Novartis AG · 小分子 · 小分子
MF-59 是一种小分子，由Novartis AG研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)。
| 商品名 | MF59 |
| 公司 | Novartis AG |
| 药物类别 | 小分子 |
| 给药途径 | Injectable (Others) |
| 状态 | Approved |
MF-59 针对 1 个适应症，涉及 1 个治疗领域。
| 治疗领域 | 疾病/病症 | 分期 |
|---|---|---|
| Surgical and medical procedures | Oral appliance application | ✓ Approved |
Amitay-Laish Iris I, Mitsunaga Keila K, Ortiz-Romero Pablo L PL, de Masson Adèle A et al.
Cos Heidy H, Valenzuela Cristian D CD, Moaven Omeed O, Leonard Grey G et al.
Readmission is considered as a surgical quality indicator. More data regarding predictors of readmission and outcomes after surgery for colorectal liver metastasis are needed. Using a propensity score match to create a 1:2 match of cases:controls for 90-day. Readmission, the matching variables used for balance included age, tumor size, estimated blood loss, and type of resection (minor or major). T-tests were used for continuous measures, Fisher's exact test was used for categorical data, and the Kaplan-Meier method was used to estimate survival. p < 0.05 was considered significant. Retrospectively examined 935 patients with CLM from 2000 to 2018. Using a propensity score match to create a 1:2 match of cases:controls for 90-day. Readmission, the matching variables used for balance included age, tumor size, estimated blood loss, and type of resection (minor or major). T-tests were used for continuous measures, Fisher's exact test was used for categorical data, and the Kaplan-Meier method was used to estimate survival. p < 0.05 was considered significant. 935 patients were included in the initial sample with 896 eligible for inclusion in the propensity matching. The average age of the population was 59% and 59% male. Overall readmission rate was 8.0%. Median time to readmission was 14 days. In the propensity score matched sample, readmitted patients had higher rates of organ space infection (28% vs 2% and p < 0.0001), bile leak (26% vs 1% and p < 0.0001), and liver failure (9% vs 2% and p = 0.042). There was no difference in LOS (7 days versus six days and p = 0.40), overall survival (median 39.7 vs 41.0 months and p = 0.79), or rate of adjuvant therapy (68% for both and p > 0.99). Patients readmitted for intermediate and late complications after surgery for CLM can recover and receive adjuvant therapy with no adverse effect on overall survival. Organ space infection, bile leak, and liver failure are highly associated with readmission.
Oswald Laura L, Dvorak Fabian F, Jamieson Jeremy P JP, Heinrichs Markus M et al.
As stress levels rise globally, it is critical to understand whether stress promotes or inhibits prosocial behavior. The literature to date provides inconclusive evidence on this question. Here, we investigated whether the effects of stress on prosocial behavior depend on the interaction partner's social role. Specifically, 121 young adults (59 men, 62 women, age range = 18 - 34 years) performed the Trier Social Stress Test for Groups (TSST-G) before dividing resources among themselves and either another participant (i.e., a peer) or a TSST-G jury member (i.e., the stressor). We found that participants behaved less prosocially toward a stress-inducing TSST-G jury member compared to a peer across various behavioral measures (i.e., trust, trustworthiness, sharing, punishment). Overall, our results suggest that individuals adapt their behavior toward others depending on the social role of their interaction partner, behaving more prosocially toward potential allies than toward those who thwart social goals. More broadly, our study highlights the importance of considering situational variables when examining the effect of stress on prosocial behavior.
Ye Jianhong J, Liang Weina W
This prospective study compared the Marsh and Schnider pharmacokinetic models for propofol target-controlled infusion (TCI) during anesthetic induction in obese patients undergoing elective cardiac surgery. A total of 118 patients were randomly assigned to either the Marsh or Schnider group (n = 59 each). The primary outcome was the performance error (ΔC = measured minus predicted plasma concentration) during and after TCI. Secondary outcomes included hemodynamic pharmacokinetic-pharmacodynamic (PK-PD) model, anesthetic depth (BIS), cardiac function (LVEF, SV), electrocardiographic PK-PD model (QTc, QTcd), and recovery profiles. While no significant differences in ΔC were observed during TCI, the Marsh model demonstrated significantly lower ΔC at all time points after TCI cessation (p < 0.05). Compared to the Schnider group, the Marsh group also showed higher BIS values, better preserved LVEF and SV, shorter QTc/QTcd intervals, reduced propofol requirements, and shorter recovery times (all p < 0.05). In conclusion, under the conditions of this study, in which propofol TCI was configured using total body weight for the Marsh model and lean body weight for the Schnider model, the Marsh model provided more accurate plasma concentration control, better hemodynamic stability, and improved recovery profiles compared with the Schnider model for anesthetic induction in obese cardiac surgery patients.
Brown Stephanie R SR, Heneghan Julia A JA, Badke Colleen C, Dziorny Adam C AC et al.
ObjectiveUse of vasoactive medications is common in pediatric intensive care units (ICUs), however evidence to guide medication selection is limited likely resulting in practice variation. Our objective was to describe the use of vasoactive infusions across ICUs and sites.DesignRetrospective cohort study using the multi-institutional PICU Data Collaborative (PDC) database.SettingFour pediatric ICUs (PICUs) and three cardiac ICUs (CICUs) from the U.S. participating in the PDC.PatientsPatients admitted to a participating ICU between 2010 and 2022 who received a vasoactive infusion within 7 days of ICU admission.InterventionsNone.Measurements and Main ResultsA vasoactive infusion was administered within the first 7 days of admission in 16,959 (22%) out of a total of 75,953 ICU encounters. CICU encounters comprised 20% of all ICU encounters but 60% of those with a vasoactive infusion. The most frequently used vasoactive medications were milrinone (63%) and epinephrine (59%). We found a statistically significant difference in the frequency of each vasoactive infusion between PICU sites (P < 0.001) and between CICU sites (P < 0.001). The median peak vasoactive inotrope score (VIS) was 10 [IQR 5.5-20] and 8 [IQR 5-12.5] among PICU and CICU encounters respectively.ConclusionsWe found significant variability in the frequency of vasoactive infusion medication use between sites and type of ICU. Further investigation is needed to understand what impact this practice variability has on patient outcomes.
Toyoda Natsumi N, Yanagisawa Nobuyuki N, Watanabe Reiko R, Doi Masatomo M et al.
Most meningiomas are classified as WHO CNS grade 1 and have a favorable prognosis when completely resected. In contrast, intracranial recurrence and metastasis are frequently observed in grade 2-3 meningiomas, although extracranial spread is rare. A 59-year-old Japanese male presented with numbness on the right side of face and diplopia, and imaging revealed a lesion extending from the right middle cranial fossa to the paranasal sinuses and right optic canal. Histology revealed epithelioid nests and spindle cells with high cellularity. The epithelioid component formed whorl-like structures resembling meningothelial cells, with focal necrosis, bizarre nuclei and lower mitotic activity, which is consistent with atypical meningioma of the meningothelial subtype. In contrast, the spindle cell component demonstrated poor morphological differentiation and high mitotic activity. Immunohistochemistry revealed that the meningothelial cells were positive for epithelial membrane antigen and were partially positive for progesterone receptor. The spindle cells were negative for these markers and weakly positive for smooth muscle actin. The final diagnosis was anaplastic meningioma (WHO CNS grade 3) with sarcomatous features showing smooth muscle differentiation. Extensive extracranial metastases via the sarcomatous element involved 12 extracranial organs, including common sites such as the lungs, bones, and liver, indicating unusually widespread dissemination. This report describes an anaplastic meningioma with multiple extracranial metastases. The extensive multiorgan involvement and rapid progression by the autopsy confirmation distinguish this as a rare case with markedly greater malignancy than typically reported.
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