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PO

polio vaccine (OPV, Bio Farma / tOPV, Bio Farma)

✓ Approved

Bio Farma · 疫苗 · 疫苗

什么是 polio vaccine？

polio vaccine 是一种疫苗，由Bio Farma研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名OPV, Bio Farma, tOPV, Bio Farma
公司Bio Farma
药物类别疫苗, 大分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Bio Farma

治疗适应症

polio vaccine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresPolio immunisation✓ Approved

相关研究文献

PubMedFrontiers in global women's health2026-08-05

Awareness, factual knowledge, attitudes, and acceptability of human papillomavirus vaccination among adult women in Palestine: a cross-sectional study.

Amro Alhareth M AM, Safadi Leen M LM, Fahoum Shahd R SR, Deeb Salahaldeen S et al.

Human papillomavirus (HPV) is a major preventable cause of cervical cancer, yet awareness and uptake of HPV vaccination remain suboptimal in many settings. Evidence regarding women's HPV-related awareness, factual knowledge, and vaccine acceptability in Palestine remains limited. This study assessed awareness, factual knowledge, attitudes, self-reported uptake, willingness, and perceived barriers related to HPV infection and HPV vaccination among adult women in Palestine. A cross-sectional online survey was conducted between October 2025 and February 2026 among women aged ≥18 years residing in Palestine. The questionnaire assessed sociodemographic characteristics, HPV and HPV vaccine awareness, factual knowledge, attitudes, vaccine uptake, willingness to receive or recommend vaccination, and perceived barriers. A 12-item factual knowledge score was calculated, and higher factual knowledge was defined as ≥7 correct responses. Descriptive statistics, subgroup analyses, and multivariable logistic regression were performed. Among 424 adult women included in the final analysis, 220 (51.9%) had heard of HPV and 146 (34.4%) had heard of the HPV vaccine. The mean factual knowledge score was 4.03 ± 2.72 out of 12, and 90 participants (21.2%) had higher factual knowledge. Self-reported HPV vaccine uptake was low (13.0%), whereas willingness to receive the vaccine was higher (55.2%). Lack of awareness (55.8%) and concern about vaccine safety (22.8%) were the most frequently reported barriers among unvaccinated women. In expanded adjusted analyses, prior HPV awareness, prior HPV vaccine awareness, and more supportive HPV-vaccination attitudes were independently associated with higher factual knowledge. Higher factual knowledge and supportive attitudes were associated with self-reported vaccine uptake, while willingness among unvaccinated women was most strongly associated with supportive vaccination attitudes. Adult women in Palestine demonstrated limited HPV-related awareness and low factual knowledge, together with low self-reported HPV vaccine uptake. The gap between willingness and uptake, combined with the predominance of awareness and safety concerns as reported barriers, suggests a need for culturally appropriate education, provider-led counseling, and improved access to reliable HPV vaccine information. Findings should be interpreted cautiously given the cross-sectional design and online convenience sampling.

PMID 42553322
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PubMedClinical kidney journal2026-08-05

Lipid parameters but not inflammatory indices predict hepatitis B vaccine responses in hemodialysis patients.

Ekici Hilal H, Mirza Arzu A, Baltacı Sevgi S, Eren Davut D et al.

Hepatitis B virus (HBV) vaccination is essential in hemodialysis (HD) populations, yet seroprotection remains suboptimal. Inflammation-related hematologic indices are frequently used in clinical practice, but their ability to predict HBV vaccine response in HD patients is uncertain. We evaluated clinical and laboratory determinants of HBV vaccine response, with a focus on lipid-derived indices and inflammatory ratios. In this multicenter retrospective study, adult HD patients followed between 2015 and 2025 who received at least three doses of HBV vaccine and had available anti-HBs measurements were included (n = 341). Vaccine response was defined as anti-HBs ≥10 IU/L; non-response as <10 IU/L. Neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), neutrophil percentage-to-albumin ratio (NPAR), and lipid ratios (TG/HDL, TC/HDL, LDL/HDL) were calculated. Additional analyses using percentile-based categorization of NPAR confirmed the absence of a significant association with vaccine response. Multivariable logistic regression and receiver operating characteristic analyses were performed. After the primary vaccination series, seroprotection was 77.4% and increased to 88.6% after revaccination/boosters; it declined to 78.3% at 1 year and 69.2% at 2 years. Non-responders were older and had higher triglyceride levels and lower HDL cholesterol levels. In contrast, inflammatory indices (NLR, PLR, MLR, and NPAR) did not differ significantly between groups. These indices also demonstrated limited discriminative ability for predicting vaccine response. In multivariable analysis, HDL cholesterol remained positively associated with vaccine response [odds ratio (OR): 1.046, 95% confidence interval (CI): 1.006-1.086, P = .022], and triglyceride levels were negatively associated with vaccine response (OR: 0.992, 95% CI: 0.984-0.999, P = .024). The TG/HDL ratio showed borderline statistical significance (OR: 1.235, 95% CI: 0.983-1.551, P = .070), suggesting a potential but limited contribution to vaccine response prediction. In HD patients, hematologic inflammatory indices were not informative for HBV vaccine response, whereas an atherogenic lipid profile-particularly lower HDL and higher triglycerides-showed a consistent association. Lipid parameters may support risk stratification and tailored post-vaccination monitoring strategies.

PMID 42553896
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PubMedEnergy & fuels : an American Chemical Society journal2026-08-05

Hydrothermal Liquefaction of Digestate and Copyrolysis of Hydrochar-Straw Blends: An Integrated Approach for Bio-crude and Biochar Production.

Grottola Corinna Maria CM, Marotta Giusy G, Amato Davide D, Di Lauro Francesca F et al.

Anaerobic digestion converts wet biogenic wastes into biogas and a byproduct, the digestate, which is a wet material rich in carbon and nutrients widely used in agriculture. However, the large amount produced determines some limitations in this exploitation, thus different thermochemical processes are under investigation. The hydrothermal liquefaction (HTL) process is considered a viable thermochemical route to convert high-water-content biomasses into a liquid energy vector, the bio-crude. However, considerable uncertainties remain regarding the use of the HTL solid residue, the hydrochar (HC), which is not regulated as soil amendment. Thus, its transformation into biochar, already recognized by law as soil improver, could be a promising valorization route. In this context, copyrolysis of HC with abundant agricultural residues may represent an effective strategy to further improve resources' valorization. This study proposes an integrated approach that combines the conversion of digestate through HTL into bio-crude and copyrolysis of hydrochar and straw (S), an abundant agricultural waste to produce biochar. HTL of digestate has been performed in a 500 mL batch autoclave reactor and optimized, based on the biocrude yield and properties, investigating different temperatures (300 and 350 °C) and isothermal reaction times (0-30 min). HC produced under the optimal operating conditions for bio-crude production and S have been pyrolyzed individually and in blends with varying compositions (10-50 wt % S) under slow pyrolysis conditions at a final temperature of 450 °C. Pyrolysis products' yields and properties of biochars have been investigated to assess the compliance of biochar with EU Fertilizing Products Regulation (EU 2019/1009) and to identify possible nonlinear effects arising from the combination of the two feedstocks. Results show high biochar yields in the range of 42.8-62.9 wt % and high H/C ratios in the range of 0.68 to 0.61 which comply with the threshold limits imposed by the EU regulations.

PMID 42553783
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PubMedInternal medicine journal2026-08-05

Critical role of vaccination in preventing severe coronavirus disease 2019: perspectives from clinical outcomes in an Australian kidney transplant recipient cohort.

Tharmaraj Dhakshayini D, Naidu Paayal P, Baptista Mohana M, McBride Sarah S et al.

Kidney transplant recipients (KTRs) disproportionately experience severe COVID-19 infections. We previously identified concern regarding vaccine-induced rejection as a barrier to vaccine uptake. This study assesses COVID-19 vaccine uptake, infection outcomes and allograft rejection in KTRs during the delta and omicron waves (BA.1/BA.2). This cohort study included all adult KTRs with a functioning allograft at 22 March 2021 at our centre. KTR and vaccination-related risk factors for the primary outcome of severe COVID-19 infection (requiring hospitalisation) and the secondary outcomes of death and all COVID-19 infections were assessed using Cox proportional hazards models. Rejection risk following infection/vaccination was also assessed. Of the 986 included KTRs, there were 333 (33.8%) COVID-19 infections, 79 (23.7%) severe infections and 13 deaths (n = 13/333, 3.9%). Vaccine number was the most significant modifiable predictor of severe infection (adjusted hazards ratio, per additional dose, 0.5; 95% confidence interval, 0.40-0.65, P < 0.001) and death. While older age also predicted severe infection and death, lower estimated glomerular filtration rate, history of diabetes and previous allograft rejection predicted severe infection. Male gender was the only predictor of all infections. Mycophenolate dose, prednisolone use and vaccine type did not predict infection or severe disease. Infections and vaccinations did not increase the risk of rejection. KTRs should be encouraged to be optimally vaccinated to prevent severe disease and can be reassured about the low risk of allograft rejection. Risk factors that compound the state of immunocompromise and severe COVID-19 infections should prompt vigilance and targeted interventions to mitigate these risks.

PMID 42554002
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PubMedChemistry (Weinheim an der Bergstrasse, Germany)2026-08-05

An Integrated Bio-Based Film With Dynamic Covalent Networks for Coupled pH-Responsive Release and Colorimetric Reporting.

Wang Tongtong T, Sun Hui H, Weng Yunxuan Y

A multifunctional smart film was fabricated via dynamic Schiff base cross-linking between quaternary ammonium chitosan (HACC) and dialdehyde cellulose (DAC), enabling the integrated encapsulation, controlled release, and visual indication of curcumin within a single matrix without external sensors. Structural analyses (FTIR, XPS) confirmed the formation of the pH-responsive dynamic network. Curcumin incorporation significantly enhanced the film's performance, increasing tensile strength (TS) by ∼60%, improving barrier properties, and providing potent antioxidant activity (DPPH scavenging efficiency approaching 90%). The swelling behavior and release kinetics of the films were highly pH-dependent. Rapid burst release dominated by nonFickian diffusion was observed under acidic conditions (pH 4.0), whereas slow, sustained Fickian diffusion-controlled release occurred in neutral and alkaline environments (pH 7.0 and 9.0). Owing to the intrinsic chromophoric properties of curcumin, the films displayed distinct and reversible pH-dependent color changes, transitioning from bright yellow in acidic media to reddish-brown in alkaline conditions, enabling intuitive visual monitoring of environmental changes. This work demonstrates an effective strategy for designing bio-based innovative packaging materials that integrate sensing, protection, and controlled release functions within a unified, dynamically responsive polysaccharide network.

PMID 42554479
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PubMedSmall methods2026-08-05

Multidimensional Protein Corona Analysis Toward Predictive Nano-Bio Interface Design.

Hou Mingxuan M, Chen Minglong M, Liu Shiyong S

Nanoparticles entering biological fluids are rapidly coated by proteins and other biomolecules, converting their synthetic surfaces into biologically active nano-bio interfaces. These coronas regulate colloidal stability, immune recognition, cellular uptake, biodistribution, pharmacokinetics, cargo delivery, and toxicity. Yet a protein list obtained by mass spectrometry captures only part of this interface. Corona identity and function are also shaped by protein organization, binding stability, exchange dynamics, conformational changes, and molecular accessibility. Here, we discuss recent progress in protein corona isolation and analysis from a question-oriented analytical perspective, with emphasis on how centrifugation, magnetic recovery, affinity- or chemistry-enabled capture, chromatography, filtration, and field-flow fractionation (FFF) influence the fidelity, integrity, and comparability of recovered coronas. We then examine how proteomic profiling can be integrated with binding measurements, interfacial structural analysis and functional validation to distinguish descriptive corona signatures from biologically meaningful mechanisms. We further consider how biofluid composition, disease state, tissue interfaces and cellular environments remodel corona identity, presentation, and bioactivity. Finally, we argue that standardized reporting, computational modeling, and AI-enabled approaches are essential for converting protein corona datasets into reproducible and predictive knowledge that can guide the design of drug delivery systems and precision nanomedicines.

PMID 42552660
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