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zinc acetate dihydrate (Wilzin / Wilzin)

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Recordati S.p.A. · 小分子 · 小分子

什么是 zinc acetate dihydrate？

zinc acetate dihydrate 是一种小分子，由Recordati S.p.A.研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Wilzin, Wilzin
公司Recordati S.p.A.
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Recordati S.p.A.

治疗适应症

zinc acetate dihydrate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersHepato-lenticular degeneration✓ Approved

相关研究文献

PubMedCarbohydrate polymers2026-06-13

Correlating polymer solution and membrane fabrication with morphological and permeation properties of cellulose acetate ultrafiltration membranes.

Pires Rita F RF, Valente Margarida P MP, Rodrigues Flávia S C FSC, Charas Ana A et al.

Cellulose acetate (CA) membranes were prepared by phase inversion using three fixed solvent compositions (30/53, 31/52 and 35/48 wt% of formamide/acetone) while varying the air exposure time prior to immersion (0, 10, and 30 s). The influence of the percentage of formamide and evaporation time on the membrane structure and performance was investigated through scanning electron microscopy (SEM) and atomic force microscopy (AFM) characterization, pure water permeation, and molecular weight cut-off (MWCO) measurements. Results demonstrated that evaporation time was a key factor in controlling the membrane morphology. Short evaporation times favored fast demixing and the formation of macrovoids, while longer evaporation times (30 s) suppressed these defects and produced smoother selective layers. The CA(35)-30 membrane exhibited the most favorable properties, including a water permeability of 36.0 L/h/m2/bar, an MWCO of 35.0 kDa, low surface roughness (RMS = 1.81 nm), and an asymmetric structure free of macrovoids and surface stripes.

PMID 42285671
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PubMedJournal of hazardous materials2026-06-13

Stage-dependent zinc detoxification and allocation in rice revealed by Zn isotopes and transporter expression.

Zhao Zhenjie Z, Gao Ting T, Wu Qiqi Q, Liu Chengshuai C et al.

Zinc (Zn) is essential for rice but becomes toxic under excess supply, yet the processes governing Zn uptake, long-distance transport, and organ allocation remain unclear. Here we combine Zn stable isotopes (δ66Zn), transport efficiencies (φ), and expression of OsZIP4 and OsZIP1 (ZIP-family influx/efflux transporters), and OsHMA2 (a heavy metal ATPase mediating xylem loading) to quantify Zn homeostasis across a Zn gradient at tillering and maturity. Under sufficient Zn, whole-plant δ66Zn was lighter than the nutrient, indicating net uptake favoring light isotopes. Under high Zn, whole-plant δ66Zn shifted heavier, consistent with preferential exclusion/export of light Zn and supported by strong OsZIP1 induction. Shoots were consistently lighter than roots across treatments and stages, evidencing persistent kinetic fractionation during xylem loading. Development further modulated bulk flux independently of isotopic selectivity: at tillering, high Zn sharply reduced root-to-stem transport efficiency (φ2/φ1) while the Zn isotope fractionation factor between root and plant sap (ε2) changed little, indicating restricted translocation and enhanced root detoxification; at maturity, φ2/φ1 remained high with pronounced OsHMA2 upregulation, sustaining long-distance Zn delivery. Meanwhile, Zn excess rerouted Zn away from grains and toward vegetative pools, coinciding with strong OsZIP4 suppression in leaves. These patterns reveal a stage-dependent switch from "restricted transport and root detoxification" at tillering to "maintained transport but altered allocation" at maturity under Zn excess.

PMID 42284776
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PubMedBioresource technology2026-06-13

Self-Compensation besides porosity nanoarchitectonics in carbons derived from High-Carbon peat moss as High-Performance electrode materials for supercapacitors and Zinc-Air batteries.

Cai Yuyan Y, Wang Shihao S, Wu Yufei Y, Zhang Yuhua Y et al.

Biomass-derived carbons hold great potential as multifunctional electrode materials for applications in energy storage and conversion. Herein, we reveal the self-compensation mechanism besides porosity nanoarchitectonics in carbons converted from high-carbon peat moss for high-performance electrode materials. Firstly, carbons are prepared from whole peat moss plant by lignin removal at room temperature and chemical activation at 700 °C, where the high cellulose content in leaf is disclosed to contribute to mesopore formation and the lignin-rich stem containing oriented channels results in macropore generation. Although the obtained carbon possesses a medium specific surface area of 651.0 m2 g-1, the hierarchical porosity provides ideal pathways for fast charge storage and transport, thereby demonstrating a high capacitance of 260.0F g-1 at 1 A g-1 as a supercapacitor electrode material. Alternatively, hydrothermal treatment of whole peat moss plant at 180 °C leads to its partial carbonization, accompanied with the formation of abundant carbon dots. Further pyrolysis of the obtained carbon intermediate at 950 °C improves its graphitization, but decreases the specific surface area to 419.8 m2 g-1 due to structural collapse. However, benefiting from the stem-leaf compensatory mechanism during hydrothermal carbonization, the incorporation of carbon dots endows the carbons with abundant active sites for oxygen reduction reaction (ORR), providing an onset potential at 0.94 V vs. RHE and a half-wave potential at 0.84 V vs. RHE in alkaline solution. A full-cell zinc-air battery device with the obtained carbons as the cathode catalyst delivers a high power density of 171 mW cm-2 and good durability.

PMID 42285536
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PubMedJournal of environmental management2026-06-13

Development of membrane bioreactor using biopolymer recovered from corncob waste for tannery wastewater treatment.

Udayakumar Sathya S, Prabhu S Melvin SM, Minnalkodi Senguttuvan Keerthana Rani KR

This study presents the novel development and application of a cellulose acetate membrane synthesized from corncob waste, an agrowaste, in a submerged membrane bioreactor (MBR) system for treating real tannery wastewater. Corncob-derived cellulose biomaterial was used to fabricate the hollowfibre membranes for the very first time. Phase inversion method was used with N-methyl-2-pyrrolidone (NMP) as solvent and polyvinylpyrrolidone (PVP) as the pore-forming additive. Fourier Transform Infrared Spectroscopy (FTIR) confirmed successful acetylation with characteristic ester peaks at 1736 cm-1, along with key cellulose backbone features. The membrane was integrated into a lab-scale aerobic MBR treating real tannery wastewater with an average feed COD of 2550 mg/L, TSS of 1080 mg/L, NH4+-N of 162 mg/L, and TDS of 7440 mg/L. COD value decreased up to 856 mg/L during biological degradation process and the permeate had the average COD value of 640 mg/L, achieving overall removal efficiency of 75%. Initially, NH4+-N during acclimation process had dropped up to 141 mg/L and then finally reached the value of 55 mg/L. Membrane flux declined steadily from 26.18 to 3.89 L/m2·h as mixed liquor suspended solids (MLSS) increased from 8000 to 12,000 mg/L. The flux recovery ratio (FRR) after chemical cleaning with 0.5% NaOCl was 49.94% for the cellulose acetate membrane and 74.98% for the PVDF membrane, suggesting that further surface modifications or pretreatment steps may be necessary to enhance antifouling properties of biopolymer-based membranes. To improve the final effluent quality, ozonation was applied to the permeate for 60 min. This advanced oxidation step further reduced COD from 640 mg/L to 220 mg/L and significantly removed residual colour.

PMID 42284846
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PubMedCommunications chemistry2026-06-13

Selective cellulose fibril release from hardwoods libriform tissue.

von Usslar Felicitas F, Günaydın Büşra Ece BE, Zollfrank Cordt C

Cellulose fibrils are a renewable and biodegradable resource, but their extraction typically requires complete destruction of the original wooden matrix. We present a targeted strategy that enables selective liberation of cellulose microfibrils while preserving the integrity of the surrounding native wood structure. By combining partial delignification with localized surface modification using the ionic liquid 1-butyl-3-methylimidazolium acetate ([Bmim][OAc]), we enable selective liberation and separation of cellulose microfibrils without bulk dissolution or structural damage. This spatially confined treatment exploits the intrinsic anisotropy of the native cellulose architecture, allowing controlled fibril release while maintaining the original orientation and structural framework. These findings reveal how precise chemical interventions can expand the toolbox of cellulose chemistry and unlock new opportunities for advanced wood-based material engineering.

PMID 42286238
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PubMedJournal of applied toxicology : JAT2026-06-13

Epirubicin Alters Pancreatic Autophagy and Insulin Synthesis Through a Zinc-Dependent Mechanism.

Afşar Ebru E, Eranıl Işıl I

Epirubicin (EPI) can cause metabolic side effects, including chemotherapy-related diabetes, partly through oxidative stress that disrupts zinc (Zn) homeostasis and impairs autophagy. This study investigated the effects of EPI on Zn regulation and autophagy in the pancreas, as well as the modulatory role of N-acetylcysteine (NAC). Rats received EPI (9.6 mg/kg) by intraperitoneal injection (i.p.) followed 1 h later by NAC (50 or 300 mg/kg, i.p.). Glucose homeostasis was assessed using the Homeostatic Model Assessment (HOMA-IR), and β-cell function was assessed using HOMA-β levels. Plasma insulin levels, as well as insulin, proinsulin, beclin, autophagy-related proteins (ATG5), Microtubule-Associated Protein 1 Light Chain 3 (LC3), phosphorylated Akt (p-Akt), mechanistic target of rapamycin complex 1 (mTOR1), cleaved caspase-3, Zrt/Irt-like Protein 10 (ZIP10), and the proliferation marker Ki-67 in pancreatic tissue, were measured using commercial ELISA kits. Total oxidant status (TOS) and total antioxidant status (TAS) were measured using commercial colorimetric assay kits, and the oxidative stress index (OSI) was calculated. Zn levels in pancreatic tissue and plasma samples were measured using a colorimetric method. Morphological changes in the pancreas were assessed by hematoxylin and eosin staining. As a result, in the EPI group, oxidative stress and ZIP10 levels increased, whereas Zn levels decreased, as well as pancreatic autophagy, proliferation, and insulin synthesis increased. Oxidative stress decreased in both the EN-50 and EN-300 groups, with a more pronounced decrease in the EN-300 group. Furthermore, in the EN-300 group, pancreatic Zn, ZIP10, autophagy, and proliferation levels decreased, whereas mTOR1 levels increased. The pancreatic insulin synthesis observed in the EN-50 group was not observed in the EN-300 group. In conclusion, the increased autophagy observed in the Epi group may reflect an adaptive response to oxidative stress. The effects of NAC on oxidative stress may be dose-dependent, and high-dose NAC administration may suppress EPI-induced autophagy via mTOR1-mediated signaling. Furthermore, the relationship among Zn levels, autophagy, and insulin synthesis observed in the experimental groups may contribute to a better understanding of EPI-associated diabetogenic alterations.

PMID 42286405
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