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DTwP-HepB-Hib-IPV vaccine (Easysix)

✓ Approved

Panacea Biotec Limited · 重组蛋白 · 重组蛋白

什么是 DTwP-HepB-Hib-IPV vaccine?

DTwP-HepB-Hib-IPV vaccine 是一种重组蛋白,由Panacea Biotec Limited研发。该药已获批,用于治疗相关适应症,给药途径:Injectable (Others)、Intramuscular (IM) Injection。

药物档案

商品名Easysix
公司Panacea Biotec Limited
药物类别重组蛋白, 疫苗
给药途径Injectable (Others), Intramuscular (IM) Injection
状态Approved

治疗适应症

DTwP-HepB-Hib-IPV vaccine 针对 5 个适应症,涉及 2 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsDiphtheria✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsPertussis✓ Approved
Infections and infestationsTetanus✓ Approved
Surgical and medical proceduresPolio immunisation✓ Approved

相关研究文献

PubMedJournal of interpersonal violence2026-08-06

Seeing Violence Differently: Gendered Patterns of Parental Intimate Partner Violence and Adolescent Outcomes.

Lakshman Maya M, Bissoon Zephorah Z, Padilla Medina Diana M DM, D'Amato-Orloff Alexa A et al.

Growing up in a household with intimate partner violence (IPV) is associated with a range of adverse behavioral and relational outcomes during adolescence and across the life course. Less is known about how caregiver gender and type of IPV shape these outcomes, or whether associations differ by adolescents' race/ethnicity and sex assigned at birth. We used data from 2,437 adolescents (1,178 girls, 1,259 boys) from Waves 3 to 6 (ages 3-15) of the Future of Families and Child Wellbeing Study. Using survey-weighted linear regression and moderation analyses, we examined associations between maternal and paternal IPV during childhood and adolescent delinquency, aggression, and teen dating violence (TDV). In adjusted models, paternal physical IPV and maternal controlling IPV were each associated with higher levels of adolescent aggression, as was childhood physical abuse. Parental IPV was not significantly associated with adolescent delinquency or TDV. However, girls whose mothers experienced physical IPV were less likely to report physical TDV victimization compared to girls whose mothers did not. Moderation analyses indicated that Black adolescents whose mothers experienced controlling IPV had lower aggression scores than their White counterparts. These findings highlight the importance of considering caregiver gender and IPV type in assessing adolescent risk. Interventions for youth exposed to IPV may benefit from screening for co-occurring family risks, including child maltreatment, addressing gender-specific needs, and strengthening caregiver access to prevention and support services.

PMID 42557800
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PubMedNature communications2026-08-06

The deubiquitinase USP4 stabilizes the SCFFBXO24 ubiquitin E3 ligase to regulate immunity in experimental pneumonia.

Yurtsever Ilknur I, Farkas Daniela D, Cornwell Alex A, Joseph Jessica A JA et al.

The ubiquitin E3 ligase SCFFBXO24 targets key proteins for degradation that regulate important biological processes, but the mechanisms controlling cellular concentrations of its receptor subunit, F-box only protein 24 (FBXO24), remain unknown. Here, Haemophilus influenzae type B (HiB), an important cause of pneumonia, protects FBXO24 from lysosomal degradation in THP-1 macrophage cells by reducing its ubiquitylation levels. We identified that the ubiquitin-specific peptidase 4 (USP4) mediates FBXO24 deubiquitylation and stabilization in response to HiB infection in a TLR4 receptor-dependent manner. In experimental HiB pneumonia, either nanoparticle delivery of encapsulated USP4 siRNA or targeted genetic disruption of Fbxo24 in mice led to increased alveolar mononuclear cells coupled with reduced bacterial loads, attenuated pulmonary edema and decreased lung injury severity compared to control mice. Collectively, these findings demonstrate the ability of a bacterial pathogen to exploit a deubiquitylation mechanism to preserve cellular levels of an E3 ligase component, thereby impairing innate host defense responses.

PMID 42552308
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PubMedMilitary medicine2026-08-06

Empowering Safety: The Case for a Decision-making App for Military Partners Facing Intimate Partner Violence.

Berry-Cabán Cristóbal S CS, Nash Lauren N LN, Beltran Thomas A TA, Robichaux Krystal N KN et al.

Introduction Intimate partner violence (IPV) is an important public health concern among military-connected populations, but help-seeking, disclosure, and safety planning may be shaped by military-specific factors, including command structure, relocation, housing dependence, and privacy concerns. This exploratory study described self-reported IPV experiences, resource awareness, and perceptions of a hypothetical military-specific decision-making and safety-planning smartphone application among women recruited from a primary care medical clinic at Fort Bragg, North Carolina. Materials and Methods Using a single-site convenience sample, 18 female service members and civilians completed a 106-item online survey adapted from selected National Intimate Partner and Sexual Violence Survey domains and supplemented with study-specific questions. Analyses were descriptive only. The study was not designed to estimate population prevalence, compare subgroups, evaluate app effectiveness, or assess implementation feasibility. Results Within this small clinical sample, 9 of 18 participants reported IPV-related experiences during the previous 24 months. Emotional abuse and coercive control were the most commonly reported experiences. Reported health and social concerns included difficulty sleeping, chronic pain, financial stress, and resource needs related to housing, legal, community, and advocacy services. Awareness and prior use of IPV-related apps were low; however, 13 of 17 respondents expressed interest in a confidential, military-relevant IPV prevention or safety-support app. Conclusion These findings should be interpreted as descriptive and hypothesis-generating. They suggest low awareness of existing digital IPV resources and preliminary interest in a military-specific safety-support tool within this small convenience sample. Larger studies are needed to evaluate recruitment feasibility, acceptability, sustained use, safety, help-seeking outcomes, and implementation considerations in military-connected populations.

PMID 42560214
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PubMedThe Veterinary clinics of North America. Small animal practice2026-08-06

Companion Animal Vaccine Hesitancy: Current Evidence and Practical Communication Strategies.

Hartley Ashley N AN, Ng Zenithson Z, Ludwig Claire E CE, Pritchard Jessica C JC

This review article summarizes the emergence of vaccine hesitancy in companion animal medicine and its parallels with human health care. Factors influencing pet owner vaccination decisions include concerns about safety, necessity, cost, overvaccination, and misinformation. Current literature suggests veterinarians remain the most trusted source of vaccine information and play a central role in maintaining vaccine confidence. The article reviews available data on companion animal vaccination trends, owner attitudes, and veterinary team perceptions while highlighting communication strategies, including motivational interviewing and presumptive recommendations, that may improve vaccine acceptance and strengthen preventive health care delivery.

PMID 42557112
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PubMedVaccine2026-08-06

A systematic review of knowledge, attitudes, and behaviour towards Japanese encephalitis vaccination.

Nepali Rebika R, King Catherine C, Leask Julie J, Campbell Emma E et al.

Three billion people globally are at risk of Japanese Encephalitis (JE), a mosquito-borne disease primarily spread by Culex mosquitoes. Despite the availability of JE vaccine, uptake is limited and a deeper understanding of people's knowledge, attitudes, and behaviours (KABs) towards JE vaccine is needed to improve this. This study systematically reviewed the existing research on KABs towards JE vaccination, with a view to informing JE vaccine program delivery, policy and practice. Seven bibliometric databases, grey literature and references of included studies were searched for primary studies on KABs towards JE vaccination. Search outputs were independently screened; data were extracted and synthesised descriptively. Of the 26 studies included, most were conducted in JE endemic countries and examined four participant groups: travellers from non-endemic settings, caregivers of vaccine recipients and non-traveller adults from endemic settings, and vaccine providers/advocates from both settings. Of the few studies, adult vaccine recipients had low knowledge and awareness of the vaccine, whereas caregivers' knowledge and awareness were higher. Attitudes towards JE vaccination were generally positive and KABs were often influenced by health workers, community leaders, risk perception, cost, time constraints, migration, and vaccine availability and accessibility. There were limited KABs studies regarding JE vaccination using rigorous and consistent methodological approaches. This review highlights the barriers to JE vaccination and the role of health professionals and vaccine advocates in JE vaccination programs. Focusing on empowering these groups is key to increasing JE vaccine uptake across different populations.

PMID 42556299
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PubMedHealth promotion international2026-08-06

'I took the vaccine to protect myself': determinants of COVID-19 vaccine confidence in Indigenous communities in Northwest Territories, Canada.

Kolahdooz Fariba F, Zakkar Moutasem M, Manning Claire C, Omidimorad Afsaneh A et al.

Vaccine hesitancy is a persistent global health challenge. This project explored attitudes towards and utilization of COVID-19 vaccination, as well as suggestions to improve utilization within Indigenous communities in Northwest Territories, Canada. Utilizing a cross-sectional design, this project spanned two phases: 10 communities in Phase 1 (April to November 2021), and 11 in Phase 2 (August 2022-January 2023). Self-identifying Indigenous adults (≥18 years) were invited. Quantitative and qualitative data were collected via a semi-structured interviewer-administered questionnaire. In Phase 1 (n = 124; mean age = 41.6 years; 63.7% women) and Phase 2 (n = 221; mean age = 43.6 years; 66.21% women), 78.2% and 87.2% of participants had received at least one dose, respectively. In Phase 1, 67.2% reported not being concerned about the vaccine, and 61.2% believed the benefits outweighed the risks. In Phase 2, 56.2% of participants agreed all eligible individuals should be vaccinated, and 59.2% agreed the vaccine prevented serious outcomes. Bivariate analyses revealed that negative attitudes towards COVID-19 severity, vaccine safety, and effectiveness were significantly associated with lower intention to receive a COVID-19 vaccine in the future. Qualitative insights revealed factors of vaccination hesitancy, including: concerns about safety, efficacy, and necessity; a need for information; and distrust in government. Reasons for utilization included: trust in vaccine safety; perceived necessity; and employment and travel requirements. COVID-19 vaccine utilization in Indigenous communities is high, yet hesitancy persists due to safety and efficacy concerns, and distrust in government. Culturally safe strategies, improved communication, and equitable access are essential to sustaining confidence and future pandemic preparedness.

PMID 42560160
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