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minocycline hydrochloride

✓ Approved

PreCision Dermatology · 小分子 · 小分子

什么是 minocycline hydrochloride？

minocycline hydrochloride 是一种小分子，由PreCision Dermatology研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

公司PreCision Dermatology
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, PreCision Dermatology

治疗适应症

minocycline hydrochloride 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Infections and infestationsStreptococcal infection✓ Approved

相关研究文献

PubMedBMJ open2026-06-13

Minocycline hydrochloride ointment-assisted periodontal treatment of stage III/IV periodontitis associated with type 2 diabetes mellitus targeting Chinese people: study protocol for a randomised controlled trial.

Zhao Hongqiao H, Lin Sichi S, He Lu L, Zhen Min M et al.

Scaling and root planing (SRP) combined with adjunctive antibiotic therapy is widely adopted in the management of periodontitis in patients with type 2 diabetes mellitus (T2DM), with the aims of ameliorating glycaemic control, alleviating local inflammation and facilitating periodontal tissue regeneration. As a topically administered adjunctive antibiotic for periodontal treatment, minocycline hydrochloride (MH) ointment has shown favourable clinical efficacy in systemically healthy patients with periodontitis. However, robust evidence supporting its clinical efficacy and potential glycaemic-improving effects in patients with periodontitis complicated by T2DM remains limited. The present study is designed to test the null hypothesis that no significant differences in clinical outcomes exist between SRP combined with MH and SRP alone in the management of periodontitis among patients with T2DM, with its primary objective to investigate whether MH as an SRP adjunct confers superior clinical benefits to SRP alone. We will conduct a randomised, single-blind, placebo-controlled clinical trial. 56 patients with T2DM-associated stage III/IV periodontitis will be recruited from the Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China. Eligible participants will be randomised into two groups: the experimental group will undergo SRP combined with topically administered MH ointment and the control group will undergo SRP with a matched placebo. The primary outcomes will include probing depth (PD) changes at periodontal pocket sites with a baseline PD ≥6 mm at 6 months post-baseline, with a specific focus on the percentage of such sites with PD reduced to ≤5 mm. The secondary outcomes will comprise PD changes at pocket sites with a baseline PD ≥5 mm at 6 months post-baseline, as well as clinical attachment loss, the plaque index, bleeding index, the levels of IL-1β, IL-17, calprotectin and insulin levels in gingival crevicular fluid and serum, complete blood count, blood biochemistry, including glycated haemoglobin levels, and the composition of subgingival plaques at baseline, and 2 and 6 months post-baseline. This study was approved by the Ethics Committee of Peking University School and Hospital of Stomatology (PKUSSIRB-2024102139b). Results will be published in a peer-reviewed scientific journal. ChiCTR2400092305. V.3.1 (date: 6 January 2026).

PMID 42285579
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PubMedCarbohydrate polymers2026-06-13

In situ NMR investigation of the native chemical ligation (NCL) of N-terminal cysteines to alginate.

Bučak Gasser David D, Steindorfer Tobias T, Neshchadin Dmytro D, Gescheidt Georg G et al.

Polysaccharide-peptide conjugates constitute an important class of biomaterials for tissue engineering scaffolds and glycoconjugate vaccines. Yet, benign and chemoselective synthetic strategies that operate under aqueous, physiologically relevant conditions remain scarce. Herein, we present a proof-of-concept approach for the traceless conjugation of N-terminal l-cysteines to alginate. A glycine-derived thioester functionality was synthesized and covalently introduced onto the uronic acid residues of alginate (DS = 0.47), as confirmed by 1H and 13C NMR and ATR-IR spectroscopy. The resulting alginate-thioester derivative served as a hydrolytically stable and chemoselective reactive handle for the native chemical ligation (NCL) of l-cysteine hydrochloride (l-cys·HCl) and the dipeptide l-cysteinylglycine (l-cys-gly). The ligation reactions were monitored in situ by kinetic 1H NMR spectroscopy. Control experiments of the alginate-thioester derivative with alternative biological nucleophiles glycine and l-lysine showed no reactivity (1H NMR), thus confirming the selectivity toward the thiol functionality of N-terminal l-cysteines under the provided conditions (0.1 M PO43- buffer, pH 7, 25 °C). This work establishes a convenient aqueous method to prepare peptide-polysaccharide conjugates in which the peptide is linked to the polysaccharide exclusively through stable amide bonds, without the incorporation of exogenous linker molecules or the use of conventional coupling agents or protecting groups.

PMID 42285655
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PubMedAlcoholism treatment quarterly2026-06-12

10-Butyl Ether Minocycline (BEM) Reduced Ethanol Consumption in Binge Drinking Mice.

Panthagani Praneetha P, Shaik Abdul A, Liu Xiaobo X, Sanchez Jordan J et al.

Alcohol use disorder (AUD) is a complex brain disease with high morbidity, mortality, and limited treatment options, causing significant societal burden. Minocycline, well known for its anti-inflammatory and immunomodulatory properties, could potentially treat AUD but its antimicrobial activity would be inessential, and even a liability, for long-term treatment in AUD patients. 10-Butyl Ether Minocycline (BEM) was synthesized to retain minocycline's off-target actions and eliminate antimicrobial properties. We hypothesized that BEM would reduce high ethanol consumption in common murine models of binge drinking without affecting ethanol elimination. The Drinking-In-the-Dark (DID) paradigm was used to assess BEM's efficacy in reducing binge-like ethanol consumption. BEM dose-responsively reduced ethanol consumption in both female and male mice. Ethanol elimination following administration of both BEM and ethanol was evaluated using gas chromatography. BEM had no effect on ethanol metabolism in either sex, suggesting that its mechanism is independent and, thus, should not exacerbate ethanol-related toxicity when the two are taken together. Previous findings showed BEM effectively reduced chronic ethanol consumption. Future studies are underway to evaluate BEM's potential as an AUD treatment, which so far have shown BEM to be safer than minocycline and inexpensive to produce.

PMID 42282118
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PubMedAntimicrobial agents and chemotherapy2026-06-12

Molecular epidemiology and emerging tet(X)-associated resistance of Elizabethkingia spp. in Taiwan, 2016-2022.

Huang Yu-Tsung Y-T, Kao Cheng-Yen C-Y, Kuo Han-Yueh H-Y, Kao Li-Ting L-T et al.

Elizabethkingia species are opportunistic gram-negative pathogens associated with nosocomial infections and limited therapeutic options. Longitudinal data characterizing antimicrobial resistance and molecular determinants in Taiwan remain scarce. A total of 191 non-duplicate Elizabethkingia clinical isolates were collected at the National Taiwan University Hospital between 2016 and 2022. Species identification was confirmed by 16S rRNA sequencing. Elizabethkingia anophelis predominated (81.7%), followed by E. meningoseptica (9.9%) and E. miricola (7.9%). No major clone was identified. Genes involved in sialic acid metabolism were detected as follows: glmS in 93.2% (178/191), glmM in 97.4% (186/191), nagB in 98.4% (188/191), neuC2 in 24.5% (46/191), and neuC in 2.1% (4/191) of isolates. Antimicrobial susceptibility testing showed very high nonsusceptibility for most agents (≥99.5%). Lower rates of nonsusceptibility were observed for levofloxacin (MIC50/MIC90 = 1/>8 µg/mL; 68.6% susceptible), ciprofloxacin (2/>4 µg/mL; 49.2%), tigecycline (4/>8 µg/mL; 23.0%), and rifampin (>8/>16 µg/mL; 19.9%). Using the breakpoint for other non-Enterobacterales, minocycline was active against all isolates (100.0%, 191/191); however, applying the S. maltophilia criteria, 42 isolates (22.0%) were nonsusceptible to minocycline. Among tetracycline determinants, tet(X) was detected in 22 isolates (11.5%) and tet(K) in 2 isolates (1.0%). With the criteria of S. maltophilia, 10 tet(X)-positive isolates (10/22, 45.5%) showed non-susceptibility to minocycline, implying that tet(X) may contribute to the elevated MIC of minocycline. Our surveillance revealed a rapid increase in resistance to fluoroquinolones and rifampin and the emergence of tet(X)-mediated tetracycline resistance in Elizabethkingia spp. These findings underscore the need for continued molecular monitoring and region-specific antimicrobial stewardship.

PMID 42283562
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PubMedMaterials (Basel, Switzerland)2026-06-12

Facile Preparation of a Plasmon-Enhanced Ag-CuO/TiO2 for the Efficient Visible-Light-Driven Photodegradation of Tetracycline Hydrochloride.

Cui Lianmin L, Ren Li L, Chen Zhi Z, Zhu Benfeng B et al.

Water pollution caused by antibiotics is a growing problem. Therefore, photodegradation by efficient catalysts is an environmentally friendly technology that can effectively degrade organic pollutants in water. In this work, a method was innovatively used to prepare a ternary heterostructure of plasmon-enhanced Ag-CuO/TiO2. The composite was synthesized through a facile stepwise strategy involving the formation of CuO nanorods, TiO2 coating, and subsequent deposition of Ag nanoparticles on their surface using AgNO3, enabling intimate interfacial contact among the different components. The prepared samples were characterized by XRD, HRTEM, XPS, and UV-Vis. The chemical composition of the composite Ag-CuO/TiO2 showed a Cu/Ti atomic ratio of 2.58, as well as a Ag/Cu ratio of 0.91. The UV-Vis spectrum reveals the largest absorption peak at 550 nm for the composite Ag-CuO/TiO2. The prepared Ag-CuO/TiO2 composites were applied to the visible-light degradation of tetracycline hydrochloride, with the photocatalytic degradation rate reaching 80.7% under the optimal conditions within 60 min, which is significantly better than CuO and CuO/TiO2 without silver nanoparticles. Capture experiments indicated that h+ are involved during the course of the photodegradation and that h+ are the main active substances. Furthermore, the proposed mechanism for the photodegradation of the Ag-CuO/TiO2 composites is given. It has potential applications in the treatment of organic pollutants in water.

PMID 42279842
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PubMedMaterials (Basel, Switzerland)2026-06-12

Revealing the pH-Dependent Adsorption Dynamics of Tetracycline Hydrochloride on Phosphoric Acid-Activated Corncob Biochar.

Zhao Qiang Q, Zhao Gaotian G, Zhang Yalei Y, Yan Yangyang Y et al.

Aquaculture wastewater containing tetracycline hydrochloride (TCH) poses significant environmental problems and health risks. We investigated the adsorption of TCH onto phosphoric acid-activated corncob biochar (PCC) as a sustainable and efficient removal strategy. PCC was synthesized from cob feedstock activated by phosphoric acid under a pyrolysis temperature of 300 °C in a limited-air atmosphere. It was characterized extensively, revealing a high specific surface area (1071.75 m2/g), high porosity with total pore volume of 0.912 cm3/g, and abundant surface functional groups including phosphate, carboxylic, and amine groups. Batch adsorption experiments demonstrated an ultrahigh adsorption capacity for TCH, with a maximum theoretical capacity (Langmuir model) of 953.62 mg/g at 313 K. Its adsorption isotherms transfer from Langmuir type to Freundlich type as temperature rises, indicating a transition from monolayer to multilayer adsorption. The adsorption kinetics were governed by a synergistic mechanism involving surface adsorption and a pore-filling effect (intra-particle diffusion). Critically, the adsorption dynamics exhibit an intra-particle diffusion-controlled process at a low pH (3.0) during the final stage of adsorption. Strong hydrogen bonding led to high initial adsorption rates, and the adsorption converted to diffusion-controlled mode eventually. In contrast, at higher pH (≥7.0), electrostatic repulsion between PCC adsorbents and TCH molecules hindered intra-particle diffusion, causing the final adsorption stage to deviate from diffusion control. This work provides comprehensive insights into the pH-dependent interfacial interactions and kinetics governing TCH removal by corncob-derived, phosphoric acid-activated biochar.

PMID 42279913
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