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epinephrine (Emerade)

✓ Approved

Bausch + Lomb Corporation · 小分子 · 小分子

什么是 epinephrine？

epinephrine 是一种小分子，由Bausch + Lomb Corporation研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)。

药物档案

商品名Emerade
公司Bausch + Lomb Corporation
药物类别小分子
给药途径Injectable (Others)
状态Approved
来源： ClinicalTrials.gov, Bausch + Lomb Corporation

治疗适应症

epinephrine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Immune system disordersAnaphylactic reaction✓ Approved

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Field-based assessment of selected pharmaceuticals, pesticides and sediment metals using macrofauna and nematode communities in False Bay, South Africa.

Mazeka Buyani B, Tshingana-Bali Bomikazi B, Murgatroyd Olivia O, Moser Justin J et al.

False Bay supports high biodiversity but is increasingly subjected to anthropogenic pressures, including urbanisation and harbour activities. This study aimed to (1) quantify selected pharmaceuticals (e.g., acetaminophen, carbamazepine, diclofenac), herbicides (atrazine and metolachlor) and metals (Cu, Fe, Mn, Pb and Zn), (2) examine their spatial distribution, and (3) assess their potential effects on benthic assemblages. Sampling was conducted between 18 April and 14 June 2021 across 19 stations. Pharmaceuticals and herbicides were widely detected in seawater (LDL - 1.1 ng/L) and sediments (LDL - 54.6 ng/g), with higher concentrations in sediments, indicating their role as long-term contaminant reservoirs. Spatial patterns revealed localised enrichment near wastewater discharge zones and urbanised areas. Metal concentrations (1.6-7732 μg/g) were similarly elevated in anthropogenically influenced areas. However, risk quotient (RQ) remained <0.1 and metal concentrations were below ERL thresholds, suggesting a low potential of acute biological effects. Benthic assemblages were diverse and typical of coastal sandy environments, with no significant relationships detected between contaminant concentrations and community metrics. Nematode indices (MI and ITD) indicated good to high ecological quality. The single sampling design and family-level taxonomic resolution may have limited the detection of sub-lethal, chronic or species-specific responses. While contaminants are widespread and accumulate in sediments, their current concentrations are unlikely to cause acute ecological impacts benthos. However, chronic effects and the presence of unmonitored contaminants cannot be excluded. Long-term monitoring and higher taxonomic resolution are recommended to better understand and access cumulative ecological risks.

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PubMedJournal of environmental management2026-06-13

Chitosan-based carbonaceous adsorbent for wastewater treatment applications.

Thiviya Punniamoorthy P, Wickramasinghe Minola M, Rajapakshe Hashini H, Gamage Ashoka A et al.

Chitosan-based adsorbents have drawn considerable attention due to their effective removal of hazardous pollutants, such as heavy metal ions, microplastics, and organic pollutants, including phenols, dyes, fertilizers, pesticides, herbicides, and pharmaceuticals. However, the practical application of chitosan is limited by its relatively low adsorption capacity, poor mechanical properties, and susceptibility to dissolution in acidic solutions. Therefore, chitosan is commonly modified using different techniques, including chemical and physical approaches, or combined with other adsorbent materials to enhance its structural stability and adsorption properties. Chitosan has been integrated with various materials, including natural polymers (e.g., cellulose, chitin/chitosan, starch, alginate), clay minerals (e.g., perlite and montmorillonite), inorganic materials (e.g., zeolite, metal oxides, and metal-organic frameworks), and carbonaceous materials (e.g., graphene oxide, activated carbon, biochar, and carbon nanotubes). Among these, carbonaceous materials are promising materials, due to their high surface area, porosity, and stability, which significantly improve the mechanical properties, thermal stability, and electrical properties, as well as adsorption capacity. This review focuses on chitosan-based carbonaceous composite materials as adsorbents and covers several aspects, including their synthesis methods, structural and surface characteristics, mechanical properties, and adsorption performance as well as their applications in wastewater treatment, particularly for the removal heavy metals, dyes, organic pollutants (such as oil, fertilizers, antibiotics, and pharmaceuticals), nuclear wastes, and pathogenic microoganisms.

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PubMedNature communications2026-06-13

Direct Asymmetric α-C Conjugate Addition of Aminomethylphosphonate Enabled by Carbonyl/Iminium Double Organoactivation.

Ji Pengwei P, Yang Xingdie X, Ling Weibo W, Zhang Songnan S et al.

As important bioisosteres of α-amino acids, chiral α-aminophosphonic acids exhibit broad bioactivities and are widely employed in pharmaceuticals. Direct asymmetric α-C conjugate addition of aminomethylphosphonate to α,β-unsaturated ketones is an intriguing strategy to make bioactive chiral phosphonic 1-pyrrolines. However, this transformation remains challenging due to the low α-C-H acidity of the aminomethylphosphonate, significant steric hindrance from the phosphonate moiety and interference by side reactions. In this work, we report the direct enantioselective α-C conjugate addition of NH2-unprotected aminomethylphosphonate to α,β-unsaturated ketones, by applying an organo-organo double activation strategy that employs pyridoxal to activate aminomethylphosphonates into reactive carbanions, while concurrently using pyrrolidine to convert α,β-unsaturated ketones into active iminium species. Various chiral phosphonic 1-pyrrolines are synthesized in high yields with excellent diastereo- and enantioselectivity (up to 99% yield, > 20:1 dr, 99% ee). Furthermore, the methodology can be extended to a one-pot sequential synthesis of structurally diverse quaternary α-aminophosphonate derivatives.

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PubMedNature communications2026-06-13

Thermochemical Treatment of Wastewater Residual Solids for Global Mitigation of Emerging Contaminants.

Feng Jianan J, Guest Jeremy S JS

Emerging contaminants are ubiquitous across the environment, posing rising ecological and public-health threats. Through a global data compilation, we show wastewater residual solids, by-products of wastewater treatment, represent a concentrated reservoir of emerging contaminants, capturing an estimated 20%, 24%, and 13% of global releases of microplastics, pharmaceuticals, and antibiotic resistance genes, respectively. This concentration creates a strategic intervention point where eliminating emerging contaminants within wastewater residual solids can substantially reduce environmental loading. Leveraging this opportunity requires next-generation technologies such as thermochemical processing capable of near-complete emerging contaminant destruction. Simulation-based evaluation suggests thermochemical wastewater residual solids management exhibits overlapping cost and greenhouse gas emission ranges with conventional systems, with average costs typically higher and average greenhouse gas emission consistently lower. The Global North faces higher costs yet greater investment capacity, whereas the Global South benefits economically but faces infrastructure gaps. Collectively, this analysis provides insights into intercepting emerging contaminants, reframing wastewater systems as active planetary defenses.

PMID 42285948
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PubMedJournal of intensive care medicine2026-06-13

Variability in Vasoactive Medication use Across Pediatric Intensive Care Units: A PICU Data Collaborative Study, 2010-2022.

Brown Stephanie R SR, Heneghan Julia A JA, Badke Colleen C, Dziorny Adam C AC et al.

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PubMedAquatic toxicology (Amsterdam, Netherlands)2026-06-13

Developmental and behavioral toxicity of citalopram in zebrafish early life stages: Neurochemical alterations, oxidative stress responses, and transcriptomic signatures.

Liu Yanhua Y, Li Manting M, Yu Jianqiu J, Yu Fanrui F et al.

Citalopram (CTP), a selective serotonin reuptake inhibitor, is frequently detected in aquatic environments and may reach elevated levels in effluent-impacted hotspots. This study aimed to characterize the developmental and neurobehavioral toxicity of CTP in zebrafish early life stages across an exposure gradient and to identify associated multi-level biological signatures. Zebrafish embryos/larvae were exposed to CTP (0, 0.5, 5, 50, and 500 μg/L) from 0 to 168 h post-fertilisation (hpf) under semi-static renewal to assess early-life toxicity and associated mechanistic signatures. CTP elicited non-monotonic locomotor responses, with increased activity at lower concentrations and behavioral suppression at higher concentrations. Consistent with these behavioral alterations, oxidative stress responses were biphasic: SOD activity increased significantly at lower concentrations but was suppressed at the highest concentration, while lipid peroxidation was significantly elevated under high exposure. Neurochemical analysis showed reduced 5-hydroxytryptamine and γ-aminobutyric acid at higher concentrations, co-occurring with behavioral alterations. RNA-seq at 168 hpf indicated enrichment of clock-related annotations and altered expression of selected clock-associated transcripts; rhythmicity cannot be inferred without time-series sampling. Overall, CTP induced multi-level developmental and neurobehavioral toxicity in zebrafish, accompanied by redox dysregulation and neurotransmitter perturbations. These findings highlight the value of integrating behavioral, biochemical, neurochemical, and transcriptomic endpoints for hazard characterization of neuroactive pharmaceuticals in effluent-influenced aquatic environments.

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