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KH

KH-741 (KH 741 / KH741)

✓ Approved

Chengdu Kanghong Pharmaceutical · 小分子 · 小分子

什么是 KH-741？

KH-741 是一种小分子，由Chengdu Kanghong Pharmaceutical研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名KH 741, KH741
公司Chengdu Kanghong Pharmaceutical
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Chengdu Kanghong Pharmaceutical

治疗适应症

KH-741 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Psychiatric disordersBipolar I disorder✓ Approved

相关研究文献

PubMedFrontiers in psychiatry2026-08-06

Effects of visual art therapy on depressive symptoms in adults: a systematic review and meta-analysis.

Guo Zhenhua Z, Liu Yingcong Y, Zhu Shan S, He Yupeng Y

To systematically evaluate the intervention effects of visual art therapy on depressive symptoms in adults, and to examine its impact on anxiety symptoms. A systematic search was conducted in databases including CNKI, WanFang Data, VIP, Chinese Biomedical Literature Database (CBM), PubMed, Web of Science, Cochrane Library, and Embase from inception to March 2026. Randomized controlled trials were included in which visual art therapy was used to intervene in depressive symptoms among adults (≥18 years).Meta-analysis was performed using Stata 18.0 software.The primary outcome was depressive symptoms, measured by scales such as the BDI, GDS, HADS-D, and SDS, and the secondary outcome was anxiety symptoms, measured by scales such as the BAI, HADS-A, and SAS. Fixed-effect or random-effect models were selected according to the level of heterogeneity, and subgroup analyses were conducted. A total of 12 randomized controlled trials involving 741 adults were included, with 377 participants in the intervention group and 364 in the control group.The meta-analysis showed that visual art therapy effectively alleviated depressive symptoms (SMD = -0.81, 95% CI: -1.16 to -0.46, P < 0.00001) and anxiety symptoms (SMD = -0.69, 95% CI: -0.90 to -0.48, P < 0.00001) in adults.Subgroup analyses indicated that interventions with a duration of <12 weeks, <12 sessions in total, and a single-session length of ≤60 minutes were associated with larger effect sizes for the improvement of depressive symptoms; improvements in anxiety symptoms were more pronounced in intervention protocols characterized by higher frequency (>12 sessions), shorter overall duration (≤6 weeks), and shorter single-session length (≤60 minutes). As a non-pharmacological intervention, VAT has potential as an adjunctive approach for alleviating depressive and anxiety symptoms in adults. https://www.crd.york.ac.uk/PROSPERO/view/CRD420261371354, identifier CRD420261371354.

PMID 42558632
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PubMedNeurosurgical review2026-08-03

Intrawound vancomycin powder for infection prevention in neurosurgical patients: a retrospective cohort study.

Tejada-Pineda Maria Fernanda MF, Ortega-Porcayo Luis Alberto LA, Reyes-Madrigal Francisco F, Romano-Feinholz Samuel S et al.

Surgical site infections (SSIs) are the most frequent healthcare-associated infections in surgical patients and are largely preventable. Neurosurgical procedures are particularly vulnerable due to inherent risk factors. While intrawound vancomycin has been extensively studied in spinal surgery, evidence in cranial procedures remains limited. We performed a retrospective cohort study of 741 patients undergoing cranial or spinal neurosurgery between November 2014 and February 2024. The primary outcome was the 90-day SSI rate, defined in accordance with CDC surveillance criteria for neurosurgical procedures. Secondary analysis evaluated associations between infection and operative duration, cerebrospinal fluid (CSF) leaks, reintervention, use of surgical drains, emergency surgery, and hospital stay. After applying exclusion criteria, 548 patients were included: 291 received topical vancomycin powder and 257 served as controls. Infection occurred in 3.1% of the vancomycin group versus 8.6% of controls, representing a 64% reduction in infection risk (RR = 0.36; 95% CI: 0.17-0.77). No adverse events related to vancomycin were observed. CSF leak was the strongest independent predictor of infection, with 26.9% of patients with a leak developing SSI versus 4.6% without (RR = 6.14; 95% CI: 2.8-13.5). Reintervention was also a significant predictor, increasing infection risk by 2.53 times (RR = 2.53; 95% CI: 1.5-4.12). Drain use showed an association in chi-square analysis (RR of 2.17; 95% CI: 1.25-3.75). Operative duration, emergency surgery, and hospital stay were not significantly associated. Intrawound vancomycin was significantly associated with reduced postoperative SSIs in cranial and spinal neurosurgery.

PMID 42545515
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PubMedBiochemical and biophysical research communications2026-08-02

Design, synthesis, and biological evaluation of novel HuR inhibitors.

Li Zheng Z, Yang Xue-Long XL, Yu Yue Y, Xu Liang L et al.

A series of novel HuR inhibitors were designed and synthesized. Evaluation of HuR binding affinity and antitumor activity against MDA-MB-231 cells demonstrated that most compounds exhibited potent HuR engagement and pronounced antitumor effects. Notably, compound 7a displayed a Kᵢ of 0.098 μM for HuR binding and an IC50 of 1.33 μM against MDA-MB-231 cells, representing several-fold improvements over the positive control KH-39. Mechanistically, 7a induces cancer cell apoptosis by reducing the expression levels of prosurvival proteins encoded by HuR target mRNAs, including XIAP, Bcl-2, and Survivin, without altering HuR protein abundance. Molecular docking and molecular dynamics simulations of 7a, 7b, 7c in complex with HuR identified key hydrophobic interactions with residues I113, Y26, and Y63, an ionic interaction with R131, and a hydrogen bond with R97; additionally, 7a formed two supplementary hydrogen bonds with N25 and Y26. Simulations further indicated that hydrophobic interactions constitute the dominant driving force for binding. Collectively, these results highlight compound 7a as a promising HuR-targeted lead for anticancer development.

PMID 42543056
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PubMedScience advances2026-07-31

Simultaneous Mars-orbit observations reveal Kelvin-Helmholtz instability-driven bulk atmospheric ion escape.

Zhang Chi C, Dong Chuanfei C, Poh Gangkai G, Halekas Jasper J et al.

Atmospheric ion escape driven by the solar wind is a key process controlling the long-term loss of the Martian atmosphere. Localized plasma clouds can carry substantial fluxes of planetary ions away from Mars, representing episodes of bulk escape. However, their origin has remained unclear due to the absence of simultaneous upstream measurements. Using joint observations from the MAVEN and Tianwen-1 missions, which provide real-time upstream monitoring, we present direct evidence that these plasma clouds are nonlinear wave packets generated by the Kelvin-Helmholtz instability (KHI). The spatial scale of KH waves is constrained for the first time via two-point measurements. Ion fluxes within plasma clouds are one to two orders of magnitude higher than those in typical steady-state escape channels. Our results indicate that KHI is an important process for solar wind coupling to planetary upper atmospheres and plays a crucial role in shaping atmospheric ion escape for unmagnetized planets.

PMID 42536743
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PubMedNigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria2026-07-31

Beyond Repeats: Intragenic Variants in FMR1 and Their Contribution to Fragile X Syndrome Pathogenesis.

Latunji Abayomi A

Fragile X Syndrome (FXS), the most common inherited cause of intellectual disability, is typically caused by expansion of a CGG triplet repeat in the 5' untranslated region (5'-UTR) of the FMR1 gene. Growing evidence indicates that intragenic mutations in FMR1, including single-nucleotide variants (SNVs) and structural changes, can also alter FMR1 function without the classical pathogenic expansion of CGG repeats. This study re-analysed publicly available next-generation sequencing (NGS) data from BioProject PRJNA745542 using a reproducible Galaxy-based bioinformatics workflow to identify non-repeat intragenic FMR1 variants. Of 18 available datasets, 11 paired-end Illumina samples passing quality control (Phred > 30) were analysed for non-repeat intragenic FMR1 variants. Ninety-one unique variants were identified: 61 single-nucleotide variants (SNVs), 26 insertions/deletions (indels), three mixed (complex) variants, and one multi-nucleotide polymorphism (MNP), producing 1,107 predicted gene effects. SnpEff predicted sixteen variants to have high or moderate impact, predominantly within the KH1 and KH2 RNA-binding domains of FMRP. Most predicted effects (94.3%) were intronic or non-coding, suggesting a possible regulatory role in the expression or processing of FMR1 transcripts. These preliminary findings warrant validation in larger cohorts of subjects with verified disease status. High-impact KH-domain variants are predicted to disrupt hydrogen bonding required for FMRP RNA-binding and mRNA transport. This study extends the known mutation spectrum of FMR1 and supports the development of comprehensive NGS-based diagnostic assays that combine intragenic SNV and indel detection with quantitative CGG repeat analysis. Further studies using cellular or animal models are needed to validate the candidate variants identified and their potential role in Fragile X syndrome pathogenesis.

PMID 42537027
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PubMedOrganic chemistry frontiers : an international journal of organic chemistry2026-07-30

1,4-Dihydropyrrolo[3,2-b]pyrrole as a new electron-donor in the construction of triarylmethyl radicals.

Godlewski Bartosz B, Grudzień Krzysztof K, Aleshkevych Pavlo P, Koszarna Beata B et al.

A diverse range of triarylmethyl radicals bearing the 1,4-dihydropyrrolo[3,2-b]pyrrole (DHPP) scaffold and its π-expanded analogs was prepared for the first time, including a structurally unique architecture in which an electron-donating moiety and the radical center are in close through-space proximity. For the first time, triarylmethyl radicals were prepared via electrochemical oxidation. Compared with classical oxidation, the yields were higher. Moreover, a methodology transforming 1,4-dihydropyrrolo[3,2-b]pyrrole into corresponding radicals via Buchwald-Hartwig amination was developed. This method provides easy access to N-linked triarylmethyl radicals via a convergent protocol with complete preservation of open-shell character. Linking the tris(2,4,6-trichlorophenyl)methyl radical with various electron-donating scaffolds bearing a DHPP core revealed that the stronger the electron donor, the weaker and more bathochromically shifted was the CT band. Luminescence of these open-shell dyes, except for radical-bearing 1,4-dihydropyrrolo[3,2-b]indole (Φ F = 1.9 × 10-4), was below the limit of detection, which corresponded to extremely small oscillator strengths for the D1 → D0 transition. A clear correlation was observed between increasing ionization potentials (decreasing electron-donating strength) and ε values throughout the series of radicals. A diradical in which two tris(2,4,6-trichlorophenyl)methyl scaffolds were bridged with 1,4-dihydropyrrolo[3,2-b]pyrrole lacked emission, but it had a significantly bathochromically shifted absorption band (λ max abs = 741 nm).

PMID 42529419
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