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grass pollen vaccine (DepiQuick)

✓ Approved

Laboratorios LETI · 治疗药物

什么是 grass pollen vaccine？

grass pollen vaccine 是一种治疗药物，由Laboratorios LETI研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Oral (PO)、Subcutaneous Injection、Sublingual (SL)/Oral Transmucosal。

药物档案

商品名DepiQuick
公司Laboratorios LETI
给药途径Injectable (Others), Oral (PO), Subcutaneous Injection, Sublingual (SL)/Oral Transmucosal
状态Approved
来源： ClinicalTrials.gov, Laboratorios LETI

治疗适应症

grass pollen vaccine 针对 3 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Respiratory, thoracic and mediastinal disordersAsthma✓ Approved
Immune system disordersHypersensitivity✓ Approved
Immune system disordersSeasonal allergy✓ Approved

相关研究文献

PubMedPlant biotechnology journal2026-08-05

The OsWRKY15-OsSUT3 Regulatory Module Enhances Rice Pollen Fertility by Mediating Sucrose Allocation to Anthers.

Li Qiuping Q, Zhang Chunlong C, Wang Shuaibing S, Chen Jin J et al.

Sucrose transport and starch accumulation are crucial carbohydrate metabolic processes in rice, playing essential roles during late pollen development to ensure pollen maturation, fertility and high grain production. However, the molecular mechanisms regulating sucrose transport and starch accumulation during rice pollen development remain elusive. In this study, we bred and characterized a semi-fertile rice pollen variant, sfp10, which is derived from highland terraced red rice from Yunnan, China. This variant showed insufficient starch accumulation in pollen, reduced pollen fertility and decreased seed setting compared to the wild type. Using map-based cloning, CRISPR/Cas9 mutagenesis and gene complementation, the OsSUT3 gene, which causes the sfp10 variant, was shown to encode a sucrose transporter (SUT) that transports sucrose into pollen for starch synthesis, ensuring pollen viability and fertility. Additionally, transcriptome analysis identified OsWRKY15, a WRKY transcription factor that exhibits a highly similar spatiotemporal expression pattern to OsSUT3 in late-developing panicles. Yeast one-hybrid, EMSA, dual-luciferase reporter and ChIP-seq assays demonstrated that OsWRKY15 directly binds to the promoter region of OsSUT3 and upregulates its expression. Mutation of OsWRKY15 significantly reduced OsSUT3 expression and impaired pollen fertility and seed setting and these defects were further exacerbated in the wrky15/OsSUT3-KO double-knockout lines, while OsSUT3 overexpression in the wrky15 background significantly rescued pollen fertility and seed setting. These findings demonstrate that the OsWRKY15-OsSUT3 regulatory module is essential for sucrose transport and starch accumulation during late pollen development in rice, providing new insights into the transcriptional regulation of carbon allocation to anthers for rice fertility and grain production.

PMID 42552817
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PubMedFrontiers in global women's health2026-08-05

Awareness, factual knowledge, attitudes, and acceptability of human papillomavirus vaccination among adult women in Palestine: a cross-sectional study.

Amro Alhareth M AM, Safadi Leen M LM, Fahoum Shahd R SR, Deeb Salahaldeen S et al.

Human papillomavirus (HPV) is a major preventable cause of cervical cancer, yet awareness and uptake of HPV vaccination remain suboptimal in many settings. Evidence regarding women's HPV-related awareness, factual knowledge, and vaccine acceptability in Palestine remains limited. This study assessed awareness, factual knowledge, attitudes, self-reported uptake, willingness, and perceived barriers related to HPV infection and HPV vaccination among adult women in Palestine. A cross-sectional online survey was conducted between October 2025 and February 2026 among women aged ≥18 years residing in Palestine. The questionnaire assessed sociodemographic characteristics, HPV and HPV vaccine awareness, factual knowledge, attitudes, vaccine uptake, willingness to receive or recommend vaccination, and perceived barriers. A 12-item factual knowledge score was calculated, and higher factual knowledge was defined as ≥7 correct responses. Descriptive statistics, subgroup analyses, and multivariable logistic regression were performed. Among 424 adult women included in the final analysis, 220 (51.9%) had heard of HPV and 146 (34.4%) had heard of the HPV vaccine. The mean factual knowledge score was 4.03 ± 2.72 out of 12, and 90 participants (21.2%) had higher factual knowledge. Self-reported HPV vaccine uptake was low (13.0%), whereas willingness to receive the vaccine was higher (55.2%). Lack of awareness (55.8%) and concern about vaccine safety (22.8%) were the most frequently reported barriers among unvaccinated women. In expanded adjusted analyses, prior HPV awareness, prior HPV vaccine awareness, and more supportive HPV-vaccination attitudes were independently associated with higher factual knowledge. Higher factual knowledge and supportive attitudes were associated with self-reported vaccine uptake, while willingness among unvaccinated women was most strongly associated with supportive vaccination attitudes. Adult women in Palestine demonstrated limited HPV-related awareness and low factual knowledge, together with low self-reported HPV vaccine uptake. The gap between willingness and uptake, combined with the predominance of awareness and safety concerns as reported barriers, suggests a need for culturally appropriate education, provider-led counseling, and improved access to reliable HPV vaccine information. Findings should be interpreted cautiously given the cross-sectional design and online convenience sampling.

PMID 42553322
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PubMedClinical kidney journal2026-08-05

Lipid parameters but not inflammatory indices predict hepatitis B vaccine responses in hemodialysis patients.

Ekici Hilal H, Mirza Arzu A, Baltacı Sevgi S, Eren Davut D et al.

Hepatitis B virus (HBV) vaccination is essential in hemodialysis (HD) populations, yet seroprotection remains suboptimal. Inflammation-related hematologic indices are frequently used in clinical practice, but their ability to predict HBV vaccine response in HD patients is uncertain. We evaluated clinical and laboratory determinants of HBV vaccine response, with a focus on lipid-derived indices and inflammatory ratios. In this multicenter retrospective study, adult HD patients followed between 2015 and 2025 who received at least three doses of HBV vaccine and had available anti-HBs measurements were included (n = 341). Vaccine response was defined as anti-HBs ≥10 IU/L; non-response as <10 IU/L. Neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), neutrophil percentage-to-albumin ratio (NPAR), and lipid ratios (TG/HDL, TC/HDL, LDL/HDL) were calculated. Additional analyses using percentile-based categorization of NPAR confirmed the absence of a significant association with vaccine response. Multivariable logistic regression and receiver operating characteristic analyses were performed. After the primary vaccination series, seroprotection was 77.4% and increased to 88.6% after revaccination/boosters; it declined to 78.3% at 1 year and 69.2% at 2 years. Non-responders were older and had higher triglyceride levels and lower HDL cholesterol levels. In contrast, inflammatory indices (NLR, PLR, MLR, and NPAR) did not differ significantly between groups. These indices also demonstrated limited discriminative ability for predicting vaccine response. In multivariable analysis, HDL cholesterol remained positively associated with vaccine response [odds ratio (OR): 1.046, 95% confidence interval (CI): 1.006-1.086, P = .022], and triglyceride levels were negatively associated with vaccine response (OR: 0.992, 95% CI: 0.984-0.999, P = .024). The TG/HDL ratio showed borderline statistical significance (OR: 1.235, 95% CI: 0.983-1.551, P = .070), suggesting a potential but limited contribution to vaccine response prediction. In HD patients, hematologic inflammatory indices were not informative for HBV vaccine response, whereas an atherogenic lipid profile-particularly lower HDL and higher triglycerides-showed a consistent association. Lipid parameters may support risk stratification and tailored post-vaccination monitoring strategies.

PMID 42553896
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PubMedJournal of experimental botany2026-08-05

Stronger drought tolerance in C4 compared to C3 grass crops is achieved via both avoidance and resistance strategies.

Boisseaux Marion M, Nadal Miquel M, Albuquerque Caetano C, Gomez Jesse J et al.

Grasses comprise many of the world's major cereal crops, yet the physiological mechanisms underlying their resilience to environmental stress remain unclear. While C4 grasses tend to display higher water use efficiency than C3 grasses, little is known about the underlying physiological and structural dynamics during mild and severe dehydration. We tested the sequence of decline with dehydration in leaf, root and whole plant hydraulic functions, and in leaf gas exchange and photochemistry (Fv/Fm) across three C3 and three C4 grass crop species, along with their rehydration capacity post-dehydration. We observed distinct strategies between the C3 and C4 species in response to water stress. The three C4 species experienced their peak intrinsic water-use efficiency earlier during dehydration, displayed greater hydraulic supply relative to demand, and had higher turgor loss points. The three C4 species also showed greater resistance to photochemical damage and embolism under severe dehydration. The three C4 species had higher leaf capacitance, and experienced greater leaf shrinkage than the three C3 species. Our findings reveal that variation among photosynthetic types can be associated with contrasts in both drought avoidance and resistance traits, contributing to a broader understanding of how different photosynthetic pathways influence plant performance under stress.

PMID 42552788
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PubMedJournal of plant research2026-08-05

Stylar curvature and its influence on the reproductive assurance in Passiflora foetida.

Das Sani S, Mili Marami M, Paul Suman S, Datta Badal Kumar BK

Reproductive assurance represents a key adaptive strategy in flowering plants, and many floral traits have evolved or been modified to ensure successful reproduction under environmental uncertainty. In Passiflora foetida L., styles exhibit varying degrees of curvature, giving rise to three distinct (fully curved, semi-curved, and erect) flower types during anthesis, each characterized by a different potential to ensure reproductive success. In this study, for the first time, the relationships among stylar curvature, pollen deposition, pollinator visitation, fruit set, and seed set were quantified under natural and controlled pollination treatments. The results showed that fully curved styles received the highest stigmatic pollen loads and exhibited the greatest fruit and seed set. Semi-curved flowers displayed intermediate reproductive success, whereas erect flowers recorded the lowest values across all reproductive parameters. The major pollinators, carpenter bees (Xylocopa spp.) and the giant honey bee (Apis dorsata), differed in visitation rates and single-visit effectiveness. However, pollination success depended strongly on stylar position. Stylar position played a decisive role in determining whether these visits resulted in successful fertilization. Notably, only fully curved flowers were capable of setting fruit through autonomous self-pollination, highlighting that stylar curvature serves as a mechanism of reproductive assurance under conditions of pollinator scarcity or unreliability.

PMID 42552447
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PubMedInternal medicine journal2026-08-05

Critical role of vaccination in preventing severe coronavirus disease 2019: perspectives from clinical outcomes in an Australian kidney transplant recipient cohort.

Tharmaraj Dhakshayini D, Naidu Paayal P, Baptista Mohana M, McBride Sarah S et al.

Kidney transplant recipients (KTRs) disproportionately experience severe COVID-19 infections. We previously identified concern regarding vaccine-induced rejection as a barrier to vaccine uptake. This study assesses COVID-19 vaccine uptake, infection outcomes and allograft rejection in KTRs during the delta and omicron waves (BA.1/BA.2). This cohort study included all adult KTRs with a functioning allograft at 22 March 2021 at our centre. KTR and vaccination-related risk factors for the primary outcome of severe COVID-19 infection (requiring hospitalisation) and the secondary outcomes of death and all COVID-19 infections were assessed using Cox proportional hazards models. Rejection risk following infection/vaccination was also assessed. Of the 986 included KTRs, there were 333 (33.8%) COVID-19 infections, 79 (23.7%) severe infections and 13 deaths (n = 13/333, 3.9%). Vaccine number was the most significant modifiable predictor of severe infection (adjusted hazards ratio, per additional dose, 0.5; 95% confidence interval, 0.40-0.65, P < 0.001) and death. While older age also predicted severe infection and death, lower estimated glomerular filtration rate, history of diabetes and previous allograft rejection predicted severe infection. Male gender was the only predictor of all infections. Mycophenolate dose, prednisolone use and vaccine type did not predict infection or severe disease. Infections and vaccinations did not increase the risk of rejection. KTRs should be encouraged to be optimally vaccinated to prevent severe disease and can be reassured about the low risk of allograft rejection. Risk factors that compound the state of immunocompromise and severe COVID-19 infections should prompt vigilance and targeted interventions to mitigate these risks.

PMID 42554002
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