triamcinolone acetonide (Azmacort 134a / KI03216 / Azmacort CFC)

Pseudohypopyon following Triamcinolone and Silicone Oil Tamponade in a Phakic Eye.

Zhao Michael Y MY, Rohowetz Landon J LJ, Flynn Harry W HW

Effectiveness of High-Volume Corticosteroid Injection Diluted with Saline in Subacromial Impingement Syndrome: A Randomized Trial.

Yıldızhan Rıdvan R, Cüce İsa İ, Veziroğlu Enes E, Çakır Taha Furkan TF et al.

The aim of this study was to determine whether the efficacy of high-volume, ultrasound-guided subacromial injection with corticosteroid (CS) diluted with normal saline is superior to that of low-volume injection in patients with subacromial impingement syndrome (SIS). This study included 70 patients diagnosed with SIS. Patients were randomized into either the high-volume CS injection group [1 mL, 40 mg triamcinolone acetonide (TA); 1 mL, 2% lidocaine; 8 mL normal saline mixture] or the low-volume CS injection group (1 mL, 40 mg TA; 1 mL, 2% lidocaine; 1 mL normal saline mixture). Additional instructions for a home exercise program were provided after the injection. Assessments were made at baseline and 4- and 12-weeks post-injection, using the following measurements: Shoulder Pain and Disability Index (primary outcome); visual analogue scale (pain); active range of motion measurements (abduction, flexion, and external and internal rotations); and Western Ontario Rotator Cuff Index. There were no significant differences between the groups in terms of demographic or shoulder-pain-related data at baseline. Both groups showed significant improvements in all outcomes at 4- and 12-weeks post-injection. However, there was no significant difference between the groups for any outcome. Post-injection adverse events and drug consumption during follow-up were comparable between the groups. All outcome measures significantly improved in both the high- and low-volume injection groups, with no significant between-group differences. This suggests that high-volume CS injections provide no additional benefit over low-volume injections for reducing pain and improving function in patients with SIS.

Ionizable Lipid-Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties.

Thatte Ajay S AS, Nachod Benjamin E BE, Baena Julia J, Muscat-Rivera Jenna J et al.

Lipid nanoparticles (LNPs) are a leading platform for nucleic acid delivery, yet their intrinsic adjuvanticity poses a significant materials design challenge for applications requiring immunological quiescence. Here, we report a modular engineering strategy that incorporates FDA-approved corticosteroids into LNP formulations, creating a new class of steroid LNPs with tunable anti-inflammatory properties. Through systematic screening of steroid and cholesterol substitution ratios, we establish structure-property relationships governing mRNA encapsulation efficiency, physicochemical characteristics, and inflammation suppression. Triamcinolone (TRI) emerges as our lead steroid, with 50% cholesterol substitution in SM-102 LNPs preserving physicochemical characteristics. Importantly, we show that optimal substitution ratios are ionizable lipid-dependent-80% for MC3 and 50% for SM-102 and ALC-0315-revealing fundamental design principles for these dual-functional LNPs. In an endotoxemia mouse model, TRI LNPs administered intramuscularly maintain mRNA delivery efficacy while reducing inflammatory cytokines by ∼4-fold compared to SM-102 LNPs. In a multiple sclerosis mouse model, TRI LNPs delivering therapeutic mRNA promote antigen-specific tolerance in spinal cord tissue and protect against paralysis. Compared to SM-102 LNPs, TRI LNPs reduce inflammatory cytokines by ∼3-fold and prolong protection against paralysis. Together, our work introduces a generalizable materials design strategy for engineering LNPs with tunable immunomodulatory properties to expand their therapeutic utility.

Correction: Comparative Evaluation of Therapeutic Effects of Boric Acid and Triamcinolone in Nasal Polyp Culture.

Türe Nurullah N, Gündüz Meliha Koldemir MK, Kaymak Güllü G, Sezgin Ayşe Koçak AK et al.