Drug Database
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lamivudine + raltegravir (MK 0518B / Dutrebis / MK0518B)

✓ Approved

Merck & Co. · · 小分子

什么是 lamivudine + raltegravir?

lamivudine + raltegravir 是一种小分子,由Merck & Co.研发。该药已获批,用于治疗相关适应症,给药途径:Oral (PO)。

药物档案

商品名MK 0518B, Dutrebis, MK0518B
公司Merck & Co.
药物类别小分子
给药途径Oral (PO)
状态Approved

作用机制

分子靶点

lamivudine + raltegravir 作用于 1 个分子靶点:

gag-pol, HIV-1 (gag-pol)
需要更深入的分析?Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

lamivudine + raltegravir 针对 1 个适应症,涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsAcquired immunodeficiency syndrome✓ Approved

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Co-transcriptional splicing: Distinct phases, mutual benefits, and basis for nuclear architecture.

Shao Changwei C, Zhang Zhenwei Z, Fu Xiang-Dong XD

Co-transcriptional splicing is the process by which splicing takes place on nascent RNA before transcription terminates. Imaging- and sequencing-based technologies have revealed co-transcriptional splicing in eukaryotes, but more interesting questions arise about the mechanisms mediating such a process and its functional impact. This forum article summarizes recent advances in understanding co-transcriptional splicing.

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PubMedBrain and behavior2026-06-13

Altered Dorsolateral Prefrontal Activation in Response to Verbal Fluency Task and Whole-Brain Resting-State Functional Connectivity Strength in Acute Carbon Monoxide Poisoning.

Pan Jian-Qing JQ, Liang Qun-Jun QJ, Tang Ming-Xing MX, Duan Lian L et al.

The study aims to investigate changes in brain activity during the verbal fluency task (VFT) and resting-state brain network features in patients with acute carbon monoxide (CO) poisoning using functional near-infrared spectroscopy (fNIRS). We also explored the relationship between cognitive function and the fNIRS-derived features of oxyhemoglobin (Oxy-Hb) concentration curves in the cerebral cortex. We first performed a cross-sectional study in patients with acute CO poisoning and healthy controls between January and December 2024. The fNIRS-derived features (centroid and mean) of the Oxy-Hb curve in the frontotemporal cortex during VFT were compared between CO poisoning patients and healthy controls. The functional connectivity of brain networks in patients with acute CO poisoning during the resting state was also analyzed to identify factors representing network features of the cerebral cortex in patients with acute CO poisoning. We then performed a prospective cohort study to compare the brain activity changes after the hyperbaric oxygen therapy in patients with acute CO poisoning. The study included 29 patients with CO poisoning and 28 healthy controls. During the VFT, the centroid of the Oxy-Hb curve in Brodmann area 46 was significantly lower in CO poisoning patients compared to the healthy controls (p < 0.01). The centroid and mean values of Brodmann area 46 exhibited a significant positive correlation with Mini-Mental State Examination scores, while the mean value was positively correlated with VFT scores. Mean values in Brodmann areas 11 and 38 were significantly lower in CO poisoning patients (both p < 0.05). The average whole-brain resting-state functional connectivity strength (FCS) was significantly lower in CO poisoning patients compared to healthy controls (p < 0.05), with significant differences in FCS observed in 39 pairs of channels (p < 0.01). Twenty sessions of hyperbaric oxygen therapy resulted in improved FCS (p < 0.01) and centroid values for the Oxy-Hb curve in the left dorsolateral prefrontal cortex during the VFT (p < 0.05). The centroid values of the Oxy-Hb curve in the left dorsolateral prefrontal cortex during the VFT, along with the average whole-brain resting-state FCS, potentially could serve as characteristic indicators of brain function in patients with acute CO poisoning.

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PubMedNeuroImage2026-06-13

Structural co-modulation: An individualized measure of inter-component interactions in source-based morphometry.

Kotoski Aline A, Soleimani Najme N, Wiafe Sir-Lord SL, Kinsey Spencer S et al.

Source-based morphometry (SBM) is a powerful multivariate method for identifying covarying structural brain networks. However, standard SBM provides only a single loading value per component for each subject, which limits the characterization of relationships between these components. We propose a novel technical co-modulation approach to derive an individualized, network-like measure of structural brain organization. This method transforms the subject-specific SBM loading vector into a symmetric co-modulation matrix by computing the vector's outer product. Each element of this matrix quantifies the pairwise interaction between structural components, creating a subject-specific fingerprint. Analogous in structure to a functional connectivity matrix where each element represents the relationship between a pair of networks, this matrix maps their joint structural prominence, reflecting how strongly two networks co-occur within an individual. To demonstrate the utility of this method, we applied it to structural MRI data from 210 patients with schizophrenia (SZ) and 195 healthy controls (HC) from the fBIRN psychosis dataset using functional networks as priors for SBM. We observed widespread reductions in structural co-modulation in the SZ group, particularly within and between visual, default-mode, and cognitive control networks. Furthermore, co-modulation patterns were significantly correlated with cognitive performance and clinical symptom severity in patients. Structural co-modulation provides a robust framework for quantifying individualized relationships between structural brain features, overcoming key limitations of standard SBM and offering a new avenue for integrating structural and functional brain analyses.

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Compulsive Sexual Behaviors, Pornography Consumption, and Co-Occurring Disorders Among College Students.

Moon Evan J EJ, Garos Sheila S, Kraus Shane W SW, Borgogna Nicholas C NC

Problematic pornography use (PPU) and other compulsive sexual behaviors (CSBs) are associated with numerous psychosocial consequences, with a higher frequency in men than women. However, less is known about the frequency and relationship between PPU, CSBs, depression, and alcohol use problems, especially among college students who may endorse these behaviors at higher rates. This study sought to identify the relationship between co-occurring CSBs, PPU, alcohol use problems, and depression across gender (77% women, 23% men) in a sample of college students (N = 1126). Participants completed an anonymous online survey. Categorical modeling (i.e., chi-square tests and binary logistic regressions) was utilized to identify base rates and odds ratios of clinically significant PPU and CSBs among individuals with alcohol use problems and depression. Men, relative to women, reported PPU and co-occurring alcohol use problems and depression at higher rates. Less significant gender differences were observed across co-occurring CSBs, alcohol use problems, and depression. Alcohol use problems were moderately to strongly associated with CSBs. Depression was associated with PPU in women. Co-occurring alcohol use problems and depression were moderately associated with CSBs. This study highlights the role of gender in potential comorbidities between PPU and CSBs in young adults, as well as the need for greater research examining the consequences of PPU, CSBs, and co-occurring disorders.

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PubMedScientific reports2026-06-13

Clinical and genomic characterization of Influenza A co-infection with SARS-CoV-2 and Influenza B: a respiratory surveillance study in Assam, India.

Sarmah Neelanjana N, Siddique Aktarul Islam AI, Dutta Mousumi M, Jakharia Aniruddha A et al.

Influenza and SARS-CoV-2 are the primary contributors to seasonal respiratory infections and frequently co-circulate, creating significant health challenges. The present respiratory surveillance study was conducted in Dibrugarh, Assam, India from January 2025 to August 2025 to investigate the genomic characteristics of circulating viruses and identify potential co-infections. Overall, 4,948 respiratory samples were screened using multiplex real-time PCR, followed by subtyping of Influenza A and Influenza B. Next-generation sequencing (NGS) was performed in selected positives of SARS-CoV-2 and Influenza A. Genomic analysis included mutational profiling, phylogenetic analysis and N-glycosylation site prediction using bioinformatics tools. Two co-infection cases were detected: one involving Influenza A (H3N2) with SARS-CoV-2 (Omicron XFG lineage) and another involving Influenza A (H3N2) with Influenza B (Victoria lineage). Both patients experienced mild illness without hospitalisation. NGS revealed that the Influenza A (H3N2) viruses belonged to clade 3C.2a1b.2a.2a.3a.1 while SARS-CoV-2 sequence was classified under the Omicron XFG lineage. Mutational analysis of the HA gene showed several amino acid differences compared to the reference vaccine strain A/Darwin/6/2021. N-glycosylation analysis predicted conserved sites at positions 79, 181, 262, and 301 in all strains along with an additional predicted site at position 110 in both co-infection cases. Although the co-infection cases presented with mild clinical manifestations, the observed genomic variations indicate a potential role of co-infecting viruses in shaping viral evolution. Given the limited genomic data available from Northeast India, the study underscores the need for sustained large scale follow up and genomic surveillance to monitor emerging mutations and target future vaccine strategies.

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PubMedBMC health services research2026-06-13

Co-creating an action to promote health literacy among parents with immigrant backgrounds.

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Health literacy is a resource that enables individuals to make health related choices to promote and protect their health and that of those around them. For parents, health literacy is essential to access and use information and services in ways that support their child's health. Immigrant parents may face health literacy challenges due to language barriers, differing approaches to managing child health and parenting, unfamiliar services, and divergent expectations of services and staff. Since parental health literacy is linked to child health outcomes, addressing the needs of immigrant parents may help prevent avoidable inequities in child health. Few studies have developed and tested interventions to promote health literacy among parents with immigrant backgrounds. Based on results from a needs assessment conducted in a culturally and linguistically diverse population in Oslo, Norway, we aimed to co-create an action to promote parental health literacy. We undertook a two-phase co-creation process drawing on methods from the Optimising Health Literacy and Access (Ophelia) Process and the James Lind Alliance Priority Setting Partnership. In phase one, we collected action ideas from a broad range of stakeholders; analysed and synthesised the ideas; facilitated prioritisation workshops with user representatives; and selected one idea for co-design. In phase two, we co-designed the action with user representatives; and conducted quality-improvement cycles in the clinical setting. In phase one, 14 immigrant parents and 59 staff from different disciplines generated 302 action ideas. Analysis reduced these to a short-list of 22 ideas which were prioritised by user representatives (parents and staff) resulting in two Top-10 lists. Five priorities overlapped and one of these was selected for development: improving communication on services provided by the family health clinic. In phase two, we operationalised this idea by co-designing short, multilingual, animated videos about follow-up at the clinic. The videos were refined through five iterative quality improvement cycles with input from 43 end users (parents and staff). We successfully engaged user representatives, stakeholders and end users across multiple stages of co-creation and co-designed a health literacy action. The videos developed were completed to the stage of feasibility testing in the clinical setting.

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