Reliance Life Sciences Private Limited · FSHR · 重组蛋白
recombinant FSH 是一种重组蛋白，由Reliance Life Sciences Private Limited研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。
| 商品名 | FostiRel |
| 公司 | Reliance Life Sciences Private Limited |
| 药物类别 | 重组蛋白 |
| 分子靶点 | FSHR |
| 给药途径 | Injectable (Others), Subcutaneous Injection |
| 状态 | Approved |
recombinant FSH 作用于 1 个分子靶点：
| FSHR | follicle stimulating hormone receptor (FSHRO, ODG1) |
recombinant FSH 针对 1 个适应症，涉及 1 个治疗领域。
| 治疗领域 | 疾病/病症 | 分期 |
|---|---|---|
| Reproductive system and breast disorders | Infertility female | ✓ Approved |
Frontiers Production Office
[This corrects the article DOI: 10.3389/fmicb.2026.1806270.].
Nishida Kei K, Horinouchi Yuma Y, Mie Masayasu M, Kobatake Eiry E
Anti-fouling of material surfaces is a major concern in the performance of biomedical materials in biological environments. Surface modification of polymeric materials is an effective strategy for controlling the anti-fouling properties of biomedical materials. Synthetic polymers such as poly(ethylene glycol) (PEG), which exhibit high bioinertness and anti-fouling properties, are widely used. Peptide-based anti-fouling materials are gaining attention because of their biocompatibility, long-term biodegradability, and structural diversity. In this study, we explored the potential of antifreeze protein type I (AFP) from winter flounder as a peptide-based anti-fouling material. AFP possesses a simple α-helical structure of approximately 30 amino acid residues and presents an amphiphilic interface consisting of an ice-binding surface and a hydrophilic surface. We constructed a recombinant AFP that can be modified on a glass substrate and evaluated its anti-fouling properties. The AFP-modified substrates significantly suppressed the adsorption of plasma proteins, such as human albumin, fibrinogen, and fibronectin. Furthermore, adhesion of human ovarian cancer SKOV3 cells and mouse platelets to the substrates was suppressed by AFP modification. Notably, tandem-repeat AFP constructs exhibited high resistance to proteolytic enzymes, such as trypsin. These findings highlight the potential of recombinant AFP as a potential peptide-based anti-fouling material for biomedical applications.
Ye Tian T, Fan Wenqian W, Du Linqing L, Li Jing J et al.
In controlled ovarian stimulation (COS) cycles, premature progesterone elevation (PPE) on the HCG trigger day is associated with adverse pregnancy outcomes after in vitro fertilization-embryo transfer (IVF-ET). The aim of this study was to analyze the influencing factors of PPE with the early-follicular phase long-acting GnRH-a long protocol (EFLL) and to explore a dynamic risk-assessment nomogram for PPE to inform risk stratification and early clinical adjustment. This was a single-center, retrospective cohort study. Patients who underwent their first IVF cycle at our center from January 2019 to December 2019 were included. All patients were treated with the EFLL protocol. Patients were randomly assigned to the training or validation cohort for nomogram development and testing at a ratio of 8:2. After excluding collinear variables, the remaining candidate predictors were screened by the LASSO regression model, and the nomogram was constructed by multivariate logistic regression analysis. Receiver operating characteristic (ROC) curves and calibration curves with bootstrap were used to evaluate the performance of the nomogram. DCA was used to analyze the clinical efficacy of the model. A total of 5193 cycles were included-4154 cycles in the training cohort and 1039 cycles in the validation cohort. The incidence of PPE in the training cohort was 20.51%. Multivariate logistic regression showed that BMI, basal FSH, basal progesterone (bP), AMH, AFC, total duration of Gn, total dosage of exogenous HMG, FSH and P on the 6th day of Gn were found to be independent influencing factors of PPE, and a nomogram model was constructed accordingly. The areas under the ROC curves of the training cohort and the validation cohort were 0.683 (95% CI = 0.663-0.702) and 0.622 (95% CI = 0.583-0.662), respectively. The calibration curve showed that the predicted risk of the model was in good agreement with the actual results in both cohorts. Decision curve analysis (DCA) demonstrated the clinical value of this nomogram. Our nomogram for estimating PPE demonstrates modest discriminative ability and may serve as a preliminary risk stratification tool in COS cycles. It may assist clinicians in identifying patients at higher risk of PPE, thereby informing clinical judgment.
Refaat Marina M, Sebakhy Khaled O KO, Saad Menna-T-Allah M MM, ElRakaiby Marwa M et al.
Phenolic compounds pose a major threat to water pollution due to their high toxicity. Enzymes have emerged over recent years to act as a green alternative for cleaning up and utilizing phenolic compounds in nature. DyP peroxidases, a member of the oxidoreductase family, have shown promising ability to convert dyes into harmless compounds and have been found indispensable tools for green polymerization. In this study, three recombinant DyP peroxidases were used to convert pyrogallol (PG) into a polymer which upon characterization using Fourier-transform infrared spectroscopy (FT-IR), Raman spectroscopy, powder X-ray diffraction (XRD) and scanning electron microscopy (SEM) have revealed intricate details characteristic of poly(pyrogallol) (PPG). The synthesized polymer showed a rigid structure, with potential use in material science applications such as coatings or binding agents, as well as broader aspects in environmental and biomedical research.
Wolff Andrea A, Dahlen Ivy I, Singavi Arun A
A 75-year-old female with no prior history of bleeding disorders presented to the emergency department with spontaneous sublingual hematoma, hemarthrosis, hemotympanum, and cutaneous ecchymoses. She denied anticoagulant use, recent trauma, or underlying systemic disease. Initial laboratory findings revealed an isolated prolonged activated partial thromboplastin time (aPTT) that failed to correct with mixing studies. Factor VIII activity was markedly reduced, and the presence of factor VIII inhibitors was confirmed, leading to a diagnosis of acquired hemophilia A (AHA). Management included recombinant activated factor VII (rFVIIa) for hemostatic control, corticosteroids for immunosuppression, and weekly rituximab for inhibitor eradication. During her hospital course, serial monitoring demonstrated a decreasing inhibitor titer and improving coagulation profile. She was discharged and completed four weeks of rituximab and a steroid taper, with complete normalization of coagulation profile and inhibitor eradication within four weeks. This case underscores the importance of recognizing AHA in patients with unexplained bleeding and prolonged aPTT. Prompt diagnosis and targeted therapy are critical in reducing morbidity and mortality associated with this rare but potentially life-threatening disorder.1,2. Acquired hemophilia A, spontaneous bleeding, factor VIII inhibitors, prolonged aPTT, Bethesda assay, recombinant activated factor VII (rFVIIa), immunosuppressive therapy.
Zhu Sihui S, Tang Haibao H, Jones Tyler T, Fumia Nathan N et al.
Variations of meiosis, which normally halve genetic complements prior to fertilization, can have profound consequences. For example, whole-genome duplications (polyploidy) have shaped the evolution and diversification of most angiosperm lineages. The century-long success of sugarcane interspecific hybrids has been attributed to unusual female restitution-an unreduced maternal gamete fusing with a normal haploid paternal gamete1,2. Here we generated haplotype-resolved genomes of octoploid Saccharum officinarum LA Purple and decaploid Saccharum spontaneum US56-14-4. Eight F1 hybrids between these species exhibited 2:1 maternal to paternal genomic ratios, with 2 assemblies revealing canonical haploid sets of approximately 40 paternal and approximately 80 maternal chromosomes. The maternal chromosomes comprise 40 pairs of duplicated, partially recombined sister chromatids that retain around 62.5% of maternal genetic diversity, characteristic of second division restitution. Using single-molecule long-read sequencing and a novel algorithm that is broadly applicable to polyploid genomes, we identified two classes of recombination breakpoints, including a previously unrecognized configuration supported by both recombinant and non-recombinant reads, across all hybrids and diagnostic of second division restitution. These findings resolve a century-old cytological debate, add new insights into meiotic variations, and offer a genomic approach to accelerate genetic gain in this globally critical sugar and bioenergy crop.
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