antithrombin III (Neuart)

Highly efficient dual-channel doublet emission in lanthanide cerium(III) complex.

Li Yujia Y, Fang Peiyu P, Xiong Zeyou Z, Zheng Jiayin J et al.

Dual-channel luminescent materials are attractive due to their unique electronic structures and potential applications in various fields. Different from traditional dual-channel emitters with closed-shell structure showing singlet fluorescence and/or triplet phosphorescence, we demonstrate herein dual-channel cerium(III) complexes with open-shell structure showing doublet 5d-4f emission from the central Ce(III) ion. By systematically designing and studying a series of cerium(III) complexes Ce(Tp4Me)(Bp4Me)2, Ce(Tp4Me)2(Bp4Me) and Ce(Tp4R)3 (R = Me, Cl, I) with gradually varied coordination numbers from seven to eight and nine, respectively, it is found that the nine-coordinated complexes Ce(Tp4R)3 showed crowded coordination environments and longer coordination bonds, which underwent a coordination structural relaxation after high energy light excitation, resulting in a new channel emission. This work demonstrates an intriguing dual-channel doublet emission phenomenon in lanthanide Ce(III) complexes and will inspire new insights both into the design of novel lanthanide-based luminescent materials and dual-channel luminescent materials.

Editorial: Digital technology in the management and prevention of diabetes, volume III.

Nag Pushpita P, Shen Yun Y, Zou Xiantong X, Hu Gang G

Editorial: Increasing importance of patients-generated real world data for healthcare policy decisions about medicinal products: volume III.

Choon Wai Yee WY, Lee Kenneth K C KKC, Scuffham Paul P, Li Shu Chuen SC et al.

Sub-emergency versus emergency or delayed free flap coverage for Gustilo III upper limb fractures: With reduced infection, enhanced limb salvage, and improved functional recovery.

Zhou Feiya F, Jiang Wenjing W, Liu Huachen H, Wang Jinwu J et al.

Gustilo type III open fractures of the upper extremity present severe soft‑tissue and bony injuries. Free flap reconstruction is standard, but the optimal timing remains debated. This study aimed to assess the association between timing of coverage and postoperative infection rates. In this observational cohort study, 85 patients with upper limb Gustilo III fractures (2018-2024) were allocated to three groups based on clinical decision: emergency (same anesthetic, n = 25), sub‑emergency (within 72 h, n = 26), or delayed (>72 h, n = 34). Demographics, perioperative data, and complications were analyzed. Multivariable logistic regression was performed but limited by low event numbers. Baseline characteristics were comparable except for higher Injury Severity Score (ISS) in the delayed group (p = 0.001). Infection rates were 4.0% (1/25) in emergency, 3.8% (1/26) in sub‑emergency, and 29.4% (10/34) in delayed group (p = 0.001). Osteomyelitis, flap necrosis, and bone defects occurred almost exclusively in the delayed group. Multivariable analysis (13 total infections) did not identify timing as an independent predictor (p = 0.831); higher ISS, longer operative time, and extended hospital stay showed trends but were not statistically significant. Functional recovery (QuickDASH, SF‑12 PCS) was superior in both early groups. Patient satisfaction was highest in the sub‑emergency group. In this observational study, free flap coverage beyond 72 h was associated with higher unadjusted infection rates; however, this finding cannot be interpreted causally due to severe confounding-by-indication, as the delayed cohort sustained significantly higher baseline trauma severity (ISS). Emergency and sub-emergency (<72 h) coverage demonstrated comparable favorable outcomes, suggesting that the sub-emergency window represents a safe, logistically advantageous alternative LEVEL OF EVIDENCE: III; Therapeutic.