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lamivudine + raltegravir (MK 0518B / Dutrebis / MK0518B)

✓ Approved

Merck & Co. · · 小分子

什么是 lamivudine + raltegravir?

lamivudine + raltegravir 是一种小分子,由Merck & Co.研发。该药已获批,用于治疗相关适应症,给药途径:Oral (PO)。

药物档案

商品名MK 0518B, Dutrebis, MK0518B
公司Merck & Co.
药物类别小分子
给药途径Oral (PO)
状态Approved

作用机制

分子靶点

lamivudine + raltegravir 作用于 1 个分子靶点:

gag-pol, HIV-1 (gag-pol)
需要更深入的分析?Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

lamivudine + raltegravir 针对 1 个适应症,涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsAcquired immunodeficiency syndrome✓ Approved

相关研究文献

PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-08-05

Cobalt Single Atoms Enhance Ethanol Electrooxidation on Pt/CeO2.

Jiang Haoran H, Xiao Yikun Y, Wang Zichen Z, Ouyang Min M et al.

The commercialization of direct ethanol fuel cells (DEFCs) requires the development of electrocatalysts with high activity, high durability, and robust resistance to CO poisoning in the ethanol oxidation reaction (EOR), but there is still a significant challenge to overcome. In this work, we modulated the electronic structure of Pt by incorporating Co,N-co-doped porous carbon (CoNPC) and nanostructured CeO2 (nCeO2) to construct an enhanced catalyst (Pt/nCeO2@CoNPC) for EOR. The CoNPC with Co single atoms not only provides high electrical conductivity and abundant anchoring sites but also participates in electronic modulation. The synergistic electronic effect induced by Co single atoms and nCeO2 modulates the electronic environment of Pt, thereby tuning its binding affinity toward critical reaction intermediates of EOR. Furthermore, the presence of nCeO2 promotes the oxidative removal of CO* species through providing abundant OH* and inducing interfacial electronic effect. As a result, Pt/nCeO2@CoNPC shows strong resistance to CO poisoning, preserves 73% of its original performance following 500 cycles, and presents a remarkable mass activity (1591 mA mgPt -1).

PMID 42554135
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PubMedPNAS nexus2026-08-05

Disclosing the costs of co-holding liquid assets and high-interest debt has limited impact on behavior.

Batista Rafael M RM, Mao Ella E, Sussman Abigail B AB, Mahoney Neale N et al.

Why do consumers simultaneously maintain low-yield liquid assets and high-interest revolving debt? This behavior, known as "co-holding," affects 23% of credit card users in our sample from a major international bank and costs the typical co-holder hundreds of dollars annually in unnecessary interest charges. Our analysis of 38 months of detailed banking records reveals that co-holding is remarkably persistent, with typical co-holders maintaining this behavior for most months observed. Our analysis also reveals that co-holding is not a static financial position: co-holders regularly deposit and withdraw from asset accounts while simultaneously making new credit card purchases. To test whether co-holding could be addressed through information disclosure, we conducted a large-scale field experiment ( n = 125 , 328 ), providing clear information about co-holding behavior and its costs. Customers received targeted messages through their bank's mobile app, where they could easily transfer money from assets to pay down debt. Despite sufficient power to detect economically small effects, we found no meaningful changes in debt repayment amount, though customers did respond in other ways-making more frequent repayments and paying above required minimums. These results challenge explanations based on limited attention or information gaps and suggest that simple information disclosure, even when carefully designed and delivered through trusted channels, may not effectively address costly financial behaviors.

PMID 42553849
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PubMedPhysical chemistry chemical physics : PCCP2026-08-05

The dynamics of the reaction between Co3O4/SiO2 and synthesis gas in a magnetic field.

Chernavskii P A PA, Kharlanov A N AN, Lunin B S BS

The reaction of a Co3O4/SiO2 catalyst with synthesis gas (CO : H2 = 1 : 1) was studied using in situ magnetometry in programmable temperature and isothermal modes. Changes in magnetic induction and the formation rate of CO2 were used to monitor the dynamics of the reaction. Then, a simple kinetic model was used to estimate the rate ratios of the following reactions: Co3O4 + CO → CoO + CO2 and CoO + CO → Co + CO2. The effect is observed both in the synthesis gas and in pure CO. It was demonstrated that an external magnetic field exerts a multidirectional influence on the rates of these reactions. As the magnetic field strength increases, the rate of the first reaction decreases, while that of the second increases. This suggests that the process is spin-dependent.

PMID 42554185
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PubMedAlzheimer's & dementia : the journal of the Alzheimer's Association2026-08-05

Plasma p-tau217 detects Alzheimer's disease co-pathology in cerebral amyloid angiopathy: Comparison to CSF biomarkers in the ANGMAR cohort.

Fernández-Lebrero Aida A, Jiménez-Balado Joan J, García-Escobar Greta G, Contador José J et al.

Cerebral amyloid angiopathy (CAA) frequently co-occurs with Alzheimer's disease (AD), generating mixed vascular-neurodegenerative phenotypes. Plasma phosphorylated tau (p-tau)217 is a robust biomarker of AD, but its performance in CAA remains unclear. We studied 231 participants, including 50 patients with CAA (Boston v2.0), 154 with AD, and 27 cognitively unimpaired controls. Plasma p-tau217 was measured on an automated platform and compared to cerebrospinal fluid (CSF)-defined AD status. Associations with magnetic resonance imaging (MRI) markers of CAA burden were evaluated. Among CAA participants, 29 met CSF criteria for AD co-pathology. Plasma p-tau217 discriminated CAA patients with and without AD co-pathology (area under the curve = 0.920) and showed no association with MRI markers of CAA burden. Predefined cut-offs (≥ 0.27 pg/mL and ≥ 0.34 pg/mL) yielded high accuracy for identifying AD co-pathology within CAA. Plasma p-tau217 shows high diagnostic accuracy for identifying AD co-pathology in CAA and is not associated with MRI markers of CAA burden, supporting its specificity for AD-related pathology.

PMID 42552750
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PubMedRSC advances2026-08-05

Insights into the adsorption behaviors of pristine and Fe-doped WX2 (X = S, Se) monolayers for harmful gases (CO, NO, H2S).

Tri Nguyen Ngoc NN, Ho Dai Q DQ, Trung Nguyen Tien NT

In this study, we employ density functional theory with the vdW-DF2 functional to investigate the adsorption and sensing ability of toxic gases, including CO, NO, and H2S, on pristine and Fe-doped WX2 monolayers (X = S, Se). Gas adsorptions on the pristine surfaces of WS2 and WSe2 are considered weak physisorption, and configurations are stabilized by noncovalent interactions, including C/N/O⋯S/Se and H⋯S/Se hydrogen bonds. Fe doping enhances the adsorption of CO, NO, and H2S molecules on the WX2 surfaces. The configurations are contributed by C/N/O/S⋯Fe chemical bondings in these systems. The analyses of charge density difference and density of states reveal the formation of surface interactions upon gas adsorption. Noticeably, high sensitivity to NO is observed compared to CO and H2S, especially for Fe-WX2 surfaces. This finding shows that WX2 monolayers yield good sensitivity for small gases, while the Fe-doped surfaces are promising candidates for sensing and capturing toxic gases, especially CO, NO, and H2S, across various environments.

PMID 42553387
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PubMedFrontiers in medicine2026-08-05

Co-creating palliative care education across contexts: faculty experiences from a Ghana-Canada partnership for primary health care strengthening.

Gyakobo Mawuli Kotope MK, Amponsah Abigail Kusi AK, Owusu-Ansah Michael M, Agbeko Anita Eseenam AE et al.

Palliative care education developed in high-income settings often requires significant contextual adaptation to address the needs of diverse clinical and cultural environments. Globally, strengthening palliative care is increasingly recognized as critical to achieving the health-related sustainable development goals (SDGs), Universal Health Coverage (UHC), and strong primary health care (PHC)-oriented systems. Despite this, access to palliative care remains limited globally, particularly in low-and middle-income countries. Co-creation provides a collaborative approach to developing relevant and equitable curricula that can support the integration of palliative care into primary care and advance progress toward UHC and the SDGs; however, little is known about how this process unfolds in transnational partnerships, particularly in West Africa. This study aims to describe how Ghanaian and Canadian faculty experienced the co-creation and delivery of a palliative care training programme. We conducted a qualitative study using semi structured interviews with faculty from Kwame Nkrumah University of Science and Technology (KNUST; Ghana) and the University of Toronto (UofT; Canada) who co-developed and facilitated a palliative care course between 2023 and 2025 under the Africa Health Collaborative (AHC). Purposive sampling included all eligible faculty participants. Interviews were conducted in person, audio-recorded, transcribed, de-identified, and analyzed using inductive thematic analysis. Sampling continued until conceptual depth was reached. Ten faculty described five interconnected themes to characterize their co-creation experience. Navigating culture and context required ongoing adaptation of teaching approaches and clinical content to ensure relevance. The co-creation process evolved from initial uncertainty and vulnerability toward trust, cohesion, and shared ownership. Communication was central, serving both as a pedagogical focus and as a foundation for collaboration. Participants described professional and personal growth, including expanded perspectives and enhanced teaching practices. Co-creation was also viewed as a promising model for future curriculum development, although barriers such as limited preparation time, technological challenges, and initial apprehension were identified. Within this Ghana-Canada partnership, co-creation functioned as a relational and adaptive process that supported contextually grounded curriculum development and collaborative learning. These findings provide insight into the experiential and relational dimensions of co-creation in global health education and may inform similar partnerships, while highlighting the importance of contextual adaptation in resource-diverse settings.

PMID 42553587
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