若生智能
Drug Database
PR

propafenone hydrochloride (propafenone, SR / propafenone SR / Rythmol SR)

✓ Approved

GSK · SCN5A · 小分子

什么是 propafenone hydrochloride？

propafenone hydrochloride 是一种小分子，由GSK研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名propafenone, SR, propafenone SR, Rythmol SR
公司GSK
药物类别小分子
分子靶点SCN5A
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, GSK

作用机制

分子靶点

propafenone hydrochloride 作用于 1 个分子靶点：

SCN5Asodium voltage-gated channel alpha subunit 5 (CMD1E, SSS1)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

propafenone hydrochloride 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersAtrial fibrillation✓ Approved
Cardiac disordersVentricular fibrillation✓ Approved

相关研究文献

PubMedJournal for immunotherapy of cancer2026-06-13

Extracorporeal photopheresis versus systemic immunosuppression for treatment of immune-related adverse events: clinical outcomes from the prospective two-arm PRIA study.

Wein Lisa L, Ertl Carolin C, Ruf Theresa T, Morak Monika M et al.

Immune checkpoint inhibitor-induced immune-related adverse events (irAEs) can be steroid-refractory (sr) or steroid-dependent (sd), requiring second-line therapy. Evidence guiding optimal management of sr/sd-irAEs while preserving antitumor efficacy is scarce. This study compared extracorporeal photopheresis (ECP) with systemic immunosuppressants (IS) for treatment of sr/sd-irAEs. This prospective two-arm study included 46 patients (23 ECP, 23 IS) with 12 distinct types of irAEs across 6 tumor entities, all classified as steroid-refractory or steroid-dependent. Toxicities affected the gastrointestinal tract, skin, lung, musculoskeletal system, and serosal membranes, with up to seven prior irAE treatment lines. Patients received six cycles of ECP or investigator's choice IS over 12 weeks. Longitudinal assessments included clinical irAE outcomes, quality of life (QoL), and tumor response. ECP was more frequently used in patients with multi-toxicity (39% vs 9%; p=0.02) and multi-resistance to prior second-line immunosuppression (39% vs 17%; p=0.19). At week 12, ECP showed a lower cumulative corticosteroid exposure (395 mg vs 1,260 mg prednisolone equivalent; p=0.03), significantly improved QoL (p=0.01), and a numerically higher irAE response rate without statistical significance compared with IS (94% vs 81%; p=0.85). In advanced cutaneous melanoma, ECP was associated with superior overall survival (15 vs 10 months; p=0.02), and longer progression-free survival (9 vs 3 months; p=0.01). No significant safety concerns were observed with ECP; one fatality in the IS group was infection-related. ECP demonstrated clinical outcomes comparable to IS in sr/sd-irAEs, with significantly lower cumulative corticosteroid exposure and improved QoL. Furthermore, ECP was associated with a favorable safety profile and showed no evidence of compromised antitumor activity. A multicenter trial is planned for further investigation. NCT05700565.

PMID 42285609
阅读全文 →
PubMedJournal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC2026-06-13

Moving Beyond Unexplained Recurrent Pregnancy Loss: Are We Still Missing the Genetic Diagnosis in SOGC Guidelines?

Dahdouh Elias M EM, Sylvestre Camille C, Balayla Jacques J, Sharara Fady I FI et al.

The recently published SOGC guideline on recurrent pregnancy loss (RPL) provides a rigorous, evidence-based framework for investigation and management. However, emerging evidence suggests that contemporary genetic technologies are under-integrated. Advances in chromosome microarray analysis (CMA) and next-generation sequencing (NGS) demonstrate that fetal aneuploidy accounts for a substantial proportion of RPL, even after two losses. Systematic genetic testing of products of conception could significantly reduce the proportion of "unexplained" RPL, refine prognosis, and guide individualized management. Conditional use of preimplantation genetic testing (PGT), including PGT-A for aneuploidy and PGT-SR for structural rearrangements, in selected patients may further improve patient-centred outcomes.

PMID 42285507
阅读全文 →
PubMedBMJ open2026-06-13

Minocycline hydrochloride ointment-assisted periodontal treatment of stage III/IV periodontitis associated with type 2 diabetes mellitus targeting Chinese people: study protocol for a randomised controlled trial.

Zhao Hongqiao H, Lin Sichi S, He Lu L, Zhen Min M et al.

Scaling and root planing (SRP) combined with adjunctive antibiotic therapy is widely adopted in the management of periodontitis in patients with type 2 diabetes mellitus (T2DM), with the aims of ameliorating glycaemic control, alleviating local inflammation and facilitating periodontal tissue regeneration. As a topically administered adjunctive antibiotic for periodontal treatment, minocycline hydrochloride (MH) ointment has shown favourable clinical efficacy in systemically healthy patients with periodontitis. However, robust evidence supporting its clinical efficacy and potential glycaemic-improving effects in patients with periodontitis complicated by T2DM remains limited. The present study is designed to test the null hypothesis that no significant differences in clinical outcomes exist between SRP combined with MH and SRP alone in the management of periodontitis among patients with T2DM, with its primary objective to investigate whether MH as an SRP adjunct confers superior clinical benefits to SRP alone. We will conduct a randomised, single-blind, placebo-controlled clinical trial. 56 patients with T2DM-associated stage III/IV periodontitis will be recruited from the Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China. Eligible participants will be randomised into two groups: the experimental group will undergo SRP combined with topically administered MH ointment and the control group will undergo SRP with a matched placebo. The primary outcomes will include probing depth (PD) changes at periodontal pocket sites with a baseline PD ≥6 mm at 6 months post-baseline, with a specific focus on the percentage of such sites with PD reduced to ≤5 mm. The secondary outcomes will comprise PD changes at pocket sites with a baseline PD ≥5 mm at 6 months post-baseline, as well as clinical attachment loss, the plaque index, bleeding index, the levels of IL-1β, IL-17, calprotectin and insulin levels in gingival crevicular fluid and serum, complete blood count, blood biochemistry, including glycated haemoglobin levels, and the composition of subgingival plaques at baseline, and 2 and 6 months post-baseline. This study was approved by the Ethics Committee of Peking University School and Hospital of Stomatology (PKUSSIRB-2024102139b). Results will be published in a peer-reviewed scientific journal. ChiCTR2400092305. V.3.1 (date: 6 January 2026).

PMID 42285579
阅读全文 →
PubMedPhysical review letters2026-06-13

Probing Site-Specific Magnetism in Time-Reversal-Odd Antiferromagnet via Electric Field-Induced Nonreciprocal Directional Dichroism.

Matsumoto Koei K, Hayashida Takeshi T, Kimura Tsuyoshi T

We investigated the optical absorption spectra of the time-reversal-odd antiferromagnet ErCrO_{3} under an applied electric field (E). This material, with its two distinct magnetic sites (Er^{3+} and Cr^{3+}), exhibits successive antiferromagnetic (AFM) transitions at T_{N}≈133  K and T_{SR}≈10  K. We observed nonreciprocal directional dichroism induced by E (ENDD) in the AFM phases, spanning the near-infrared to visible light regions. The phenomenon is explained by the electrotoroidic effect, where a magnetic toroidal moment is induced by the applied electric field. We also found that the spatial distributions of ENDD-reflecting magnetic domain structures-obtained at photon energies corresponding to Er^{3+}  f-f and Cr^{3+} d-d transitions, were in good agreement. The result indicates a strong interplay between Er^{3+} 4f and Cr^{3+} 3d moments in the AFM phases of this rare-earth orthochromite. The combination of ENDD spectroscopy and microscopy is a powerful tool for elucidating site-specific magnetic information in time-reversal-odd antiferromagnets such as altermagnets.

PMID 42285062
阅读全文 →
PubMedMetallomics : integrated biometal science2026-06-13

Phosphate availability modulates elemental homeostasis in rainbow trout hepatocytes: compositional ionomics illuminates system-wide adjustments.

Jeyasingh Punidan D PD, Hrdlicka Nicholas N, Baker Kristina D KD, Sherman Ryan E RE et al.

Phosphorus (P) is central to biology, yet it remains unclear whether P limitation acts as an isolated nutrient constraint or as a perturbation to a dynamical elemental network. We tested this using the rainbow trout liver cell line RTL-W1 by manipulating phosphorus supply (0, 10% and 100% of normal supply; P0, P10, P100) and quantifying proliferation, protein content, metabolic activity, membrane integrity, and multielement composition. Phosphorus supply significantly altered cell proliferation and protein accumulation, with higher P supporting greater growth. Metabolic activity was affected by P supply, whereas membrane integrity remained largely stable, indicating altered allocation rather than generalized cellular damage. Compositional ionomic analysis revealed that phosphorus perturbation restructured the multielement network. At Day 3, treatment effects were strongest for P, K, and S. By Day 6, additional elements, including Sr and Mn, exhibited coordinated shifts relative to the P100 reference. Compositional data analysis showed that elemental imbalances shifted through time, consistent with flux rebalancing in an open system rather than static homeostasis. If phosphorus limitation were mechanistically independent, multielement composition would remain stable aside from P itself. Instead, phosphorus perturbation induced coordinated shifts across the ionome, consistent with rebalancing in open material systems.

PMID 42285544
阅读全文 →
PubMedCarbohydrate polymers2026-06-13

In situ NMR investigation of the native chemical ligation (NCL) of N-terminal cysteines to alginate.

Bučak Gasser David D, Steindorfer Tobias T, Neshchadin Dmytro D, Gescheidt Georg G et al.

Polysaccharide-peptide conjugates constitute an important class of biomaterials for tissue engineering scaffolds and glycoconjugate vaccines. Yet, benign and chemoselective synthetic strategies that operate under aqueous, physiologically relevant conditions remain scarce. Herein, we present a proof-of-concept approach for the traceless conjugation of N-terminal l-cysteines to alginate. A glycine-derived thioester functionality was synthesized and covalently introduced onto the uronic acid residues of alginate (DS = 0.47), as confirmed by 1H and 13C NMR and ATR-IR spectroscopy. The resulting alginate-thioester derivative served as a hydrolytically stable and chemoselective reactive handle for the native chemical ligation (NCL) of l-cysteine hydrochloride (l-cys·HCl) and the dipeptide l-cysteinylglycine (l-cys-gly). The ligation reactions were monitored in situ by kinetic 1H NMR spectroscopy. Control experiments of the alginate-thioester derivative with alternative biological nucleophiles glycine and l-lysine showed no reactivity (1H NMR), thus confirming the selectivity toward the thiol functionality of N-terminal l-cysteines under the provided conditions (0.1 M PO43- buffer, pH 7, 25 °C). This work establishes a convenient aqueous method to prepare peptide-polysaccharide conjugates in which the peptide is linked to the polysaccharide exclusively through stable amide bonds, without the incorporation of exogenous linker molecules or the use of conventional coupling agents or protecting groups.

PMID 42285655
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多propafenone hydrochloride