with higher revision risk (OR 1.52 [1.13 to 2.05]), but lower arthrofibrosis (OR 0.92 [0.86 to 0.98]) and manipulation under-anesthesia rates (OR 0.69 [0.62 to 0.77]). Subgroup analyses demonstrated that celecoxib was associated with higher rates of wound dehiscence, surgical site infection, and blood loss anemia, while ibuprofen was associated with an increased risk of surgical site infection. Patients who received concurrent NSAIDs with DOAC prophylaxis following TKA had higher rates of wound complications, infection, and all-cause revision, despite lower rates of arthrofibrosis-related outcomes. These findings demonstrate a clinically relevant trade-off and emphasize the importance of patient-specific risk stratification and cautious NSAID selection when used concurrently with DOAC therapy after TKA.

PMID 42285321
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PubMedCarbohydrate polymers2026-06-13

Oxidative deboronation of boronic acids by hydrogen peroxide in planta generates borate for cross-linking of rhamnogalacturonan II.

Sharma Deepak D, Thorne Kristen K, Bharadwaj Vivek S VS, Matthes Michaela S MS et al.

Vascular plants require boron to cross-link the rhamnogalacturonan-II (RG-II) domain of pectin to form functional cell walls. Boronic acids, which form reversible esters with cis-diols like borate, have been proposed to influence RG-II cross-linking, though the mechanism remains unclear. We used suspension-cultured rose cells adapted to grow without boron to investigate the effect of boronic acids on RG-II dimerization. When grown with phenylboronic acid (PBA) as the sole boron source, nearly all RG-II was crosslinked, whereas methylboronic acid (MBA) only partially restored cross-linking. In contrast, in vitro assays showed that homogeneous RG-II monomers did not dimerize with alkyl or aryl boronic acids unless supplemented with hydrogen peroxide (H₂O₂), which oxidatively converts boronic acids to boric acid. Real-time NMR spectroscopy and density functional theory calculations provided insight into the reaction mechanism and energetics of oxidation respectively. Together, our data show that exogenous boronic acids are a source of boric acid for plants, and that the deboronation reaction generates aryl or alkyl alcohol byproducts that can undergo further chemical modification in planta. The fate and potential roles of these byproducts in planta remain to be determined.

PMID 42285657
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PubMedJournal of medical case reports2026-06-13

The youngest reported oropharyngeal leech infestation: severe anemia without airway obstruction in a 6-month-old Ethiopian infant: a case report.

Oljira Amanuel Mesfin AM, Kelbessa Samuel Kefiyalew SK, Shorro Boka Imiru BI, Mekonen Bekele Abera BA et al.

Infestation of the oropharynx by a leech is uncommon, especially in young children, and can cause major bleeding because leech saliva contains the anticoagulant hirudin. This case, which presents oropharyngeal leech infestation causing severe anemia without obstruction of the airway in a 6-month-old infant, is the youngest ever documented. Parents from rural Ambo brought in an Oromo male infant of 6 months of age, complaining of oral bleeding, decreased oral intake, hematemesis, dark stool, and agitation that had occurred throughout the previous two days. Although there was no respiratory distress, a physical examination revealed blood-stained oral mucosa and a dark brown substance in the oropharynx; a complete blood test showed severe anemia (Hb 7.3 g/dL). The bleeding immediately stopped after removal of a 2.5 cm long leech by Magill forceps from the oropharyngeal wall under direct visualization with a rigid laryngoscope. Blood transfusions, antibiotics, and an iron suspension were given, and the patient's complete recovery was confirmed by an outpatient follow-up after discharge. In environments with limited resources, this case highlights the importance of preventing such rare but dangerous infestations by improving water sanitation, adhering to safe feeding practices, and quickly suspecting parasitic causes in infants exhibiting unexplained bleeding.

PMID 42286657
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PubMedJournal of clinical medicine2026-06-12

Ibuprofen vs. Acetaminophen After Delivery in Women with Hypertensive Disorders of Pregnancy: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Cumic Jelena J, Anicic Radomir R, Mirkovic Mladen M, Ristic Jovana J et al.

Background/Objectives: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for postpartum pain management. However, previous studies have indicated that NSAIDs may increase systolic blood pressure, particularly in patients receiving antihypertensive therapy. The aim of the present study was to assess whether postpartum ibuprofen administration is associated with a higher risk of severe postpartum hypertension and increased mean arterial pressure (MAP) compared with acetaminophen. Methods: A systematic literature search was conducted in PubMed, Scopus, and Web of Science to identify relevant studies. Only randomized controlled trials were considered eligible for inclusion. For dichotomous outcomes, effect sizes were expressed as risk ratios (RRs) with corresponding 95% confidence intervals (CIs). For continuous outcomes, mean differences (MDs) with 95% CIs were calculated. Statistical heterogeneity among studies was assessed using the I2 statistic. A fixed-effects model was applied in cases of low heterogeneity (I2 < 20%). Results: No significant difference was observed in the prevalence of severe postpartum hypertension between the ibuprofen and acetaminophen groups (RR 1.07, 95% CI 0.84 to 1.35; p = 0.59; I2 = 0%). Similarly, MAP did not differ significantly between groups (MD -0.05 mmHg, 95% CI -1.53 to 1.42; p = 0.94; I2 = 0%). Conclusions: No increased risk of postpartum hypertension or difference in mean arterial pressure was observed between the ibuprofen and acetaminophen groups, supporting the safety of ibuprofen for postpartum analgesia in women with hypertensive disorders of pregnancy.

PMID 42278905
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