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DTwP-HB-Hib vaccine (Pentavac SD, SSI / Pentavac PFS, SSI)

✓ Approved

Serum Institute of India Pvt. Ltd. · 疫苗 · 疫苗

什么是 DTwP-HB-Hib vaccine？

DTwP-HB-Hib vaccine 是一种疫苗，由Serum Institute of India Pvt. Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名Pentavac SD, SSI, Pentavac PFS, SSI
公司Serum Institute of India Pvt. Ltd.
药物类别疫苗
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved
来源： ClinicalTrials.gov, Serum Institute of India Pvt. Ltd.

治疗适应症

DTwP-HB-Hib vaccine 针对 4 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsDiphtheria✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsPertussis✓ Approved
Infections and infestationsTetanus✓ Approved

相关研究文献

PubMedFood research international (Ottawa, Ont.)2026-08-07

Fabrication of meat-mimicking emulsion gels using oligochitosan-decorated hemoglobin and gelatin as a fat replacer.

Cheng Chengpeng C, Li Shaobo S, Chen Li L, Yun Xueyan X et al.

Hemoglobin (Hb) can be employed to adjust the color of emulsion gels, thereby compensating for deficiencies in appearance and flavor when used as an animal fat substitute. However, the inherent instability of heme restricts its broader application as a food ingredient. In this study, transglutaminase-catalyzed glycosylation was applied to prepare oligochitosan-modified Hb complexes (OMHC), which were incorporated into emulsion gels to produce meat-colored oil-in-water systems. Glycosylation between oligochitosan and Hb was confirmed by polyacrylamide gel electrophoresis and validated through free amino group analysis. Increasing the oligochitosan-to-Hb ratio from 2:1 to 3:1 resulted in the highest grafting degree, reaching 41.82%. Compared with untreated Hb, OMHC significantly improved the emulsifying capacity, thermal stability, and pH stability of the emulsion gels. The effects of OMHC concentration (0, 0.3, 0.6, 1.2, and 1.8 wt%) were systematically investigated. OMHC addition increased the gel's a* value from -0.79 to 2.68 and b* value from 5.85 to 18.02, producing a natural yellowish-red hue. Rheological analysis revealed that higher OMHC concentrations elevated gelation onset temperature and enhanced gel strength, as indicated by an increase in G' at 20 °C. Fourier transform infrared spectroscopy confirmed hydrogen bonding between OMHC and gelatin, while microscopic observations demonstrated the formation of a uniform, dense gel network. These findings highlight the potential of OMHC to stabilize Hb and advance the application of meat-colored emulsion gels as saturated fat replacers in both processed meat products and plant-based alternatives.

PMID 42562472
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PubMedJournal of medical cases2026-08-07

Mandibular Osteomyelitis and Acute Soft Head Syndrome in an Adolescent With Sickle Cell Disease.

Almugahwi Abdulelah Abdulrahman AA, Al-Ansari Rehab Yusuf RY

Sickle cell disease (SCD) is a type of inherited disorder of hemoglobin characterized by recurring vaso-occlusive pain crises that affect many organ systems. Although it is uncommon, involvement of the orofacial region, such as the mandible area and jaw, can lead to a mandibular osteomyelitis, which can cause serious morbidity and diagnostic uncertainty. We describe a 17-year-old male Saudi patient with SCD who initially complained of bodily ache before developing fever, facial swelling, frontoparietal head swelling, and elevated inflammatory markers. The image resembled an odontogenic abscess along with frontoparietal head collection. However, the patient's clinical history, painful crises, elevated inflammatory markers, and high Hb S% along with further radiological study were all compatible with a mandibular osteomyelitis along with acute soft head syndrome. Vigorous supportive care with exchange transfusions to lower Hb S%, antibiotic support, and multidisciplinary consultation was all part of the management. The patient was steadily getting better, and after 1 month from starting management, all of the facial and head swelling had completely disappeared. In conclusion, this case highlights the presentation of two uncommon SCD manifestations: mandibular osteomyelitis and acute soft head syndrome in young SCD patient. Additionally, it demonstrated how crucial it is to keep mandibular crisis (osteomyelitis) as a differential diagnosis for orofacial pain in SCD patients and how lowering Hb S% is important for treating such instances.

PMID 42564257
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PubMedThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2026-08-07

Simultaneous Administration of Human Papillomavirus (HPV) Vaccine With Other Recommended Vaccines Among Adolescents Aged 13-17 years, National Immunization Survey-Teen (NIS-Teen), United States, 2023.

Pingali Cassandra C, Yankey David D, Chen Michael M, Elam-Evans Laurie D LD et al.

To investigate the percent of adolescents who receive human papillomavirus (HPV) vaccine with one or more other vaccines recommended for adolescents in a single medical visit. Data from the 2023 National Immunization Survey-Teen were analyzed. Timing of receipt of HPV vaccine, tetanus, diphtheria, and acellular pertussis vaccine (Tdap), quadrivalent meningococcal conjugate vaccine (MenACWY), and influenza vaccine was assessed using provider-reported vaccination histories. In 2023, among adolescents aged 13-17 years, 69.5% received HPV vaccine with one or more other vaccines recommended for adolescents in a single medical visit. In addition, 47.8% received specifically HPV vaccine, Tdap, and MenACWY together in a single medical visit. The HPV vaccine is commonly given with other vaccines recommended for adolescents in a single medical visit. These findings demonstrate variation in simultaneous vaccination patterns, suggesting that flexibility in the recommended adolescent vaccination schedule allows for different approaches to vaccination across clinical settings and family preferences while maintaining adherence to the recommended schedule.

PMID 42565767
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PubMedHealth SA = SA Gesondheid2026-08-07

Comparative analysis of COVID-19 vaccine and booster acceptance among healthcare workers in public and private sectors in KwaZulu-Natal, South Africa.

Manickum Viloshini K VK, Mathibe Lehlohonolo J LJ

The coronavirus disease 2019 (COVID-19) pandemic posed unprecedented global health challenges, necessitating accelerated COVID-19 vaccine development. However, vaccine and booster hesitancy among healthcare workers (HCWs) presented a barrier globally and in South Africa (SA). This study aimed to determine the level of vaccine and booster acceptance among HCWs in public, private and public-private sectors in KwaZulu-Natal (KZN), SA, and to identify the key reasons of vaccine and booster acceptance and refusal. This study was conducted across KZN. A quantitative, descriptive, cross-sectional survey was conducted from October 2024 to April 2025 among doctors, nurses and pharmacists using an online questionnaire. Three hundred and thirty-one HCWs participated in this study with a reliable and standardised questionnaire. Data analysis included descriptive and inferential statistics. Relevant ethics committees and participants provided ethical approval. Average vaccine acceptance rate for vaccine and booster was 92.4% (n = 306) and 73.7% (n = 244), respectively. Public-private recorded the highest acceptance rates for vaccine (96.3%) and booster (85.1%). Primary reasons for vaccine refusal included vaccine-related illness in family (52.4%, n = 11) and rapid development and safety concerns (64%, n = 16), predominantly among private sector. Main booster refusal reasons included safety of multiple booster doses (50%, n = 32) and antibodies from previous COVID-19 infection, mostly in the public sector. Addressing complex determinants of vaccine hesitancy across healthcare sectors necessitates an integrated and sustained approach reinforced by multidisciplinary stakeholder engagement. This study contributes to future pandemic preparedness and vaccination programmes by elucidating reasons influencing vaccine acceptance and refusal among HCWs.

PMID 42564541
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PubMedInfectious diseases and therapy2026-08-07

Can We Compare Adverse Event's Attributable Risk Using a Self-Controlled Case Series Design for Vaccine Safety? A Guillain-Barré Syndrome Use Case.

Liang Caihua C, Chilson Erica L EL, Wu Joanne J, Kelly Scott P SP et al.

Estimating attributable risk (AR) through self-controlled case series (SCCS) analyses alone may limit generalizability because SCCS only incorporate vaccinated patients with the outcome (e.g., Guillain-Barré syndrome [GBS]) who may differ from the recommended vaccinee population. We aimed to demonstrate background event incidence rates' impact on vaccine-specific GBS ARs and to standardize ARs across different vaccine studies by applying a generalizable, population-based GBS background rate to better estimate the expected population-level ARs. We identified post-licensure SCCS vaccine studies and GBS background rates using US Medicare data via targeted literature review. GBS control period rates from SCCS vaccine studies were extracted or calculated. Population-level ARs were calculated for each vaccine using two published and two hypothetical background GBS rates and the original SCCS-generated incidence rate ratios (IRRs). Published vaccine-specific GBS IRRs ranged from 2.02 (95% CI 0.93-4.40) for RSVpreF to 4.96 (95% CI 1.43-17.27) for recombinant zoster vaccine (RZV). Study-specific ARs per 100,000 doses ranged from 0.28 (H1N1) to 0.90 (RSVpreF). Vaccines with lower control period GBS rates had a lower attributable risk for a given IRR. After standardization using external background GBS rates, population-level ARs were higher for vaccines with higher IRRs. For example, when using the H1N1 vaccine control period rate as the GBS background rate for AR calculation, RSVpreF had the lowest AR per 100,000 doses (0.21) and RZV the highest (2.26). AR calculation is dependent on the control period event rate within a given SCCS analysis. ARs derived exclusively from SCCS analyses may lead to incorrect conclusions regarding an adverse event's absolute risk in regulatory communications due to a lack of external validity. Using a representative background rate from the recommended vaccinee population, along with SCCS-derived IRR, offers a more consistent approach to calculate the expected population-level AR and supports vaccine risk-benefit assessments.

PMID 42562995
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PubMedJournal of community health2026-08-07

HPV Vaccination Predictors Among College Students.

Lee Alyssa A, Kirby Kiley Brady KB, Werthmann Derek D, Daniel Casey L CL

College students remain at increased risk for acquiring human papillomavirus (HPV), yet HPV vaccination coverage remains suboptimal despite the availability of a safe and effective vaccine. This study examined predictors of HPV vaccination and HPV- and HPV vaccine-related knowledge, beliefs, and hesitancy among undergraduate students at a southern United States university. An online cross-sectional survey was administered to undergraduate students aged 18-26 years in November 2024. Descriptive statistics summarized participant characteristics, vaccination status, and HPV-related measures. Multinomial logistic regression models were used to examine factors associated with HPV vaccination status while estimating adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Among 1,127 respondents (mean age, 20.1 years), most were female (74.1%), White (74.9%), and insured (90.4%). Overall, 48.4% reported receiving at least one dose of the HPV vaccine, with only 21.7% completion. More than 30% were unsure of their HPV vaccination status. HPV knowledge, HPV vaccine knowledge and beliefs, and vaccine hesitancy were all independently associated with vaccination status (all p < 0.001). Participants with stronger positive HPV vaccine beliefs and lower vaccine hesitancy had significantly greater odds of reporting HPV vaccination. In secondary analyses, both provider and parental recommendation were significantly associated with younger age at initiation. HPV vaccination initiation and completion remain low among college students, with substantial gaps in knowledge, awareness, and confidence. College campuses represent an important setting for interventions that improve HPV-related knowledge, strengthen vaccine confidence, increase awareness of personal vaccination status, and promote vaccination to reduce future HPV-associated cancers.

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