若生智能
Drug Database
FR

Fraction F (Fraction F / Ateroid / Ateroid 200)

✓ Approved

Gentium · 治疗药物

什么是 Fraction F？

Fraction F 是一种治疗药物，由Gentium研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)、Oral (PO)。

药物档案

商品名Fraction F, Ateroid, Ateroid 200
公司Gentium
给药途径Injectable (Others), Intravenous (IV), Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Gentium

治疗适应症

Fraction F 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersDementia Alzheimer's type✓ Approved

相关研究文献

PubMedBMC medical imaging2026-06-13

Preoperative assessment of intratumor heterogeneity using intravoxel incoherent motion MRI for survival prediction in high-grade gliomas: a feasibility study.

Wang Xingrui X, Wang Yuanzheng Y, Wang Xiaoqing X, Liu Fang F et al.

Intratumor heterogeneity (ITH) is closely associated with poor prognosis in high-grade gliomas (HGGs). This study aimed to characterize ITH and explore potential imaging markers that predict overall survival (OS) in HGGs using intravoxel incoherent motion magnetic resonance imaging (IVIM MRI)-based spatially explicit analysis. Sixty-five HGG patients who underwent surgical resection were analyzed. Preoperative IVIM MRI images were collected and processed to obtain true diffusion coefficient (D) and perfusion fraction (f) maps. Tumor regions of interest were segmented, and the k-means algorithm was applied to cluster the D and f image voxels for generating spatial habitats and extracting quantitative image features. Kaplan-Meier analysis and Cox proportional hazards were used to compare variables and patient subgroups. Three spatial habitats were identified: Habitat 1 (hypo-vascular, hyper-cellular), Habitat 2 (hypo-cellular), and Habitat 3 (hyper-vascular). In the multivariate Cox regression analysis, isocitrate dehydrogenase (IDH) genotype (hazard ratio [HR] = 0.298, P = 0.003) and volume percentage (pVol) of Habitat 1 (HR = 6.155, P = 0.01) showed prognostic significance, with the model yielding a concordance index of 0.756. A pVol value of Habitat 1 below 47.6% predicted survival benefits in patients with HGG and IDH wild-type gliomas, as well as in those with HGG who underwent subtotal resection (median OS improvement: 11, 11, and 8 months, respectively). Spatial habitats identified via IVIM MRI may aid in characterizing cellular and vascular heterogeneity in HGGs, with the pVol of hypo-vascular, hyper-cellular habitat potentially serving as an independent predictor of patient survival.

PMID 42286511
阅读全文 →
PubMedToxicological sciences : an official journal of the Society of Toxicology2026-06-13

Tetrabromobisphenol S (TBBPS)-induced developmental toxicity in zebrafish embryos: impacts on cytoskeletal proteins during gastrulation.

Serradimigni Rosemaria R, Sabatini Heidi M HM, Chouinard Christopher C, Dasgupta Subham S

3,3',5,5'-Tetrabromobisphenol S (TBBPS) is an emerging brominated flame retardant that is widely detected in the environment, yet its toxic effects remain poorly understood. The objective of this study was to use zebrafish as a model and determine effects of TBBPS exposure on gastrulation stages of embryogenesis. We initiated TBBPS exposures (0 or 40 µM) at 0.75 hours post fertilization (hpf), phenotyped hourly through cleavage, blastula, and gastrula stages, and showed that TBBPS-treated embryos exhibited delay in development beginning at ∼4 hpf, a stage corresponding to early gastrulation, with significant mortality during late-gastrulation. To examine the genetic basis of TBBPS-induced effects, we conducted mRNA sequencing on exposures from 0.75-7 hpf, revealing downregulation of cytoskeletal organization and tight junction assembly. We then fluorescent-stained for multiple cytoskeletal and tight junction proteins (α-tubulin, β-tubulin, ZO-1, F-actin) following exposures to a wide range of TBBPS concentrations (0, 0.004, 0.04, 0.4, 4 and 40 µM). F-actin expression was consistently upregulated across all exposed TBBPS concentrations. To determine whether activation of p38, a key regulator of F-actin polymerization, plays a role in TBBPS-induced F-actin disruption, we co-exposed embryos with TBBPS (0 or 40 µM) and a known p38 inhibitor (5 µM SB 203580) and assessed developmental phenotypes and F-actin levels. Treatment with p38 inhibitor significantly rescued TBBPS-induced effects, with co-exposure groups exhibiting cell stages and F-actin expression similar to controls. Collectively, these findings demonstrate that TBBPS exposures target gastrulation stages and define a novel mechanism in which TBBPS increases F-actin polymerization through p38/MAPK signaling pathways.

PMID 42286410
阅读全文 →
PubMedBMC cancer2026-06-13

Preclinical evaluation of a fluorinated bifendate derivative in triple-negative breast cancer: integrated in vitro and in vivo evidence of antitumor activity.

Lin Lisa Zongyong LZ, Huang Hai-Yi HY, Peng Yuanyuan Y, Lin Guo-Qiang GQ et al.

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited therapeutic options and poor clinical outcomes. Bifendate (DDB), a clinically used hepatoprotective agent, has shown modest antitumor activity. This study evaluated the antitumor activity of a fluorinated bifendate derivative (F-α-DDB-derivative) in TNBC models. MDA-MB-468 cells were treated with DDB or F-α-DDB-derivative to assess cell viability, migration, apoptosis, and Ki-67 expression. Antitumor efficacy and preliminary safety were further evaluated in a nude mouse xenograft model. F-α-DDB-derivative reduced cell viability in a concentration-dependent manner and showed greater potency than DDB, with a 24 h IC₅₀ of 25.06 µg/mL versus 105.00 µg/mL for DDB. At 25 µg/mL, F-α-DDB-derivative significantly inhibited migration compared with the control group, reduced Ki-67 expression, increased apoptosis, and showed stronger antitumor activity than DDB in most evaluated assays. In vivo, intraperitoneal administration of F-α-DDB-derivative (20 mg/kg, every other day for 14 days) significantly suppressed tumor growth and reduced final tumor weight compared with both the control and DDB groups. No significant abnormalities in body weight or serum biochemical markers were observed under the tested conditions. Fluorination enhanced the antitumor activity of DDB in TNBC models. F-α-DDB-derivative represents a promising fluorinated lead compound for further preclinical investigation.

PMID 42286551
阅读全文 →
PubMedSoins; la revue de reference infirmiere2026-06-13

[Implementation of an ETP program for patients with heart failure and reduced ejection fraction in cardiovascular rehabilitation].

Diancoff Danièle D, Slama-Chaudhry Anbreen A, Graf Guillaume G

This article describes the implementation of a program that incorporates therapeutic education into the care of patients with heart failure and reduced left ventricular ejection fraction who are admitted to a hospital-based cardiovascular rehabilitation program. This approach aims to empower patients to take an active role in managing their health.

PMID 42285598
阅读全文 →
PubMedScientific reports2026-06-13

Pharmacological treatments and clinical events in newly diagnosed heart failure patients stratified by ejection fraction in Japan.

Sato Naoki N, Okami Suguru S, Yoshikawa-Ryan Kanae K, Yamashita Satoshi S et al.

There is a limited understanding of the uptake of pharmacological treatments and incidence of clinical events in newly diagnosed heart failure (HF) patients, stratified by left-ventricular ejection fraction (LVEF) in contemporary clinical settings in Japan. A retrospective cohort study was conducted using a nationwide Japanese hospital database to evaluate the patterns of HF medications and clinical events in adult patients with a first confirmed HF diagnosis from January 1, 2020-July 31, 2023 (n = 16,001). Fine-Gray sub-distribution hazard models were applied to assess factors associated with HF medication initiations and clinical events. Overall, 5473 (34.2%), 3053 (19.1%), and 7475 (46.7%) patients with HF with reduced ejection fraction, mildly reduced ejection fraction (HFmrEF), and preserved ejection fraction (HFpEF) were included, respectively. Within the first 6 months, prescription rates of HF medications were: angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, or angiotensin receptor blocker-neprilysin inhibitor (65.6%), beta-blockers (57.6%), mineralocorticoid antagonists (55.7%), and sodium-glucose cotransporter-2 inhibitors (33.2%), with the lowest rates in HFpEF patients. The increase in prescription rates between 6 and 12 months was modest across all medication classes. One-year incidence rates per 100 person-years (95% confidence interval) of in-hospital all-cause mortality and in-hospital cardiovascular death were 23.0 (22.1-24.0) and 16.6 (15.8-17.4), respectively. HFmrEF and HFpEF were associated with lower hazards of treatment initiation for most HF medications, whereas the risks of in-hospital all-cause mortality and in-hospital cardiovascular death did not differ significantly across all LVEF subtypes. The findings underscore the suboptimal uptake of pharmacological treatments, despite the poor prognosis of newly diagnosed HF patients. The disparities in initiations of recommended treatments reaffirm the importance of properly implementing evidence-based therapies within each LVEF subtype.

PMID 42286257
阅读全文 →
PubMedBMC medical imaging2026-06-13

Photon-counting CT for paraspinal muscle fat quantification compared with MRI proton density fat fraction.

Shu Dingbo D, Wang Jianping J, Liang Ding D, Zhao Li L et al.

To evaluate photon-counting CT (PCCT) derived 70 keV attenuation values and virtual noncontrast fat fraction (VNC FF) in quantifying paraspinal muscle fat infiltration, using MRI proton density fat fraction (PDFF) as the reference standard. In this prospective study, 76 adults with low back pain underwent same-day lumbar PCCT and 6-echo q-Dixon MRI within a 2-hour interval. The cohort consisted of 76 participants (38 men, 38 women), with a mean age of 47.7 ± 14.0 years and a mean body mass index (BMI) of 24.6 ± 3.3 kg/m². VNC FF represents a material decomposition-based fat fraction obtained from PCCT. Regions of interest (ROI) were bilaterally drawn in the multifidus, erector spinae, and psoas major at four intervertebral disc levels (L2/3-L5/S1). Correlation analysis, linear mixed-effects regression, Bland-Altman analysis, and receiver operating characteristic analysis were performed. The 70 keV CT values showed a strong correlation with MRI PDFF at the ROI level (r = - 0.931), outperforming VNC FF (r = 0.876). At the subject level, correlations were consistently strong across intervertebral disc levels (r range, - 0.964 to - 0.975 for CT values; 0.766 to 0.896 for VNC FF) and muscle groups (r range, - 0.881 to - 0.984 for CT values; 0.827 to 0.966 for VNC FF). Regression modeling enabled derivation of an internally calibrated CT fat fraction (CTFF), which closely approximated MRI PDFF within the study cohort. Agreement in categorical fat infiltration grading (< 10%, 10-30%, 30-50%, > 50%) was moderate (κ = 0.623). For binary classification at the 30% threshold, CTFF demonstrated excellent diagnostic performance (AUC = 0.993, 95% CI: 0.990-0.997). PCCT-derived 70 keV CT values showed strong agreement with MRI PDFF and enabled internal regression-based estimation of paraspinal muscle fat, with excellent diagnostic performance for fat infiltration classification.

PMID 42286523
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多Fraction F