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erythromycin (erythromycin, KV)

✓ Approved

Lumara Health · 治疗药物

什么是 erythromycin?

erythromycin 是一种治疗药物,由Lumara Health研发。该药已获批,用于治疗相关适应症,给药途径:Oral (PO)。

药物档案

商品名erythromycin, KV
公司Lumara Health
给药途径Oral (PO)
状态Approved

治疗适应症

erythromycin 针对 1 个适应症,涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsSalmonellosis✓ Approved

相关研究文献

PubMedJournal of the science of food and agriculture2026-08-06

Degradation of ochratoxin A and aflatoxin B1 in goat milk by dielectric barrier discharge cold plasma: effects on quality attributes.

Fu Shangchen S, Han Yike Y, Zhang Xianglin X, Liu Mengjia M et al.

Feed- and food-borne mycotoxins are an important concern in dairy safety, and heat-stable toxins are difficult to remove by conventional thermal processing. In this study, aflatoxin B1 (AFB1) and ochratoxin A (OTA) were selected as representative parent mycotoxins, and an artificially contaminated goat milk model was used to evaluate the ability of dielectric barrier discharge cold plasma (DBD-CP) to reduce these compounds. The immediate effects of DBD-CP on microbial load and selected quality attributes were also assessed. The reduction of AFB1 and OTA increased with increasing voltage and treatment time, and followed first-order kinetic behavior. After treatment at 50 kV for 4 min and 30 kV for 10 min, AFB1 reduction reached 64.3% and 54.3%, respectively, whereas the corresponding OTA reduction efficiencies were 69.1% and 63.1%. DBD-CP treatment also effectively reduced the microbial load of goat milk, achieving microbial inactivation comparable to pasteurization when the applied voltage exceeded 30 kV or the treatment time was longer than 6 min. In terms of quality attributes, moderate DBD-CP treatment, especially 30 kV for ≤6 min or <40 kV for 4 min, caused limited changes in pH, titratable acidity, particle size distribution, lactose, protein, soluble solids, and microstructure. In contrast, higher voltage or prolonged exposure resulted in more evident physicochemical and microstructural changes. DBD-CP reduced parent AFB1, OTA, and microbial load in artificially contaminated goat milk while largely preserving selected quality attributes under moderate treatment conditions. These findings support its potential as a complementary non-thermal approach for goat milk processing. © 2026 Society of Chemical Industry.

PMID 42560153
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PubMedThe Review of scientific instruments2026-08-06

Ferrite-loaded nonlinear interference double transmission line generating secondarily modulated microwaves.

Ulmaskulov M R MR, Ulmaskulov E M EM, Ovchinnikova L Yu LY

This paper presents a study of a ferrite coaxial interference double transmission line comprising two assemblies of ferrite rings with different diameters. The assembly of smaller diameter rings is located inside the assembly of larger diameter rings; the gap between the assemblies is several tens of micrometers. This double line provided secondary modulation of a rapidly damped oscillation with an effective frequency of ∼22 GHz, which was an order of magnitude higher than that of the primarily modulated oscillation. The peak-to-peak amplitude of the secondarily modulated oscillations was several tens of percent of the amplitude of the leading peak, which reached a maximum of about -250 kV. The results of the study give grounds to believe that secondary modulation occurs due to secondary spin waves, and its feasibility is mainly determined by the magnetization precession angle.

PMID 42560151
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PubMedScientific reports2026-08-06

Integrated One-Health analysis of antimicrobial resistance, biofilm formation, and genetic relatedness of Enterococcus spp. at the human-food interface.

Ahmed Heba A HA, El Feky Tamer M TM, Shalaby Marwa M, Elsotohy Mahmoud E ME et al.

Enterococcus species are opportunistic pathogens and reservoirs of antimicrobial resistance (AMR) that can be transmitted through food chain. This study investigated Enterococcus faecalis and Enterococcus faecium isolated from retail meat, workers and consumers within a One Health framework. A total of 250 samples yielded 50 (20%) isolates, which were analyzed for antimicrobial resistance, virulence genes, biofilm formation, and RAPD-PCR genotyping. This study provides an integrated One Health assessment linking food contamination, occupational exposure, and human colonization. Beef meat showed the highest isolation rate, and E. faecium predominated among consumers. High resistance rates were observed for rifampin (94%, 47/50), erythromycin, and tetracycline (88%, 44/50, each), while vancomycin resistance was low (8%, 4/50). Multidrug resistance was observed in 88% of isolates, and MAR index ranged from 0.07 to 0.86 (average = 0.43). Biofilm formation occurred in 68% (34/50) of isolates, with moderate strength predominated. Resistance genes were widely distributed, particularly tetL (88%, 44/50), while esp (84%, 42/50) and gelE (68%, 34/50) were the most prevalent virulence genes. RAPD-PCR revealed five clusters with moderate discriminatory power (D = 0.729), demonstrating genetic relatedness across sources. Importantly, the co-occurrence of resistance, virulence, and biofilm traits across genetically related isolates highlights the possibility of the food chain as a potential transmission interface. These findings highlight the role of Enterococcus species in AMR dissemination within a One-Health framework.

PMID 42557279
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PubMedAntonie van Leeuwenhoek2026-08-06

Antimicrobial resistance in Staphylococcus pseudintermedius isolated from asymptomatic and symptomatic dogs in Montevideo, Uruguay: characterization of MRSP strains and genetic determinants of resistance.

Diana Leticia L, Lancaster Elizabeth E, Mastroianni Lucas L, Iriarte Andres A

Staphylococcus pseudintermedius is a common opportunistic pathogen in dogs and an increasing concern in veterinary medicine due to rising antimicrobial resistance, particularly to methicillin. This study aimed to characterize resistance profiles and genetic mechanisms in isolates from healthy and diseased dogs in Montevideo, Uruguay. A total of 133 isolates was analyzed (83 from clinical infections and 50 from asymptomatic carriers). Antimicrobial susceptibility was assessed by disk diffusion following veterinary guidelines. Resistance genes and SCCmec types were detected by PCR. Ten representative isolates underwent whole genome sequencing. High resistance rates were observed for penicillin (81%), erythromycin (49.6%), and clindamycin (45%). Overall, 48.9% of isolates were multidrug-resistant. Phenotypic resistance to oxacillin was detected in 26% of isolates; however, 23% carried mecA gene and were therefore classified as genotypic MRSP. These isolates were more frequent among dogs with clinical infections. These strains showed higher resistance to all antimicrobials tested. SCCmec type V was the most prevalent, and greater genetic diversity was found among isolates from symptomatic dogs. Genomic analysis revealed circulating strains of unassigned sequence types (STs), a variety of resistance genes within specific lineages, the circulation of SCCmec XIV cassette carrying strains, and an Oxacillin-susceptible Methicillin-resistant Staphylococcus pseudintermedius (OS-MRSP) isolate. These findings demonstrate the clinical and epidemiological relevance of S. pseudintermedius in Uruguay and the role of asymptomatic dogs as reservoirs of resistant strains. The results emphasize the need for surveillance, prudent antimicrobial use, and integrated control strategies within a One Health framework.

PMID 42560413
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-08-05

Synergistic Relaxor Engineering and Microstructural Densification Enable Ultrahigh Energy Storage in BNT-Based Lead-Free Ceramics.

Zhao Yang Y, Wu Yu Y, Chen Fukang F, Nie Xinru X et al.

Lead-free dielectric ceramics with simultaneously high recoverable energy-storage density and efficiency are highly desirable for pulsed-power capacitors, yet their performance is fundamentally limited by the trade-off among polarization strength, hysteresis loss, and breakdown strength. Here, we report a multiscale synergistic strategy in (0.94-x)(Bi0.5Na0.5)TiO3-0.06KNbO3-xSrTiO3 [(0.94-x)BNT-0.06KN-xST] ceramics by coupling relaxor regulation with microstructural densification. KN incorporation induces R3c/P4bm local phase coexistence in the BNT matrix, weakening long-range ferroelectric order and initiating a transition toward a relaxor state. Further ST addition enhances local structural heterogeneity, random fields, and polar nanoregions, leading to highly reversible polarization with suppressed hysteresis. In parallel, tape casting produces a dense and homogeneous microstructure, effectively mitigating defect-induced field concentration and enhancing breakdown strength. The optimized x = 0.32 composition exhibits a high breakdown strength of 804 kV cm-1 and delivers an ultrahigh recoverable energy density of 10.1 J cm-3 with an efficiency of 97.6% at 820 kV cm-1. Frequency- and temperature-dependent measurements at 450 kV cm- 1 further demonstrate robust energy-storage behavior under the tested field condition. This work establishes a disorder-engineered relaxor strategy combined with microstructural densification to reconcile polarization reversibility and electric-field endurance in lead-free dielectric ceramics.

PMID 42554004
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PubMedMedical physics2026-08-05

A comparison of relative stopping power derived by fast kV-switching dual-energy CT, single-energy CT, and proton CT in phantom and tissue.

Wang Hazel H, Qu Yanling Y, Li Yang Y, Dedes George G et al.

The accuracy of relative stopping power (RSP) is a critical aspect for safe treatment planning in proton therapy. Dual-energy CT (DECT) has the ability to estimate RSP more accurately than conventional single-energy CT (SECT) due to its improved material separation. RSP accuracy is commonly determined in homogeneous phantom material as it can be more challenging to determine in heterogeneous biological tissues. Proton CT (pCT) is a modality that directly determines RSP and can be used as a comparative benchmark for evaluating the RSP accuracy of DECT and SECT derived values across homogeneous and heterogeneous material. In this study, DECT was compared to SECT in both homogeneous phantom inserts of known RSP and heterogeneous tissue samples of unknown RSP using pCT as a quantitative reference. The purpose of this study was to assess the ability of DECT to improve RSP estimation over SECT in unknown RSP of heterogeneous tissues. A variety of homogeneous phantom inserts were scanned using pCT, DECT, and SECT. The estimated RSP from each imaging modality was compared to the RSP of each insert directly measured using a multilayer ionization chamber (MLIC). Scans of heterogeneous tissue samples were also acquired using pCT, DECT, and SECT. The images from each modality were registered and a variety of tissue regions of interest were contoured. The percent difference of DECT and SECT derived RSP values compared to pCT was calculated across both homogeneous phantom and heterogeneous tissue regions and compared. The mean absolute percentage error for the inserts compared to the known RSP was 1.6% ± 1.6% in pCT, 1.1% ± 1.6% in DECT, and 4.6% ± 6.2% in SECT. For inserts with relative electron density greater than 0.93 and excluding true water and aluminum, DECT average percent difference compared to pCT was -0.5% ± 0.02% while in SECT it was -1.5% ± 0.07%. In biological tissue, excluding enamel, the average percent difference for DECT compared to pCT was -0.3% ± 1.1%, while for SECT the percent difference compared to pCT was 0.6% ± 3.0%. Fast kV-switching DECT obtained smaller RSP deviations from pCT compared to SECT in homogeneous tissue-equivalent phantom inserts. In heterogeneous tissue samples, DECT maintained improved RSP accuracy compared to SECT.

PMID 42555230
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