若生智能
Drug Database
OR

Ortho-ACI

✓ Approved

Orthocell Pty, Ltd. · 细胞治疗 · 细胞治疗

什么是 Ortho-ACI？

Ortho-ACI 是一种细胞治疗，由Orthocell Pty, Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Surgical Implantation。

药物档案

公司Orthocell Pty, Ltd.
药物类别细胞治疗
给药途径Surgical Implantation
状态Approved
来源： ClinicalTrials.gov, Orthocell Pty, Ltd.

治疗适应症

Ortho-ACI 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersChondropathy✓ Approved

相关研究文献

PubMedApplied and environmental microbiology2026-08-05

Characterization of successive ortho-methyl oxidation of the priority pollutant 2,4-xylenol by a Rieske oxygenase system in Pseudomonas putida NCIMB 9866.

Meng Haiqin H, Pan Shun S, Chai Zening Z, Zhou Lixiang L et al.

The catabolism of the priority environmental pollutant 2,4-xylenol requires bacteria to oxidize its ortho-methyl group. Its exact biochemical mechanism is uncharacterized until now. In this study, we resolve key metabolic bottlenecks in Pseudomonas putida NCIMB 9866. We demonstrate that functionally redundant Rieske oxygenase systems ensure the robust ortho-methyl oxidation of 2,4-xylenol. On the para-methyl oxidation branch, PchA2 acts as the main aldehyde dehydrogenase. It shows significantly higher catalytic efficiency than the previously reported PchA. Additionally, we characterized PmmA1B1, a newly identified three-component Rieske oxygenase system responsible for ortho-methyl oxidation, which is supported by two redundant isoenzymes (PmmA2B2 and PmmA3B3), by recruiting the shared endogenous ferredoxin Orf05169. The PmmA1B1-Orf05169 system catalyzes the successive oxidation of the ortho-methyl group of 4-hydroxy-3-methylbenzoate to a carboxyl group, yielding the high-value pharmaceutical precursor 4-hydroxyisophthalate. Structural and kinetic data revealed that the active site architecture of PmmA1 enables efficient successive oxidation, distinguishing it from isoenzymes PmmA2B2 and PmmA3B3 that, when coupled with Orf05169, catalyze only incomplete oxidation. Overall, these results complete the 2,4-xylenol catabolic pathway by defining the enzymes required for both para- and ortho-methyl oxidation. They also reveal functional redundancy as an adaptive feature of microbial aromatic degradation and establish Rieske oxygenases as biocatalysts for converting methylated aromatic pollutants into value-added chemicals.IMPORTANCEMethylated aromatics like 2,4-xylenol pose ongoing environmental risks and are primary targets for bioremediation. We know how bacteria break down many simple aromatics, but the precise ways that enzymes bypass the steric and electronic hurdles of hindered methyl groups remain unclear. In this study, we characterized a novel three-component Rieske oxygenase, PmmA1B1-Orf05169, capable of a rare successive oxidation that turns an ortho-methyl group directly into a carboxyl group. We also found parallel, redundant oxygenase pathways that protect the bacterium's ability to degrade 2,4-xylenol during environmental stress or genetic loss. This discovery not only completes the metabolic map of 2,4-xylenol but also provides a robust biocatalytic tool for the green synthesis of 4-hydroxyisophthalate, a high-value pharmaceutical precursor.

PMID 42554493
阅读全文 →
PubMedPhysical chemistry chemical physics : PCCP2026-08-05

Positional isomerism-driven solvatochromism and excited-state behavior in ortho- and para-hydroxy bromobenzylidene Schiff bases: a combined experimental and DFT investigation.

Gülseven Sıdır Yadigar Y, Berber Halil H, Sıdır İsa İ

This study presents a comprehensive investigation of how hydroxyl positional isomerism governs the solvatochromic response and excited-state behavior of bromobenzylidene Schiff base derivatives. Two structurally related isomers, SB-oOH and SB-pOH, were synthesized and systematically analyzed using combined spectroscopic and quantum chemical approaches. The results reveal a striking contrast in photophysical behavior arising solely from the substituent position. SB-oOH exhibits weak solvent-dependent spectral shifts, attributed to intramolecular O-H⋯N hydrogen bonding that restricts π-electron delocalization and stabilizes a localized excitation (LE) state. In contrast, SB-pOH displays pronounced positive solvatochromism, large Stokes shifts, and strong solvent sensitivity, consistent with increased polarizability and stronger light-matter interaction, whereas SB-oOH maintains a more rigid and less responsive electronic structure. Quantitative solvatochromic analysis using linear solvation energy relationship (LSER) models demonstrates that SB-oOH is primarily influenced by nonspecific dielectric interactions, while SB-pOH is strongly governed by both solvent polarity and hydrogen-bonding effects. Theoretical calculations based on density functional theory (DFT) and time-dependent DFT (TD-DFT) support these findings, revealing enhanced HOMO-LUMO separation, a reduced energy gap, and increased electronic delocalization in the para-substituted system. Furthermore, optical band gap and refractive index analyses confirm that the enhanced ICT characteristic of SB-pOH, as supported by the combined experimental and theoretical results, is consistent with increased polarizability and stronger light-matter interactions, whereas SB-oOH maintains a more rigid and less responsive electronic structure. Thus, this study demonstrates that subtle structural variation through hydroxyl positional isomerism can induce profound changes in electronic structure and excited-state dynamics. These findings provide a clear structure-property relationship and offer a rational strategy for designing Schiff base-based functional materials with tunable optoelectronic properties. This study highlights positional isomerism as an effective molecular design tool for controlling excited-state processes.

PMID 42554189
阅读全文 →
PubMedRSC advances2026-08-04

Synthesis of nitric oxide releasing conjugated ortho-hindered nitroarenes and their application in dual-action antimicrobial peptide-mimics.

Attard Samuel T ST, Aquib Md M, Gmedhin Hatu H, Boyer Cyrille C et al.

This study reports the synthesis of a range of novel peptide-mimicking antimicrobials with conjugated ortho-hindered nitroarenes (CONAs) for nitric oxide release. These peptide-mimics were rationally designed, building from a previously established anthranilamide peptide-mimicking scaffold and synergistically substituting aromatic capping groups for aromatic CONAs. CONAs were synthesised via a novel synthetic pathway, avoiding the use of highly toxic CrO3 and red fuming nitric acid, in fewer steps and good-excellent yields compared to previously reported methods. Of the synthesised peptide-mimics, one formed a self-assembling low molecular weight hydrogel, and their gel properties were characterised by rheology, atomic force microscopy and circular dichroism. The synthesised compounds released NO when exposed to 530 nm light, and their antimicrobial activity was measured via a minimum inhibitory concentration assay, with one compound exhibiting activity against Gram-positive Staphylococcus aureus at 8 µg mL-1.

PMID 42549081
阅读全文 →
PubMedChemistry (Weinheim an der Bergstrasse, Germany)2026-08-04

Synthesis and Structures of Novel Chiral Cyclic Hypervalent Iodine(III) Reagents for Metal-Free Ligand-Transfer Reactions.

Valzer Emmanuel E, Sotiropoulos Jean-Marc JM, Miqueu Karinne K, Pouységu Laurent L et al.

The preparation of novel chiral λ3-iodane reagents bearing transferable halogen-, oxygen- or carbon-based ligands is described. Among these hypervalent iodine(III)-based compounds are (i) the first chiral bis(cyano-λ3-iodane), whose bis(benziodazolone) structure is derived from an enantiopure cyclohexyldiamine-based bis(amidoiodoarene), and (ii) the two first chiral benziodoxolones bearing a carbon-based ligand (i.e., cyano and trifluoromethyl groups) together with a lactate moiety ortho-positioned to the iodine(III) atom. The proposed iodine-containing heterocyclic structures of these new λ3-iodanes are supported by x-ray diffraction analyses and DFT calculations. Their capacity to transfer their ligand(s) in an asymmetric fashion to different substrates (i.e., β-ketoesters, naphthols, and oxindoles) was also examined.

PMID 42549512
阅读全文 →
PubMedThe Journal of chemical physics2026-08-04

Inelastic scattering of H2CCO ketene induced by He atoms and non-LTE analysis.

Jrad Abdelhak A, Naouai Manel M, Ndengué Steve S

This work deals with the rotational inelastic scattering of ketene (H2CCO) by helium atoms. A new three-dimensional potential energy surface is computed by adopting the explicitly correlated coupled cluster approach with single, double, and perturbative triple excitation [CCSD(T)-F12a] connected to the augmented-correlation consistent-polarized valence triple zeta (aug-cc-pVTZ) Gaussian basis set. A global minimum with a well depth of V = -57.48 cm-1 for (R = 5.93 bohr, θ = 89°, ϕ = 90°) is identified. Quantum scattering calculations involving the 16 lowest states up to JKaKc=817 for ortho form of ketene (o-H2CCO) and the 10 lowest ones up to JKaKc=909 for para form (p-H2CCO) are performed via the close coupling (CC) method up to total energy E = 500 cm-1. Then, rate coefficients are derived for both forms over the temperature range of 5-90 K using the Maxwell-Boltzmann distribution. A predominance of the transitions with ΔJ = ΔKc = 1 for both o-H2CCO and p-H2CCO is obtained. Radiative transfer investigation of excitation and brightness temperatures, as well as optical depth, under non-local thermodynamic equilibrium (non-LTE) conditions for several observed lines is also performed by exploring the determined rate coefficients.

PMID 42550099
阅读全文 →
PubMedChemical science2026-08-04

Regioisomeric carbazole-dicyano-dioxin AIDF emitters for efficient triplet harvesting, two-photon absorption and bioimaging.

Bera Anwesha A, Dutta Madhusudan M, Malik Ajay J AJ, Ambhore Madan D MD et al.

Integrating aggregation-induced emission (AIE) with thermally activated delayed fluorescence (TADF) offers a useful strategy to achieve efficient triplet harvesting in the condensed phase. Here, we report three carbazole-dicyano-dioxin donor-acceptor regioisomers (oCN1, oCN2, and pCN) that exhibit pronounced aggregation-induced delayed fluorescence (AIDF) from solution to aggregates, neat films and crystals. Oxygen incorporation and peripheral tert-butyl groups make the molecular framework more rigid and help suppress aggregation caused quenching. These substitutions also promote twisted donor-acceptor geometries. In addition, subtle ortho/para changes in connectivity tune the charge-transfer character, the singlet-triplet energy gaps, and the reverse intersystem crossing dynamics. In THF-water mixtures, all isomers display clear AIDF signatures, with PLQYs up to 63% and microsecond delayed lifetimes, enabled by up to ∼20-fold suppression of internal conversion (IC) upon aggregation. In neat films, all these isomers exhibit bright green to yellow-orange emission with PLQYs of 78%, 31% and 54% for oCN1, oCN2, and pCN, respectively. Moreover, all three regioisomers exhibit an RISC rate of ∼105 s-1 in neat films. This fast RISC rate is attributed to the small singlet-triplet energy gap and appreciable spin-orbit coupling. The strong charge-transfer character and robust AIDF further enable efficient two-photon bioimaging and the fabrication of converted LEDs.

PMID 42549103
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多Ortho-ACI