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Fraction F (Fraction F / Ateroid / Ateroid 200)

✓ Approved

Gentium · 治疗药物

什么是 Fraction F？

Fraction F 是一种治疗药物，由Gentium研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)、Oral (PO)。

药物档案

商品名Fraction F, Ateroid, Ateroid 200
公司Gentium
给药途径Injectable (Others), Intravenous (IV), Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Gentium

治疗适应症

Fraction F 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersDementia Alzheimer's type✓ Approved

相关研究文献

PubMedJournal of Korean biological nursing science2026-08-07

The effect of an osteoarthritis adaptation program on biological, psychological, and social integrity variables and quality of life in older women with osteoarthritis in Korea: a quasi-experimental study.

Seo Hye Sim HS, Eun Young Y, Jeon Mi Yang MY

This study aimed to determine whether an osteoarthritis adaptation program increased biological, psychological, and social integrity variables and quality of life in older women with osteoarthritis in Korea. This study employed a non-equivalent control group pretest-posttest design, allocating 51 older women with osteoarthritis to an experimental group (26 participants) and a control group (25 participants). The program was conducted thrice weekly for 12 weeks, with each session lasting 60 to 90 minutes. It combined exercises (flexibility, muscle strength, and aerobic) and education (pain control, nutrition management, and compliance). Pain differed significantly between the groups (F = 12.10, p < .001), and the time-group interaction was also significant (F = 23.65, p < .001). Difficulty in daily living did not show significant differences between the groups (F = 3.88, p = .055), although the time-group interaction was significant (F = 39.57, p < .001). Depression showed a significant difference between the groups (F = 7.24, p = .010), as did the time-group interaction (F = 9.17, p = .002). Social support also differed significantly between the groups (F = 46.07, p < .001), and the time-group interaction was significant (F = 45.22, p < .001). Quality of life showed significant differences between the groups (F = 29.04, p < .001), and the time-group interaction was also significant for this variable (F = 64.32, p < .001). The osteoarthritis adaptation program effectively improved biological, psychological, and social integrity variables in older women with osteoarthritis. Therefore, this program offers considerable benefits to older women with chronic osteoarthritis, emphasizing its value for individuals with osteoarthritis living in the community.

PMID 42563739
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PubMedVirologica Sinica2026-08-07

Stabilization of prefusion hMPV F improves manufacturability and protective immunity across hMPV lineages.

Qu Changbin C, Zou Jingjing J, Niu Dongyu D, Wu Qingxin Q et al.

Human metapneumovirus (hMPV) is a major cause of pediatric acute lower respiratory tract infections (ALRTIs), yet vaccine development has been hindered by the intrinsic metastability of the prefusion F glycoprotein (pre-F). Here, we used a structure-based design strategy to stabilize hMPV pre-F while preserving neutralization-sensitive epitopes. By applying combined stabilizing elements, including disulfide bonds, a designed salt bridge, and a trimer-interface sequence swap, we generated VM-874, a pre-F-stabilized trimer that was expressed at high levels in 293F cells and exhibited improved thermal stability and stress-resistant antigenicity. VM-874 also retained binding to multiple conformation-sensitive monoclonal antibodies following thermal and storage stress. VM-874 elicited high serum neutralizing titers against both hMPV A2 and B1 strains and conferred protection in BALB/c mice and cotton rats, as evidenced by reduced pulmonary viral burden and attenuated lung pathology after challenge. Although VM-874 elicited antibodies that cross-bound respiratory syncytial virus (RSV) F protein, no RSV-neutralizing activity was detected, underscoring the need to distinguish cross-reactivity from heterologous protection in combined RSV/hMPV vaccine strategies.

PMID 42562214
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PubMedAngewandte Chemie (International ed. in English)2026-08-07

Crystal Void Fraction-Engineered Fe-S Catalysts for Self-Sustaining Li-CO2 Mars Batteries.

Wei Tianchen T, Su Leyi L, Wu Liang L, Liu Yuchun Y et al.

Efficient energy storage is vital for self-sustaining Martian exploration. Li-CO2 batteries are promising by utilizing the Martian atmosphere (∼95% CO2) as active materials. Fe-S minerals, abundant on Mars, offer a viable candidate for cathode catalysts, yet their structural diversity necessitates a rational selection criterion. Here, we propose crystal void fraction as a governing descriptor correlating with affinity toward critical oxygen-containing species, Li2CO3 and singlet oxygen (1O2). Higher void fraction with decreased Fe-S6 octahedra packing density upshifts the d-band center and brings the z-containing orbitals closer to the Fermi level. Given the pronounced O-2pz character of Li2CO3 band-edge states and the π* orbital of 1O2 frontier orbital, symmetry matching along surface orbitals with z-directional components strengthens orbital coupling, correlating higher crystal void fractions with increased affinity for oxygen-containing species. Crucially, this affinity exhibits a dual role. High void fraction promotes Li2CO3 decomposition but 1O2-induced catalyst degradation, while low void fraction exhibits the opposite tendency. Marcasite with moderate void fraction achieves an optimal balance, achieving 88% energy efficiency and 1000 h cycle life. This work establishes crystal void fraction as a predictive metric for screening suitable catalysts for achieving activity-stability trade-off, and provides a promising landscape for in-situ resource utilization on Mars.

PMID 42565649
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PubMedChemical communications (Cambridge, England)2026-08-07

Synchronizing proton and electron transfer via hydrogen-bond bridging between carboxylated nanocellulose and C3N5 for efficient H2O2 photosynthesis.

Wang Zhaoqiang Z, Yan Di D, Yu Yaqin Y, Liu Xin X et al.

Here, we report a hydrogen-bond bridging strategy to combine carboxylated nanocellulose (f-CNF) with nitrogen-rich carbon nitride (C3N5). This strategy constructs a hydrogen-bond network that spatially facilitates the transfer of photogenerated charge carriers and the rapid supply of protons through interactions with C3N5. More critically, the carboxyl-rich f-CNF serves as an efficient proton donor to drive the directional migration of protons from f-CNF to C3N5, accurately enriching electron accumulation sites with protons and achieving synchronous conversion of protons and electrons. As a result, the catalyst presents a high H2O2 production rate of 1473 µmol L-1 h-1.

PMID 42565223
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PubMedGeriatrics & gerontology international2026-08-07

Impact of Narrative Nursing and Cognitive Behavioral Rehabilitation on Cognitive Function and Anxiety in Patients With Alzheimer's Disease.

Shao Rui R, Li Wenzhu W, Su Hang H, Zhou Shuang S et al.

Alzheimer's disease (AD) progressively impairs cognitive function and quality of life (QoL). Patients frequently experience anxiety, which may accelerate cognitive decline. This study aimed to investigate the effects of narrative nursing combined with cognitive behavioral rehabilitation on cognitive function and anxiety in AD patients. In this randomized controlled trial, 172 AD patients were assigned to a control group (conventional care, n = 86) or an observation group (additional 6-month narrative nursing and cognitive behavioral rehabilitation, n = 86). Outcomes were assessed at baseline and after the 6-month intervention using validated Chinese versions of the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Generalised Anxiety Disorder-7 (GAD-7), Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL), and Quality of Life in Alzheimer's Disease (QoL-AD) scales. Baseline characteristics, including age (mean: 68.5 ± 10.2 years), sex distribution (57.6% men), body mass index (22.95 ± 3.44 kg/m2), disease duration (5.32 ± 0.79 years), and baseline cognitive scores (MMSE: 19.25 ± 2.88; MoCA: 17.00 ± 2.55), did not differ significantly between groups. After 6 months of intervention, the observation group demonstrated greater improvement in cognitive function (MMSE: F = 4.461, p = 0.039; MoCA: F = 5.441, p = 0.040), anxiety (GAD-7: F = 14.937, p < 0.001), ADL (ADCS-ADL: F = 11.967, p < 0.001), and QoL (QoL-AD: F = 7.307, p < 0.001) than the control group. Adherence was high (92%), with no significant group differences. Missed sessions were primarily attributable to acute illness, transportation difficulties, or family commitments. Medication regimens (cholinesterase inhibitors, memantine, and antidepressants) remained stable between groups, with no significant interaction with the intervention. Narrative nursing combined with cognitive behavioral rehabilitation can effectively increase cognitive function, reduce anxiety, and improve the ADL and QoL of patients with AD. ISRCTN10742199.

PMID 42562777
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PubMedDie Ophthalmologie2026-08-07

[71/f + 3/m with a red eye : Preparation for the medical specialist examination ophthalmology: part 4].

Tornow Caroline C, Chenot Jean-François JF

PMID 42565823
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