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alfuzosin hydrochloride + solifenacin (Solitral)

✓ Approved

Ranbaxy Laboratories Limited · ADRA1A · 小分子

什么是 alfuzosin hydrochloride + solifenacin？

alfuzosin hydrochloride + solifenacin 是一种小分子，由Ranbaxy Laboratories Limited研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Solitral
公司Ranbaxy Laboratories Limited
药物类别小分子
分子靶点ADRA1A, CHRM3
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Ranbaxy Laboratories Limited

作用机制

分子靶点

alfuzosin hydrochloride + solifenacin 作用于 2 个分子靶点：

ADRA1Aadrenoceptor alpha 1A (ALPHA1AAR, ADRA1C)
CHRM3cholinergic receptor muscarinic 3 (HM3, EGBRS)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

alfuzosin hydrochloride + solifenacin 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Reproductive system and breast disordersBenign prostatic hyperplasia✓ Approved

相关研究文献

PubMedLuminescence : the journal of biological and chemical luminescence2026-08-06

Fluorescence Analysis of Propranolol Hydrochloride Using Mercaptoacetic Acid-Capped Cadmium Sulfide Quantum Dots and Mechanism of Reaction Process.

Chen Yilei Y, Wang Xiaolin X, Wu Zitong Z, Chen Jinyang J et al.

Propranolol hydrochloride (PRO-HCl), a nonselective β-adrenergic receptor blocker, is widely utilized in the treatment of various medical conditions including hypertension, angina pectoris, cardiac arrhythmias, migraine prophylaxis, and certain anxiety disorders. In this study, we developed a simple, convenient, and sensitive quantitative detection method for PRO-HCl in aqueous environments, based on the fluorescence generated from the reaction between Cadmium sulfide quantum dots (CdS QDs) and PRO-HCl at room temperature. The synthesized CdS QDs were thoroughly characterized using fluorescence spectroscopy, UV-Vis spectrophotometry, and Fourier-transform infrared spectroscopy (FTIR) to investigate their optical and structural properties. Our experimental results demonstrated a significant enhancement in the fluorescence intensity of CdS QDs in the presence of low concentrations of propranolol hydrochloride. Through systematic optimization of experimental conditions, we established a linear relationship between the fluorescence intensity of CdS QDs and PRO-HCl concentration within the range of 0.002-8 mg·L-1. The linear regression equation was determined to be Y = 0.6479X + 0.0685 with a correlation coefficient (R2) of 0.9858, and the detection limit was found to be 0.002 mg·L-1. Furthermore, we investigated the potential reaction mechanism between CdS QDs and PRO-HCl. To validate the practical application of CdS QDs, the proposed method was successfully employed for the determination of PRO-HCl in spiked environmental water samples, demonstrating the effectiveness and reliability of the CdS QDs-based detection system.

PMID 42560119
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PubMedDrug design, development and therapy2026-08-06

Compound Chamomile and Lidocaine Hydrochloride Gel in Oral Diseases: A Review of Current Evidence and Potential Applications.

Wang Zhongli Z, Zeng Xuelian X, Song Yingli Y, Li Miaomiao M et al.

Oral diseases frequently entail microbial infections or mucosal damage, typically accompanied by pain and discomfort. Present pharmaceutical interventions for oral conditions in clinical settings are constrained by their singular therapeutic effects, insufficient pain relief, and practical inconveniences. The exploration of novel compound medications holds promise for augmenting clinical treatment outcomes. Compound chamomile and lidocaine hydrochloride gel (CCLHG) represents a composite formulation endowed with analgesic, anti-inflammatory, and wound healing properties, showcasing auspicious potential in oral disease management. This article summarizes the articles of CCLHG in treating various oral diseases. Electronic databases PubMed, Embase, Web of Science, Cochrane Library, Wangfang, China National Knowledge Infrastructure and China Science and Technology Journal Database were searched from inception to August 30, 2025. A total of 1413 articles were searched. 27 articles were finally included. Our analysis reveals preliminary therapeutic potential of CCLHG in managing periodontal diseases, oral mucosal conditions, pericoronitis, dry socket syndrome, peri-implantitis, and related maladies. However, given the overall limited sample sizes, variability in methodology, and generally moderate-to-low quality of the included studies, these findings warrant caution. Further high-quality investigations are therefore essential to substantiate its clinical utility.

PMID 42558651
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PubMedNeuropharmacology2026-08-06

M3 muscarinic receptor antagonism attenuates cocaine-induced hippocampal oligodendroglial changes and relapse-like behavior in male mice.

Yamada Jun J, Maeda Shoichiro S, Okamura Ayumi A, Iinuma Kyoko M KM et al.

Acetylcholine (ACh) signaling regulates oligodendrocyte lineage progression via muscarinic ACh receptors (mAChRs), yet its role in cocaine-induced myelin-associated and relapse-like changes remains unexplored. Here, we examined whether hippocampal cholinergic and oligodendroglial alterations were associated with cocaine-related outcomes and pharmacologically sensitive to M3-preferential antagonism. Adult male C57BL/6J mice were subjected to cocaine-conditioned place preference (CPP), extinction, and cocaine-primed reinstatement, and treated with benztropine (BZT), the M1-selective mAChR antagonist VU0255035, or the M3-preferential mAChR antagonist solifenacin (SOL). Cocaine conditioning increased dorsal hippocampal ACh levels and reduced the expression of selected myelin-related genes and oligodendroglial transcription factors, including Mbp, Plp, Olig2, and Olig1, predominantly in the dorsal hippocampus. These changes were accompanied by reduced myelin basic protein (MBP) immunoreactivity, increased cholinergic terminal apposition to oligodendrocyte-lineage cells, and upregulation of Chrm3 in O4-sorted hippocampal oligodendrocytes. BZT reduced cocaine-primed reinstatement and increased Mbp and Plp expression and MBP immunoreactivity in several hippocampal layers. BZT also normalized cocaine-induced changes in Fosb, ΔFosb, Creb, and Slc6a3 in the dorsal hippocampus, whereas dorsal Bdnf remained different from vehicle-treated controls. SOL reduced reinstatement relative to both cocaine-conditioned and VU0255035-treated mice. SOL also increased open-arm time and entry ratio in the elevated plus maze test relative to cocaine-conditioned mice. In CD140a-sorted oligodendrocyte precursor cell-derived cultures, SOL increased MBP-positive oligodendrocyte volume relative to cocaine alone; however, the lack of a SOL-VU0255035 difference precluded conclusions about subtype specificity. These findings provide evidence consistent with a contribution of M3-sensitive muscarinic mechanisms to cocaine-associated oligodendroglial and behavioral alterations.

PMID 42556717
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-08-06

Buried Interface Modulation via Molecular Dipole Passivation for High-Efficiency Methylammonium-Free Pb-Sn Perovskite Solar Cells.

Xie Fobao F, Liu Weixuan W, Xiong Bowen B, Goga Uliana U et al.

Methylammonium-free (MA-free) Pb-Sn perovskites are highly attractive for next-generation materials due to their ideal bandgaps. However, the efficiency and stability of Pb-Sn perovskite solar cells (PSCs) are still limited by severe Sn2+ oxidation and mismatched energy-level alignment at the buried interface. Herein, a dipole passivation strategy is developed by introducing 4-(trifluoromethyl) benzamidine hydrochloride (TFBA) at the PEDOT: PSS/perovskite interface of Pb-Sn PSCs. Benefiting from its multifunctional chemical groups and strong dipole properties, TFBA simultaneously passivates the Pb-Sn perovskite-related defects and inhibits the deprotonation of -SO3H in PSS through hydrogen-bonding and coordination interactions, thereby suppressing acidity-induced interfacial degradation. Consequently, the TFBA-modified interface exhibits highly quality Pb-Sn perovskite films and more favorable energy-level alignment. As a result, the optimized Pb-Sn PSCs deliver a power conversion efficiency (PCE) of 22.48%, with an open-circuit voltage (Voc) of 0.894 V and a fill factor (FF) of 81.74%, which is highest values of Voc × FF among the reported MA-free Pb-Sn PSCs. Moreover, the unencapsulated device retains 88.7% of its initial efficiency after 1500 h storage in N2 atmosphere.

PMID 42560659
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PubMedLuminescence : the journal of biological and chemical luminescence2026-08-06

Green Spectrofluorometric Method for Labetalol Determination Based on Electron Transfer Inhibition With Density Functional Theory Validation and Statistical Design Optimization.

Al Shmrany Humood H, Alqahtani Ali A, Alqahtani Taha T, Alshehri Adil A et al.

A novel spectrofluorimetric method for sensitive determination of labetalol hydrochloride was developed based on photoinduced electron transfer (PET) blocking mechanism through acidification-induced fluorescence enhancement. Upon acidification, the secondary amine functionality of labetalol undergoes protonation, resulting in five-fold fluorescence enhancement at 415-nm emission when excited at 298 nm. Quantum mechanical calculations revealed the electronic structure changes underlying the PET mechanism, with protonation causing 3.17-eV HOMO stabilization and decreased electron density on the secondary amine nitrogen that effectively eliminates electron transfer quenching. Subsequently, D-optimal experimental design systematically optimized the PET blocking conditions. The ANOVA analysis demonstrated statistical significance of the reduced two-factor interaction (2FI) model (F-value = 26.25, p < 0.0001) with satisfactory fit statistics (R2 = 0.9459), identifying 0.6-M acetic acid, 5-min incubation time, and water-ethanol mixture as optimal conditions. The method was validated according to ICH guidelines exhibiting excellent linearity in the range of 10-300 ng/mL, detection limit of 3.23 ng/mL, and precision below 1.6% RSD. Furthermore, successful applications to pharmaceutical formulations and biological samples (plasma) demonstrated recoveries ranging from 96.36% to 104.97%. The developed PET-blocking approach provides an environmentally sustainable alternative for labetalol determination, eliminating toxic derivatization reagents while maintaining analytical reliability and sensitivity.

PMID 42557999
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PubMedCureus2026-08-06

Transient Bilateral Fixed Dilated Pupils Following Papaverine Use During Intracranial Microvascular Decompression: A Case Report.

Idayathulla Shajahan S, Nawaz Shoaib S, Shaikh Nissar N, Nainthramveetil Mansoor M et al.

Fixed dilated pupils at the end of neurosurgical procedures are typically considered an ominous sign, often indicating acute brain injury, brainstem compression, or herniation, and are associated with poor neurological outcomes. However, pharmacological causes must also be considered. Papaverine hydrochloride, a vasodilator commonly used during intracranial surgery for the management of cerebral vasospasm, has been rarely reported to cause transient pupillary dilation and fixation. We describe the case of a 48-year-old woman with hemifacial spasm who underwent retrosigmoid craniotomy and microvascular decompression of the left facial nerve. The intraoperative course was uneventful under total intravenous anesthesia. Papaverine (200 mg) was locally infiltrated to relieve vasospasm of the anterior inferior cerebellar artery. At the conclusion of surgery, bilateral fixed dilated pupils (7 mm, nonreactive) were observed, raising concern for catastrophic intracranial pathology. Urgent neuroimaging was planned. However, within 15 minutes, the patient developed spontaneous respiratory effort, responded to commands, and her pupils returned to normal size and reactivity. She was extubated uneventfully and subsequently made a complete recovery, being discharged home on postoperative day 6. This case highlights a rare but important confounding effect of papaverine infiltration during neurosurgery. Papaverine may induce transient mydriasis mimicking signs of devastating neurological injury. Awareness of this phenomenon is critical for anesthesiologists, neurosurgeons, and critical care teams to avoid unnecessary interventions and guide appropriate postoperative decision-making.

PMID 42559265
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