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ID

idoxuridine (idoxuridine, APR / Apridin C / Apridin)

✓ Approved

Pierre Fabre S.A. · · 小分子

什么是 idoxuridine？

idoxuridine 是一种小分子，由Pierre Fabre S.A.研发。该药已获批，用于治疗相关适应症，给药途径：Topical。

药物档案

商品名idoxuridine, APR, Apridin C, Apridin
公司Pierre Fabre S.A.
药物类别小分子
分子靶点,
给药途径Topical
状态Approved
来源： ClinicalTrials.gov, Pierre Fabre S.A.

作用机制

分子靶点

idoxuridine 作用于 2 个分子靶点：

(UL30)
(UL30)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

idoxuridine 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsHerpes simplex✓ Approved
Congenital, familial and genetic disordersCongenital herpes simplex infection✓ Approved

相关研究文献

PubMedThe Journal of school health2026-08-05

Soda and Sports Drink Consumption and Life Stressors Among High School Students: Youth Risk Behavior Survey, 2023.

Goding Sauer Ann M AM, Saelee Ryan R, Pierce Samantha L SL, Merlo Caitlin L CL et al.

Life stressors might influence health behaviors, including frequent sugar-sweetened beverage (SSB) consumption. We described associations between life stressors and soda/sports drink (SD) consumption among US high school students. We tested associations between life stressors and daily (≥ 1 time/day) and heavy daily (≥ 3 time/day) consumption of soda/SD using the 2023 national Youth Risk Behavior Survey (daily n = 12,308; heavy daily n = 11,980). We calculated prevalence ratios (aPRs) and 95% confidence intervals (CI) adjusted for grade, sex, weight perception, and race and ethnicity. Not experiencing the stressor was the reference group. Daily consumption was significantly higher among those who experienced unstable housing (aPR = 1.6, 95% CI = 1.2, 2.2), lacking a household adult trying to meet basic needs (aPR = 1.3, 95% CI = 1.1, 1.5), bullying at school (aPR = 1.3, 95% CI = 1.2, 1.4), missing school due to safety concerns (aPR = 1.3, 95% CI = 1.1, 1.5), or feeling unfairly disciplined at school (aPR = 1.2, 95% CI = 1.1, 1.3). Results for heavy daily consumption were similar. Initiatives to reduce soda/SD consumption could benefit students with relatively high consumption prevalence, including those experiencing life stressors. The prevalence of consuming soda/SD was higher among US high school students who experienced life stressors than those who did not.

PMID 42552744
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PubMedClinics in colon and rectal surgery2026-08-05

Shared Decision-Making in the Surgical Management of Rectal Cancer: Comparing Low Anterior Resection and Abdominoperineal Resection Using a Patient Decision Aid.

Hickey Kala K, Ivankovic Victoria V, Boushey Robin R, Apte Sameer S SS

Low rectal cancer is surgically managed with one of two primary procedures: low anterior resection (LAR) or abdominoperineal resection (APR). Each procedure has a unique profile of potential complications, oncologic outcomes, and quality-of-life impacts. The acceptability of these outcomes is highly driven by patient values. Consequently, shared decision-making is essential to selecting the optimal procedure for each patient. Evidence has shown that patient decision aids (PtDAs) improve patient knowledge, reduce decisional conflict, and support value-congruent decisions. This review describes the development of a rectal cancer PtDA for the choice between LAR and APR. This PtDA was designed according to the International Patient Decision Aid Standards and Ottawa Decision Support Framework. Evaluation of this rectal cancer PtDA demonstrated increased patient knowledge, reduced decisional conflict, and enhanced patient preparedness for decision-making. Despite strong evidence for their utility, PtDAs remain underutilized. This review highlights key barriers in implementing PtDAs and proposes strategies to facilitate the effective integration of PtDAs into surgical practice.

PMID 42553907
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PubMedFrontiers in cardiovascular medicine2026-08-04

Effects of the active parts of Yangxin Tongmai Formula on myocardial injury and spatial metabolic remodeling in rats with myocardial ischemia-reperfusion injury.

Ye Di D, Wang Yi Y, Zhao Ziyuan Z, Lin Caiyue C et al.

To investigate the protective effects of the active parts of Yangxin Tongmai Formula (apr-YTF) against myocardial ischemia-reperfusion injury (MIRI) in rats from the perspective of spatial metabolic remodeling. A rat model of MIRI with blood stasis syndrome was established. Rats were randomized into Control, Model, Vehicle, and apr-YTF groups. apr-YTF was administered by gavage for 14 days. Cardiac function and myocardial injury were assessed by echocardiography, serum myocardial enzyme assays, triphenyltetrazolium chloride (TTC) staining, and hematoxylin and eosin (HE) staining. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was used to analyze the spatial distribution patterns and metabolic profiles of differential metabolites in myocardial tissue. apr-YTF significantly improved left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS), reduced serum creatine kinase (CK), creatine kinase-MB isoenzyme (CK-MB), lactate dehydrogenase (LDH), and lactate dehydrogenase 1 (LDH1) levels, decreased infarct size, and alleviated myocardial fibrosis and inflammatory infiltration. MALDI-MSI identified 1,282 metabolites, including 702 MIRI model-associated differential metabolic features, mainly including amino acids, nucleotides, and glycerophospholipids. The MIRI group exhibited extensive metabolic remodeling involving lipid, amino acid, nucleotide metabolism, and cofactor biosynthesis pathways. After apr-YTF intervention, 17 reversed differential metabolic features showed recovery trends. The active parts of Yangxin Tongmai Formula ameliorated myocardial injury and were associated with partial correction of spatial metabolic remodeling in rats with MIRI.

PMID 42548831
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PubMedThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2026-08-04

Driving Under the Influence of Cannabis Among US Young Adults Who Use Cannabis: Evidence From the 2021-2024 National Survey on Drug Use and Health.

Tang Yuni Y, Rudisill Toni Marie TM

To estimate the prevalence of driving under the influence of cannabis (DUIC) and identify associated factors among US young adult drivers reporting past-year cannabis use. This cross-sectional study analyzed pooled 2021-2024 National Survey on Drug Use and Health. The analytic data were restricted to drivers aged 18-25 years who reported past-year cannabis use (N = unweighted 17,141; weighted N = 10,814,381). The outcome was self-reported past-year DUIC. Independent variables included demographics, substance use, mental health, cannabis-related perceptions, and driving behaviors. These relationships were assessed by modified Poisson regression. The weighted prevalence of DUIC was 28.0%, representing approximately over three million young adults. DUIC prevalence increased with cannabis use frequency, from 2.51 times higher among those using cannabis 12-49 days (adjusted prevalence ratio [APR]: 2.51; 95% confidence interval [CI]: 2.29-2.75) to 3.63 times higher among those reporting use on 300-365 days (APR: 3.63; 95% CI: 3.60-3.76), compared with those using cannabis 1-11 days. Cannabis use disorder (APR: 2.34; 95% CI: 2.06-2.65), simultaneous alcohol and cannabis use (APR: 1.29; 95% CI: 1.28-1.30), and perceived easy cannabis availability (APR: 2.36; 95% CI: 2.33-2.39) were also associated with higher prevalence of DUIC. Nonenrollment in school and living in a state with a medical cannabis law were associated with lower DUIC prevalence. DUIC is highly prevalent among US young adults who use cannabis, with a clear graded association across categories of cannabis use frequency. Public health interventions should address frequent use, cannabis use disorder, alcohol-cannabis co-use, and perceived cannabis availability.

PMID 42550121
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PubMedPhytomedicine : international journal of phytotherapy and phytopharmacology2026-08-04

Corrigendum to "Quercetin counteracts monosodium glutamate to mitigate immunosuppression in the thymus and spleen via redox-guided cellular signaling" [Phytomedicine. 2024 Apr;126:155226].

Das Debasmita D, Banerjee Arnab A, Manna Krishnendu K, Sarkar Deotima D et al.

PMID 42547379
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PubMedSmall science2026-08-04

Injectable Artificial Photoreceptors: STEM Cell Functional Integration and in vivo Electrophysiological Validation in Retinal Degeneration Models.

Izadian Afshin A, Torkashvand Ali A, McCall Benjamin Allan BA, Gao Yong Y et al.

In this study, an injectable artificial photoreceptor (APR) is engineered to transduce visible light into cell-level electrical stimulation via localized surface plasmon resonance to restore vision in patients with vision loss. APRs comprise gold nanoparticles (AuNPs) with poly (vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) dielectric coating and are integrated onto a high-permittivity barium titanate core. This yields a stable nanocomposite with maximum absorbance in the green band at around 525 nm. APRs were evaluated in vitro using human pluripotent stem cell-derived retinal ganglion cells (hRGCs) exposed to light stimulation. In vivo efficacy was assessed following intravitreal injection of APRs in the rd1 mouse model, and functional outcomes were evaluated using visual evoked potentials (VEPs) and pupillary light reflex (PLR) testing. In vitro, optical stimulation of hRGCs in the presence of APRs increased multielectrode-array (MEA) firing. This shifted cellular metabolism toward mitochondrial oxidative phosphorylation without inducing apoptosis. In rd1 mice, intravitreal APR delivery produced robust restoration of light-evoked retinal activity in explant MEAs and improved functional readouts in vivo, validated by enhanced PLR and increased N1 amplitudes on flash VEPs. This study demonstrates that a fully injectable nanophotonic prosthesis can restore light responsiveness in a retinal degeneration model without the need for implanted electronics or genetic modification.

PMID 42549431
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