若生智能
Drug Database
PR

propafenone hydrochloride (propafenone, SR / propafenone SR / Rythmol SR)

✓ Approved

GSK · SCN5A · 小分子

什么是 propafenone hydrochloride？

propafenone hydrochloride 是一种小分子，由GSK研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名propafenone, SR, propafenone SR, Rythmol SR
公司GSK
药物类别小分子
分子靶点SCN5A
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, GSK

作用机制

分子靶点

propafenone hydrochloride 作用于 1 个分子靶点：

SCN5Asodium voltage-gated channel alpha subunit 5 (CMD1E, SSS1)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

propafenone hydrochloride 针对 2 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Cardiac disordersAtrial fibrillation✓ Approved
Cardiac disordersVentricular fibrillation✓ Approved

相关研究文献

PubMedWorld neurosurgery2026-08-08

Functional Outcome and Procedure-Related Subarachnoid Hemorrhage in Primary M2 Occlusion: Impact of Initial Thrombectomy Strategy and Procedural Factors.

Nishi Yuji Y, Sakamoto Yuki Y, Aoki Junya J, Suzuki Kentaro K et al.

The optimal thrombectomy strategy for primary middle cerebral artery M2 occlusion remains uncertain, particularly with respect to procedural safety. We retrospectively analyzed 180 consecutive patients with primary M2 occlusion treated with mechanical thrombectomy between January 2011 and August 2025. Patients were classified as contact aspiration first (CA-first) or stent retriever first (SR-first). Procedure-related subarachnoid hemorrhage (SAH), defined broadly to include asymptomatic minor SAH detected on 24-hour post-procedural non-contrast CT, occurred in 52 patients (29%), more frequently after SR-first than CA-first (39% vs 18%, p=0.003). Reperfusion success and functional outcome were similar between strategies. In multivariable analysis, smaller occluded vessel diameter, higher number of device passes, and SR-first strategy were independently associated with SAH. These findings were robust in complementary sensitivity analyses, including a model excluding pass count, inverse probability of treatment weighting (IPTW), and multiple imputation combined with IPTW. SAH was associated with worse outcome in univariable but not multivariable analysis, likely reflecting overall procedural complexity and baseline severity rather than an independent effect on outcome.

PMID 42567223
阅读全文 →
PubMedANZ journal of surgery2026-08-08

The Learning Curve in Minimally Invasive Right Colectomy: Challenges, Metrics, and Future Perspectives, a Systematic Review.

Elisa Reitano R, Stefano Granieri G, Giorgio Badessi B, Noemi Zorzetti Z et al.

Minimally invasive right colectomy (MIRC) is the gold standard for the treatment of right-sided colonic diseases, particularly in cancer patients. However, mastering this procedure requires overcoming a significant learning curve (LC). This systematic review (SR) analyzes existing evidence on LC in MIRC. This SR was conducted according to the PRISMA guidelines. The PubMed, Scopus, EMBASE, and Cochrane Library databases were screened without time restrictions up to June 2024. The risk of bias was assessed for individual studies according to the ROBINS-I tools, while the certainty of the evidence was assessed according to the GRADE approach. The protocol was registered on PROSPERO (ID: CRD42024507060). Nine cohort studies published between 2005 and 2022 met the inclusion criteria. The median number of cases needed to overcome the LC for MI-RC was 26 (range 13-55), 25 (range 18-55) procedures for the laparoscopic, and 27 (range 13-44) for the robotic approach. The comparison between the learning and the proficiency phase shows a significant reduction of operative time (MD: -41.51 min; p = 0.0027) and postoperative morbidity (OR = 0.49; p = 0.043) after the LC was achieved. No differences were detected in the estimated blood loss (MD: -3.3 mL; p = 0.77), whit a significantly high heterogeneity (I2 = 68.8%). The lack of standardization in defining and assessing the LC contributes to the heterogeneity of findings among studies. The development of standardized guidelines is essential to improve colorectal surgical training.

PMID 42568102
阅读全文 →
PubMedBMJ public health2026-08-08

Data retrieval and harmonisation for individual participant data meta-analysis in the context of a neglected tropical disease: challenges and lessons from the Infectious Diseases Data Observatory visceral leishmaniasis data platform.

Dahal Prabin P, Phulgenda Sauman Singh SS, Buck Gemma G, Stepniewska Kasia K et al.

Individual participant data meta-analysis (IPD-MA) is the gold-standard approach for evidence synthesis. Poverty-related infectious diseases, a context in which standalone trials often have small sample sizes and consequently observe relatively few treatment failures, can benefit from this approach. In collaboration with the global research community, the Infectious Diseases Data Observatory (IDDO) has developed a data platform for visceral leishmaniasis (VL)-a neglected tropical disease (NTD), primarily to facilitate IPD-MA aimed at addressing questions of public health importance. Initially, a systematic review (SR) was undertaken to identify relevant trials since 1980 and study authors were invited to collaboratively develop the platform and participate in two IPD-MAs. IPD non-retrievability (data loss) was tracked and defined as unsuccessful attempts to contact study authors, or when the authors explicitly stated data loss, or declined participation. The SR identified 147 VL trials (1983-2019), of which IPD was shared to the IDDO platform from 31 (21.1%). Reasons for data non-retrievability of 116 studies included: authors' retirement (n=42, 36.2%), data were lost (n=30, 25.9%), authors' non-response (n=22, 19.0%), authors were no longer contactable (n=17, 14.7%) and a lack of clarity over data ownership (n=5, 4.3%). The median sample size was 226 (IQR: 120-542, range: 30-1,143) for retrieved studies compared with 81 (IQR: 34-151, range: 7-3,126) for non-retrieved studies. No IPD were retrieved from trials published pre-2000 (0%, 0/63). Following solicitation, the median time to complete data harmonisation was 633 days (n=29 studies). Data solicitation and harmonisation steps remain underappreciated challenges in undertaking IPD-MA, particularly for NTDs where resources are severely limited. A critical mass of IPD from historical VL trials is no longer retrievable. It is imperative that further loss of such valuable data from ongoing and future trials is prevented.

PMID 42568999
阅读全文 →
PubMedVeterinary journal (London, England : 1997)2026-08-08

Injectable antibiotics reprogram the gut microbiota-immune-resistome axis in ducks before detectable changes in growth performance.

Li Xiaokun X, Xia Yingjia Y, Fan Jingbo J, Jiang Fengxi F et al.

The widespread use of injectable antibiotics in intensive poultry production disrupts gut microbial balance and host immune function, potentially affecting nutrient utilization and promoting antimicrobial resistance. To assess the effects of injectable antibiotics on the gut microbiota, host immunity, tissue accumulation, and antimicrobial resistance in ducks, we systematically evaluated six commonly used injectable antibiotics-gentamicin sulfate, oxytetracycline, florfenicol, tylosin tartrate, lincomycin hydrochloride, and enrofloxacin. Although no statistically significant differences were observed in the feed conversion ratio and organ indices over the 28-day trial, antibiotic exposure disrupted microbiota-organ associations, suggesting subclinical effects despite the absence of detectable phenotypic differences. Enzyme-linked immunosorbent assay results showed a clear class-dependent accumulation of antibiotics in muscle tissues, with tylosin tartrate and enrofloxacin persisting through day 28. Single-molecule real-time full-length 16S rRNA sequencing revealed a significant decline in Escherichia coli abundance and an enrichment of several Gram-positive taxa, indicating a marked restructuring of the gut microbiota following antibiotic exposure. Antibiotic residues in tissues were associated with drug-specific enrichment patterns of antibiotic resistance genes (ARGs) and altered host innate immune-related transcriptional profiles, including changes in inflammatory cytokine expression (IL-6, IL-10, and TNF-α). Furthermore, an integrative microbiota-immunity-residue-ARG network was constructed, revealing a conserved association framework centered on TLR2, NF-κB1, TLR4, and IL-6 as network hubs. Collectively, these findings indicate that injectable antibiotics are associated with coordinated alterations in host-microbiota-resistance interactions before measurable growth changes occur. These results provide an integrative framework for evaluating antibiotic-associated risks in poultry production.

PMID 42551728
阅读全文 →
PubMedResearch and practice in thrombosis and haemostasis2026-08-08

Identification of a protein S-binding site in the C2 domain of factor VIII light chain.

Furukawa Shoko S, Takeyama Masahiro M, Nogami Keiji K

We demonstrated that protein S (PS) directly impairs the intrinsic tenase complex, independent of activated protein C (APC), by competitively inhibiting the binding of factor (F)IXa to the A2 domain (residues 488-490) and light chain (LCh) of FVIIIa. This study investigated the PS-binding sites within the FVIII-LCh subunit. Binding interactions between PS and the FVIII-LCh were characterized using ELISA, a synthetic C2-domain peptide (residues 2228-2240), and surface plasmon resonance. The interacting residue was examined using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride-mediated crosslinking and N-terminal sequencing. The functional role of the identified site (K2239) was evaluated using recombinant FVIII mutants and FXa generation assays assessing sensitivity to PS-mediated and APC/PS-mediated inhibition. PS bound to the FVIII-C2 domain and competitively inhibited FIXa binding to the LCh. Using a synthetic peptide (2228-2240) and crosslinking, lysine 2239 (K2239) was identified as a residue contributing to PS interaction. A recombinant FVIII-K2239A mutant showed reduced binding affinity to PS (K d, 6.7 vs 3.5 nM) and impaired PS-mediated inhibition of FXa generation. This effect was additive with mutations in the previously identified A2-domain site (S488A/R489A/R490A). Importantly, while the A2 site contributed to APC/PS-dependent inactivation, the contribution of K2239 to this process appeared limited, suggesting a more prominent role in the APC-independent pathway. Factor VIII residues 488 to 490 and 2239 participate in APC-independent interaction with PS, while residues 488 to 490 also contribute to the APC/PS-dependent inactivation of FVIIIa.

PMID 42568798
阅读全文 →
PubMedJournal of economic entomology2026-08-08

Stage-specific predation and functional response of Orius insidiosus (Hemiptera: Anthocoridae) toward Diaphorina citri (Hemiptera: Psyllidae) and differential toxicity of formulated pesticide mixtures.

Silva Gabriel Tadeu de Paiva GTP, Yamamoto Pedro Takao PT

The Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Psyllidae), is the main vector of Huanglongbing (HLB), the most destructive disease affecting citrus production worldwide. Sustainable management of this pest requires the integration of biological and chemical control strategies. This study evaluated the predatory capacity, functional response, and insecticide selectivity of Orius insidiosus (Say) (Hemiptera: Anthocoridae) toward D. citri. Predation assays showed that O. insidiosus consumed all developmental stages of D. citri, with higher predation on eggs and nymphs. Functional response analysis revealed a Type II response, with high efficiency at low prey densities (attack rate = 3.62; handling time = 0.04), corresponding to a maximum consumption of approximately 25 prey per predator. Predation bioassay indicated significant differences in toxicity, with acetamiprid + bifenthrin, abamectin + cyantraniliprole, and alpha-cypermethrin + teflubenzuron causing >90% mortality, whereas glyphosate, azoxystrobin + difenoconazole, and chlorantraniliprole + abamectin showed lower toxicity (<50%). Concentration-response analyses indicated lower susceptibility of O. insidiosus compared to D. citri, with LC50 values ranging from 1.23 to 99.50 mg ml-1 for the predator and from 0.0016 to 1.187 mg ml-1 for the pest. All insecticides were classified as selective (SR > 1), although ecological risk varied. Probit substitution analysis indicated low predicted mortality (<90%). Overall, O. insidiosus is an efficient predator of D. citri, and further studies on its development and reproduction when preying on this pest are required. The tested pesticide mixtures showed selectivity, and further studies are needed to evaluate their efficacy at reduced application rates.

PMID 42567833
阅读全文 →

注册免费账户还可查看另外 9996 篇文献

免费注册查看全部文献 →

了解更多propafenone hydrochloride