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ketoprofen spray

✓ Approved

Giuliani · PTGS1 · 小分子

什么是 ketoprofen spray？

ketoprofen spray 是一种小分子，由Giuliani研发。该药已获批，用于治疗相关适应症，给药途径：Transdermal。

药物档案

公司Giuliani
药物类别小分子
分子靶点PTGS1, PTGS2
给药途径Transdermal
状态Approved
来源： ClinicalTrials.gov, Giuliani

作用机制

分子靶点

ketoprofen spray 作用于 2 个分子靶点：

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

治疗适应症

ketoprofen spray 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Hepatobiliary disordersHepatitis✓ Approved
Musculoskeletal and connective tissue disordersMusculoskeletal pain✓ Approved

相关研究文献

PubMedJournal of dairy science2026-06-13

Impact of pulsed electric field technology on whey protein isolate.

Ryan Elizabeth L EL, McDougal Owen M OM

A commercially available pulsed electric field (PEF) system has been used to treat a 23% total solids solution of whey protein isolate (WPI) before spray drying. The 3 trials conducted for this study used PEF parameters within the range of 17-21 kV/cm for field strength and 8-15 kJ/L for specific energy. PEF treatment led to a decrease in solution viscosity by as much as 32.8% within 24 h., increased the solubility of spray-dried powder up to 12.2%, and increased the emulsifying activity index (EAI) and emulsion stability index (ESI) by 6.5 times and 250%, respectively, as compared with the non-PEF control. Assessment of protein structure was conducted by gel electrophoresis, circular dichroism (CD), fluorescence spectroscopy, and differential scanning calorimetry (DSC) with only a minor effect on β-strand by CD with the highest PEF treatment, medium and high PEF treatments affected fluorescence intensity, and increased enthalpy associated with denaturation by DSC. These minor changes may explain the changes in physical and functional properties for the PEF treated WPI. This study provides physical and functional property data for the first instance of commercially relevant concentrated WPI being treated through a PEF flow cell at a rate of 170 L/hr.

PMID 42285489
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PubMedInternational journal of biological macromolecules2026-06-13

Synergistic stabilization of Pickering emulsions by agar-chitosan composite particles and their potential for improving the bioavailability of lipophilic simvastatin.

Du Lipeng L, Han Xinyu X, Zhang Xingtao X, Wu Xiao X et al.

Natural biopolymer-based Pickering emulsions have emerged as promising green delivery systems for lipophilic bioactives. Agar exhibits excessive hydrophilicity with poor amphiphilic balance. Chitosan has limited solubility at physiological pH and weak independent gelation capacity. Simvastatin is a widely used lipid-lowering drug with an oral bioavailability of only about 5% due to poor aqueous solubility and gastrointestinal instability. To address these critical gaps, agar-chitosan composite particles (AGCS) were fabricated via spray-drying to stabilize Pickering emulsions for simvastatin delivery. FT-IR confirmed that electrostatic and hydrogen bonding modulated composite particle amphiphilicity. This resulted in a 97.27° contact angle and reduced interfacial tension of 13.5 mN/m. The emulsions exhibited exceptional stability at pH greater than 5 and salt levels less than 150 mmol/L. They also retained structural integrity after heat treatment up to 100 °C. This stability arose from a dual mechanism involving a dense interfacial film and a self-assembled three-dimensional gel network. Rheological analysis revealed elastic-dominated behavior supporting a 95% encapsulation efficiency at 60% oil phase fraction. In vitro digestion demonstrated that composite emulsion gels protected simvastatin from gastric degradation while enhancing bioaccessibility to 33.5% compared to free simvastatin. This work elucidates the synergistic stabilization mechanism of agar-chitosan composite particles. These particles overcome the individual limitations of native polysaccharides. The findings highlight their potential as a green biocompatible carrier for lipophilic drug delivery in biomedicine and the food industry.

PMID 42285454
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PubMedPest management science2026-06-13

Identification of broadly expressed nervous system-related genes as effective RNAi targets in the brown marmorated stink bug, Halyomorpha halys.

Panda Nirakar N, Koch Aline A, Amineni Venkata Partha Sarathi VPS

The brown marmorated stink bug, Halyomorpha halys (BMSB), is an invasive polyphagous pest causing major losses in fruit and field crops in Europe and the Americas. With insecticide options increasingly limited by resistance and regulatory restrictions, RNA interference (RNAi) offers a species-specific alternative. As RNAi is fully functional in BMSB following hemolymph injection, we evaluated neuronal and neuron-associated genes as systemic RNAi targets using dsRNA microinjection. A literature screen of >80 insect RNAi targets identified 12 neuronal/synaptic genes, from which five were selected in BMSB: acetylcholinesterase (HhAChE), alpha-soluble NSF attachment protein (HhAsnap), Shaker (HhSh), tyrosine hydroxylase (HhTh) and Ras opposite protein (HhRop). Previously published transcriptomic data showed HhAChE, HhSh and HhTh were enriched in brain/central nervous system, whereas HhAsnap and HhRop were broadly expressed at higher abundance. Adults injected with dsRNA (334-364 bp; 2 μL, 1000 ng/μL) targeting HhAsnap or HhRop showed strong mortality: 96.8% (30/31) and 100% (34/34) by Day (D)13, respectively (log-rank, P < 0.0001). By contrast, there was no significant difference between insects injected with dsRNA targeting HhAche, HhSh and HhTh and the negative controls. Feeding assays showed >60% reductions in salivary sheath formation from D4 to D8 after dsAsnap or dsRop treatment. Quantitative real-time (qRT)-PCR at 72 h confirmed ~58% knockdown of HhRop, whereas HhAChE and HhAsnap showed no significant whole-body depletion. Broadly and highly expressed targets (HhAsnap, HhRop) were associated with strong mortality and feeding suppression, whereas brain-enriched targets did not. Expression breadth and transcript abundance appear critical for RNAi responsiveness in BMSB, identifying HhAsnap and HhRop as promising candidates for oral or spray-based RNAi control. © 2026 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

PMID 42285902
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PubMedJournal of pharmaceutical sciences2026-06-12

Stabilization of spray-dried monoclonal antibody formulations with polymeric excipients.

Patil Chanakya D CD, Arte Kinnari Santosh KS, Sapkota Rachana R, Huang Yijing Y et al.

Spray drying is an emerging continuous manufacturing approach with significant potential for producing stable solid formulations of biologic drug products such as peptides, proteins and oligonucleotides. However, these sensitive molecules on exposure to thermal, shear, and interfacial stresses during spray drying may experience structural perturbations that compromise long-term stability. This study evaluated several polymeric excipients as stabilizers in spray-dried monoclonal antibody formulations and compared their performance with conventional sugar excipients, trehalose and mannitol. Formulations were prepared at a 1:1 (w/w) protein-to-excipient ratio and spray dried, and the resulting powders were subjected to accelerated storage at 40°C. Particle size distribution, morphology, and residual moisture content were characterized. Protein physical stability and secondary structure were evaluated using size exclusion chromatography and solid-state Fourier transform infrared spectroscopy, respectively. Solid-state nuclear magnetic resonance spectroscopy and X-ray photoelectron spectroscopy were used to study protein-excipient phase miscibility and particle surface composition, respectively, in the spray-dried solids. Hydrolyzed gelatin provided the most robust stabilization of the mAb, resulting in a fivefold reduction in monomer loss compared to trehalose after 90 days storage at 40°C. (2-Hydroxypropyl)-β-cyclodextrin showed stabilization comparable to trehalose while reducing the mAb surface exposure. High molecular weight polyvinylpyrrolidone (PVP K90) showed better mAb stabilization compared to its low molecular weight grade (PVP K30). Whereas dextran, sodium carboxymethyl cellulose, and hydroxypropyl methylcellulose were less effective in their ability to stabilize the mAb. These findings highlight the critical role of excipient selection in improving the stability of spray-dried monoclonal antibody formulations.

PMID 42276211
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PubMedMaterials (Basel, Switzerland)2026-06-12

Design Analysis for Controlling Spray Particle Size of Ultrasonic Nozzles Using Piezoelectric Ceramic Vibrators.

Lee Su-Ho SH, Lim Sunghyun S, Choi Myeong-Gwang MG, Hwang Jae-Eun JE et al.

This study aims to demonstrate the feasibility of controlling particle size through a mathematical model in the design of industrially applicable ultrasonic spray nozzles by utilizing the vibrational characteristics of piezoelectric ceramics. A piezoelectric ceramic composition with a low sintering temperature and excellent thermal stability (Curie temperature above 300 °C) was developed and used as a ceramic vibrator. Furthermore, the resonance frequency and nozzle displacement were calculated using the COMSOL program and applied to a mathematical model to design an ultrasonic nozzle capable of producing a spray particle diameter of approximately 30 μm. The designed ultrasonic nozzle was fabricated, and its spray characteristics were analyzed. The consistency of the spray characteristics was examined by comparing them with the mathematical model based on changes in ultrasonic nozzle length, resonance frequency, and fluid viscosity. When the ultrasonic nozzle horn length was 22 mm, the resonance frequency was found to be 42.1 kHz, and at a flow rate of 65 mL/min. the average spray particle size was approximately 30-40 μm, indicating fine and uniform particles. In addition, it can be seen that as the length of the nozzle horn increases, the resonance frequency decreases, reducing the supply energy delivered to the liquid, and the particle size increases as shown in the mathematical analysis. The theoretical separation energy required to atomize pure water at a flow rate of 65 mL/min. is 2100 J, which was found to be greater than all energy loss occurring during the atomization process. However, it can be seen that as the length of the ultrasonic nozzle increases, the maximum atomization volume increases, and as viscosity increases, the energy required to separate a single atomized particle becomes greater.

PMID 42279899
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PubMedMolecules (Basel, Switzerland)2026-06-12

Populus nigra Bud Extract as a Standardized Alternative to Propolis: Evidence of Compositional Similarity-Functional Properties of an Oral Spray Containing Populus nigra Bud Extract.

Mattoli Luisa L, Lugli Andrea A, Burico Michela M, Fodaroni Giada G et al.

Populus nigra buds contain resinous exudates rich in flavonoids, phenolic acids, terpenoids and other bioactive constituents. These exudates are the main botanical source of European Poplar-type propolis. Since hive-collected propolis shows strong botanical, geographical and hive contaminant variability, P. nigra bud resin exudate represents an attractive, standardizable and reproducible alternative for obtaining natural-complex ingredients. This study investigates the compositional relationship between Propolgemma® standardized P. nigra buds (PBHE) and European propolis (PHE) hydroalcoholic extracts through integrated analytical approaches and evaluates the functional bioactivity of PBHE and a related oral spray formulation (Propolgemma® spray forte, PBHE-SF). Untargeted metabolomic fingerprinting revealed clear clustering of P. nigra bud exudate with European propolis, demonstrating high compositional similarity. Targeted analyses confirmed that PBHE belongs to the poplar-type propolis family, while retaining additional bud-derived constituents such as salicylates, lignins and tannins, typical of bud tissue and largely absent from hive-collected propolis. Functionally, PBHE showed concentration-dependent antioxidant activity and significant inhibition of Streptococcus pyogenes biofilm at sub-MIC levels. PBHE, incorporated into a patented oral spray formulation (PBHE-SF), demonstrated strong mucoadhesion, high resistance to salivary wash-off, retention of antioxidant flavonoids on epithelial substrates and a mechanical barrier effect, reducing LPS-induced IL-6 release by 39%. It also showed dispersion of pre-formed S. pyogenes biofilms. PBHE emerges as a reproducible, plant-derived, bee-independent alternative to European propolis. Its chemical consistency, functional reliability, independence from bee foraging and from hive-derived contaminants improve the therapeutic potential on mucosal protection in medical device formulations and the suitability for scalable, controlled and industrially sustainable production.

PMID 42280141
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