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atenolol + bendroflumethiazide (TenBen / Amoretic LD / Amoretic)

✓ Approved

Warner Chilcott PLC · ADRB1 · 小分子

什么是 atenolol + bendroflumethiazide？

atenolol + bendroflumethiazide 是一种小分子，由Warner Chilcott PLC研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名TenBen, Amoretic LD, Amoretic
公司Warner Chilcott PLC
药物类别小分子
分子靶点ADRB1, SLC12A3
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Warner Chilcott PLC

作用机制

分子靶点

atenolol + bendroflumethiazide 作用于 2 个分子靶点：

ADRB1adrenoceptor beta 1 (B1AR, RHR)
SLC12A3solute carrier family 12 member 3 (NCCT, NCC)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

atenolol + bendroflumethiazide 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersHypertension✓ Approved
Renal and urinary disordersRenal failure✓ Approved

相关研究文献

PubMedThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2026-06-10

Approach to the Preoperative Pharmacological Management of Catecholamine-Secreting Tumors in Children: A Case Series and Review.

Dollimer Olivia O, Raschka Mike M, Dassenko David D

Catecholamine-secreting tumors (CSTs) are an uncommon tumor in pediatrics that can result in hypertensive crisis secondary to catecholamine release from the tumor cells. Pheochromocytoma is the tumor type most associated with excessive catecholamine release, but paragangliomas and neuroblastoma tumors can also generate and release excessive amounts of catecholamines. Surgical resection is typically the treatment of choice for these tumor types; however, manipulation during surgical resection can lead to further catecholamine release. If the patient's adrenergic receptors are not fully inhibited before undergoing surgery, the patient is at risk for experiencing additional hypertensive crises and arrhythmias due to the catecholamine release secondary to the surgery. Although studies have identified sequential α- and β-adrenergic blockade as a prerequisite for surgery to minimize the effects of further catecholamine release during resection, there is little guidance regarding medication timing, dosing, and testing to ensure the pediatric patient has adequately suppressed adrenergic receptors before surgery. Further, with recent shortages of the first-line medication treatment options for this indication, it is vital to establish a treatment plan with alternative treatments for use during drug shortages. This case series describes the successful use of enteral phenoxybenzamine and parenteral phentolamine for α-adrenergic blockade, coupled with enteral atenolol and parenteral esmolol or labetalol for β-adrenergic blockade, in 9 pediatric patients with CST before surgical resection of the tumors. Eight patients underwent a phenylephrine challenge, and all demonstrated appropriate α-blockade preceding tumor removal.

PMID 42267065
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PubMedBMJ open2026-06-09

Association between hypertension status and severity and tinnitus: a cross-sectional analysis of the Fasa adult cohort study.

Najibi Amirhossein A, Bazmi Sina S, Moradi Mehrnaz M, Mohammadi Zahra Z et al.

Previous studies and meta-analyses suggest an association between hypertension and tinnitus; however, the influence of hypertension severity and control status remains unclear. We aimed to investigate the association between hypertension and tinnitus in detail using a large, population-based dataset from a rural setting.DesignObservational cross-sectional study.SettingSheshdeh, Fasa, Iran. We analysed data from 9775 individuals in the general population, aged 35-70 years, excluding those with a history of cancer, pregnancy or medical conditions known to cause tinnitus, such as stroke, seizures or multiple sclerosis. Additionally, although the study design aimed to exclude participants using aminoglycosides because of their significant ototoxic effects, no such users were identified during the study period. Hypertension was defined as a systolic blood pressure (SBP) of ≥140 mm Hg or a diastolic blood pressure (DBP) of ≥90 mm Hg on at least two separate measurements or as current use of antihypertensive medications following a prior diagnosis. These medications included ACE inhibitors, angiotensin receptor blockers, diuretics, aldosterone antagonists and atenolol. Stage I hypertension was classified as an SBP of 140-159 mm Hg or a DBP of 90-99 mm Hg, while stage II was defined as an SBP of ≥160 mm Hg or a DBP of ≥100 mm Hg. Controlled blood pressure was defined as values below these thresholds. Tinnitus, assessed by a self-reported questionnaire, was defined as a continuous wheezing sound in the ear persisting for more than 1 week. Among participants (4446 males, 5309 females; mean age 48.55 (SD 9.53) years), the prevalence of tinnitus and hypertension was 7.4% and 19.3%, respectively. Hypertension was significantly associated with higher odds of tinnitus (adjusted OR=1.34; 95% CI 1.10 to 1.62). Notably, even participants with controlled hypertension had a 27% increased odds (OR=1.27; 95% CI 1.02 to 1.59) compared with normotensive individuals. The odds were highest in those with uncontrolled grade II hypertension (OR=2.08; 95% CI 1.25 to 3.47), demonstrating a dose-response relationship. Our findings suggest a positive association between hypertension and tinnitus, with odds increasing alongside the severity and poor control of hypertension. Importantly, even controlled hypertension was associated with elevated odds, indicating that tinnitus screening may be warranted in all hypertensive patients, regardless of control status. These results underscore the need for heightened clinical awareness and further research into the pathophysiological mechanisms linking vascular health and auditory symptoms.

PMID 42259562
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PubMedCureus2026-06-08

Post-traumatic Exacerbation of Grade II L5-S1 Spondylolisthesis Requiring Surgical Stabilization.

Blanco Espinosa Elizabeth E, Cruzata Matos Idania I, Matos Furones Yelka Y, Cuni Hernandez Ana B AB et al.

Spondylolisthesis is characterized by the forward movement of one vertebra over the one beneath it, most frequently occurring at the L5-S1 level due to its biomechanical susceptibility. Although often asymptomatic, it may become clinically significant when underlying instability is exacerbated by external factors. Low-energy trauma can unmask previously undiagnosed spondylolisthesis, resulting in acute pain, neurological symptoms, and functional impairment. We report the case of a 51-year-old woman with a history of hypertension treated with atenolol, with no prior medically documented history of chronic low back pain or spinal pathology (noting that this information was obtained retrospectively from patient history after resolution of acute intoxication). She presented with severe low back pain following a fall from standing height while under the influence of alcohol. The pain was progressive, refractory to analgesia, with a reported intensity of 9/10 on the Visual Analog Scale (VAS), and associated with paresthesia and impaired ambulation. No standardized functional outcome scores were available pre- or post-operatively, which limits functional outcome comparison. Imaging studies, including magnetic resonance imaging (MRI), revealed Grade II L5-S1 spondylolisthesis with degenerative disc changes, canal narrowing, and suspected neural compression, without evidence of acute fracture. Computed tomography (CT) was not available at presentation for independent review, and prior external imaging reports were not retrievable. Given persistent symptoms after failed conservative management and clinical evidence of neurological progression, the patient underwent posterior lumbar stabilization with pedicle screw instrumentation at L5-S1. The procedure performed was posterior instrumented fusion with pedicle screw fixation and posterolateral arthrodesis. The postoperative course was uneventful, with improvement in pain and mobility and resolution of sensory symptoms. The VAS score improved from 9/10 preoperatively to 2/10 at the six-week follow-up. The patient was discharged on postoperative day 3 and showed continued improvement at six months. This case highlights that low-energy trauma may reveal previously asymptomatic spondylolisthesis. Early recognition, appropriate imaging, and timely surgical intervention are essential for optimal outcomes. Posterior instrumentation remains a reliable treatment option when tailored to clinical presentation. However, functional outcome measures and long-term radiographic fusion assessment were not available, limiting interpretation of definitive recovery.

PMID 42255775
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PubMedEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences2026-06-06

Synergistic impact of 3D multicellular architecture and capillary-like flow on intestinal drug permeability.

Dias Sofia S, Costa Sofia S, Barros Sofia S, Leite Pereira Catarina C et al.

Understanding intestinal drug permeability requires in vitro systems capable of reproducing both the structural complexity and the dynamic fluidic environment of the human gut. Traditional two‑dimensional (2D) models, although widely used in Absorption, Distribution, Metabolism and Excretion (ADME) screening, offer limited physiological relevance and often fail to predict in vivo absorption. Three‑dimensional (3D) models and microfluidic technologies have emerged as promising tools to address these limitations by incorporating multiple cell types, extracellular matrix components, and biomechanical cues. In this study, we compared the permeability of three model drugs, metoprolol (high permeability), atenolol (moderate permeability), and colchicine (low permeability), across a 2D Caco‑2/HT29‑MTX coculture and an advanced 3D intestinal model composed of the same epithelial cells, stromal fibroblasts embedded in a collagen-alginate matrix, and a basolateral endothelial layer mimicking the vascular compartment. Both systems were evaluated under static conditions and under dynamic basolateral flow using the PDMS‑free MIVO® millifluidic platform designed to reproduce capillary‑like fluid dynamics. Permeability and TEER measurements revealed consistently higher transport across the 3D model than the 2D system, confirming its enhanced physiological relevance. Dynamic flow further increased permeability in both models, with the most pronounced effect observed for metoprolol, whose permeation was highest under dynamic 3D conditions. Flow also accelerated TEER decline in the 3D setup, suggesting increased barrier stress associated with elevated transport. Overall, integrating 3D multicellular architecture with physiologically relevant flow substantially improves the predictive capacity of intestinal in vitro models. These findings support dynamic 3D systems as advanced tools for drug permeability assessment and early‑stage drug development.

PMID 42248264
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PubMedAquatic toxicology (Amsterdam, Netherlands)2026-05-30

From cells to organisms: an integrative assessment of pharmaceutical toxicity and mixture effects.

Panni Michela M, Mezzelani Marica M, d'Errico Giuseppe G, Vitale Matteo M et al.

Pharmaceuticals are ubiquitously detected in all environmental matrices and the continuous exposure of non-target aquatic species can impair their metabolic pathways, leading to unknown long-term effects. In this study, the ecotoxicological potential of 16 environmental pharmaceuticals and 7 mixtures (psychiatric, cardiovascular, lipid-lowering, non-steroidal antinflammatory drugs, and antidiabetics) were evaluated in 6 different biological models. In vivo ecotoxicological bioassays (algal growth inhibition, oyster and sea urchin embryotoxicity, bacterial bioluminescence inhibition) were combined to in vitro tests on fish hepatic (PLHC-1) and gill (RTgill-W1) cell lines. A quantitative Weight of Evidence approach was applied to better compare the biological significance of all tested experimental conditions. Results on ecotoxicological bioassays demonstrated different sensitivity of the tested species, with higher effects observed in terms of embryotoxicity and/or algal growth inhibition. Among cell lines, PLHC-1 exhibited selective toxicity towards specific active principles, whereas RTgill-W1 showed broader susceptibility. Psychiatric drugs were the most reactive therapeutic class in all biological models, whereas atenolol, naproxen, paroxetine, venlafaxine and carbamazepine-10,11-epoxide exhibited the greatest toxicity among all investigated compounds. Despite this study did not support a formal mixture-toxicity framework, mixture responses varied among combinations and models, and composition appeared more important than mixture size under the tested conditions. Overall, the selected biological models exhibited distinct species-specific response patterns following mixture exposure. By integrating measured effects into synthetic hazard indices, the quantitative Weight of Evidence approach demonstrated the potential of effect-based tools to prioritize future studies on environmental pharmaceuticals.

PMID 42214195
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PubMedTherapeutic advances in urology2026-05-25

The causal association between seven drugs and erectile dysfunction: a Mendelian randomization study.

Zhan Jian J, Liu Jing J, Huang Yilan Y, Jiang Longyang L

Many studies have shown that patients develop erectile dysfunction (ED) after taking or aggravating certain drugs. However, other studies have considered such conclusions to be inaccurate. To explore the genetically predicted associations between drug treatment and ED, we used publicly available genome-wide association study (GWAS) data to evaluate the relationship between seven drug treatment regimens and ED using two-sample Mendelian randomization (MR) analysis. In this study, a two-sample Mendelian randomized design was used to evaluate the causal relationship between 40 drugs and the risk of ED using publicly available pooled data from the GWAS. We employed five methods for MR analysis: MR-Egger, weighted median, inverse variance weighted (IVW), simple mode, weighted mode, MR-Egger intercept test, MR pleiotropy residual sum, and outlier global test to identify horizontal pleiotropy. Cochran's Q statistics were used for instrument heterogeneity tests, and the leave-one-out method was used for sensitivity analysis. The results showed that simvastatin (p = 0.023), ramipril (p = 0.041), metformin (p = 0.00061), gliclazide (p = 0.015), atorvastatin (p = 0.037), atenolol (p = 0.0052), aspirin (p = 0.051), and simvastatin, and five other drugs were potentially associated with ED. After excluding confounding single-nucleotide polymorphisms (SNPs), the p-value of aspirin was slightly above 0.05, suggesting that aspirin may not have a potential causal relationship with ED, warranting further investigation to confirm this finding. No potential causal relationships were found between the remaining 33 exposures and ED. Genetically predicted associations suggest that there may be potential causal relationships between simvastatin, ramipril, metformin, gliclazide, atorvastatin, atenolol, and ED, which require further research.

PMID 42182083
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