Drug Database
LE

leuprolide

✓ Approved

AimPharma · GNRHR · 小分子

什么是 leuprolide?

leuprolide 是一种小分子,由AimPharma研发。该药已获批,用于治疗相关适应症,给药途径:Injectable (Others)、Intramuscular (IM) Injection。

药物档案

公司AimPharma
药物类别小分子, 多肽类
分子靶点GNRHR
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved

作用机制

分子靶点

leuprolide 作用于 1 个分子靶点:

GNRHRgonadotropin releasing hormone receptor (HH7, GRHR)
需要更深入的分析?Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

leuprolide 针对 4 个适应症,涉及 3 个治疗领域。

治疗领域疾病/病症分期
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Prostate cancer✓ Approved
Reproductive system and breast disordersEndometriosis✓ Approved
Endocrine disordersPrecocious puberty✓ Approved
Reproductive system and breast disordersUterine fibrosis✓ Approved

相关研究文献

PubMedAngewandte Chemie (International ed. in English)2026-08-06

Phase-Inversion Engineering of Covalent Organic Framework Microspheres for Advanced Water Purification.

Zhou Huina H, Zhang Ning N, Li Yingying Y, Li Dongxue D et al.

Covalent organic frameworks (COFs) are porous, crystalline polymers with broad application prospects. However, their microcrystalline powder morphology severely limits their practical implementation. Herein, a general phase-inversion spherical shaping strategy is reported, enabling the conversion of powdered COFs into robust microspheres with a radially hierarchical pore structure. This method is mild and scalable and has been validated across eight COFs with distinct topologies. The resulting microspheres retain approximately 90% of the intrinsic adsorption capacity of the pristine materials. As a representative demonstration, TAPB-DMTP-COF microspheres were employed in a fixed-bed continuous-flow water treatment system, where 1 g of the material effectively purified over 18 L of real water containing a mixture of bisphenols, with each concentration at 200 ppb, while maintaining high performance over 20 regeneration cycles. More notably, the TAPB-DMTP-COF microspheres themselves possess intrinsic catalytic activity for peroxymonosulfate activation, enabling sequential adsorption enrichment and catalytic degradation within the same fixed-bed column without metal modification. This work establishes a versatile COF shaping platform that extends the application scope of COFs from adsorption to advanced oxidation, offering a viable pathway to overcome a critical bottleneck in their industrial implementation.

PMID 42559969
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PubMedBiofabrication2026-08-06

Viscoelasticity-tuned hyaluronic acid-gelatin microcarriers with thermoresponsive polymer grafts for scalable cell expansion and gentle harvesting.

Amsar Rizka Musdalifah RM, Xiangting Lin L, Wang Jun-Sheng JS, Lin Shuian-Yin SY et al.

Three-dimensional (3D) cell culture using microcarriers is an effective strategy for scalable cell expansion; however, conventional enzymatic detachment can compromise cell viability, surface proteins, and native signalling. We report viscoelasticity-tuneable hyaluronic acid (HA)-gelatin microspheres as microcarriers, engineered with a thermoresponsive polymer coating to enhance cell attachment and enable gentle harvesting. Gelatin-only (GLA), gelatin-HA (G-HA), and gelatin-HA-L-lysine (G-HA-L) microspheres were fabricated. HA incorporation and lysine functionalization were used to tune microsphere mechanics and interfacial stability. Frequencysweep rheology revealed that HA-containing formulations exhibited higher elastic dominance (G' > G″) and a broader, more stable viscoelastic response than gelatin-only and a commercial gelatin microcarrier benchmark, with G-HA-L showing the most favorable balance of stiffness and damping (highest G'/G″ across the tested window). The microspheres were subsequently coated with poly (N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-AAc)), producing a temperature-responsive interface. Importantly, the thermoresponsive coating enhanced early cell attachment, particularly on G-HA-L (reaching ~70% within 4 h and approaching ~90% by 24 h), outperforming both coated G-HA and commercial microcarriers. For harvesting, lowtemperature conditioning markedly improved cell release and recovery compared to trypsinonly controls, consistent with temperature-triggered polymer swelling facilitating detachment. Collectively, these results demonstrate that coupling viscoelastic microcarrier design with thermoresponsive surface engineering provides a promising platform for efficient cell growth and gentle, process-friendly harvesting, with potential applications in tissue engineering and regenerative medicine.

PMID 42556418
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PubMedScience advances2026-08-05

Sharp nanothorn-equipped ionogel microrobots for targeted periodontitis therapy.

He Dongqing D, Zou Zhaolei Z, Jin Dongdong D, Guo Zichang Z et al.

Periodontitis necessitates targeted therapy due to its high prevalence, progressive tissue destruction, and systemic disease links. Conventional mechanical debridement and pharmacological treatments are limited by complex periodontal barriers, including viscous crevicular fluid and resilient biofilms, which impede bacterial eradication and drug delivery. Here, we engineered magnetically actuated microrobots with gold nanothorns for disrupting biofilms and penetrating mucus barriers. Fabricated by encapsulating curcumin in antibacterial ionogel microspheres with asymmetric magnetic deposition and nanothorn functionalization, these microrobots enabled precise magnetic navigation in viscous media, while penetrating a biomimetic mucus analog, enhancing periodontal retention, and mechanically dislodging biofilms. Furthermore, ethanol-responsive release of curcumin enhanced its bioavailability, thereby scavenging free radicals and modulating macrophage phenotypes to alleviate inflammation. Guided by a toothbrushing-inspired handheld magnetic controller, microrobots evaluated using in vivo murine models demonstrated reduced inflammation, inhibited bone resorption, improved tissue health, and oral microbiota remodeling toward ecological balance, showing promise for targeted periodontitis therapy.

PMID 42555738
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PubMedProceedings of the National Academy of Sciences of the United States of America2026-08-05

Graded oxidation state calcium phosphate graphene oxide modulates the mechanical and biological behavior of bone matrices.

Hosseini Fatemeh S FS, Kan Ho-Man HM, Whitfield Taraje T, Argyrou Chrysoula C et al.

Calcium phosphate graphene (CaPG) is a promising reinforcement for polymeric bone matrices, yet the impact of graphene oxide (GO) oxidation on CaPG chemistry and matrix performance remains unclear. Our previous work demonstrated that 5 wt% CaPG provides optimal mechanical and biological performance of poly (lactic-co-glycolic acid) (PLGA) matrix. The present study isolates GO oxidation as the sole variable while maintaining a fixed 5 wt% CaPG loading. CaPG was synthesized under three oxidation conditions: Low Phosphate-High Oxygen at 50 °C, High Phosphate-High Oxygen at 100 °C, and High Phosphate-Low Oxygen at 156 °C and incorporated into the PLGA microspheres. Our results have shown that oxidation state regulates oxygen functional group density, calcium phosphate incorporation, hydrophilicity, and hydration behavior, which collectively modulate mechanical properties and osteogenic activity of the matrix. These findings demonstrate that oxidation can serve as a key tunable factor that generates distinct physicochemical and biological profiles, establishing oxidation programming as a practical approach for creating adaptable CaPG-reinforced PLGA matrices for diverse bone regeneration needs.

PMID 42555641
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PubMedRegenerative medicine2026-08-04

Two-layered electrospun nanofibrous mat loaded chitosan nanoparticles, growth factors and hair follicle bulge stem cells can promote wound healing in rat.

Moghaddam Asma A, Orazizadeh Mahmoud M, Bayati Vahid V, Nejaddehbashi Fereshteh F

Wound healing remains a demanding medical problem despite significant advances in regenerative medicine. Mesenchymal, hair follicle and pluripotent stem cells are candidate populations for therapeutically relevant applications. Hair follicle bulge stem cells with scaffolds and growth factors can promote the healing of wounds. This study explores a dual-layer electrospun nanofibrous wound dressing composed of PCL/SSD and PCL/COLL, enhanced with chitosan nanoparticles loaded with EGF and bFGF growth factors. Hair follicle bulge stem cells were seeded onto the scaffold and transplanted into rat skin wounds. FE‑SEM confirmed that the chitosan microspheres were uniformly spherical, ranging from nanoscale to ~1 µm. Thermal analysis showed a 28% weight loss up to 250°C and major degradation between 230°C and 450°C, indicating good thermal stability. About 50% of the encapsulated EGF and bFGF (6.5 ng from 2 mg microspheres) was released within 24 h, followed by sustained release. Biological assays demonstrated strong cell attachment, enhanced collagen deposition, and rapid tissue remodeling, with complete skin regeneration achieved by day 14. These findings suggest that a two-layered electrospun nanofibrous mat incorporating chitosan nanoparticles, growth factors, and hair follicle bulge stem cells significantly enhances wound healing in a rat model.

PMID 42549962
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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-08-04

Durable Seawater Electrolysis Enabled by Spherical Electrostatic Repulsion and Catalyst-Support Interaction.

Gao Hanqing H, Zeng Jinjue J, Yang Yifei Y, Sun Wei W et al.

The electrolysis of seawater driven by renewable energy for hydrogen production represents a promising strategy toward net-zero emissions. The high concentration of chloride ions (Cl-) in seawater not only competes with the oxygen evolution reaction (OER) at the anode but also causes corrosion of the catalyst material. The construction of electrostatic shielding via anions on the catalyst surface can repel Cl-. However, studies on regulating anion distribution through designed geometries to maximize such repulsion remain limited. Herein, a sphere-like catalyst, constructed with a heterojunction of carbonate-intercalated nickel-iron layered double hydroxides in situ grown on malachite microspheres (MM), exhibits enhanced catalytic durability and activity. The spherical electrostatic field induced by carbonate anions protects the catalyst, and the catalyst-support interaction (CSI) tunes the electronic structure of active sites to boost OER. Finally, the assembled electrolyzer demonstrates outstanding durability over 1000 h and a voltage of 1.83 V at a current density of 1 A per cm2. This spherical geometrical design of electrostatic protection offers insights into catalyst optimization for seawater electrolysis.

PMID 42550129
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