若生智能
Drug Database
AB

abuse-deterrent extended release tablet technology

✓ Approved

Inspirion Delivery Technologies · 治疗药物

什么是 abuse-deterrent extended release tablet technology？

abuse-deterrent extended release tablet technology 是一种治疗药物，由Inspirion Delivery Technologies研发。该药已获批，用于治疗相关适应症，给药途径：Others。

药物档案

公司Inspirion Delivery Technologies
给药途径Others
状态Approved
来源： ClinicalTrials.gov, Inspirion Delivery Technologies

治疗适应症

abuse-deterrent extended release tablet technology 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresOral appliance application✓ Approved

相关研究文献

PubMedPest management science2026-06-13

Controlled-release herbicide spheres: co-crystallization of 2,4-dichlorophenoxyacetic acid with l-menthol via green oiling-out process for low leaching and high activity.

Zhang Xuzhao X, Fang Lan L, Wang Haiting H, Xiao Yuntian Y et al.

Excessive pesticide soil leaching (>99% loss) poses a critical environmental challenge. This study aimed to develop carrier free, slow release herbicide particles by integrating crystal engineering and spherical particle technology. A 2,4 dichlorophenoxyacetic acid-l menthol cocrystal was synthesized solvent free into spherical particles (D50 = 100-600 μm). These cocrystal particles reduced solubility by 21.6%, decreased dissolution rate by >50%, and reduced soil leaching by up to 93%, eliminating the need for carriers and avoiding secondary pollution. The release mechanism was governed by a multiscale diffusion limited process: enhanced hydrogen bonding networks elevated lattice energy, while solution mediated recrystallization transformed nanofibrous microstructures into diffusion restricting lamellar domains. Kinetic modeling indicated a transition from Fickian to hindered diffusion. Biological validation demonstrated superior weed control efficacy against chicory and shepherd's purse. This integrated approach establishes a sustainable paradigm for precision agrochemical delivery by significantly reducing environmental leaching while maintaining high herbicidal activity. © 2026 Society of Chemical Industry.

PMID 42286805
阅读全文 →
PubMedInternational journal of pharmaceutics2026-06-13

Determination of compartment properties of press-coated tablets by non-destructive terahertz technology.

Leung Chi Ki CK, Brauns Henry H, Ward-Berry Jasper N JN, Finke Jan H JH et al.

Compared to conventional film coating, press-coated tablets (PCTs) excel in their suitability for heat- and moisture-sensitive drugs and in their ability to produce thicker functional coats with higher drug loading. Previous work has demonstrated the importance of porosity to the mechanical properties of PCTs, but determining the porosities of the press coating separately from the tablet cores in the finished tablets remains challenging. Terahertz time-domain spectroscopy (THz-TDS) overcomes this challenge and non-destructively interrogates the PCT's compartment properties, including porosity, mass, height and thickness. The THz-TDS results align with reported literature values, are more physically consistent, and more closely reflect PCT compartments than the conventional method, which is affected by elastic recovery and material loss during physical separation of compartments. The robust THz-TDS approach is demonstrated with a range of PCT geometries, and its sensitivity to defective PCTs is confirmed. Its non-destructiveness permits the systematic determination of the material, process, and structural properties of each PCT, enabling more comprehensive analysis. With a thorough mechanical understanding of PCTs enabled by THz-TDS, predictive models can be developed to support Quality by Design (QbD) or Quality by Digital Design (QbDD) of PCTs.

PMID 42285380
阅读全文 →
PubMedScientific reports2026-06-13

Optimizing circular industrial integration for sustainable yarn production with remanufacturing: a carbon policy-based modelling approach.

Sahadevan Vishnupriya Kalathil VK, Thomas Abin A, Mishra Umakanta U

The rapid expansion of the textile industry presents critical challenges in achieving sustainable consumption and production. In response, this study develops an integrated sustainable production model for the yarn sector. The proposed model incorporates investments in green technology and wastewater purification systems, assessing their influence on both economic performance and environmental sustainability. The average integrated total profit of the system is optimized, and the model's practicability is demonstrated through a numerical illustration. The findings reveal that upcycling old garments enhances overall profitability by an average of 5.13% under both carbon pricing policies. Furthermore, while the CCT mechanism reduces green investment costs by 3.18%, the CT policy achieves a 2.29% reduction, highlighting the superior emission mitigation efficiency of the CCT approach. The suggested model advances sustainable production-consumption in the yarn industry by repurposing banana waste for yarn, and adopting the extended producer responsibility (EPR) directive, all while maintaining system profitability.

PMID 42286030
阅读全文 →
PubMedBMC health services research2026-06-13

Assessment of violence against patients by healthcare providers at the point of service delivery in Sekyere south district.

Bosompem Barbara Owusu BO, Twum Peter P, Acheampong Princess Ruhama PR, Mensah Kofi Akohene KA

While violence against healthcare workers has been widely studied, violence against patients (VAP) by healthcare professionals remains underreported and poorly addressed. Scrutinizing patients' feedback is crucial to understanding VAP, preventing abuse recurrence, and strengthening the healthcare system's integrity. The purpose of the study was to help determine the prevalence, extent, and healthcare workers category associated with VAP. Quantitative research approach was used and was non-interventional descriptive cross-sectional. Data collected was analyzed using descriptive statistics, Chi-square, logistic regression and bivariate regression in SPSS (version 22). 368 patients and 37 management members from six health facilities in Sekyere South District, Ghana. Simple random sampling was used. Sexual and physical abuse were the least common forms of VAP, reported by 2% and 4% of respondents, respectively. Verbal abuse and negligence accounted for about 70% of cases. Despite VAP reporting rates being low: physical abuse (< 6%) and discrimination (~ 8%) being the least and most reported respectively. Healthcare workers with more years of practice are more likely to receive reports than those with fewer years. The study highlights various forms of VAP by healthcare workers, including physical, verbal, sexual, discrimination, and negligence, with discrimination being most common. There is major underreporting of VAP. Notably, records staff, doctors, and midwives/nurses are significantly associated with various types of VAP.

PMID 42286707
阅读全文 →
PubMedGlycobiology2026-06-13

Siglec-15 binds mucin-domain glycoproteins with extended glycans and marks an osteoclast-like, matrix remodeling myeloid state in human tumors.

Derosiers Nohelly N, Aguilar William W, Lewis Hyeon-Gyu S HS, MacDonald Morgann M et al.

Siglec-15 has emerged as a therapeutic target in cancer, yet the glycan determinants and protein scaffolds that mediate engagement between Siglec-15-expressing myeloid cells and tumor cells remain incompletely defined. Here, we investigated the molecular basis of Siglec-15 recognition of cancer cells and examined transcriptional as well as functional programs associated with Siglec-15 expression in tumor-associated myeloid populations. Using immunoprecipitation-mass spectrometry in the pancreatic cancer cell line AsPC-1, we identified multiple mucin-domain glycoproteins enriched in Siglec-15 pulldowns. Disruption of glycan structures demonstrated that both complex N-glycans and extended mucin-type O-glycans contribute to optimal Siglec-15 binding. To define the myeloid population associated with Siglec-15 in human tumors, we interrogated publicly available single-cell RNA sequencing datasets and found that SIGLEC15 expression is enriched within a subset of tumor-associated myeloid cells exhibiting transcriptional features linked to osteoclast differentiation and extracellular matrix remodeling. Finally, in a THP-1 coculture model, Siglec-15 was further associated with DAP12-dependent tumor-induced expression of the osteoclast markers ACP5 and MMP9, together with increased release of IL-1β and IL-6. Collectively, these findings identify glycan and glycoprotein features that support Siglec-15 binding to malignant cells and associate SIGLEC15 expression with osteoclast-like and matrix-remodeling myeloid programs in human cancers, providing a framework for mechanistic studies of this glyco-immune checkpoint.

PMID 42286920
阅读全文 →
PubMedJournal for immunotherapy of cancer2026-06-13

Lymph node fine-tuning FcγR signaling boosts anti-PD-1 therapy.

Guérin Marion V MV, Ruggiu Mathilde M, Feldmann Lea C LC, Corre Béatrice B et al.

Anti-PD-1 monoclonal antibody (mAb) therapy promotes the emergence of new T cell clonotypes within tumors, suggesting de novo priming in the periphery. Yet, the mechanisms that mobilize these additional T cells remain poorly defined. We investigated the impact of anti-PD-1 mAbs on circulating T cell dynamics and their recruitment into tumor-draining lymph nodes (TDLNs) using multiple transgenic mouse models, including FcγR-deficient and type I interferon receptor-deficient mice. To dissect the role of FcγR engagement, we compared an Fc-silent anti-PD-1 LALAPG variant alongside conventional anti-PD-1 antibodies, and further extended our study to an additional immune checkpoint inhibitor for comparison. These approaches were complemented by experiments in FcγR-humanized mice using a human IgG4 anti-PD-1 mAb. In parallel, the effects of the therapeutic IgG4 antibody nivolumab were evaluated in human cell-based assays using dynamic imaging. Here, we demonstrate that anti-PD-1 mAbs promote the recruitment of circulating T cells into TDLNs, resulting in an expanded anti-tumor T cell response. This influx was part of a general reactive lymphadenopathy that required FcγR engagement and type I IFN production, leading to a burst of chemokine release. These results were extended to FcgR-humanized mice treated with a human IgG4 variant of the anti-PD-1 mAb and were similarly observed with another immune checkpoint inhibitor, anti-TIM-3, broadening this mechanism as a major one during checkpoint blockade in the LN. Our results reveal a previously unrecognized role for low to moderate FcγR engagement in TDLNs, which amplifies the anti-tumor T-cell response elicited during anti-PD-1 therapy.

PMID 42285607
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多abuse-deterrent extended release tablet technology