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blood substitute (Volplex / Volplex)

✓ Approved

Sinclair · 细胞治疗 · 细胞治疗

什么是 blood substitute？

blood substitute 是一种细胞治疗，由Sinclair研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名Volplex, Volplex
公司Sinclair
药物类别细胞治疗
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Sinclair

治疗适应症

blood substitute 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Surgical and medical proceduresAdjuvant therapy✓ Approved

相关研究文献

PubMedScientific reports2026-06-13

Physico-mechanical and chemical performance of Portland cement modified with eggshell powder for sustainable construction.

Sanusi Abdulganiyu A, Ndububa Emmanuel Eberechukwu EE, Adeleke Adekunle Akanni AA, Obianyo Ifeyinwa Ijeoma II et al.

Cement is one of the most used materials in the construction industry. Its production contributes about 8% to the global emissions. This study explores the use of eggshell powder (ESP) that contains over 80% calcium carbonate (CaCO3) as a partial substitute for ordinary Portland cement (OPC), such as Types B and D, to substitute limestone within the cement matrix. The physical (consistency and setting time), compressive strength, and chemical (Scanning Electron Microscope with Energy Dispersive Spectroscopy, (SEM-EDS), and X-ray Diffraction (XRD), X-ray fluorescence (XRF)) properties were evaluated against British, Indian, and established standards in the literature. The results showed that cement consistency (31-35%) and setting times were within acceptable limits according to BS EN 197-1 (initial ≥ 60 min) and IS 8112 (initial ≥ 30 min, final ≤ 600 min). The mechanical strength of the samples exceeded the required strength (42.5 N/mm2) recommended by the British Standards, except for samples B10N and D10N, which showed strength reductions of 8.4% and 12.3%, respectively. The SEM-EDS and XRD analyses confirmed a high CaCO3 content in the samples. The study suggests that incorporating ESP into OPC should not exceed 5% by weight, as higher proportions could negatively impact the cement's physical and strength properties. This approach will promote environmental sustainability by using agro-waste while ensuring the cement remains suitable for construction.

PMID 42286071
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PubMedCarbohydrate polymers2026-06-13

The rheological behavior, particle properties and supramolecular structure of low acyl gellan gum fluid gels: impact of the calcium concentration before fluid gel formation.

D'Oria Gabriele G, Zhu Yanshen Y, Limbach Hans Joerg HJ, Hartmann Christoph C et al.

Fluid gels are jammed microgel suspensions obtained by shearing a gelling hydrocolloid during its sol-gel transition. This study focused on calcium-induced low acyl gellan gum (LAGG) fluid gels and investigated the impact of calcium concentration before fluid gel formation on the resulting rheological behavior, fluid gel particle properties, and supramolecular structure. The elasticity and yield stress of fluid gels and quiescently cooled gels reached a maximum when the calcium concentration was increased from 0.78 to (approx.) 30 mmol/kg. Small angle X-ray scattering (SAXS) of fluid gels revealed a progressive increase in gel network connectivity up to the calcium concentration where the peak in rheological properties was observed followed by a less interconnected network at calcium concentrations above the peak. Furthermore, rheological measurements supplemented with free calcium and zeta-potential measurements, support that the decrease after the peak in rheological response is due to the combination of fluid gel particle softening with a decrease in surface charge. The results of this study enable to establish clearer links between rheological behavior, particle properties and supramolecular structure of calcium-induced LAGG fluid gels. This work enables a more effective design of fluid gel properties for different applications from food to pharma and biomaterials.

PMID 42285681
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PubMedAAPS PharmSciTech2026-06-13

Twin-Screw Melt Granulation with Mannitol: High-Drug-Loaded Immediate-Release Tablets of Caffeine.

Buczkowska Elzbieta Maria EM, Kukuls Kirils K, Horváth Zoltán Márk ZM, Frolova Alīna Jaroslava AJ et al.

High drug-loaded immediate-release formulations can be produced using a solvent-free and continuous melt-granulation method with a twin-screw extruder. Known and widely used high-molecular-weight and hydrophobic melt-binders result in weak tablets and negatively influence the disintegration and dissolution of tablets. Thus, this work aimed to probe mannitol as a melt-binder at a concentration of 30 wt.% and to investigate the effect of twin-screw melt granulation processing temperature and screw speed on the preparation of high drug-loaded immediate-release caffeine tablets with superior mechanical properties. A two-level design of experiment with three center points was used for the screening of the effect of barrel temperature and screw speed on granules and tablets properties. Model drug caffeine was mixed with mannitol (Parteck® M100), while a Pharma 11 extruder with helix feed screw elements and without a nozzle was used for twin-screw melt granulation. Processing conditions were found to significantly influence the solid state of ingredients and the quality of granules. Mannitol, as a melt-binder at a concentration of 30 wt.% at given processing conditions, was proven as an efficient melt-binder for high drug-loaded immediate-release tablets with superior mechanical properties.

PMID 42286306
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PubMedActa otorrinolaringologica espanola2026-06-13

Comparative Analysis of Septoplasty and Septorhinoplasty Using CFD techniques: Towards Personalized and Precision Nasal Surgery.

Míguez Marta Fernández MF, Pena Alberto Cabana AC, Antúnez Alejandro Pardo AP, Burgos Manuel Antonio MA et al.

Nasal obstruction is a common complaint in otolaryngology. Choosing between septoplasty or septorhinoplasty may be challenging due to anatomical variability. Computational fluid dynamics (CFD) has emerged as a complementary, patient-specific tool enabling bilateral simulation and virtual planning, allowing simulation of post-surgical outcomes under physiological conditions. Virtual surgeries were performed on patients with nasal obstruction using Flowgy® software. For each patient, three anatomical models were simulated: baseline, virtual septoplasty, and virtual septorhinoplasty (with turbinoplasty when indicated). CFD analysis was used to assess pressure drop (ΔP), flow symmetry (Φ), and nasal resistance (R), among other airflow parameters. Comparative data were analysed to determine the functional impact of each intervention. In all five cases, septoplasty resulted in improvements in pressure drop ranging from 10.5% to 50.9%, as well as changes in resistance ranging from +2.98% to -64.3%. Septorhinoplasty provided additional functional gains in pressure (up to 44.8%) and resistance (up to 51%) in selected cases. Based on the analysis, surgical benefit thresholds were proposed: ≥30% improvement in ΔP or R from baseline to justify septoplasty, and ≥20-30% additional benefit over septoplasty to indicate septorhinoplasty. CFD analysis is a valuable adjunct in functional nasal surgery, enabling personalised decision-making. While not a substitute for clinical judgement, CFD-guided planning may enhance the selection of surgical strategy and reduce unnecessary interventions.

PMID 42285298
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PubMedFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2026-06-13

Bisphenol S induces hepatic steatosis and insulin resistance through AMPK inhibition and endoplasmic reticulum stress.

Sepúlveda-Fragoso Vinicius V, Dos Reis Emanuelle Barreto EB, de Souza Carvalho Laureano Thais T, Stockler-Pinto Milena Barcza MB et al.

Bisphenol S (BPS), a common substitute for bisphenol A, has emerged as a widespread environmental contaminant, yet its metabolic effects remain poorly understood. Increasing evidence links BPS exposure to metabolic dysfunction-associated steatotic liver disease (MASLD), although the underlying mechanisms are unclear. Here, we investigated the metabolic effects of chronic BPS exposure (4, 25, and 50 μg/kg/day for 12 weeks) in C57BL/6 mice and evaluated its impact on human Huh-7 hepatocytes. In vivo, exposure to 25 μg/kg/day exhibited obesogenic potential, while all doses induced insulin resistance and promoted hepatic micro- and macrovesicular steatosis. BPS triggered endoplasmic reticulum (ER) stress and suppressed AMP-activated protein kinase (AMPK) phosphorylation, disrupting hepatic lipid and glucose metabolism. Consistently, BPS exposure in Huh-7 cells induced ER stress, reduced AMPK activity, and impaired insulin-stimulated Akt phosphorylation, indicating decreased insulin sensitivity. Notably, pharmacological activation of AMPK attenuated BPS-induced inhibition of insulin signaling, identifying AMPK as a key mediator of BPS-driven metabolic dysfunction in hepatocytes. Collectively, these findings demonstrate that BPS promotes hepatic steatosis and insulin resistance by activating ER stress and inhibiting AMPK, highlighting BPS as a potential environmental contributor to MASLD and related metabolic disorders.

PMID 42285293
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PubMedLancet (London, England)2026-06-13

Diagnosis and treatment of postpartum haemorrhage: a race against time.

Coomarasamy Arri A, Devall Adam J AJ, Bell Sarah S, Sindhu Kulandaipalayam N KN et al.

Postpartum haemorrhage (PPH) is common, affecting an estimated 13% of women having vaginal birth and 31% of women having caesarean birth. Successful management of PPH requires early and accurate diagnosis and effective treatment. A systematic review found that subjective visual estimation of blood loss misses 52% of PPH diagnoses at vaginal birth (pooled sensitivity 48%, 95% CI 44-53), and probably more at caesarean birth. The WHO-International Federation of Gynecology and Obstetrics-International Confederation of Midwives consolidated guidelines on PPH therefore recommend objective quantification of blood loss with products such as a calibrated blood collection drape. When supported by a robust implementation strategy and a first-response treatment bundle, objective measurement of blood loss and monitoring of vital signs has been shown to diagnose PPH accurately and early, and improve clinical outcomes. Refractory PPH can progress to life-threatening PPH, which should be managed by a multidisciplinary team providing aggressive resuscitation and targeted treatment. Saving the life of a woman with excessive postpartum bleeding is a race against time. The six delays to avoid are: (1) in the diagnosis (by use of objective cumulative blood loss measurement and early trigger criteria), (2) in the first-response treatment (by authorising midwives to administer all components of a standardised bundle of interventions), (3) in the escalation (by use of explicit escalation criteria and red flags), (4) in the use of temporising measures (eg, non-pneumatic anti-shock garment), (5) in the identification and targeted management of any specific causes of bleeding, and (6) in the provision of blood and blood products. Quick actions to avoid these delays can mean the difference between life and death for a woman with PPH.

PMID 42285120
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