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calcium carbonate + vitamin D3 (Ideos)

✓ Approved

Innothera · VDR · 小分子

什么是 calcium carbonate + vitamin D3？

calcium carbonate + vitamin D3 是一种小分子，由Innothera研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Ideos
公司Innothera
药物类别小分子
分子靶点VDR
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Innothera

作用机制

分子靶点

calcium carbonate + vitamin D3 作用于 1 个分子靶点：

VDRvitamin D receptor (NR1I1, PPP1R163)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

calcium carbonate + vitamin D3 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedInternational journal of microbiology2026-08-05

Ureolytic Rhizobacteria for Cadmium Remediation: Contribution of Bioadsorption and Bioaccumulation During Microbially Induced Carbonate Precipitation in Liquid Medium Assays.

Adarme-Duran Carlos A CA, Castillo Elianna E, Brandão Pedro F B PFB

Microbially induced carbonate precipitation (MICP) is a recognized bioremediation strategy for mitigating toxic metal pollution; however, the relative contributions of bioprecipitation, biosorption, and bioaccumulation to cadmium (Cd) removal during MICP remain underexplored. This study assessed Cd immobilization by six rhizosphere ureolytic bacterial strains from different genera in liquid medium and quantified the metal distributed among the bioprecipitated, biosorbed, and bioaccumulated fractions. Minimum inhibitory concentration assays showed Cd tolerance ranging from 90 to 300 mg L-1. The strains presented total Cd removal efficiencies of 64.9%-99.8% within 120 h. Notably, Cd removal occurs mainly under 48 h. Biosorption assays revealed substantially lower Cd removal compared with bioprecipitation experiments. Comparative analysis of Cd bioprecipitation and biosorption assays, combined with sequential extraction, demonstrated that bioadsorption plays a significant role in the removal of Cd via MICP. Precipitates characterization further confirmed coprecipitation of Cd with vaterite, a calcium carbonate polymorph. These findings elucidate an important role of biosorption in Cd immobilization during MICP, highlighting the need to evaluate removal mechanisms when assessing bacterial MICP potential, as different mechanisms can lead to distinct long-term stability outcomes.

PMID 42553454
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PubMedSaudi journal of anaesthesia2026-08-05

Perioperative total tau as a biomarker of postoperative delirium after major cardiac surgery: A prospective cohort study.

Mahmoud Mohamed R MR, Abdelwahab Ali T AT, Abdelzaher Tarek A TA, Ali Mohamed M MM et al.

Postoperative delirium is a frequent and serious complication in older adults undergoing cardiac surgery with cardiopulmonary bypass (CPB). Identifying blood-based biomarkers of neuronal injury could facilitate early risk stratification. Total tau (t-tau), a microtubule-associated protein released during axonal damage, may serve as a candidate marker. In this prospective cohort study, 89 adults aged ≥60 years undergoing elective cardiac surgery with CPB were evaluated. Plasma t-tau levels were measured preoperatively and on postop D1 and D3. Cognitive and functional outcomes were assessed. Delirium was diagnosed in 53% of patients on Postop D1 and 42% on postop D3. T-tau increased significantly from baseline (median 1.46 pg/mL) to postop D1 (3.13 pg/mL; P < 0.001), declining on postop D3 (1.89 pg/mL; P < 0.001 vs baseline). Patients with delirium had significantly higher t-tau levels postoperatively and greater t-tau changes from baseline. Postop D1 t-tau independently predicted postop D3 delirium (OR 4.16, 95% CI 2.39-7.23; P < 0.001). Receiver operating characteristic analysis showed excellent diagnostic performance, with an AUC of 0.905 for postop D1 tau levels in predicting postoperative delirium on postop D3. Dynamic elevations in t-tau may predict postoperative delirium and neurocognitive decline after cardiac surgery with CPB. Therefore, t-tau may represent a promising candidate biomarker requiring external validation for risk stratification and monitoring of early postoperative delirium in older surgical patients.

PMID 42553828
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PubMedJournal of the science of food and agriculture2026-08-05

Study on the changes and mechanisms on the quality of beef tripe during tenderization.

Yu Peipei P, Zhu Shijin S, Wang Lishi L, Gao Pei P et al.

The quality characteristics of salted beef tripe were investigated throughout the multi-stage tenderization process, encompassing cleaning, pre-cooking, alkaline treatment (sodium carbonate), water soaking and final cooking. The underlying tenderization mechanism was elucidated through the assessment of collagen content, water status and microstructural evolution. Alkaline treatment with sodium carbonate functions as a highly effective approach to tenderize salted beef tripe. Morphological observations demonstrated a sequential transformation characterized by tissue expansion post-washing, followed by contraction after pre-cooking. Sodium carbonate treatment served as the pivotal tenderization step, inducing pronounced tissue swelling and structural integrity. Water distribution analysis revealed significant dynamic shifts in free and immobile water proportions during tenderization. Free water exhibited an initial increase, followed by a decrease and subsequent rebound, whereas immobile water inversely decreased, increased and then declined. Scanning electron microscopy revealed structural evolution in salted beef tripe: transitioning from a compact morphology to distinct muscle fiber organization post-cleaning, followed by fiber fragmentation after sodium carbonate treatment. Texture analysis demonstrated a substantial reduction in shear force confirming the efficacy of alkaline tenderization. This study provided a theoretical and practical basis for controlling the tenderization process and quality of salted beef tripe. © 2026 Society of Chemical Industry.

PMID 42554220
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PubMedAngewandte Chemie (International ed. in English)2026-08-05

Redox-Pathway Reconstruction in Carbonate Electrolyte to Achieve Durable Na─S Battery.

Liu Mengting M, Hu Ling-Jiao LJ, Wang Long L, Guan Zhao-Kun ZK et al.

The practical performance of room-temperature sodium-sulfur (RT Na─S) batteries in low-solubility carbonate electrolytes is fundamentally constrained by slow "solid-solid" sulfur conversion, causing incomplete redox reactions and rapid capacity fading. Herein, we propose a catalytic strategy via "confinement-pyrolysis" that restructures this static reaction into a dynamic "solid-liquid-solid" pathway. By employing a hierarchical porous framework with atomically dispersed metal sites, the conversion kinetics of sodium polysulfides (NaPSs) are dramatically accelerated. This reconstruction enables continuous liquid-phase intermediates and circumvents the high diffusion barriers of solid-state reactions, as confirmed by density functional theory (DFT) calculations. By simulating long-term cycling through controlled Na2S deposition, we employed local dipole moment change (Δμ) tracking to reveal the exceptional electronic structure stability and effective lowering of key energy barriers during long-term cycling. As a result, the Fe-N-C/S cathode exhibits outstanding electrochemical performance, delivering a reversible capacity of 799 mAh g-1 at 1 Ag-1 with a capacity decay rate of 0.075% per cycle, and exhibiting an ultralow capacity decay rate of 0.024% per cycle over 2000 cycles at 2 Ag-1. This work elucidates that redox-pathway reconstruction is a pivotal strategy to overcome the inherent kinetic limitations of the conventional mode in carbonate-based Na─S batteries.

PMID 42554371
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PubMedHuman nutrition & metabolism2026-08-05

Growth outcomes and nutrient adequacy in children with disabilities in the West Bank: Associations with disability severity and socioeconomic factors.

Qasrawi Radwan R, Thwib Suliman S, Issa Ghada G, Al Taweel Rand R et al.

Children with disabilities are at increased risk of nutritional inadequacy, yet data from resource-constrained settings are limited. This study examined the association between disability severity, etiology, socioeconomic and demographic factors, and nutritional status among children with disabilities in the West Bank, Palestine. A cross-sectional study was conducted among 118 children with disabilities aged 6 to 18 years. Disability severity was assessed using the Disability Rating Scale. Anthropometric status was evaluated using World Health Organization (WHO) Z-scores, and dietary intake was assessed using two 24-h recalls and a semi-quantitative Food Frequency Questionnaire. Nutrient adequacy and the Mean Adequacy Ratio were calculated relative to dietary reference standards. Micronutrient inadequacy was widespread, with vitamin A and vitamin D intake below recommended levels in all participants and calcium inadequacy exceeding 95%. Inadequate micronutrient intake was more common among adolescents (57.1%) and low-income households (46.2%). Stunting was more frequent among younger children (51.2%) and those in institutional care (34.1% vs. 14.3%). Disability severity was significantly associated with BMI-for-age (F = 14.455, p < 0.001) and height-for-age (F = 5.149, p = 0.025). Energy (χ2 = 12.851, p = 0.025), carbohydrate (χ2 = 16.700, p = 0.005), and magnesium intake (χ2 = 37.563, p < 0.001) varied across severity levels. Children with disabilities in the West Bank face substantial micronutrient inadequacy, with nutritional risk associated with functional severity and socioeconomic context. Integration of routine nutritional screening within disability services is warranted to address critical nutrient gaps and support growth and functional outcomes.

PMID 42553471
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PubMedCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2026-08-05

Stent Underexpansion Prediction Is Improved by Intravascular Ultrasound-Based Distance-Averaged Calcium Angles.

Wang Jia-Jie JJ, Liu Hang H, Yao Yian Y, Wu Minyu M et al.

Calcified coronary lesion, assessed by intravascular ultrasound (IVUS)-based maximum calcium angle, is an important predictor for stent underexpansion. We aimed to determine whether the mean of all calcium angles measured within a specified distance from the maximum calcium site (distance-averaged) using IVUS was associated with stent underexpansion. Patients undergoing IVUS-guided percutaneous coronary intervention (PCI) with drug-eluting stent implantation between 2016 and 2022 in a single tertiary center were retrospectively analyzed. Pre-PCI IVUS was used to assess the angles of calcified plaque every 1 mm; a total of 11 calcium angles were measured within 5 mm of the maximum calcium site. The endpoint was percent stent expansion, and stent underexpansion was defined as percent stent expansion < 70%. In the analysis of 87 stent underexpansions that occurred among 292 patients, distance-averaged calcium angles were significantly associated with stent underexpansion. Discrimination increased when using distance-averaged calcium angles instead of maximum calcium angle, with the area under the receiver operating characteristic curve (AUC) ranging from 0.75 (95% CI, 0.69-0.82) for 10 mm-averaged calcium angles to 0.77 (95% CI, 0.72-0.83) for 2 mm-averaged calcium angles (p < 0.05). Compared to 2 mm-averaged calcium angles, increasing measuring distance did not result in significant improvement in AUC. Distance-averaged calcium angles were associated with stent underexpansion. Compared with maximum calcium angle, distance-averaged calcium angles improved the prediction of stent underexpansion. Among these, 2 mm-averaged calcium angles may be a simpler, equally accurate approach to predicting stent underexpansion.

PMID 42552752
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