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ketoprofen spray

✓ Approved

Giuliani · PTGS1 · 小分子

什么是 ketoprofen spray?

ketoprofen spray 是一种小分子,由Giuliani研发。该药已获批,用于治疗相关适应症,给药途径:Transdermal。

药物档案

公司Giuliani
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Transdermal
状态Approved

作用机制

分子靶点

ketoprofen spray 作用于 2 个分子靶点:

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析?Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ketoprofen spray 针对 2 个适应症,涉及 2 个治疗领域。

治疗领域疾病/病症分期
Hepatobiliary disordersHepatitis✓ Approved
Musculoskeletal and connective tissue disordersMusculoskeletal pain✓ Approved

相关研究文献

PubMedInternational journal of biological macromolecules2026-08-08

Curdlan as a heat-irreversible gel wall material in electrostatic spray-dried solid/oil/water probiotic microcapsules: Thermal resistance and storage stability.

Liu Xiaobing X, Liang Zhiqiang Z, Li Jiarui J, Wang Yuying Y et al.

In this study, to develop a robust probiotic delivery system, high molecular weight 1,3-β-D-glucan curdlan gum (CUR) was employed as a functional wall material. It was combined with whey protein isolate and high oleic sunflower oil to prepare solid/oil/water (S/O/W) emulsion microcapsules using electrostatic spray drying (ESD) technology. Additionally, pectin and high oleic sunflower oil were utilized as functional wall materials. All the microcapsules exhibited low water content (3.66%-5.04%) and water activity (aw 0.178-0.230), which is beneficial for long-term storage stability. Following drying, the survival rate of probiotics in each treatment group exceeded 90%. It is worth noting that the microcapsules containing 5% CUR exhibit the most effective overall protective effect: following heat treatments of 63 °C for 30 min and 75 °C for 10 min, the loss of viable bacteria was only 1.18 and 1.39 Log CFU/g, respectively. After 12 weeks of storage at 4 °C and 25 °C, the survival rates were maintained at 93% and 66%, respectively. Its excellent performance is attributed to the fact that CUR can form a dense gel network structure at high temperatures, which effectively blocks heat transfer and oxygen penetration. Scanning electron microscopy and Fourier-transform infrared spectroscopy confirmed that microcapsules containing 5% CUR form a relatively dense physical barrier and maintain structural integrity. The above results demonstrate that incorporating CUR into a S/O/W emulsion system, combined with ESD technology, is a promising strategy for wall materials to enhance the thermal tolerance and shelf-life stability of probiotic microcapsules.

PMID 42567385
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PubMedFood research international (Ottawa, Ont.)2026-08-07

Spray-dried microencapsulation as a strategy for stabilizing chlorophyll-rich extracts: pigment profiling, digestive fate, and in vitro biological activity with and without Cu2+ incorporation.

Turkiewicz Igor Piotr IP, Tkacz Karolina K, Brzezowska Jessica J, Wojdyło Aneta A

The limited stability and digestive functionality of chlorophyll-rich systems remain major challenges in the development of functional green powders. This study aimed to investigate the stabilization, transformation, and biological functionality of chlorophyll-rich extracts microencapsulated using spray drying and freeze drying, with particular emphasis on carrier composition and copper-mediated pigment modification. Native and Cu2+-treated chlorophyll-rich extracts were encapsulated using inulin, soy protein isolate (SPI), and their binary system. Unlike previous studies focused primarily on storage stability, the present work simultaneously evaluated pigment transformations, digestive behavior, antioxidant capacity, and dipeptidyl peptidase-4 (DPP-4) inhibitory activity in native and Cu-modified chlorophyll systems. Carrier composition exerted a stronger influence than drying technique on pigment stability and functional properties. The highest total chlorophyll content was observed for powders obtained from the chlorophyll-rich extract by spray drying with SPI (247.39 mg 100 g-1 dry weight (dw)), whereas the formulation based on copper-modified chlorophyll-rich extract (Cu-ChRE) produced by freeze drying with inulin contained more than eight-fold lower chlorophyll levels (29.70 mg 100 g-1 dw). SPI-based systems generally promoted higher chlorophyll retention, antioxidant activity, and DPP-4 inhibitory activity, while inulin-based matrices more effectively limited secondary photooxidative transformations during storage. In the initial powders, ChRE-based formulations exhibited lower IC₅₀ values than Cu-ChRE systems (0.84-1.12 vs. 1.45-1.96 mg mL-1), indicating stronger enzyme inhibition by native pigment systems. Copper treatment improved pigment stability and reduced pheophytin formation; however, Cu-modified systems exhibited lower antioxidant and antidiabetic activity than native chlorophyll-rich extracts. Simulated gastrointestinal digestion substantially altered pigment composition and biological responses, partially restoring antioxidant capacity and enhancing DPP-4 inhibitory activity in selected formulations. The results demonstrate that stabilization strategies effective during storage do not necessarily ensure enhanced post-digestive functionality. Overall, spray-drying-based microencapsulation represents a promising alternative to Cu2+-based stabilization for the development of functional chlorophyll-rich powders with potential application in functional food systems.

PMID 42562461
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PubMedCurrent opinion in obstetrics & gynecology2026-08-07

Pain control options for intrauterine device placement and endometrial biopsy.

Passarelli Natalie N, Neill Sara S, Dutton Caryn C

To review the effectiveness of pain control methods for outpatient intrauterine device (IUD) insertions and endometrial biopsy (EMB) procedures. Several approaches to decreasing pain with ambulatory IUD placement and EMB have been evaluated in the literature. Paracervical blocks, cervical lidocaine spray, nonsteroidal anti-inflammatory drugs (NSAIDs), and anxiety reduction techniques have been shown to decrease pain reported by patients. For both IUD insertion and EMB, evidence regarding NSAIDs for intraprocedural pain is mixed, and they should be advised to decrease postprocedural cramping. A paracervical block with local anesthesia successfully targets pain but can cause discomfort with injection. Misoprostol may improve ease of IUD insertion and thus may be useful in select patients with difficult placements; however, routine use is not recommended because of increased side effects and risk of expulsion. Ultrasound-guided IUD insertion and nitrous oxide administration have also shown efficacy but are limited by cost and logistical barriers. Pain during IUD placement and EMB is multifactorial and best addressed with use of an individualized, multimodal approach. Shared decision-making should guide clinician and patient discussion for offering strategies such as preprocedural NSAIDs, lidocaine spray, paracervical blocks, and anxiety management to all patients to optimize comfort and procedural experience.

PMID 42563632
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PubMedFood chemistry2026-08-07

Design of metastable peanut protein-polyphenol complex particles for tunable flow, interfacial, and gelation properties.

Cui Shishuai S, Cao Shinuo S, Xiao Tianlong T, Zheng Yichen Y et al.

This study investigated the complexation process between peanut protein (PP) and three structurally distinct trace polyphenols-gallic acid (GA), quercetin (QR), and epigallocatechin gallate (EGCG)-followed by spray drying. Spectroscopic analysis indicated that the polyphenols, acting as liquid-phase conformational modulators, guided the peptide chains into compact, α-helix-rich structures through specific noncovalent interactions (hydrophobic embedding for quercetin, and hydrogen bonding for gallic acid and epigallocatechin gallate). Rapid dehydration during the spray-drying process dynamically locks these transient conformations into process-induced metastable particles with unique surface topologies. Functionally, GA forms smooth, low-friction particles whose properties are optimized for rapid interfacial spreading. In contrast, QR and EGCG form rigid, porous aggregates characterized by high interparticle friction; this topological structure provides mechanical interlocking, which is essential for robust Pickering emulsion stabilization, enhanced water-holding capacity, and tunable particle gelation properties. Macroscopic functional tests confirm the existence of a structure-driven fundamental trade-off between rapid interfacial spreading ability and long-term mechanical barrier formation (emulsion stability and overall gelation). This study demonstrates that trace-level polyphenol modification, combined with process-induced kinetic locking, provides a targeted strategy for designing plant protein particle systems with customized flow, interfacial, and gelation behaviors.

PMID 42561848
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PubMedFood chemistry2026-08-07

Optimization of anchovy oil microencapsulation using wall materials: effects on oxidative stability and encapsulation efficiency.

Elçi Rahime R, Durmuş Mustafa M, Köşker Ali Rıza AR, Sakarya Yetkin Y et al.

Microencapsulation is widely applied to improve the stability of highly unsaturated oils; however, the effectiveness of encapsulation largely depends on the composition of wall materials. This study systematically evaluated the influence of different wall material systems on the encapsulation efficiency and oxidative stability of spray-dried anchovy oil powders. Maltodextrin, sodium caseinate, gum arabic, and whey protein were used individually and in binary combinations as encapsulating matrices. The resulting microcapsules were characterized in terms of encapsulation efficiency, surface oil content, and lipid oxidation indicators including free fatty acids, peroxide value, and thiobarbituric acid reactive substances. Wall material composition significantly influenced both oil retention and oxidative stability. The maltodextrin-sodium caseinate system showed the highest encapsulation efficiency (73.54%) and the lowest surface oil content (3.82%), whereas formulations containing whey protein exhibited lower efficiency (50.03%) and higher oxidation. The gum arabic-sodium caseinate combination provided the greatest oxidative protection, with the lowest free fatty acid (9.32%) and peroxide values (13.46 meq O₂/kg). These findings demonstrate improved encapsulation and oxidative stability relative to previous studies, ans represents the first systematic assessment of single and binary wall-material systems for stabilizing anchovy oil, therefore offering practical insights for spray-dried lipid delivery system design in functional foods and nutraceuticals.

PMID 42561852
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PubMedJournal of the science of food and agriculture2026-08-07

Preparation of dispersible corn protein/quinoa protein/pectin heteroprotein nanoparticles by a one-pot antisolvent evaporation method.

Sun He-Bing HB, Zhang Zhe-Chen ZC, Xiao Jun-Xia JX, Huang Guo-Qing GQ

Poor water solubility, imbalanced amino acid composition, and unpleasant odor restrict the application of protein in corn gluten meal (CGM). A one-pot antisolvent evaporation method was proposed to yield water-dispersible and nutritional corn protein heteroprotein nanoparticles with quinoa protein isolate and low-methoxyl pectin (LMP). Sunflower head pectin (SHP) was the optimum LMP species and mixture pH 7.0, evaporation temperature 50 °C, and initial total solid concentration 8.0 g kg-1 yielded homogeneous nanoparticle dispersions; furthermore, the addition of 1.0 g kg-1 hydroxypropyl-β-cyclodextrin effectively masked the undesirable odor without affecting the formation of corn protein/quinoa protein/SHP heteroprotein nanoparticles (CD-CQP-HNPs). The suspension could be spray-dried to yield mild yellow powders with a protein content of 75.36% and particle size of 421.83 nm. The nanoparticles were spheric with dents on their surfaces and SHP distributed across the nanoparticles instead of a core-shell structure. CD-CQP-HNPs exhibited improved essential amino acid index of 0.87 compared with 0.84 of CGM and excellent dispersibility as evidenced by a contact angle of 34.5°, wetting time of 43.58 s, and solubility of 90%. The nanoparticle suspension could be stored at 4 °C for 3 days, 25 °C for 1 day, or in 0.2 mol L-1 NaCl (pH 3.0-7.0, 20-50 °C) for 3 h without visible aggregation. The current one-pot procedure could yield corn protein heteroprotein nanoparticles with good water dispersibility and improved amino acid composition by simple rotatory evaporation and spray drying and have potential in the industrial utilization of CGM. © 2026 Society of Chemical Industry.

PMID 42563445
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