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ketoprofen (Menamin SR / ketoprofen, Biovail / Oruvail)

✓ Approved

Roche · PTGS1 · 小分子

什么是 ketoprofen？

ketoprofen 是一种小分子，由Roche研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Menamin SR, ketoprofen, Biovail, Oruvail
公司Roche
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Roche

作用机制

分子靶点

ketoprofen 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ketoprofen 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Gastrointestinal disordersAbdominal pain✓ Approved
Hepatobiliary disordersHepatitis✓ Approved

相关研究文献

PubMedJournal of clinical medicine2026-06-12

Losmapimod, an Oral Anti-p38 MAP Kinase, Demonstrates Anti-Neuropathic and Anti-Inflammatory Effects in Rat Acute Pain.

Soued Mickael M, Hamdi Leila L, Ben Rehouma Mouna M, Mazoit Jean-Xavier JX et al.

Background: The postoperative period is a large provider of acute and chronic pain which often combine pronociceptive, neuropathic and inflammatory components. As p38 MAPkinases are involved in pain response, this study aimed to evaluate the effect of losmapimod, an oral p38 MAPkinase inhibitor at the very first stage of acute neuropathic pain. Losmapimod efficacy was also compared with other well-known pain-relieving drugs and its dose response determined after inflammatory pain. Methods: The anti-neuropathic properties of losmapimod were evaluated after acute neuropathic pain (from day 0 to day 3 after sciatic nerve ligation) using thermal and mechanical stimulation. Losmapimod was also compared with gabapentin, their respective ED50 were determined, and their interaction was studied using an isobolographic approach. The anti-inflammatory characteristics of losmapimod were assessed from day 0 to day 5 after carrageenan injection in the rat hind paw and compared with those of ketoprofen, ketamine, and morphine using paw oedema volume. Results: Losmapimod provided a potent analgesic effect after acute neuropathic pain. The ED50 with their 95% confidence intervals of losmapimod and gabapentin were 10.5 (6.9-12.9) mg/kg and 18.2 (15.0-20.3) mg/kg, respectively. Their interaction was additive. Losmapimod also had a potent anti-inflammatory effect (ED50 was 34 (19.0-246) mg/kg) with significant reduction of paw oedema (similarly to ketoprofen). Conclusions: Losmapimod showed anti neuropathic properties at the very early stage of neuropathic pain and potent anti-inflammatory properties. As previous studies have highlighted the excellent tolerance of losmapimod in human populations, this drug seems promising for acute postoperative pain, which combines both acute neuropathic and inflammatory mechanisms.

PMID 42279126
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PubMedCurrent pharmaceutical design2026-06-01

Exploring the Potential of Dendrimers in Skin Drug Delivery: Applications and Advances.

Saldanha Melria Cryshal MC, Dubey Akhilesh A, Pierre Maria Bernadete Riemma MBR

Dendrimers (DDs) have become a pioneering tool in dermatological nanomedicine thanks to their branched nanostructure, high precision, and multifunctional nature. The purpose of this review is to highlight the revolutionary potential of DDs regarding the primary barrier for skin drug delivery - the stratum corneum. The enhanced solubility, controlled drug release, and facilitated drug penetration achieved by the customized dendrimer architecture are described in terms of diffusion, degradation, and stimuli-responsive mechanisms. The latest achievements are critically assessed through the topical approaches for psoriasis, wound healing, and skin cancer treatment, as well as transdermal delivery for systemic vaccines and gene therapy. The essential aspect of surface engineering is also analyzed in terms of its dual-edged features-chemical functionalization optimizes skin affinity and therapeutic specificity while addressing toxicological issues. Quantitative data from the literature have been provided to support the benefits, such as a 4.5-fold increase in the transdermal flux of indomethacin using PAMAM G4 and 2.7-fold and 2.5-fold increases in the bioavailability of ketoprofen and diflunisal, respectively. Moreover, in the studies applying dendrimers combined with sonophoresis, the permeability results demonstrated a noticeable trend - e.g., 935.21 μg/cm2 versus 56.69 μg/cm2 permeation, which indicates the possibility of synergism with physical enhancement methods Moreover, in the studies applying dendrimers combined with sonophoresis, the permeability results demonstrated a noticeable trend - e.g., 935.21 μg/cm2 versus 56.69 μg/cm2 permeation, which indicates the possibility of synergism with physical enhancement methods. To ensure successful transfer to clinics, an increased focus on long-term safety, synthesis scalability, and reproducibility is needed. This article provides an in-depth, objective, and holistic assessment of dendrimers as a versatile, continually expanding and improving toolkit for targeted skin therapies.

PMID 42220129
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PubMedOtolaryngologia polska = The Polish otolaryngology2026-05-25

Leveraging large language models to audit perioperative total laryngectomy care: anesthetic, nutritional, and complication profiles in a real‑world cohort.

Zając Bernard B, Wierzbicka Małgorzata M, Jeziorny Mateusz M, Zalewska Klara K et al.

<p><strong>Introduction: </strong>Total laryngectomy (TL) remains the standard treatment for advanced la‑ ryngeal cancer, and its perioperative management requires close collaboration within a multidisciplinary team, including anaesthesiologists and clinical nutritionists.</p><p><strong>Aim:</strong> The aim of this study was to analyse the perioperative course of patients un‑ dergoing TL from both an anaesthesiologist's and a nutritionist's perspective, with a particular focus on the feasibility and performance of structured data extraction from electronic medical records using large language models (LLMs).</p><p><strong>Material and methods:</strong> We performed a single‑centre retrospective analysis of 43 consecutive patients undergoing TL (ICD‑9 codes 30.32, 30.39, 30.41, 30.49) be‑ tween January 2024 and April 2026. Clinical data, including physician notes (n = 845), nursing notes (n = 2578), discharge summaries (n = 173), and consultations (n = 123), were subjected to structured extraction using large language models (gemma-3-31Bit/gemma-4-26B-it). Demographics, tumour stage, length of stay (LOS), periopera‑ tive nutrition, pharmacotherapy, postoperative complications, temporal laboratory trends, and rehabilitation were analysed.</p><p><strong>Results: </strong>The cohort comprised 35 men (81%) and 8 women (19%), with a mean age of 66.4 9.8 years; pT4a (49%) and pN0 (82%) predominated. Median LOS was 15.0 days (IQR 13.1-16.5). Enteral nutrition via nasogastric tube was used in 95% of patients, and oral intake was initiated at a median of postoperative day 13. Multimodal anal‑ gesia based on intravenous paracetamol (60%), ketoprofen (47%), and metamizole (40%) was routinely employed, while strong opioids were used in only 5% of pa‑ tients. Postoperative complications occurred in 22.5% of cases, with pharyngocuta‑ neous fistula (PCF) being the most frequent (12.5%). In‑hospital mortality was 0%, and overall mortality during a median 12‑month follow‑up was 2.3%. CRP peaked on postoperative day 3 (mean 114 mg/L). Pharmacologic VTE prophylaxis was admi‑ nistered in 65% of patients.</p><p><strong>Conclusions:</strong> In TL patients, enteral feeding forms the backbone of nutritional sup‑port, and multimodal analgesia provides effective pain control, whereas VTE pro‑phylaxis and other modifiable elements of perioperative care warrant optimization within prehabilitation and ERAS-based protocols.</p><p>&nbsp;</p&gt.

PMID 42178846
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PubMedPain research & management2026-05-22

Comparative Analgesic Efficacy of Diclofenac and Ketoprofen Transdermal Patches Versus Ibuprofen Tablets for Pain Control After Initial Archwire Placement in Orthodontic Patients: A Randomized Clinical Trial.

Babaee Hemmati Yasamin Y, Toghrolian Amirhossein A

This study compared the analgesic efficacy of diclofenac and ketoprofen transdermal patches versus ibuprofen tablets for pain control following initial archwire placement in orthodontic patients. In this randomized clinical trial, 60 patients (aged 15-30 years) undergoing fixed orthodontic treatment (0.022-inch MBT brackets and 0.014-inch nickel-titanium archwires on both arches) were assigned via stratified permuted block randomization (1:1:1 ratio) to three groups (n = 20 each): 30-mg ketoprofen transdermal patches every 12 h, 15-mg diclofenac transdermal patches every 12 h, or 400-mg ibuprofen tablets every 8 h for 1 day. Pain severity was assessed using the numeric rating scale (NRS; 0-10) at baseline (immediately postplacement), 2 and 6 h, bedtime, 24 and 48 h, and 3 and 7 days. Data were analyzed by the generalized estimating equation (GEE) and the Kruskal-Wallis, Bonferroni, chi-square, and Fisher's exact tests (α = 0.05). The pain score was the lowest in the ketoprofen group, followed by the ibuprofen group, and then the diclofenac group, but the difference was not significant (p > 0.05). The pain score initially increased after archwire placement to 6 h (from 0 pain in all groups to 2.50 ± 1.64, 3.90 ± 1.25, and 3.45 ± 1.82, respectively, in ketoprofen, diclofenac, and ibuprofen groups). It subsequently decreased until bedtime, increased again at 24 h, and then followed a descending trend from 48 h to 7 days. The trend of change in the pain score over time was not significantly different among the three groups (p = 0.657). Age (p = 0.757) and gender (p = 0.153) of patients did not affect their perceived pain. Considering the comparable analgesic efficacy of ibuprofen and the tested transdermal patches, diclofenac and ketoprofen patches may be used as an alternative to ibuprofen tablets for efficient pain control after initial archwire placement. Iranian Registry of Clinical Trials: IRCT20190915044771N2.

PMID 42170735
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PubMedArtificial cells, nanomedicine, and biotechnology2026-05-22

Anticancer activity of fluoxetine Janus dendrimer against cancer cells.

Martínez-García Marcos M, Hernández-Rioja Isabel I, Barajas-Mendoza Israel I, Espinosa-Hernández Alberto A et al.

Targeting the inflammation-related molecules with nonsteroidal anti-inflammatory drugs (NSAIDs) represents a promising approach for cancer prevention/therapy. We evaluated the in vitro anticancer effects of sulindac, ketoprofen, celecoxib and the antidepressant fluoxetine, both free and coupled with synthesized dendrons and dendrimers, on the proliferation and apoptosis of human MCF-7 (human mammary adenocarcinoma), SKLU-1 (human lung adenocarcinoma) and as a control the normal monkey kidney (COS-7) cell line. The antiproliferative activity and cytotoxicity of tested NSAIDs on MCF-7 and SKLU-1 cell lines were assessed by the sulforhodamine B (SRB) assay. The tested dendrons with NSAIDs showed activity against the tumour cell lines. Significant inhibition of the growth of cancer cells was observed for the Janus dendrimers with sulindac-celecoxib, which was selective against MCF-7; and Janus dendrimers with fluoxetine were highly cytotoxic. The fluoxetine-dendrimer could be a candidate for the development of new pharmacological strategies for the treatment and prevention of MCF-7 cancer.

PMID 42167254
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PubMedPorcine health management2026-05-21

Efficacy of intranasal non-steroidal anti-inflammatory drugs on pain responses in castrated and tail-docked piglets.

de Melo Cecília Archangelo Ferreira CAF, Alves Laya Kannan Silva LKS, Pairis-Garcia Monique Danielle MD, Ferreira Juliana Bonin JB et al.

Routine piglet processing procedures, such as surgical castration and tail docking, are known to induce pain and stress, and non-steroidal anti-inflammatory drugs (NSAIDs) are commonly administered to mitigate these responses. This study evaluated the effects of processing and NSAID administration on physiological and behavioral indicators of pain and stress in male piglets. A total of 120 piglets (5 days old) were randomly assigned to one of eight treatment groups in a 2 × 4 factorial design, including sham or processed piglets receiving intranasal flunixin meglumine, ketoprofen, meloxicam, or saline solution. Piglets underwent surgical castration and tail docking or sham handling one hour after treatment administration. Plasma cortisol concentrations were assessed at baseline, 1 h, 3 h, and 24 h post-procedure, and pain-related behaviors were evaluated using the UNESP-Botucatu Pig Composite Acute Pain Scale (UPAPS). Processed piglets, both with and without NSAID administration, exhibited higher plasma cortisol concentrations than sham piglets at 1 h post-procedure, indicating an acute stress response, with concentrations returning to baseline by 3 h and 24 h. No treatment effects of NSAIDs were observed for cortisol concentrations. Behavioral assessment revealed higher UPAPS scores in processed piglets at 1 h, 3 h, and 24 h compared with sham piglets, indicating persistent pain-related responses. NSAID treatments did not consistently mitigate behavioral pain expression, although ketoprofen-treated piglets exhibited a transient reduction in UPAPS scores at 3 h post-procedure. Overall, piglet processing elicited acute physiological stress responses and sustained behavioral indicators of pain. These findings support the need for integrated analgesic strategies to more effectively mitigate post-procedural pain and improve piglet welfare.

PMID 42163397
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