minocycline hydrochloride

✓ Approved

什么是 minocycline hydrochloride？

minocycline hydrochloride 是一种小分子，由PreCision Dermatology研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

公司	PreCision Dermatology
药物类别	小分子
给药途径	Oral (PO)
状态	Approved

来源： ClinicalTrials.gov, PreCision Dermatology

治疗适应症

minocycline hydrochloride 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域	疾病/病症	分期
Infections and infestations	Streptococcal infection	✓ Approved

相关研究文献

PubMedJournal of chromatography. A2026-08-09

AQbD-guided development of a robust and green SI-RP-HPLC method for impurity profiling of an efonidipine hydrochloride ethanolate and chlorthalidone combination, with LC-MS and NMR-based identification of degradation product in efonidipine.

Bang Pranav S PS, Choudhari Vishnu P VP, Gharge Vikram S VS

Efonidipine Hydrochloride Ethanolate (EHE) and Chlorthalidone (CTD) are co-formulated for the management of hypertension owing to their complementary pharmacological actions. Ensuring accurate impurity profiling in such combination formulations is vital for maintaining drug stability, safety and regulatory compliance. However, conventional analytical techniques often face challenges related to sustainability and robustness. Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) remains a key analytical approach for impurity determination, yet the integration of Quality by Design (QbD) principles into its development is still evolving. The present study focuses on developing a novel, sustainable RP-HPLC method for impurity profiling of EHE and CTD tablets using a QbD approach and green chemistry. Chromatographic separation was achieved on a Zorbax SB C8 column (150 mm × 4.6 mm, 5 µm). Critical method parameters such as mobile phase composition and pH were systematically optimized through QbD to enhance method robustness. A photolytic degradation product of EHE was identified as Efonidipine Related Compound A, and a plausible photolytic degradation pathway was proposed. A photolytic degradation product was identified in the LC-MS and its structure was confirmed through NMR spectroscopy. The developed green method exhibited excellent resolution, precision and reproducibility across multiple batches, allowing for effective separation and quantification of impurities. This green QbD-optimized, environmentally sustainable RP-HPLC method provides a reliable and scalable solution for impurity profiling in complex pharmaceutical formulations, aligning with modern quality control and regulatory expectations.

PMID 42570622

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PubMedScientific reports2026-08-09

Dual mechanisms of peroxymonosulfate activation by a CoCuLDH/CoCuMOF composite for pollutant degradation via radical and nonradical pathways.

Mahmoud Aya S AS, Rabie Abdelrahman M AM

Peroxymonosulfate (PMS)-based advanced oxidation processes have attracted considerable attention for degrading persistent organic pollutants in wastewater. However, developing efficient and stable catalysts for PMS activation remains a challenge. This study aims to design hybrid catalysts combining layered double hydroxide (LDH) and metal-organic framework (MOF) structures to enhance catalytic performance through interfacial synergy. Two bimetallic composites, CoCu-LDH@CoCu-MOF (LM) and CoCu-MOF@CoCu-LDH (ML), were synthesized and characterized using X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, Brunauer-Emmett-Teller analysis, scanning electron microscopy, and transmission electron microscopy. Their catalytic performance was evaluated in PMS-activated degradation of organic pollutants under optimized conditions, supported by radical quenching and reusability tests. LM showed superior catalytic activity, achieving 98.9% degradation of methylene blue (MB) within 10 min., and effectively degrading other pollutants Under the same optimized conditions, the LM/PMS system also achieved 99.6% removal of crystal violet (CV) and complete (100%) removal of malachite green (MG) within 10 min, along with 91.1% removal of p-nitrophenol (PNP) and 82.7% removal of tetracycline hydrochloride (TCH) within the same time frame, confirming the broad applicability of the system toward structurally diverse organic contaminants. Mechanistic studies indicated that singlet oxygen (1O2) was the dominant reactive species, with additional contributions from hydroxyl, sulfate, and superoxide radicals. The catalyst retained 96.9% removal efficiency after three cycles. This performance is attributed to the synergistic LDH-MOF interface, which enhances reactive species generation and provides abundant active sites for efficient PMS activation.

PMID 42570977

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PubMedFrontiers in cellular and infection microbiology2026-08-08

Genomic characterization of carbapenem-resistant Acinetobacter baumannii from a specialized orthopaedic hospital in Southeast China, with phenotypic analysis of biofilm formation.

Shi Tengfei T, Xu Shaohan S, Zheng Xuexin X, Shi Weiqiang W et al.

Carbapenem-resistant Acinetobacter baumannii (CRAB) is a major threat to hospitalised patients, particularly in intensive care units and orthopaedic wards where implant-associated infections are common. However, the genomic and biofilm characteristics of CRAB in orthopaedic specialty hospitals remain poorly understood. A total of 97 non-duplicate CRAB isolates collected between 2024 and 2025 were included. Antimicrobial susceptibility testing was performed using the VITEK-2 system, and biofilm formation was quantitatively assessed by the crystal violet method. Whole-genome sequencing (WGS) was carried out on the Illumina platform to analyse multilocus sequence typing (MLST), capsular types, resistance genes and virulence genes. A phylogenetic tree was constructed based on single-nucleotide polymorphisms (SNPs). ST2 was the dominant clone (95.88%) among the 97 isolates, and KL3 was the most prevalent capsular type (83.51%). All isolates carried intrinsic blaOXA-51-like genes, predominantly blaOXA-66 (95.88%). The most common acquired carbapenemase gene was blaOXA-23 (98.97%), and two isolates carried metallo-β-lactamase (MBL) genes (blaNDM-1 and blaNDM-5, respectively). All isolates exhibited a multidrug-resistant phenotype, with low resistance rates to tigecycline (6.19%) and minocycline (7.22%), and all remained susceptible to colistin. Strong biofilm formers accounted for 91.75% of isolates, and the carriage rates of biofilm-associated genes (bap, csuABCDE, pgaABCD) exceeded 90%. Phylogenetic analysis grouped the isolates into three clonal clades, with the majority (88.66%) falling into Clade C (ST2/KL3). This clade had been circulating in China as an outbreak lineage since 2018, gradually replacing Clade B (ST2/KL2), and became the dominant clone in 2024-2025. CRAB isolates in this orthopaedic specialty hospital are dominated by the ST2/KL3 clone, which carries multiple resistance and virulence genes, exhibits a remarkably strong biofilm-forming ability, and shows a capsular switch trend from KL2 to KL3. Enhanced molecular surveillance of this dominant clone and increased attention to anti-biofilm strategies for orthopaedic implant-related infections are strongly recommended.

PMID 42568602

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PubMedVeterinary journal (London, England : 1997)2026-08-08

Injectable antibiotics reprogram the gut microbiota-immune-resistome axis in ducks before detectable changes in growth performance.

Li Xiaokun X, Xia Yingjia Y, Fan Jingbo J, Jiang Fengxi F et al.

The widespread use of injectable antibiotics in intensive poultry production disrupts gut microbial balance and host immune function, potentially affecting nutrient utilization and promoting antimicrobial resistance. To assess the effects of injectable antibiotics on the gut microbiota, host immunity, tissue accumulation, and antimicrobial resistance in ducks, we systematically evaluated six commonly used injectable antibiotics-gentamicin sulfate, oxytetracycline, florfenicol, tylosin tartrate, lincomycin hydrochloride, and enrofloxacin. Although no statistically significant differences were observed in the feed conversion ratio and organ indices over the 28-day trial, antibiotic exposure disrupted microbiota-organ associations, suggesting subclinical effects despite the absence of detectable phenotypic differences. Enzyme-linked immunosorbent assay results showed a clear class-dependent accumulation of antibiotics in muscle tissues, with tylosin tartrate and enrofloxacin persisting through day 28. Single-molecule real-time full-length 16S rRNA sequencing revealed a significant decline in Escherichia coli abundance and an enrichment of several Gram-positive taxa, indicating a marked restructuring of the gut microbiota following antibiotic exposure. Antibiotic residues in tissues were associated with drug-specific enrichment patterns of antibiotic resistance genes (ARGs) and altered host innate immune-related transcriptional profiles, including changes in inflammatory cytokine expression (IL-6, IL-10, and TNF-α). Furthermore, an integrative microbiota-immunity-residue-ARG network was constructed, revealing a conserved association framework centered on TLR2, NF-κB1, TLR4, and IL-6 as network hubs. Collectively, these findings indicate that injectable antibiotics are associated with coordinated alterations in host-microbiota-resistance interactions before measurable growth changes occur. These results provide an integrative framework for evaluating antibiotic-associated risks in poultry production.

PMID 42551728

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PubMedResearch and practice in thrombosis and haemostasis2026-08-08

Identification of a protein S-binding site in the C2 domain of factor VIII light chain.

Furukawa Shoko S, Takeyama Masahiro M, Nogami Keiji K

We demonstrated that protein S (PS) directly impairs the intrinsic tenase complex, independent of activated protein C (APC), by competitively inhibiting the binding of factor (F)IXa to the A2 domain (residues 488-490) and light chain (LCh) of FVIIIa. This study investigated the PS-binding sites within the FVIII-LCh subunit. Binding interactions between PS and the FVIII-LCh were characterized using ELISA, a synthetic C2-domain peptide (residues 2228-2240), and surface plasmon resonance. The interacting residue was examined using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride-mediated crosslinking and N-terminal sequencing. The functional role of the identified site (K2239) was evaluated using recombinant FVIII mutants and FXa generation assays assessing sensitivity to PS-mediated and APC/PS-mediated inhibition. PS bound to the FVIII-C2 domain and competitively inhibited FIXa binding to the LCh. Using a synthetic peptide (2228-2240) and crosslinking, lysine 2239 (K2239) was identified as a residue contributing to PS interaction. A recombinant FVIII-K2239A mutant showed reduced binding affinity to PS (K d, 6.7 vs 3.5 nM) and impaired PS-mediated inhibition of FXa generation. This effect was additive with mutations in the previously identified A2-domain site (S488A/R489A/R490A). Importantly, while the A2 site contributed to APC/PS-dependent inactivation, the contribution of K2239 to this process appeared limited, suggesting a more prominent role in the APC-independent pathway. Factor VIII residues 488 to 490 and 2239 participate in APC-independent interaction with PS, while residues 488 to 490 also contribute to the APC/PS-dependent inactivation of FVIIIa.

PMID 42568798

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PubMedEcotoxicology and environmental safety2026-08-08

Enrichment of bile salt hydrolase-producing bacteria mediated by tetracycline resistance genes is associated with intestinal barrier damage in Rana chensinensis tadpoles.

Pei Yuebin Y, Xu Zhangying Z, Xie Lei L, Wang Hongyuan H

Tetracycline (TET) is a pervasive contaminant in aquatic environments, yet how it reshapes gut microbiota composition and function to influence bile acid (BA) profiles and intestinal health remains poorly understood. In this study, Rana chensinensis tadpoles at Gosner stage 26 (Gs26) were exposed to environmentally relevant concentrations of tetracycline hydrochloride (10 and 100 μg/L) until metamorphic climax Gs38 and examined using a multi-pronged approach integrating histological analysis, intestinal targeted BA metabolomics, and fecal metagenomic sequencing. Our results showed that TET exposure disrupted intestinal barrier integrity in a dose-dependent manner, as evidenced by reduced enterocyte height, widened intercellular spaces, and irregular nuclear morphology. Metagenomic profiling revealed that TET treatment significantly enriched tetracycline resistance genes (e.g., tet(Q), tet(T), tetA(46), tetA(60)), which was accompanied by an increased abundance of bile salt hydrolase (BSH)-producing bacteria, including Bacteroides, Parabacteroides, and Vibrio. This microbial shift was accompanied by enhanced BA deconjugation, as reflected by a significantly increased ratio of unconjugated to conjugated BAs (p < 0.01). Notably, the enhanced deconjugation activity was paralleled by a marked accumulation of the hydrophobic and cytotoxic BA, chenodeoxycholic acid (CDCA) (p < 0.001), which was accompanied by a 73.9% reduction in total BA levels - a pattern that may reflect Farnesoid X Receptor (FXR)-mediated negative feedback regulation of hepatic BA synthesis, although this pathway was not directly examined. Furthermore, elevated CDCA levels were associated with intestinal histopathological damage. Collectively, these findings suggest a potential mechanistic cascade in which TET-induced enrichment of antibiotic resistance genes is associated with the expansion of BSH-active microbiota, together with disrupted BA homeostasis and compromised intestinal barrier function in amphibians. Causal relationships within this cascade await functional validation. Our study highlights the hidden ecological risks of antibiotic contamination in aquatic ecosystems and underscores the need for further molecular investigations into the signaling pathways involved.

PMID 42566872

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minocycline hydrochloride

什么是 minocycline hydrochloride？

药物档案

治疗适应症

相关研究文献

AQbD-guided development of a robust and green SI-RP-HPLC method for impurity profiling of an efonidipine hydrochloride ethanolate and chlorthalidone combination, with LC-MS and NMR-based identification of degradation product in efonidipine.

Dual mechanisms of peroxymonosulfate activation by a CoCuLDH/CoCuMOF composite for pollutant degradation via radical and nonradical pathways.

Genomic characterization of carbapenem-resistant Acinetobacter baumannii from a specialized orthopaedic hospital in Southeast China, with phenotypic analysis of biofilm formation.

Injectable antibiotics reprogram the gut microbiota-immune-resistome axis in ducks before detectable changes in growth performance.

Identification of a protein S-binding site in the C2 domain of factor VIII light chain.

Enrichment of bile salt hydrolase-producing bacteria mediated by tetracycline resistance genes is associated with intestinal barrier damage in Rana chensinensis tadpoles.

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