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calcium carbonate (Cimascal / Cimascal D Forte)

✓ Approved

CPEX Pharmaceuticals, Inc. · VDR

什么是 calcium carbonate？

calcium carbonate 是一种治疗药物，由CPEX Pharmaceuticals, Inc.研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Cimascal, Cimascal D Forte
公司CPEX Pharmaceuticals, Inc.
分子靶点VDR
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, CPEX Pharmaceuticals, Inc.

作用机制

分子靶点

calcium carbonate 作用于 1 个分子靶点：

VDRvitamin D receptor (NR1I1, PPP1R163)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

calcium carbonate 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

相关研究文献

PubMedInternational journal of microbiology2026-08-05

Ureolytic Rhizobacteria for Cadmium Remediation: Contribution of Bioadsorption and Bioaccumulation During Microbially Induced Carbonate Precipitation in Liquid Medium Assays.

Adarme-Duran Carlos A CA, Castillo Elianna E, Brandão Pedro F B PFB

Microbially induced carbonate precipitation (MICP) is a recognized bioremediation strategy for mitigating toxic metal pollution; however, the relative contributions of bioprecipitation, biosorption, and bioaccumulation to cadmium (Cd) removal during MICP remain underexplored. This study assessed Cd immobilization by six rhizosphere ureolytic bacterial strains from different genera in liquid medium and quantified the metal distributed among the bioprecipitated, biosorbed, and bioaccumulated fractions. Minimum inhibitory concentration assays showed Cd tolerance ranging from 90 to 300 mg L-1. The strains presented total Cd removal efficiencies of 64.9%-99.8% within 120 h. Notably, Cd removal occurs mainly under 48 h. Biosorption assays revealed substantially lower Cd removal compared with bioprecipitation experiments. Comparative analysis of Cd bioprecipitation and biosorption assays, combined with sequential extraction, demonstrated that bioadsorption plays a significant role in the removal of Cd via MICP. Precipitates characterization further confirmed coprecipitation of Cd with vaterite, a calcium carbonate polymorph. These findings elucidate an important role of biosorption in Cd immobilization during MICP, highlighting the need to evaluate removal mechanisms when assessing bacterial MICP potential, as different mechanisms can lead to distinct long-term stability outcomes.

PMID 42553454
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PubMedJournal of the science of food and agriculture2026-08-05

Study on the changes and mechanisms on the quality of beef tripe during tenderization.

Yu Peipei P, Zhu Shijin S, Wang Lishi L, Gao Pei P et al.

The quality characteristics of salted beef tripe were investigated throughout the multi-stage tenderization process, encompassing cleaning, pre-cooking, alkaline treatment (sodium carbonate), water soaking and final cooking. The underlying tenderization mechanism was elucidated through the assessment of collagen content, water status and microstructural evolution. Alkaline treatment with sodium carbonate functions as a highly effective approach to tenderize salted beef tripe. Morphological observations demonstrated a sequential transformation characterized by tissue expansion post-washing, followed by contraction after pre-cooking. Sodium carbonate treatment served as the pivotal tenderization step, inducing pronounced tissue swelling and structural integrity. Water distribution analysis revealed significant dynamic shifts in free and immobile water proportions during tenderization. Free water exhibited an initial increase, followed by a decrease and subsequent rebound, whereas immobile water inversely decreased, increased and then declined. Scanning electron microscopy revealed structural evolution in salted beef tripe: transitioning from a compact morphology to distinct muscle fiber organization post-cleaning, followed by fiber fragmentation after sodium carbonate treatment. Texture analysis demonstrated a substantial reduction in shear force confirming the efficacy of alkaline tenderization. This study provided a theoretical and practical basis for controlling the tenderization process and quality of salted beef tripe. © 2026 Society of Chemical Industry.

PMID 42554220
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PubMedAngewandte Chemie (International ed. in English)2026-08-05

Redox-Pathway Reconstruction in Carbonate Electrolyte to Achieve Durable Na─S Battery.

Liu Mengting M, Hu Ling-Jiao LJ, Wang Long L, Guan Zhao-Kun ZK et al.

The practical performance of room-temperature sodium-sulfur (RT Na─S) batteries in low-solubility carbonate electrolytes is fundamentally constrained by slow "solid-solid" sulfur conversion, causing incomplete redox reactions and rapid capacity fading. Herein, we propose a catalytic strategy via "confinement-pyrolysis" that restructures this static reaction into a dynamic "solid-liquid-solid" pathway. By employing a hierarchical porous framework with atomically dispersed metal sites, the conversion kinetics of sodium polysulfides (NaPSs) are dramatically accelerated. This reconstruction enables continuous liquid-phase intermediates and circumvents the high diffusion barriers of solid-state reactions, as confirmed by density functional theory (DFT) calculations. By simulating long-term cycling through controlled Na2S deposition, we employed local dipole moment change (Δμ) tracking to reveal the exceptional electronic structure stability and effective lowering of key energy barriers during long-term cycling. As a result, the Fe-N-C/S cathode exhibits outstanding electrochemical performance, delivering a reversible capacity of 799 mAh g-1 at 1 Ag-1 with a capacity decay rate of 0.075% per cycle, and exhibiting an ultralow capacity decay rate of 0.024% per cycle over 2000 cycles at 2 Ag-1. This work elucidates that redox-pathway reconstruction is a pivotal strategy to overcome the inherent kinetic limitations of the conventional mode in carbonate-based Na─S batteries.

PMID 42554371
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PubMedCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2026-08-05

Stent Underexpansion Prediction Is Improved by Intravascular Ultrasound-Based Distance-Averaged Calcium Angles.

Wang Jia-Jie JJ, Liu Hang H, Yao Yian Y, Wu Minyu M et al.

Calcified coronary lesion, assessed by intravascular ultrasound (IVUS)-based maximum calcium angle, is an important predictor for stent underexpansion. We aimed to determine whether the mean of all calcium angles measured within a specified distance from the maximum calcium site (distance-averaged) using IVUS was associated with stent underexpansion. Patients undergoing IVUS-guided percutaneous coronary intervention (PCI) with drug-eluting stent implantation between 2016 and 2022 in a single tertiary center were retrospectively analyzed. Pre-PCI IVUS was used to assess the angles of calcified plaque every 1 mm; a total of 11 calcium angles were measured within 5 mm of the maximum calcium site. The endpoint was percent stent expansion, and stent underexpansion was defined as percent stent expansion < 70%. In the analysis of 87 stent underexpansions that occurred among 292 patients, distance-averaged calcium angles were significantly associated with stent underexpansion. Discrimination increased when using distance-averaged calcium angles instead of maximum calcium angle, with the area under the receiver operating characteristic curve (AUC) ranging from 0.75 (95% CI, 0.69-0.82) for 10 mm-averaged calcium angles to 0.77 (95% CI, 0.72-0.83) for 2 mm-averaged calcium angles (p < 0.05). Compared to 2 mm-averaged calcium angles, increasing measuring distance did not result in significant improvement in AUC. Distance-averaged calcium angles were associated with stent underexpansion. Compared with maximum calcium angle, distance-averaged calcium angles improved the prediction of stent underexpansion. Among these, 2 mm-averaged calcium angles may be a simpler, equally accurate approach to predicting stent underexpansion.

PMID 42552752
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PubMedJournal of clinical ultrasound : JCU2026-08-05

Maternal Calcium Intake and Fetal Myocardial Performance: Prospective Mid-Gestation Echocardiography Findings Based on Questionnaire-Derived Dietary Calcium Assessment.

Demir Fatma Nazlı FN, Atalan Sümeyye Begüm SB, Kayıkçı Umutcan U, Sabır Yeliz Acar YA et al.

To investigate whether maternal dietary calcium intake during early pregnancy is associated with fetal cardiac function at mid-gestation, given the heghtened dependence of the fetal myocardium on extracellular calcium and the lack of previous studies addressing this relationship. This prospective observational study was conducted at Kastamonu Training and Research Hospital between August and November 2025. Pregnant individuals undergoing routine fetal anomaly screening were recruited. Maternal calcium intake over the preceding 3 months was quantified through a calcium-specific food frequency questionnaire. Fetal echocardiography was performed between 18 and 22 weeks of gestation by a single experienced operator. Left and right ventricular myocardial performance indices (MPI), isovolumic intervals, ejection times, E/A ratios, and cardiac morphometrics were measured. Continuous variables were analyzed using Spearman correlation and Mann-Whitney U tests, with significance defined as p < 0.05. A total of 147 participants were analyzed. Maternal calcium intake showed no significant correlations with any fetal cardiac functional parameter, including LV-IVRT (r = -0.035), LV-IVCT (r = -0.058), LV-ET (r = 0.087), MV-TEI (r = -0.102), RV-TEI (r = 0.000), or ventricular filling indices. Categorization by intake < 800 mg/day versus ≥ 800 mg/day similarly revealed no differences in systolic, diastolic, or global cardiac function (all p > 0.13). Dairy products constituted 68.6% of total calcium intake. No statistically significant association was identified between maternal total calcium intake and fetal cardiac function at mid-gestation in this cohort. However, the study may not have been sufficiently powered to exclude small differences in myocardial performance indices. In addition, the absence of an observed association may reflect physiological placental buffering of maternal calcium homeostasis or a temporal mismatch between the period of calcium exposure assessment and fetal functional evaluation. Future studies involving populations with low habitual calcium intake and incorporating biochemical markers are warranted.

PMID 42554437
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PubMedCureus2026-08-05

Use of Antibiotic-Eluting Calcium Sulfate in the Management of Post-surgical Spinal Infections and Spondylodiscitis: A Case Series.

Dave Bharatkumar R BR, Krishnan Ajay A, Mayi Shivanand C SC, Rai Ravi Ranjan RR et al.

Postoperative spinal infections, including spondylodiscitis and surgical site infections (SSI) following instrumentation, remain significant complications associated with considerable morbidity and complex management. Standard treatment often involves extensive surgical debridement, implant removal or revision, and prolonged systemic antibiotic therapy; however, achieving adequate local antibiotic concentrations can be challenging. In this retrospective case series, we evaluate the use of bioabsorbable calcium sulfate as a local antibiotic delivery system in eight adult patients (≥18 years; four women; mean age: 58.6 years) managed for post-instrumentation spinal infections between 2021 and 2025. Patient inclusion required a confirmed deep surgical site infection or spondylodiscitis with implant involvement, while patients with severe renal impairment or superficial infections were excluded. Surgical management included thorough debridement combined with implant removal or revision and, where indicated, reconstructive procedures such as corpectomy and interbody fusion. Antibiotic-loaded calcium sulfate (Stimulan, Biocomposites Ltd., Staffordshire, United Kingdom) beads were used for local antibiotic delivery based on intraoperative assessment and microbiological considerations. All patients tolerated the procedure well, with no immediate complications attributable to the calcium sulfate implantation. Favorable clinical outcomes were observed in all cases, with the resolution of symptoms, normalization of inflammatory markers, and radiological evidence of infection control during follow-up. The mean duration of hospital stay was 6.0 days. These findings suggest that antibiotic-eluting calcium sulfate is a safe and effective adjunct in the management of postoperative spinal infections, facilitating targeted local antibiotic delivery and contributing to successful infection control.

PMID 42553571
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