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influenza HA vaccine

✓ Approved

Denka Seiken · · 疫苗

什么是 influenza HA vaccine？

influenza HA vaccine 是一种疫苗，由Denka Seiken研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Subcutaneous Injection。

药物档案

公司Denka Seiken
药物类别疫苗, 大分子
分子靶点,
给药途径Injectable (Others), Subcutaneous Injection
状态Approved
来源： ClinicalTrials.gov, Denka Seiken

作用机制

分子靶点

influenza HA vaccine 作用于 2 个分子靶点：

(HA)
(HA)
需要更深入的分析？Noah AI 可解释复杂机制并与同类药物比较。

相关研究文献

PubMedJournal of dairy science2026-08-08

Yogurt fortified with hyaluronic-acid coated liposomal casein peptides: Physicochemical, antioxidant, and sensory properties.

Wang Zhimin Z, Yuan Xin X, Li Xinyi X, Zhao Cuisong C et al.

To enhance the antioxidant function of yogurt, hyaluronic acidcoated liposomes encapsulating casein-derived peptides (HA-P-Lip) were added to the yogurt, and the effects on peptide stability during storage, in vitro gastrointestinal release, antioxidant activity, as well as physicochemical and instrumental sensory properties using electronic nose and tongue were evaluated. Six formulations of yogurt were prepared: control yogurt (CY), yogurt with 0.5% casein peptides (Y+P), yogurt with 0.5% Blank-Lip (Y+Blank-Lip), yogurt with 0.5% P-Lip (Y+P-Lip), yogurt with 0.5% Blank-HA-Lip (Y+Blank-HA-Lip), yogurt with 0.5% HA-P-Lip (Y+HA-P-Lip). All samples were stored at 4°C for 21 d. Samples were taken on 0, 7, 14, and 21 d. Compared with the control yogurt (CY), the Y + HA-P-Lip exhibited decreased pH, significantly improved water-holding capacity and reduced syneresis, increased the hardness, consistency and viscosity, and improved the microstructure, making it denser and more uniform. Importantly, addition of casein peptides improved the antioxidant activity of yogurt, and HA-P-Lip effectively maintained the antioxidant activity of yogurt, which was significantly better than a group of free casein peptides added. The Y + HA-P-Lip showed better sustained peptides release in vitro gastrointestinal digestion. The analysis of electronic nose and electronic tongue indicated that the Y + HA-P-Lip showed higher response value in the volatility of alkanes, and was superior to the CY in umami and richness. HA-P-Lip demonstrated superior antioxidant activity retention and sustained peptide release during in vitro digestion without negative effects on yogurt quality. This study will provide new strategies for the application of peptide active ingredients in functional foods.

PMID 42567268
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PubMedFrontiers in immunology2026-08-08

Conserved CD4 T-cell responses correlate with antibody neutralization in solid organ transplant recipients after bivalent SARS-CoV-2 vaccination.

Stavrakis Georgia G, Roznik Katerina K, Stoddart Laila L, Johnston T Scott TS et al.

Vaccines against SARS-CoV-2 and influenza require reformulation due to viral evolution. It remains unclear how vaccination against evolving antigens influences T-cell responses and the impact of reformulation on T-cell responses to new variants in immunocompromised hosts. Solid organ transplant recipients (SOTRs) had significantly lower antibody levels following vaccination and required repeated boosting during the COVID-19 pandemic. With the introduction of the Omicron spike (S) to the bivalent mRNA vaccines in 2022, the relative contribution of T-cell responses cross-reactive for Omicron mutated S sequences was assessed via intracellular cytokine staining using peptide pools containing conserved or mutated S sequences. S-specific CD4 T cells recognize both conserved and Omicron mutated S sequences pre- and post-bivalent vaccination, even in the absence of evidence of prior infection as detected by T-cell responses to a novel peptide pool. CD4 T-cell responses to both conserved and Omicron mutated sequences correlated with antibody pseudo-neutralization of BA.5 S. Importantly, pre-bivalent conserved S CD4 T-cell responses significantly correlated with antibody pseudo-neutralization of BA.5 S post-bivalent. These results emphasize the importance of conserved and cross-reactive responses in vaccine immunogenicity, providing a mechanism through which repeated boosting enhances vaccine immunogenicity in SOTRs and other immunocompromised populations.

PMID 42568479
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PubMedWater research2026-08-08

Prediction of influenza activity in wastewater using oseltamivir biomarkers.

Bouzoukas Christoforos C, Gerokonstantis Triantafyllos-Dimitrios TD, Aalizadeh Reza R, Zafeiriadou Anastasia A et al.

Wastewater-based epidemiology (WBE) has emerged as a powerful approach for population-level surveillance of infectious diseases and pharmaceutical usage; however, integrated modeling frameworks that combine chemical and virological wastewater signals remain underexplored. In this study, we develop and evaluate multivariate models that link antiviral drug biomarkers in wastewater to influenza viral loads, prescription data, and reported case numbers, with the aim of strengthening influenza surveillance and outbreak assessment. Influenza A (IAV) and B (IBV) virus loads were quantified in wastewater samples over three consecutive influenza seasons alongside concurrent measurements of oseltamivir and its primary metabolite, oseltamivir carboxylate (OC). Multivariate regression models were constructed using oseltamivir and OC mass loads as chemical predictors. Model performance was evaluated using classical multiple linear regression, distributed lag models, and an extreme gradient boosting (XGBoost) machine-learning approach. The XGBoost consistently outperformed conventional models, enabling accurate estimation of population-normalized antiviral consumption from wastewater mass loads and demonstrating strong predictive power for both IAV and IBV concentrations. In addition, the developed models accurately estimated the number of medicated influenza patients directly from wastewater-derived biomarker's mass loads, demonstrating the potential of antiviral biomarkers to quantify disease burden at the population level. Correlations between chemical biomarkers and viral loads yielded coefficients up to 0.88, with average prediction errors of approximately ±1.1 log2 units. Importantly, the models also reliably estimated the number of medicated influenza cases directly from wastewater-derived antiviral signals. These findings demonstrate that oseltamivir and OC serve as robust chemical proxies for influenza activity and machine-learning-based WBE models can effectively translate wastewater measurements into actionable epidemiological indicators. The proposed integrated modeling framework enables retrospective analysis, supports early outbreak detection, and provides a scalable tool for public health surveillance.

PMID 42566960
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PubMedBioresource technology2026-08-08

Heterosigma akashiwo, and Prorocentrum micans microalgae ethanolic extract-based Fe2O3 magnetic nanoparticles: Green synthesis, characterization, antioxidant, and anticancer investigations.

Helmy Elsayed T ET, Sun Zihan Z, Alahmer Abdelmoniem E AE, Zheng Junjie J et al.

Microalgae's distinct biochemical characteristics and environmental benefits have made them an environmentally acceptable and sustainable platform for the synthesis of nanoparticles (NPs). The current work is in accordance with the principles of green chemistry. This study aims to establish, for the first time, an environmentally sustainable and rapid synthesis route for Fe2O3 using ethanolic extracts of Heterosigma akashiwo (H. akashiwo) and Prorocentrum micans (P. micans) microalgal species. The extracts of H. akashiwo and P. micans serve as natural surfactant-solvent systems for the preparation of Fe2O3/Ha and Fe2O3/Pm NPs respectively. We comprehensively evaluate the structural characteristics, antioxidant potential, and anticancer efficacy of the synthesized NPs. The size of NPs was reported to be 37.8 and 34.9 nm for Fe2O3/Ha and Fe2O3/Pm NPs respectively with varied forms and morphologies. Fe2O3/Ha and Fe2O3/Pm NPs showed moderate antioxidant activity. At 100  µg/mL, their ABTS radical scavenging rates were 54.5 % and 65.9 %, respectively. For DPPH activity, they reached 60.2 % and 59.1 % at 100 µg/mL. In the SOD assay, Fe2O3/Ha and Fe2O3/Pm achieved 21.5 % and 43.8 % scavenging, respectively, compared to 78.2 % for vitamin C. Furthermore, the ability of Fe2O3/Ha and Fe2O3/Pm NPs to suppress the proliferation of HCT-116 (IC50 = 51.54 ± 2.9 and 34.77 ± 2.2  μg/mL, respectively) and HepG-2 (IC50 = 73.13 ± 3.8 and 45.87 ± 2.7  μg/mL, respectively) cancer cells demonstrate their anticancer activity. Fe2O3/Ha and Fe2O3/Pm show reduced cytotoxicity toward normal WI-38 cell line. The results demonstrate the significant antioxidant and anticancer activity of prepared NPs, making them promising candidates for further research and development in biomedical and pharmacological studies.

PMID 42567291
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PubMedSleep medicine clinics2026-08-08

Central Sleep Apnea at High Altitude: From Pathophysiology to Treatment.

Perger Elisa E, Baillieul Sébastien S

At elevations above roughly 2500 m, susceptible individuals manifest central sleep apnea due to high-altitude periodic breathing (high-altitude central sleep apnea [HA-CSA]) characterized by a typical periodic breathing pattern. Mechanistically, HA-CSA develops when sleep-related decreases in respiratory drive, triggered by hypocapnia, resulting from hypoxia-induced hyperventilation, interact with increased loop gain during non-rapid eye movement sleep. Clinically, severity is mitigated by descent or supplemental oxygen. Pharmacologic strategies such as acetazolamide are effective, and sleep quality may improve with judicious hypnotic use independent of CSA severity. This article integrates the description of HA-CSA mechanisms, clinical expression, ethnic and chronic-exposure perspectives, and management strategies.

PMID 42567625
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PubMedVeterinary microbiology2026-08-08

Development and protection evaluation of a nanoparticle vaccine against transferrin-binding protein TbpBY167A of Glaesserella parasuis.

Chao Lumen L, Zhang Baoge B, Cai Yuchen Y, Zhu Chenguang C et al.

In this study, a novel nanoparticle vaccine that can efficiently display the protective antigen TbpBY167A of Glaesserella parasuis was constructed using the self-assembly property of the capsid (Cap) protein of porcine circovirus type 3 (PCV3). Traditional subunit vaccines against Glässer's disease often suffer from insufficient immunogenicity and suboptimal protective efficacy. The vaccine developed in the present study efficiently elicits both humoral and cellular immune responses via multivalent antigen display, leading to substantially enhanced overall adaptive immunity. This work therefore provides promising vaccine candidates with high safety and improved protective efficacy for the prevention and control of Glässer's disease.Monoclonal antibodies (MAbs) against TbpBY167A were generated using recombinant TbpBY167A protein expressed in E. coli and their epitope characteristics were identified and which can specifically react with TbpBY167A displayed on the surface of VLP (Virus-Like Particle). A recombinant baculovirus expressing the Cap protein of PCV3 fused with TbpBY167A at the N terminus was constructed. Guinea pigs were immunized with the nanoparticle vaccine and a conventional subunit vaccine (MBP-TbpBY167A), humoral immune responses, cytokine profiles, pathological changes, and protection rates after challenge were compared. One stable hybridoma cell line, designated 2D3, secreting MAbs against TbpBY167A was obtained, and its recognized epitope was mapped to a linear region spanning amino acids 269-275. Transmission electron microscopy confirmed that the Cap-TbpBY167A fusion protein self-assembled into homogeneous nanoparticles approximately 20 nm in diameter. Animal experiments showed that both the nanoparticle vaccine and the subunit vaccine elicited robust specific antibody responses and provided a 60% protection rate against lethal challenge. Notably, the nanoparticle vaccine group exhibited significantly milder histopathological lesions in the lungs and spleen compared with the subunit vaccine and challenge control groups. The Cap-TbpBY167A nanoparticle vaccine confers protection against lethal G. parasuis challenge and demonstrates less lesions of target organ pathology compared with the conventional subunit vaccine. The success of this study provides a novel antigen delivery strategy for the development of broad-spectrum vaccines against G. parasuis.

PMID 42567121
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