若生智能
Drug Database
GA

gangliosides (Nervomax / gangliosides, Fidia / Neurosido)

✓ Approved

Gramon · 治疗药物

什么是 gangliosides？

gangliosides 是一种治疗药物，由Gramon研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Nervomax, gangliosides, Fidia, Neurosido
公司Gramon
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Gramon

治疗适应症

gangliosides 针对 4 个适应症，涉及 3 个治疗领域。

治疗领域疾病/病症分期
Nervous system disordersDiabetic neuropathy✓ Approved
Nervous system disordersNeuropathy peripheral✓ Approved
Blood and lymphatic system disordersNeutropenia✓ Approved
Congenital, familial and genetic disordersRetinitis pigmentosa✓ Approved

相关研究文献

PubMedInternational journal of molecular sciences2026-06-12

Effects of Wheat Malt Extract on Molecular and Behavioral Markers in Aged APP/PS1 and Wild-Type Mice.

Kassenova Aliya A, Svirin Evgeniy E, Sitdikova Kseniia K, Chaprov Kirill K et al.

Growing evidence suggests an important pathogenetic role of brain-specific gangliosides in the mechanisms underlying Alzheimer's disease (AD), the most common form of dementia. Nutritional strategies targeting ganglioside sialylation-for example, through agglutinin-mediated modulation-have therefore attracted increasing research interest. In particular, wheat malt extract (WME), a food-derived source of wheat germ agglutinin (WGA) with high affinity for gangliosides, may influence molecular pathways involved in AD pathogenesis. Twelve-month-old female APPswe/PS1E9 transgenic mice, a model of AD, and wild-type (WT) littermates received WME or tap water for three weeks. Behavioral performance was subsequently assessed. Amyloid plaque burden and astrocyte activation were evaluated using Congo red staining and GFAP immunoreactivity, respectively. Gene expression of selected AD markers in the brain was quantified by RT-qPCR. Aged WT mice exhibited robust, region-specific molecular responses to WME, including upregulation of activity-dependent and synaptic plasticity genes (Arc, Egr1, Bdnf, Syp), enhancement of metabolic and insulin-related signaling (Pgc1a, Sirt1, Igf1r, Irs2), increased Cldn5 expression, and reduced pro-inflammatory Il1β expression. APP/PS1 mice exhibited limited response to WME, suggesting more persistent transcriptional signatures of synaptic impairment, metabolic dysregulation, and neuroinflammation than in WT mice. We found no significant effects of WME treatment on amyloid plaque density and behavior in APP/PS1 mice. No effects on astrocyte activation were observed in either group. These findings demonstrate that dietary WME counteracts abnormal behaviors and molecular changes in neuron plasticity, metabolic, and vascular markers under conditions of normal aging but fails to improve the hallmarks of AD pathology. This highlights the potential of WGA-containing nutrients as a preventive nutritional approach targeting pathogenic mechanisms of aging and, potentially, AD pathology.

PMID 42278520
阅读全文 →
PubMedJournal of clinical medicine2026-06-12

Clinical and Immunovirological Characteristics Associated with Cardiovascular Dysautonomia in Long COVID.

Renaudineau Yves Y, Teillaud Selena S, Chaves Sébastien De Almeida SA, Alvarez Muriel M et al.

Background/Objectives: This report is an assessment of the characteristics associated with cardiovascular dysautonomia (CVD) in the context of long Coronavirus disease (COVID), which is currently inadequately characterized. Material and Methods: A retrospective cross-sectional study was performed involving 106 patients with long COVID, including 34 individuals diagnosed with CVD, among whom eight met the criteria for Postural Tachycardia Syndrome (PoTS). The variables assessed encompassed individual characteristics (e.g., age, sex, comorbidities), immunization parameters (e.g., vaccination/viral status, timing, frequency), cellular and humoral anti-Spike and anti-Nucleocapsid (Nuc) immune responses, inflammatory and allergic biomarkers, as well as an extensive panel of common autoantibodies comprising anti-nuclear antibodies, anti-central nervous system antibodies (cerebellum, brain), and anti-peripheral nervous system antibodies (gangliosides). Results: An age < 45 years, body mass index, hyperventilation syndrome as well as a higher cumulative number of antigenic contacts (vaccinations plus infections ≥ 3) and an elevated basophil count (≥0.06 G/L) were independently associated with CVD. There was no association between CVD and inflammatory markers or common autoantibodies. Patients with PoTS criteria had a strong anti-Spike cellular immune response and increased IgG anti-Nuc humoral immunity when compared with CVD and non-CVD long COVID counterparts. Conclusions: Compared to other long COVID patients, patients with long COVID-associated CVD have distinctive clinical and immunovirological features. Our results suggest the potential role of the immune response against Spike and of allergic pathways rather than humoral autoimmunity against common autoantibodies in long COVID CVD.

PMID 42279051
阅读全文 →
PubMedJournal of translational medicine2026-06-07

Research on GM1 bound bMSCs loaded with SF hydrogel for spinal cord injury repair.

Yu Qin Q, Zhang Hai-Yan HY, Song Yan Y, Wang Ling L et al.

Monosialotetrahexosylganglioside (GM1), a major ganglioside component, is expressed in the spinal cords of mammals. Gangliosides have been shown to play important roles in various physiological processes, including neuronal protection, neurorepair, and stem cell differentiation. Bone marrow-derived mesenchymal stem cells (bMSCs) were expected to be a good source of cells for clinical transplantation and repair due to their abundance, easy accessibility and lack of ethical restrictions. They can also be induced to differentiate into neurons. However, there is still no ideal delivery material or method that allows the sustained and controlled release of GM1 and bMSCs for clinical use in spinal cord injury (SCI). Silk fibroin (SF)-based hydrogels have emerged as a promising strategy for local, controlled, and sustained drug release in the treatment of various diseases. In this study, we developed a SF-based hydrogel for the sustained delivery of GM1 and bMSCs (GM1 + bMSCs@SF hydrogel) and evaluated its therapeutic effect in a rat model of SCI. The GM1 + bMSCs@SF hydrogel showed sustained GM1 release in vitro. Treatment with the GM1 + bMSCs@SF hydrogel increased cell cycle exit and neuronal differentiation 1 (Cend1) expression, reduced neuronal pyroptosis and apoptosis, and promoted the differentiation of bMSCs into neurons. Double immunofluorescence staining confirmed a decrease in cell pyroptosis. Moreover, rats treated with the GM1 + bMSCs@SF hydrogel showed significant improvement in motor function recovery, with the Basso, Beattie and Bresnahan (BBB) score at 8 weeks reaching about 71.4% of the normal level, compared with about 30% in the SCI group. This study will minimize neuronal damage by innovatively using SF hydrogel loaded with GM1 and bMSCs for spinal cord injury repair. It will also explore the molecular mechanisms underlying post-traumatic spinal cord injury repair, opening new therapeutic avenues for spinal cord injury treatment.

PMID 42251374
阅读全文 →
PubMedJournal of chromatography. B, Analytical technologies in the biomedical and life sciences2026-05-30

Comprehensive profiling and sensitive quantification of gangliosides in mouse brain based on boron-doped TiO2 composites coupled with UPLC-cIM-MS/UPLC-QQQ-MS/MS.

Yang Shuya S, Zou Xianjun X, Chen Shuhuan S, Li Yujie Y et al.

Gangliosides (GGs) play a crucial role in the development of the mammalian nervous system. However, due to their low content and significant matrix interference, the detection of these substance poses substantial challenges. In this study, considering that gangliosides contain a glycan headgroup with sialic acid residues, boron-doped titanium dioxide composites were prepared to enrich the GGs from mouse brain tissue by utilizing the specific affinity of boric acid for cis-diols of glycan and electrostatic attraction between TiO2 and sialic acid ion. To optimize the extraction and elution parameters, a method of UPLC-QQQ-MS/MS was developed using the GGs standards, and then the extracts were analyzed by this method. The results showed that the boron-doped TiO2 material significantly reduced matrix interference, with an average enrichment factor of 2.5 and recovery ranging from 44.5% to 116.9%. The limit of detection (LOD) was 0.5-20 μg/L, and the limit of quantification is 2-70 μg/L. To discover additional and novel GGs, the extracts underwent UPLC-cIM-MS to get the comprehensive profiles of GGs. Finally, 8 subclasses and 33 molecular structures of GGs were identified, and three new substances were discovered, which showed that boron-doped titanium dioxide composites coupled with LC-cIM-MS provide an effective strategy for the highly sensitive detection of GGs. Furthermore, this approach holds a great promise for expanding studies on GGs profiles in other complex biological samples.

PMID 42215005
阅读全文 →
PubMedAnimals : an open access journal from MDPI2026-05-27

An Assessment of Anti-Ganglioside Antibodies for the Diagnosis of Avian Ganglioneuritis and Potential Correlation with Gross Lesions, Microscopic Findings and Serologic Titers in Cockatiels Challenged with Parrot Bornavirus.

Bücking Bianca B, Gartner Anna Maria AM, Herzog Sibylle S, Herden Christiane C et al.

Avian ganglioneuritis is one of the most widespread diseases of psittacines and is caused by parrot bornavirus (PaBV). It has been suggested that PaBV causes a T-cell-mediated immunopathology comparable to Borna disease virus 1 (BoDV-1). However, the factors involved in progression from infection to clinical disease in psittacines remain poorly understood. It has been proposed that autoantibodies directed against endogenous gangliosides of the central and peripheral nervous systems contribute to disease development. These anti-ganglioside antibodies have been suggested as potential diagnostic markers for birds developing clinical avian ganglioneuritis independent from the causing infectious agent. In this study, 257 plasma samples from cockatiels (Nymphicus hollandicus) experimentally infected with PaBV, with known infection status as well as defined clinical and postmortem outcomes, were submitted in a blinded manner to a commercial laboratory for anti-ganglioside antibody testing. The results were compared with the presence of anti-PaBV antibodies, clinical signs, gross pathological findings, and histopathological results. Among 25 birds with dilated proventriculi at the time of necropsy, 9 (36%) tested positive for anti-ganglioside antibodies, whereas 16 (64%) tested negative. Of 56 birds with histopathological avian ganglioneuritis, 26 (46.43%) tested positive and 30 (53.57%) tested negative. Among 33 birds without histopathological inflammatory lesions, 19 (57.58%) tested negative and 14 (42.42%) tested positive. These results indicate that no association between the occurrence of avian ganglioneuritis and the detection of anti-ganglioside antibodies was seen.

PMID 42193755
阅读全文 →
PubMedSkeletal muscle2026-05-23

Insights into the heterogeneous muscle lipidome of dysferlin-deficient mice: effects of age, muscle type, and sex.

Keenan Stacey N SN, Bayliss Jackie J, Lee Olivia O, Lloyd Erin M EM et al.

Dysferlinopathy is an age-dependent muscular dystrophy caused by loss of the membrane-associated protein dysferlin. Disease severity increases with age and selectively affects specific muscle groups, yet the molecular basis for this vulnerability remains unclear. Since lipid remodeling is a hallmark of dysferlinopathy and aging, we investigated how age, sex, and muscle fiber type interact to shape the muscle lipidome in dysferlin-deficient mice. We performed omics-scale lipid profiling across 738 lipid species and 30 lipid classes in quadriceps and gastrocnemius (fast-twitch muscles exhibiting pronounced pathology), soleus (slow-twitch) and extensor digitorum longus (EDL; fast-twitch, relatively spared) muscles from male and female dysferlin-deficient (BLA/J) and wildtype C57BL/6J (WT) mice aged 3, 10, and 26 months. Normal aging was associated with broad lipid remodeling, however, in the absence of dysferlin markedly amplified this remodeling, leading to elevations in specific triglycerides, diglycerides, cholesterol esters, gangliosides, ceramides, and sphingomyelin compared to WT muscle. Interestingly, we observed minimal sex differences between dysferlin-deficient muscles. Fast-twitch muscles, particularly quadriceps and gastrocnemius, exhibited the most extensive lipid alterations, whereas the slow-twitch soleus muscle showed relative lipid stability even at advanced age. Thus, fast-glycolytic muscles are more susceptible to age- and dysferlin-dependent lipid dysregulation than slow oxidative muscle. The preferential vulnerability of fast-twitch muscles to muscle wasting in dysferlinopathy suggests that fiber-type-dependent lipid handling contributes to selective muscle degeneration. This work defines a comprehensive lipidomic signature of disease progression and provides a framework for understanding how aging, sex, and muscle phenotype interact in muscular dystrophy.

PMID 42174676
阅读全文 →

注册免费账户还可查看另外 8159 篇文献

免费注册查看全部文献 →

了解更多gangliosides