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alpha-1 proteinase (Trypsone / Trypsan)

✓ Approved

Grifols, S.A. · SERPINA1

什么是 alpha-1 proteinase？

alpha-1 proteinase 是一种治疗药物，由Grifols, S.A.研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Trypsone, Trypsan
公司Grifols, S.A.
分子靶点SERPINA1
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Grifols, S.A.

作用机制

分子靶点

alpha-1 proteinase 作用于 1 个分子靶点：

SERPINA1serpin family A member 1 (PRO2275, nNIF)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

alpha-1 proteinase 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Congenital, familial and genetic disordersCongenital emphysema✓ Approved

相关研究文献

PubMedBiochemical pharmacology2026-06-13

Targeting neuropilin-1 attenuates 4-hydroxytamoxifen-induced stemness and sensitizes ERα-re-expressing TNBC to tamoxifen.

Yu Qinglong Q, Tang Wei W, Xiao Yani Y, Kong Ying Y et al.

Reactivating functional estrogen receptor alpha (ERα) expression represents a promising strategy for tamoxifen (TAM)-based endocrine therapy in triple-negative breast cancer (TNBC). However, TAM and its metabolites may exert potential oncogenic effects, which could compromise TAM efficacy in TNBC. Here, we report that low-dose 4-hydroxytamoxifen (4-OHT), an active metabolite of TAM, enhances stemness in TNBC cells via the Neuropilin-1 (NRP-1)/Calpain-2 (CAPN2)/β-catenin axis. Mechanistically, 4-OHT stimulates CAPN2 activation by promoting its membrane localization, increasing substrate cleavage, and inducing degradation of its endogenous inhibitor calpastatin. Activated CAPN2 suppresses ubiquitin-mediated degradation of β-catenin, leading to elevated β-catenin stability and intracellular accumulation. This enhances β-catenin transcriptional activity and ultimately promotes stemness in TNBC cells. Kaplan-Meier survival analysis showed that high NRP1 expression correlates with poorer overall survival in breast cancer patients undergoing endocrine therapy. Moreover, 4-OHT triggers Ca2+ release and ERK phosphorylation in TNBC cells through the NRP-1/PLC-γ1 pathway, thereby activating CAPN2. Finally, we demonstrate that the NRP-1 inhibitor EG00229 sensitizes ERα-re-expressing TNBC cells to TAM treatment. Our study uncovers a molecular mechanism by which 4-OHT promotes TNBC stemness via the NRP-1/CAPN2/β-catenin signaling cascade. Targeting NRP-1 may serve as a valuable strategy to improve TAM efficacy in ERα-re-expressing TNBC.

PMID 42285368
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PubMedCeska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti2026-06-13

Association of Aqueous Humor Tumor Necrosis Factor Alpha with Retinal Ganglion Cell Thickness in Juvenile versus Adult-Onset Primary Open-Angle Glaucoma.

Ilahi Fitratul F, Fitrah Fitrah F, Haq Nazhiful Kalaj NK, Alfatih Muhammad M et al.

To evaluate the association between aqueous humor tumor necrosis factor alpha (TNF-α) and retinal ganglion cell (RGC) layer in patients with juvenile open-angle glaucoma (JOAG) and their comparison with adult-onset primary open-angle glaucoma patients (POAG). This analytical cross-sectional study included 15 JOAG patients (aged 7-40 years) and 15 POAG patients (> 40 years). Aqueous Humor (AH) samples were collected during trabeculectomy, TNF-α concentrations were measured using ELISA, and RGC thickness was assessed by Optical Coherence Tomography (Cirrus HD-OCT, Carl Zeiss). Group differences were analyzed using the independent t-test, and correlations were evaluated with Pearson's test. The mean AH TNF-α level in the JOAG group (179.02 ±27.04 pg/mL) was significantly higher than in the POAG group (130.17 ±18.62 pg/mL; p.

PMID 42285746
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PubMedNeuroImage2026-06-13

Spatial generalization of peripherally encoded memories emerges before selection for report.

Kandemir G G, Olivers C N L CNL

Visual working memory has been shown to transition from location-specific to spatially generalized representations. It remains unclear what the time course of this generalization is and to which information processing stages and signals it is linked. Here we used EEG to investigate spatial generalisation of peripherally encoded stimuli before and after an item was selected for report. Thirty healthy participants memorized two orientations presented serially at fifteen degrees eccentricity to the left and right of central fixation. One of the two items was subsequently cued as task-relevant. During the delays, impulse signals were inserted to trace memoranda in potentially activity-reduced states. We observed that prior to the cue, patterns of activity transitioned from location-specific to spatially generalized states approximately 400-600 ms after onset in broadband voltage but not in oscillatory alpha signals. The picture was more mixed after the selection cue, with some evidence for both locations-specific and spatially generalized codes in alpha and broadband data. We conclude that the first stages of spatial generalization occur at sensory, pre-report levels of processing, while late stages are associated with selecting response-relevant spatial features.

PMID 42285448
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PubMedBritish journal of cancer2026-06-13

Fecal immunochemical tests from population-based colorectal cancer screening programs support prospective microbiome cohorts.

Byrd Doratha A DA, Zouiouich Sémi S, Wahl David D, Pardini Barbara B et al.

Large, prospective cohorts are needed to research the gut microbiome's role in colorectal cancer (CRC) risk. We evaluated the gut microbiome leveraging residual fecal immunochemical tests (FIT) from a CRC screening program in Turin, Italy, and conducted one of the largest population-based case-control studies across the adenoma-carcinoma sequence to date. We extracted DNA from residual FIT stool, used whole-genome shotgun sequencing, and included those with CRC (N = 44), advanced adenomas (N = 269), early adenomas (N = 134), and FIT-negative controls (N = 478). Alpha diversity, beta diversity, and species, gene, and pathway relative abundances were estimated. Multivariable logistic regression models were used to estimate associations of these metrics with colorectal neoplasms. Alpha diversity was mostly inversely associated with colorectal neoplasms, particularly early adenomas (OR: 0.45, 95% CI: 0.25-0.80; P = 0.01). Presence of oral pathogens, including Parvimonas micra, was associated with higher odds of CRC. Furthermore, Escherichia coli and Bacteroides fragilis were strongly associated with higher odds of all colorectal neoplasms. Several genes and pathways were associated with colorectal neoplasms. Our findings align with smaller studies of the gut microbiome and colorectal neoplasms, supporting that CRC screening programs provide opportunities to prospectively study the gut microbiome's association with cancer risk in large populations.

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PubMedGut pathogens2026-06-13

Integrated analysis of gastric microbiome and clinical features for the diagnosis of gastric neoplasms.

Kang Donghoon D, Shin Youngjin Y, Cho Yu Kyung YK, Park Jae Myung JM et al.

Gastric cancer (GC) progression is closely associated with microbial dysbiosis. However, microbial alterations in the intermediate stage of gastric adenoma (GA) remain under-characterized. This study investigated stage-specific microbiome changes and evaluated predictive models integrating microbial and clinical features. We analyzed 231 subjects (129 GA, 73 GC, 29 healthy controls [HC]) using 16 S ribosomal DNA sequencing of paired oral, non-lesional gastric mucosa (GM), and gastric lesion (GL) samples. Random Forest models were constructed using microbial genera and clinical features, validated via leave-one-out cross-validation. Stepwise microbial dysbiosis was observed during GC progression. Alpha diversity was significantly lower in GC-GL than in HC-GM and GA-GL. Helicobacter pylori infection was associated with reduced alpha diversity in GL samples. Genera such as Streptococcus, Neisseria, and Haemophilus were enriched in GC-GL, while Phocaeicola, Faecalibacterium, and Bifidobacterium were depleted. A gastric neoplasm prediction model incorporating 33 microbial genera and six clinical variables (age, sex, BMI, hypertension, smoking, and atrophy) demonstrated superior predictive performance (AUC = 0.830) in distinguishing gastric neoplasms from HCs, compared to models using either microbial genera (AUC = 0.790) or clinical variables (AUC = 0.715) alone. The combined model also accurately distinguished between GA and GC (AUC = 0.807). The gastric microbiome profile changes dynamically during GC progression, highlighting its potential role in tumor development. Integrating microbial signatures with clinical features enables robust classification of gastric neoplasms and may serve as a valuable adjunctive tool for diagnosis and risk stratification in endoscopic practice.

PMID 42286710
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PubMedBMC psychology2026-06-13

Validation and psychometric properties of the Arabic version of the Quality-of-Life Scale (QOLS) with a sample of general and special education teachers.

Almohayya Bander M BM, Alasim Khalid N KN

This study was performed to validate the Arabic version of the 15-item Quality-of-Life Scale (QOLS) using a sample of 401 teachers, including 235 general education teachers and 166 special education teachers. The psychometric properties of the QOLS were evaluated through exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). EFA supported a two factor solution, explaining 55.6% of the total variance, with Factor 1 reflecting personal and social well-being and Factor 2 reflecting leisure and autonomy. Internal consistency was excellent, with Cronbach's alpha and McDonald's omega coefficients of .91 and .92 for the total scale, respectively. Convergent validity was established via a strong positive correlation with the WHOQOL-Bref (r = .78), while discriminant validity was confirmed through a moderate negative correlation with the Health and Suffering Scale (r = -.57). CFA demonstrated acceptable model fit indices (CFI = 0.92, TLI = 0.90, RMSEA = 0.085, SRMR = 0.05), supporting the stability of the two-factor structure. Multi-CFA further indicated that measurement invariance was achieved across gender at configural, metric, and scalar levels, whereas full invariance was not supported across educational levels. The findings indicate that the Arabic QOLS is a reliable and valid instrument for assessing quality of life among physically active adult populations such as teachers. Implications for its application in educational and research contexts, as well as limitations regarding factor structure differences from the original QOLS, are discussed.

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