Nisshin Pharma · 小分子 · 小分子
nitroglycerin 是一种小分子，由Nisshin Pharma研发。该药已获批，用于治疗相关适应症，给药途径：Transdermal。
| 商品名 | Minitro Tape |
| 公司 | Nisshin Pharma |
| 药物类别 | 小分子 |
| 给药途径 | Transdermal |
| 状态 | Approved |
nitroglycerin 针对 1 个适应症，涉及 1 个治疗领域。
| 治疗领域 | 疾病/病症 | 分期 |
|---|---|---|
| Cardiac disorders | Angina pectoris | ✓ Approved |
Huang Lianzhan L, Zhou Jieru J, Han Yiyue Y, Mou Xiaotong X et al.
Cheng Xianting X, Wang Yifan Y, Yang Shaofan S, Liu Juan J et al.
Cervicogenic angina is a frequently overlooked non-cardiac chest pain syndrome whose clinical manifestations closely resemble those of true cardiac angina, and conventional anti-anginal medications as well as coronary interventions often yield unsatisfactory results. This report describes a 61-year-old male patient who presented with recurrent precordial pain, chest tightness, dyspnea, and numbness of the neck, shoulders and upper extremities for one year. The patient was initially diagnosed with coronary artery disease and underwent coronary intervention, but symptoms recurred shortly after the procedure and sublingual nitroglycerin was ineffective. After cardiac causes were ruled out through specialized cardiac examinations, physical examination revealed positive paravertebral tenderness and signs of nerve root compression. Cervical magnetic resonance imaging demonstrated disc herniation at C5-C7 with nerve root compression, leading to a final diagnosis of cervicogenic angina. The patient underwent ultrasound-guided pulsed radiofrequency of the cervical nerve roots and cervical sympathetic nerve combined with low-temperature plasma ablation of the cervical facet joints, followed by postoperative adjunctive treatment with duloxetine. Neck-shoulder pain and precordial discomfort improved markedly, with the visual analog scale score decreasing from 7 preoperatively to 0 at the 3-month follow-up; Cervical range of motion markedly improved; precordial pain, chest tightness, and dyspnea resolved completely without recurrence, and sleep quality improved significantly. This case suggests that cervicogenic angina should be strongly suspected in patients with recurrent chest pain after a standard cardiac work-up has excluded a cardiac origin. Ultrasound-guided radiofrequency intervention is safe and effective, providing a reliable minimally invasive treatment strategy for this easily missed condition and deserves wider clinical application.
Lotfi Amir A
Mahendiran Thabo T, De Bruyne Bernard B
Saghafi Fatemeh F, Mohammadi Farhad F, Esmaeili Mohadesah M, Shadkam Mahmoud Nouri MN et al.
Venipuncture is a common and painful procedure in neonates. Sweet solutions (sucrose and glucose) are recommended and widely used as standard care for reducing neonatal procedural pain. Topical local anesthetics may also reduce procedural pain but generally require longer application times to achieve adequate analgesia. This study investigated the efficacy and safety of a novel topical lidocaine-nitroglycerin preparation as an adjunct to standard oral sweet solutions in neonates undergoing peripheral venous catheterization. In this double-blind randomized clinical trial, 84 neonates (≥ 34 weeks gestation) undergoing peripheral venous catheterization were randomized to receive either topical lidocaine/nitroglycerin 2% or placebo ointment, applied 15 min before the procedure. All neonates in both groups received 0.5 mL of 24% oral sucrose two minutes before venipuncture as standard care. Pain was assessed using the Premature Infant Pain Profile (PIPP) and Neonatal Facial Coding System (NFCS) scales using standardized procedures and video verification. The duration of crying, time to cry onset, number of venipuncture attempts, and adverse events were recorded. Neonates treated with lidocaine-nitroglycerin topical formulation plus standard oral sucrose had significantly lower PIPP scores [7.0 vs. 8.5, P = 0.038] and NFCS scores [5.0 vs. 7.0, P < 0.001] compared with placebo ointment plus standard oral sucrose. Crying duration was significantly shorter [10 s vs. 25 s, P = 0.045], and fewer neonates required repeated venipuncture (6 vs. 14, P = 0.041). No adverse reactions or clinical signs of methemoglobinemia were observed. Topical lidocaine/nitroglycerin 2% provided rapid analgesia and reduced repeated venipuncture attempts in neonates, offering a practical strategy for pain management in the neonatal intensive care unit (NICU). Further large multicenter trials are warranted to confirm efficacy and long-term safety. The trial was registered as IRCT20190810044500N19 (22/08/2021) https://irct.behdasht.gov.ir/trial/47524 .
Koçdor Pelin P, Shomalizadeh Narges N, Salman Fatmanur Akpunar FA, Demirhan Feride F et al.
Auditory and vestibular symptoms in vestibular migraine, cochlear migraine, and Ménière's disease overlap, yet mechanisms linking migraine biology to inner ear dysfunction remain unclear. Calcitonin gene-related peptide (CGRP) is a key mediator of trigeminovascular activation and a major therapeutic target in migraine, but its contribution to cochlear dysfunction is not well defined. Using a repeated nitroglycerin (NTG) paradigm in male Wistar rats, we investigated whether a systemic migraine-like state affects cochlear function and whether these effects are dependent on CGRP. Rats received saline, NTG, or NTG followed by the CGRP receptor antagonist olcegepant (OLC). NTG increased plasma TNF-α and elevated trigeminal c-Fos; olcegepant partially normalized these markers, whereas behavioral changes in the open-field test were interpreted cautiously because baseline immobility differed across groups before treatment. NTG produced frequency-dependent changes in distortion-product otoacoustic emissions and auditory brain stem response thresholds. Electrocochleography showed limited changes, and scala media proportions did not differ significantly among groups, indicating no evidence of overt endolymphatic hydrops at the studied time point. Inner hair-cell synaptic markers showed no significant group differences for CtBP2, whereas GluR2 puncta differed between NTG and NTG + OLC (p = 0.012). Olcegepant attenuated NTG-associated cochlear functional changes and was associated with differences in postsynaptic GluR2 puncta, alongside region-specific changes in cochlear CGRP immunoreactivity. These findings support a mechanistic link between migraine-like trigeminovascular activation and early cochlear dysfunction and suggest that CGRP receptor blockade may benefit migraine patients with cochlear or vestibular symptoms. Future studies should assess females, estrous cycle tracking, hormones, and sex-specific auditory responses.
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