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KH

KH-741 (KH 741 / KH741)

✓ Approved

Chengdu Kanghong Pharmaceutical · 小分子 · 小分子

什么是 KH-741？

KH-741 是一种小分子，由Chengdu Kanghong Pharmaceutical研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名KH 741, KH741
公司Chengdu Kanghong Pharmaceutical
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Chengdu Kanghong Pharmaceutical

治疗适应症

KH-741 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Psychiatric disordersBipolar I disorder✓ Approved

相关研究文献

PubMedPlants (Basel, Switzerland)2026-06-12

Seed Hormonal Priming Improves Drought Resilience in Durum Wheat Through Modulation of Physiological and Biochemical Traits.

Zagoub Rihab R, Hmissi Manel M, Fernandez-Martinez Erika E, Garcia-Sanchez Francisco F et al.

Drought stress is one of the most severe constraints affecting wheat production worldwide. Under these conditions, the development of sustainable and economically viable strategies, such as seed priming, is essential to improve wheat performance and drought resilience. The present study carried out a greenhouse experiment on four Mediterranean durum wheat cultivars (Triticum turgidum ssp. durum Desf), i.e., Karim (Kr) and Khiar (Kh) from Tunisia and Espelta (Esp) and Mocho (Mo) from Spain, subjected to drought stress conditions, and using primed abscisic acid (ABA), indole-3-acetic acid (IAA), melatonin (Mlt), and salicylic acid (SA), and non-primed seeds. In order to assess the physio-biochemical responses of durum wheat, such as plant growth, chlorophyll, relative water content (RWC), water potential (Ψw), osmotic potential (Ψs), proline, soluble sugars, starch, glycine betaine, hydrogen peroxide, malondialdehyde, and antioxidant enzyme activities. The results showed that water stress significantly reduced plant growth, SPAD index, RWC, Ψw, and Ψs, while upregulating H2O2 and MDA levels, depending on the wheat cultivars. Soluble sugars decreased, whereas starch, glycine betaine, and proline accumulated in all cultivars. Superoxide dismutase activity was reduced (24-37%) under water stress as compared to the control condition, while APX, CAT, and POD activities significantly increased. Among the cultivars, Esp exhibited the greatest plasticity in response to water deficit, whereas Kh appeared to be most sensitive. Furthermore, the present results revealed that the priming durum wheat seeds with ABA, IAA, Mlt, and SA improved leaf hydration, particularly through soluble sugar accumulation. Seed priming also alleviated oxidative stress by reducing H2O2 and MDA levels and stimulating APX, CAT, POD, and SOD activities. Plants grown from non-primed seeds of Spanish and Tunisian cultivars exhibited differential responses to drought stress, and those derived from primed seeds showed varying degrees of enhanced drought tolerance. Espelta demonstrated a high potential for stress tolerance and responsiveness to priming, followed by Karim, whereas Khiar was the most sensitive cultivar. Overall, the cultivars can be ranked in decreasing order of stress tolerance as Esp > Kr > Mo > Kh. These findings highlight the potential of phytohormone-based seed priming as an efficient and practical approach to enhance drought resilience in durum wheat, offering promising prospects for improving crop performance and stability under increasingly water-limited conditions in the era of climate change.

PMID 42280737
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PubMedAngewandte Chemie (International ed. in English)2026-06-12

Ultrastable Non-Noble-Metal Oxygen Evolution Electrocatalyst for Industrial-Level Water Electrolysis.

Hu Zhiang Z, Yu Jingkun J, Chang Jiangwei J, Wu Han H et al.

The sluggish kinetics of alkaline oxygen evolution reaction (OER), together with the highly polarizing conditions at industrial-level ampere-scale current densities, which cause catalyst instability, motivate the search for new approaches to break the challenging activity-stability trade-off. Herein, we demonstrate that atomic carbon doping into the octahedral voids of Fe2O3 ultrathin nanosheets (C-Fe2O3 UNSs) with constructed Feoh III-O-Feoh III synergistic centers can modify the coverage of *OH intermediates and allow direct *O-*O radical coupling. This enables both structural and catalytic stabilization, as confirmed by operando spectroscopic measurements and density-functional theory calculations, with an overpotential of 227 mV to achieve 500 mA cm-2 along with 4500-h durability. When applying C-Fe2O3 UNSs in an anion exchange membrane water electrolyzer, it delivers a cell voltage of 1.72 V at 1.5 A cm-2 while operating for 2800 h from 1 to 5 A cm-2, with a degradation rate of 3.05 mV kh-1 at 3 A cm-2.

PMID 42283290
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PubMedPolymers2026-06-12

A Nano-SiO2-Based Core-Shell Hybrid as a Dual-Functional Viscosity Reducer and Pour Point Depressant for Heavy Oil.

Ji Borui B, Wang Shuo S, Sarsenbekuly Bauyrzhan B, Tao Zhen Z et al.

Heavy oil production and transportation are often restricted by high viscosity, poor mobility, and unfavorable low-temperature flow behavior, especially in waxy systems. While conventional polymer-based additives improve flow, they suffer from inadequate thermal stability, poor dispersibility in complex crude oil matrices, and insufficient multifunctionality. To address these issues, a nano-SiO2-based organic-inorganic hybrid flow improver, denoted as NSDA, was synthesized via in situ free-radical copolymerization of styrene, docosyl methacrylate, acrylic acid, and acrylamide on 3-(trimethoxysilyl)propyl methacrylate (KH-570)-modified silica surfaces. Characterization revealed that this core-shell nanohybrid structure significantly improved thermal stability and oil-phase dispersibility, maintaining nanoscale dispersion in xylene. A remarkable viscosity reduction rate of 90.2% was achieved, accompanied by a substantial pour point depression of 11 °C using only 0.5 wt% of NSDA in Liaohe heavy oil. This dual-functional performance is mainly attributed to the combined effects of the robust nano-SiO2 core and the multifunctional polymer shell, Specifically, the performance is driven by synergistic wax crystal regulation at low temperatures, alongside weakened intermolecular associations among polar heavy components and nanoparticle-assisted dispersion that govern viscosity reduction.

PMID 42280508
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PubMedPolymers2026-06-12

Low-Loading f-MXene/Fluorosilicone Hybrid Highly Hydrophobic Coatings: Anti-Photoaging Mechanism and Application in Durable Protection of Stone and Brick Cultural Heritage.

Fu Peng P, Yan Shaojun S, He Kaili K, Shi Meirong M

In the surface protection of stone and brick cultural heritage, a primary challenge is that traditional polymeric coatings are prone to photooxidative degradation under ultraviolet (UV) irradiation, and the resulting aged fragments readily block the substrate micropores, leading to a loss of "breathability". To address the performance conflict among waterproofing, breathability, and weather resistance, this study prepared few-layer Ti3C2TX MXene using a minimally intensive layer delamination (MILD) method. The poor compatibility between MXene and the fluorosilicone (FPS) resin matrix was effectively resolved through covalent modification with a silane coupling agent (KH-550). Results demonstrate that at an ultralow loading (0.5 wt%), the functionalized f-MXene is uniformly dispersed within the resin. This structure not only spontaneously constructs a hierarchical rough architecture on the surface that imparts high hydrophobicity (water contact angle of 131.6°), but its internal "labyrinth effect" also effectively blocks corrosive media. Simultaneously, the intrinsic water vapor transmission rate of the substrate is effectively maintained (with a reduction of less than 3%), and no visually perceptible color difference is generated (∆E = 1.2). Mechanically, f-MXene relies on interfacial interactions to act as a "nano-skeleton" for stress transfer, thereby increasing the uniaxial compressive strength of fragile limestone by 32.4%. Optical and spectroscopic characterizations further elucidate its anti-aging mechanism: f-MXene not only provides broadband UV shielding but also exhibits highly efficient radical scavenging activity during long-term UV aging. After 400 h of aging, the concentrations of hydroxyl and superoxide anion radicals within the system are significantly reduced, blocking the photooxidative chain reaction from the source. This work develops a composite protective material system for stone cultural heritage that simultaneously integrates high moisture permeability, minimal visual intervention, and long-term antioxidant performance.

PMID 42280558
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PubMedInfectious diseases and therapy2026-06-11

Effectiveness, Sex Differences, and Patient Experience in Real-World Use of Long-Acting Cabotegravir and Rilpivirine: Results from a Prospective Study.

González-Cordón Ana A, Calvo Júlia J, Berrocal Leire L, León-Fabo Maite M et al.

Long-acting intramuscular cabotegravir plus rilpivirine (LA-CAB/RPV) administered every 2 months (Q2M) has been available in Spain since January 2023 as a switch strategy for HIV treatment. We evaluated characteristics, effectiveness, tolerability, and acceptance, including patient-reported outcomes, stratified by sex in people with HIV switching to LA-CAB/RPV. Observational, prospective, cohort study in Hospital Clínic of Barcelona, Spain. Participant characteristics according to sex at birth and treatment effectiveness [HIV-RNA < 50 copies/mL by on treatment (OT), modified intention-to-treat (mITT), and intention to-treat (ITT) analyses] were evaluated. Self-administered electronic questionnaires were collected. From February 2023 to February 2025, 57/741 (8%) women and 684/741 (92%) men started LA-CAB/RPV, compared to 816/5901 (14%) women that continued with other antiretroviral therapy (ART) (p < 0.001) in our cohort. Women were older, had longer time since HIV diagnosis and on ART, lower nadir CD4, and were more frequently Spanish-born than men. Effectiveness by OT, mITT, and ITT in the 461 participants (29 women and 432 men) who reached week 52 of follow-up was 96%, 83%, and 83% and 99%, 92%, and 89%, respectively, without significant differences. There were 8 (1.7%) confirmed virological failures and 40 (9%) discontinuations with no significant differences by sex. Acceptance, tolerability of injections, and HIV medication burden globally improved during follow-up. Women reported more medication burden and disclosure worries than men. Compared to our general cohort, proportionally fewer women than men switched to LA-CAB/RPV. Effectiveness, adherence, tolerability, and acceptance were high without significant differences by sex. In this study, women expressed more frequent disclosure issues and showed significantly different baseline characteristics compared to men, highlighting the importance of sex-disaggregated data analysis. These results should be confirmed in larger studies.

PMID 42274912
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PubMed[Nihon koshu eisei zasshi] Japanese journal of public health2026-06-11

[Managing heat stroke in long-term care facilities: A text mining analysis of interview data].

Takahashi Kyoko K, Arai Asuna A, Ueda Kayo K

Objectives　Rising heat stress due to climate change has increased the urgency of developing resilient long-term care systems for older adults. This study examined preparedness for heat-related risks in Japanese nursing homes.Methods　This qualitative descriptive study used semi-structured interviews with eight nursing home managers across four regions of Japan: Tohoku, Kanto, Chubu, and Kyushu. Interviews addressed six domains: recognition of extreme heat as a crisis and its impact on care delivery; heat stroke prevention strategies; implementation challenges; essential prevention requirements; gaps in current practices; and concerns about future risks from heat and other disasters. Data were analyzed through text mining using KH Coder (version 3.02).Results　Co-occurrence network analysis identified 10 semantic subgraphs, categorized into three domains. (1) Heat perception included "limitations on outdoor activities" as a measure and "risk of heat-related illness" as a challenge. (2) Living environment management included "indoor temperature management," "ensuring airflow," and "maintenance of air conditioning system" as measures, and "managing localized temperature variations" and "increased electricity consumption and risk of power outages" as challenges. (3) Workload burden included "providing hydration to residents" and "differences in temperature perception between older adult residents and caregivers" as challenges.Conclusion　Preventive measures, including temperature control and adequate hydration, are implemented but increase caregiver workload as temperatures rise. Sustaining long-term care services under these conditions requires strategies that reduce routine staff burden.

PMID 42270381
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