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sitagliptin phosphate + ipragliflozin L-proline (Sujanu / MK0431J)

✓ Approved

Kotobuki Pharmaceutical Co., Ltd. · DPP4 · 小分子

什么是 sitagliptin phosphate + ipragliflozin L-proline？

sitagliptin phosphate + ipragliflozin L-proline 是一种小分子，由Kotobuki Pharmaceutical Co., Ltd.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Sujanu, MK0431J
公司Kotobuki Pharmaceutical Co., Ltd.
药物类别小分子
分子靶点DPP4, SLC5A2
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Kotobuki Pharmaceutical Co., Ltd.

作用机制

分子靶点

sitagliptin phosphate + ipragliflozin L-proline 作用于 2 个分子靶点：

DPP4dipeptidyl peptidase 4 (CD26, DPPIV)
SLC5A2solute carrier family 5 member 2 (SGLT2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

sitagliptin phosphate + ipragliflozin L-proline 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Metabolism and nutrition disordersType 2 diabetes mellitus✓ Approved

相关研究文献

PubMedCureus2026-08-05

Acute Phosphate Nephropathy Following Oral Sodium Phosphate Bowel Preparation.

Oztop Enes E

Acute phosphate nephropathy (APN) is a rare but important cause of acute kidney injury (AKI), most commonly associated with the use of oral sodium phosphate bowel preparations administered prior to colonoscopy. In this report, we describe the case of a 60-year-old female patient who developed severe AKI necessitating temporary hemodialysis after bowel preparation with a phosphate-containing laxative. Quick identification, cessation of nephrotoxic agents, aggressive intravenous hydration, and supportive hemodialysis therapy facilitated gradual renal recovery. This case points out the importance of heightened awareness of APN, particularly in patients with multiple predisposing factors.

PMID 42553916
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PubMedInternational journal of phytoremediation2026-08-05

Year-long exploratory assessment of a horizontal subsurface-flow constructed wetland containing locally sourced zeolite and planted with Cyperus alternifolius for greywater treatment in Jordan.

Banihani Loaa L, Al-Tabbal Jalal- J

In arid environments such as Jordan, greywater treatment and recycling should be decentralized for better water resource management. This study tests a lab-scale Horizontal Flow Constructed Wetland (HFCW) using locally supplied natural zeolite (Aritayn region) as a substrate and Cyperus alternifolius (Umbrella Sedge) as a phytoremediator. Four parallel reactors (M1-M4) were used in a one-year mesocosm experiment to compare zeolite substrate and vegetation treatment effects. Effluent quality was tested for compliance with Jordanian water reuse requirements (JS 893:2021) in an intermittent flow regime with a constant hydraulic retention time (HRT) of roughly 5 days. The vegetated system (M2) reduced COD and BOD5 more efficiently than the unplanted zeolite-only control (M4), with 75.2% and 65.5%, respectively. M2 disinfection eliminated 95.4% E. coli, meeting national raw vegetable irrigation criteria. Maintaining physicochemical stability, pH (6.71) and TDS (<378 mg/L) within permissible values prevented soil salinization. Greywater-fed Cyperus alternifolius grew to 84.4 cm but had high proline (1.567) and osmotic stress (54.9% RWC). HFCWs containing local zeolite and Cyperus alternifolius represent a promising preliminary step for producing safe agricultural and landscape irrigation water efficiently and cheaply. However, remaining turbidity suggests a subsequent cleaning procedure for high-purity indoor reuse.

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PubMedJournal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes2026-08-05

Effect of glutamate zerovalent iron nanoparticle and benzyl amino purine on physiology of Zea mays L. under induced mercuric chloride stress.

Ullah Sami S, Amin Fazal F, Khan Shafaq S, Rehman Ullah et al.

Mercury contamination severely threatens maize growth and development, creating gap for effective mitigation practices. The experiment assesses the ameliorative effect of Glutamate-stabilized Zerovalent Iron Nanoparticles (Glu-ZVFeNPs) and Benzyl Amino Purine (BAP), applied individually and in combination, on physiological and biochemical responses of maize exposed to 20 and 40 ppm mercuric chloride (HgCl2) stress. Results showed that HgCl2 significantly reduce growth, biomass accumulation photosynthetic pigment and biochemical traits, particularly under 40 ppm HgCl2, though stress indicators increased. Covertly, BAP and Glu-ZVFeNPs application improved plant performance under stress levels. Their combine application at 20 ppm (T4) resulted maximum shoot fresh weight (5.48 g) shoot dry weight (0.6 g), root fresh weight (1.05 g), root moisture (80.6%), leaf fresh and dry weight (1.74 and 0.23 g), leaf area (76.21 cm2) and SVI (2338). Similar treatments also increased total chlorophyll (0.051 mg/g), carotenoids (5.57 mg/g), sugar (6.55 mg/g) and protein (190.7 mg/g), while reduce proline accumulation compared with stressed plants. Combine application more improved root length, shoot length, germination, leaf dry biomass and moisture content across stress levels. These results concludes that combined BAP and Glu-ZVFeNPs synergistically mitigate HgCl2 toxicity and enhanced maize tolerance through different physiological and biochemical protection mechanisms.

PMID 42554599
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PubMedFrontiers in cardiovascular medicine2026-08-05

Uncoupling of energy metabolism and myocardial function in early left atrial dysfunction: a metabolomics study.

Jia Haiying H, An Dong D, Yang Hui H, Mei Jiajie J et al.

Left atrial (LA) dysfunction is a key preclinical phenotype of heart failure (HF), closely linked to HF progression, yet its molecular mechanisms remain unclear. Energy metabolic abnormalities may critically influence early LA dysfunction. This study aimed to explore the metabolic mechanisms underlying early LA dysfunction and develop a predictive model using metabolomics. We enrolled 315 participants, classified into early LA dysfunction and healthy control groups based on LA reservoir strain assessed via cardiovascular magnetic resonance (CMR). Targeted metabolomics was applied to detect plasma metabolites, and machine learning methods were used to construct predictive models. In addition, metabolic pathway and mediation analyses were also performed. A total of 11 metabolites were significantly altered in early LA dysfunction, including elevated short-chain acylcarnitines (C4OH, C5:1) and proline, and decreased linoleic acid. C4OH and C5:1 correlated positively, while linoleic acid negatively correlated with LA reservoir strain. These metabolites distinguished early LA dysfunction from controls effectively (AUC=0.716; 95% CI: 0.616-0.817). Mediation analysis indicated that C5:1 and C5OH exacerbated LA dysfunction partly via obesity (BMI). Energy metabolic-mechanical function uncoupling may underlie early LA dysfunction. C4OH, C5:1, linoleic acid, and proline represent potential biomarkers and candidate metabolic pathways for future therapeutic investigation for early HF detection and intervention. ChiCTR2200057991; Date of registration: 2022-03-25. URL: http://www.chictr.org.cn/showproj.aspx?proj=162316.

PMID 42553525
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PubMedJAC-antimicrobial resistance2026-08-05

Emergence of Trichophyton indotineae: in vitro susceptibility data from a mycology reference laboratory in Australia.

Roudbary Maryam M, Chen Sharon C A SCA, Vieira da Silva Ana A, Beardsley Justin J et al.

Management of Trichophyton indotineae dermatophytosis is challenged by high terbinafine resistance rates within this species. Antifungal susceptibility data for Australian T. indotineae isolates are lacking. Here we determined the in vitro activity of five antifungal agents, including olorofim, against T. indotineae to guide therapeutic choices. Forty-four clinical T. indotineae isolates (cultured from skin, 2005-2025) across several Australian jurisdictions were tested for susceptibility to itraconazole, voriconazole, posaconazole, terbinafine and olorofim using CLSI broth microdilution methodology. MIC endpoints were determined at 80% growth inhibition for azoles and terbinafine, and 100% inhibition for olorofim. Isolates with terbinafine MICs ≥0.5 mg/L were considered as non-WT or resistant. Twenty-eight of 44 (63.6%) T. indotineae isolates had terbinafine MICs ≥0.5 mg/L [geometric mean (GM) MIC 0.570 mg/L; MIC90 4 mg/L] with 21 (47.7%) displaying MICs ≥4 mg/L. The modal terbinafine MIC was 4 mg/L. Lower MICs were observed for azoles, with posaconazole demonstrating the greatest activity, i.e. posaconazole (GM 0.058 mg/L; MIC90 0.25 mg/L), itraconazole (GM 0.087 mg/L; MIC90 0.5 mg/L) and voriconazole (GM 0.201 mg/L; MIC90 1 mg/L). Olorofim demonstrated good in vitro activity with all 44 isolates exhibiting MICs  ≤ 0.06 mg/L (GM 0.023 mg/L; MIC90 0.06 mg/L). Terbinafine resistance in T. indotineae is common in Australia but not universal. Susceptibility testing can inform treatment choice. The azoles and olorofim demonstrate good in vitro activity.

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PubMedActa crystallographica. Section F, Structural biology communications2026-08-05

Crystal structure of rice L-galactose dehydrogenase.

Fujimoto Zui Z, Momma Mitsuru M, Suzuki Nobuhiro N

L-Galactose dehydrogenase plays a key role in the biosynthesis of L-ascorbic acid (vitamin C) in plants. Here, we report crystal structures of rice (Oryza sativa) L-galactose dehydrogenase in both apo and NAD+-bound forms at 1.2 and 1.8 Å resolution, respectively. Rice L-galactose dehydrogenase adopts a conserved (β/α)8-barrel fold with a well preserved NAD+-binding cleft, as in other plant L-galactose dehydrogenases. Structural comparisons revealed conformational flexibility in the first and second loop regions, which form the lid and side wall of the NAD+-binding site. These loops undergo significant rearrangement upon NAD+ binding, likely facilitating cofactor and substrate uptake. These findings suggest a flexible loop-mediated regulation of cofactor and substrate access.

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