若生智能
Drug Database
FA

Factor IX (AlphaNine SD / AlphaNine)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · F9 · 细胞治疗

什么是 Factor IX？

Factor IX 是一种细胞治疗，由Mitsubishi Tanabe Pharma Corporation研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。

药物档案

商品名AlphaNine SD, AlphaNine
公司Mitsubishi Tanabe Pharma Corporation
药物类别细胞治疗
分子靶点F9
给药途径Injectable (Others), Intravenous (IV)
状态Approved
来源： ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

作用机制

分子靶点

Factor IX 作用于 1 个分子靶点：

F9coagulation factor IX (P19, F9 p22)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

Factor IX 针对 3 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Vascular disordersExtravasation blood✓ Approved
Congenital, familial and genetic disordersFactor IX deficiency✓ Approved
Vascular disordersHaemorrhage✓ Approved

相关研究文献

PubMedCeska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti2026-06-13

Association of Aqueous Humor Tumor Necrosis Factor Alpha with Retinal Ganglion Cell Thickness in Juvenile versus Adult-Onset Primary Open-Angle Glaucoma.

Ilahi Fitratul F, Fitrah Fitrah F, Haq Nazhiful Kalaj NK, Alfatih Muhammad M et al.

To evaluate the association between aqueous humor tumor necrosis factor alpha (TNF-α) and retinal ganglion cell (RGC) layer in patients with juvenile open-angle glaucoma (JOAG) and their comparison with adult-onset primary open-angle glaucoma patients (POAG). This analytical cross-sectional study included 15 JOAG patients (aged 7-40 years) and 15 POAG patients (> 40 years). Aqueous Humor (AH) samples were collected during trabeculectomy, TNF-α concentrations were measured using ELISA, and RGC thickness was assessed by Optical Coherence Tomography (Cirrus HD-OCT, Carl Zeiss). Group differences were analyzed using the independent t-test, and correlations were evaluated with Pearson's test. The mean AH TNF-α level in the JOAG group (179.02 ±27.04 pg/mL) was significantly higher than in the POAG group (130.17 ±18.62 pg/mL; p.

PMID 42285746
阅读全文 →
PubMedBMC psychology2026-06-13

Validation and psychometric properties of the Arabic version of the Quality-of-Life Scale (QOLS) with a sample of general and special education teachers.

Almohayya Bander M BM, Alasim Khalid N KN

This study was performed to validate the Arabic version of the 15-item Quality-of-Life Scale (QOLS) using a sample of 401 teachers, including 235 general education teachers and 166 special education teachers. The psychometric properties of the QOLS were evaluated through exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). EFA supported a two factor solution, explaining 55.6% of the total variance, with Factor 1 reflecting personal and social well-being and Factor 2 reflecting leisure and autonomy. Internal consistency was excellent, with Cronbach's alpha and McDonald's omega coefficients of .91 and .92 for the total scale, respectively. Convergent validity was established via a strong positive correlation with the WHOQOL-Bref (r = .78), while discriminant validity was confirmed through a moderate negative correlation with the Health and Suffering Scale (r = -.57). CFA demonstrated acceptable model fit indices (CFI = 0.92, TLI = 0.90, RMSEA = 0.085, SRMR = 0.05), supporting the stability of the two-factor structure. Multi-CFA further indicated that measurement invariance was achieved across gender at configural, metric, and scalar levels, whereas full invariance was not supported across educational levels. The findings indicate that the Arabic QOLS is a reliable and valid instrument for assessing quality of life among physically active adult populations such as teachers. Implications for its application in educational and research contexts, as well as limitations regarding factor structure differences from the original QOLS, are discussed.

PMID 42286778
阅读全文 →
PubMedBMC psychology2026-06-13

Spanish adaptation and validation of Mishel's Uncertainty in Illness Scale (MUIS-A) in cancer patients.

Gómez-Iglesias Marta M, Fernández-Rodríguez Eduardo José EJ, Sánchez-Gómez Celia C, Fonseca-Sánchez Emilio E et al.

Uncertainty is a major factor affecting cancer patients throughout all stages of the disease. Given its impact, this study aimed to adapt Mishel's Uncertainty in Illness Scale (MUIS-A) into Spanish for cancer patients in Spain and to analyze the relationship between uncertainty and selected clinical and psychosocial variables. A descriptive cross-sectional transcultural adaptation and psychometric validation study was conducted using a prospective convenience sample of 174 cancer patients undergoing chemotherapy and/or immunotherapy. Uncertainty, socio-family support, dependence in activities of daily living, and functional status were assessed using validated questionnaires. Principal Component Analysis (PCA) and correlational analyses were performed to examine the factorial structure and associations among variables. Principal Component Analysis (PCA) supported the presence of the four dimensions of the original scale in the Spanish version. The 33-item scale showed good internal consistency (Cronbach's alpha = 0.794) and an initial explained variance of 39.26%. After an iterative item reduction process to improve factor loadings, a 26-item version was obtained, maintaining the four-factor structure, acceptable reliability (Cronbach's alpha = 0.787), and increasing the total explained variance to 44.6%. The mean uncertainty score was 73.15 ± 14.41. Most patients reported adequate social support and were independent in basic activities of daily living. A significant negative association was found between social support and uncertainty (r = - 0.315, p < 0.001). Additionally, a significant negative association was observed between uncertainty and the number of disease-related hospital admissions (Z = - 2.775, p < 0.005). The Spanish transcultural adaptation of Mishel's Uncertainty in Illness Scale is a reliable and valid tool for assessing uncertainty in cancer patients in Spain. Uncertainty was present in all participants and was significantly associated with socio-family support and disease-related hospital admissions. Its clinical application provides a practical resource for oncology nurses to facilitate psychosocial screening and tailor specific communication strategies.

PMID 42286704
阅读全文 →
PubMedEating and weight disorders : EWD2026-06-13

Development and validation of the Japanese version of Sociocultural Attitudes Towards Appearance Questionnaire-4-Revised (SATAQ-4R) among Japanese adolescents.

Saito Takumi T, Ishitsuka Kazue K, Piedvache Aurélie A, Yamaguchi Satoshi S et al.

Internalization of appearance ideals and sociocultural pressures contribute to body dissatisfaction and eating disorders. Japanese adolescents report high levels of body dissatisfaction despite relatively low body mass index compared to peers in other countries, highlighting potential cultural influences. However, the Sociocultural Attitudes Towards Appearance Questionnaire-4-Revised (SATAQ-4R) has not been validated in Japan. This study aimed to develop a Japanese version of the SATAQ-4R and examine its psychometric properties among Japanese adolescents. A nationwide population-based study was conducted in 2023 among 1,368 adolescents aged 11-17 years (girls: n = 694; boys: n = 674). Participants completed self-reported questionnaires. The factor structure of the SATAQ-4R was evaluated using exploratory and confirmatory factor analyses (EFA and CFA), internal consistency was assessed using Cronbach's alpha, and convergent validity was examined using eating-related measures. EFA suggested a five-factor 23-item structure for girls and a seven-factor 23-item structure for boys. CFA showed suboptimal fit for the female model and comparatively better fit for the male model. Most subscales showed acceptable internal consistency, although one female pressure-related subscale showed inadequate reliability. Correlations with external measures provided partial evidence of convergent validity, with associations varying by sex and subscale. These findings provide preliminary evidence for psychometric properties of the Japanese SATAQ-4R. However, suboptimal female model fit, inadequate reliability of one female subscale, and mixed convergent validity evidence indicate that the resulting Japanese models should be used with caution. Level III, cross-sectional observational study.

PMID 42286317
阅读全文 →
PubMedBiochemical and biophysical research communications2026-06-13

β-Sitosterol protects human chondrocytes from IL-1β -induced damage by inhibiting ferroptosis.

Zhang Le L, Kong Xiaochuan X, Hong Gang G, Zheng Yinfeng Y et al.

To investigate the effect of β-Sitosterol on interleukin (IL)-1β-induced chondrocyte injury and the related mechanism. An osteoarthritis model was constructed by treating immortalized human cartilage cells with IL-1β. The identity and purity of β-Sitosterol were confirmed by FTIR, 1H NMR, 13C NMR, RP-HPLC-ELSD, and UPLC-MS before cell experiments. The optimal concentrations of IL-1β and β-Sitosterol for treating cells were determined by qPCR and CCK8 assay. The cells were divided into three groups: Control group, Model group, and Model+β-Sitosterol group. Cell viability was detected by CCK8 assay. The mRNA expression of IL-18, IL-1β and tumor necrosis factor-α (TNF-α) was detected by qPCR. Collagen type II alpha 1 chain (COL2A1) and matrix metalloproteinase 13 (MMP13) expression was detected by immunofluorescence. Reactive oxygen species (ROS) and mitochondrial membrane potential were detected by flow cytometry. Malondialdehyde (MDA), Glutathione (GSH) and Fe2+ were detected by ELISA and biochemical test. Mitochondrial structure was observed by transmission electron microscopy, and the protein expression of ferroptosis related factors was detected by Western blot. After induction of chondrocytes with IL-1β, the cell viability was decreased, the gene expression of inflammatory cytokines was increased, the proportion of cells with reduced ROS content and mitochondrial membrane potential were increased, MDA and Fe2+ content were increased, and GSH content was decreased. Mitochondrial structure showed ferroptosis-like changes. The expression of COL2A1, glutathione peroxidase 4 (GPX4), solute carrier family 7 member 11 (SLC7A11), total nuclear factor erythroid 2-related factor 2 (NRF2), and nuclear NRF2 was decreased. MMP13, ANO6, and p-p38/p38 levels were increased. Treatment of chondrocytes with β-Sitosterol could reverse these changes induced by IL-1β. Spectrally confirmed, high-purity β-Sitosterol alleviated IL-1β-induced chondrocyte injury by suppressing inflammatory activation, extracellular matrix degradation, mitochondrial dysfunction, and ferroptosis-related oxidative damage, suggesting its potential as a candidate compound for osteoarthritis intervention.

PMID 42284994
阅读全文 →
PubMedTrends in pharmacological sciences2026-06-13

Chronobiomaterials for circadian-aligned brain therapeutics.

Garg Shubham S, Walters Burgundy B, Fernandez Diego C DC

Circadian rhythms are endogenous ~24 h oscillations that regulate daily changes in neural activity, metabolism, and behavior. Disruption of circadian rhythms is a hallmark of neurological and psychiatric disorders, yet most brain-directed therapies use fixed dosing schedules that do not account for time-of-day variations in drug efficacy and toxicity. Recent advances in bioengineering have led to the development of chronobiomaterials-including nanoparticles, exosomes, hydrogels, cell-based systems, and bioelectronic interfaces-that enable programmable and temporally precise control of therapeutic delivery. Here, we describe the multiscale organization of cellular and molecular circadian clocks in the brain, review chronobiomaterial platforms designed to modulate circadian phase, amplitude, and period, and discuss AI-enabled closed-loop approaches for personalized chronotherapy.

PMID 42285786
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多Factor IX