Nihon Pharmaceutical · 多克隆抗体 · 多克隆抗体
human normal immunoglobulin G 是一种多克隆抗体，由Nihon Pharmaceutical研发。该药已获批，用于治疗相关适应症，给药途径：Injectable (Others)、Intravenous (IV)。
| 商品名 | NPB01 |
| 公司 | Nihon Pharmaceutical |
| 药物类别 | 多克隆抗体, 抗体 |
| 给药途径 | Injectable (Others), Intravenous (IV) |
| 状态 | Approved |
human normal immunoglobulin G 针对 11 个适应症，涉及 5 个治疗领域。
| 治疗领域 | 疾病/病症 | 分期 |
|---|---|---|
| Skin and subcutaneous tissue disorders | Erythema multiforme | ✓ Approved |
| Nervous system disorders | Guillain-Barre syndrome | ✓ Approved |
| Skin and subcutaneous tissue disorders | Pemphigoid | ✓ Approved |
| Skin and subcutaneous tissue disorders | Pemphigus | ✓ Approved |
| Infections and infestations | Salmonellosis | ✓ Approved |
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免费注册查看全部适应症 →Elmoursi Ahmed A, Zhang Lingxiao L, Maus Marcela V MV, Barmettler Sara S
Mattar Ehab H EH, Zari Ali T AT, El-Fakharany Esmail M EM, El-Maradny Yousra A YA et al.
Egg yolk immunoglobulin Y (IgY) derived from avian sources, such as chickens, has attracted interest due to its low cost and rapid production. This study aimed to fabricate chitosan nanoparticles conjugated with IgY antibodies and polymyxin B as novel antibacterial nanocombinations to fight multi-resistant Salmonella enterica serovar Typhimurium (Salmonella Typhimurium) isolated from poultry. Chicken IgY was purified from egg yolk via caprylic acid precipitation and gel filtration. The developed polymyxin B-loaded nanocombinations, enhanced by IgY-polymyxin B-based NPs (IgY-Poly/ChNPs and IgY-coated-Poly/ChNPs), were designed to overcome the resistance limitations of polymyxin B. In this system, polymyxin B serves as the primary bactericidal agent, while the chitosan nanoparticle acts as a biocompatible carrier matrix, and the IgY coating serves as a functional shell to enhance stability and potentially interfere with bacterial surface attachment. The IgY-polymyxin B-based NPs exhibited a spherical morphology (124.2-290.7 nm) and a zeta potential of -26.5 to -46.9 mV. The formulations demonstrated potent inhibitory efficacy (12±0.98 - 21±0.91 mm) with MIC values of 0.125 to 2.0 mg/mL against Salmonella Typhimurium. These nanocombinations inhibited bacterial growth in a time- and dose-dependent manner. A significant downregulation of mcr-1 gene expression (3.97 to 8.7-fold) was observed in colistin-resistant Salmonella Typhimurium isolates, though this effect was isolate-dependent. SEM analysis showed extreme distortion in treated bacterial cells. Finally, the IgY-polymyxin B-based NPs showed minimal toxicity toward normal human skin fibroblast (HSF) cells, demonstrating them as possible candidates for future antimicrobial therapy.
Zhang Shuyi S, Feng Huan H, Liu Yarui Y, Li Yubo Y et al.
As inherent byproducts and concomitant pollutants of microplastics (MPs), plastic oligomers have received scarce attention regarding their environmental occurrence and potential risks to human health, especially in indoor environments, which serve as hotspots for plastic accumulation and the microenvironment where humans spend the majority of their lifetime. Herein, the distribution characteristics of polyethylene terephthalate (PET, the most abundant MPs in indoor dust) oligomer by-products in indoor dust were investigated, the human exposure fluxes were assessed, and the toxic effects of oligomers on the human lung were explored. The concentrations of total oligomers in indoor dust ranged from 2,620 to 184,000 ng/g (median: 50,000 ng/g, dominated by [TPA-EG]3. Infants were identified as the population at the highest risk of oligomers exposure, with the daily intake of PET oligomers via the respiratory system was as high as 1.2 ng/kg-bw/day (median). [TPA-EG]3 exposure was found to induce significant oxidative stress in lung cell model. Combined with network toxicology analysis, 10 key genes including AKT1 and MAPK1 were identified as critical targets of [TPA-EG]3-induced pulmonary toxicity. Overall, this study provides a new perspective for the comprehensive human risk assessment of MPs.
Hsu Jeremy Ting Ruei JTR, Wong Samuel Wan Ki SWK, Ping Judy Yam Wai JYW
Yu Shanshen S, Sun Jia J, Mei Xufeng X
Multiple myeloma is a hematological malignancy originating from neoplastic plasma cells, typically characterized by the presence of a monoclonal immunoglobulin. Light chain cast nephropathy is the most common cause of acute kidney injury in myeloma patients, typically presenting with elevated serum creatinine. Light-chain proximal tubulopathy is a manifestation of monoclonal light chain-associated renal injury, characterized by the accumulation of free light chains within proximal tubular cells. However, the co-occurrence of κ light-chain MM with an additional IgG-λ monoclonal band, cast nephropathy with normal serum creatinine, and light-chain proximal tubulopathy is extremely rare, posing significant challenges to diagnosis and treatment. This case report aims to enrich the clinical understanding of such rare comorbidities. A 54-year-old female was admitted due to "detection of urinary protein for 2 months". Laboratory tests showed massive proteinuria, mild anemia, normal serum creatinine, and significantly abnormal serum free light chains. Serum immunofixation electrophoresis revealed monoclonal IgG-λ and free κ chains, while urine immunofixation electrophoresis only showed free κ chain positivity. Renal biopsy confirmed κ-type cast nephropathy, with irregular lysosomes in proximal tubular epithelial cells and dominant κ light chain expression. Bone marrow examinations indicated plasma cell myeloma. The final diagnosis was the final diagnosis was confirmed as κ light-chain multiple myeloma with an additional IgG-λ monoclonal band, complicated with cast nephropathy and light-chain proximal tubulopathy. After two courses of chemotherapy, urinary protein and serum free light chain levels improved significantly, but hemoglobin decreased to severe anemia. Subsequent bone marrow aspiration indicated severe erythroid hypoplasia, then the treatment was adjusted, and the hemoglobin level improved subsequently. This rare case demonstrates that multiple myeloma can harbor two clones and can present with concurrent cast nephropathy and light chain proximal tubulopathy, even when serum creatinine remains normal. Additionally, the transient improvement followed by severe erythroid hypoplasia after chemotherapy suggests the need for close monitoring of hematopoietic complications. This case expands the clinical spectrum of biclonal gammopathy and underscores the value of comprehensive pathological evaluation for accurate diagnosis and tailored management.
Gemelga Gio G, Tuchscherer Vishwajit V, Wang Jessie J, Naik Mrinmayee M
Japanese encephalitis (JE) is a mosquito-borne flavivirus infection endemic to much of Asia and the Western Pacific. Although most infections are asymptomatic, less than 1% progress to clinical disease, typically presenting as acute encephalitis. The case fatality rate ranges from 20 to 30%, and up to half of survivors develop long-term neurological or psychiatric sequelae. While uncommon among travelers from non-endemic regions, risk increases with prolonged rural exposure or lack of vaccination. Immunocompromised individuals, including those with hematologic malignancies, may experience severe and rapidly progressive diseases. Awareness of this rare but life-threatening infection is essential when evaluating returning travelers with acute encephalopathy. A 70-year-old Lao male living in the California Central Valley with a history of multiple myeloma, hypertension, and congestive heart failure presented with progressive confusion and weakness after travel to rural Laos. His trip exceeded the recommended duration, and his Japanese encephalitis virus (JEV) vaccination status was unknown. On admission, he was febrile and encephalopathic with new-onset rigidity. Computed tomography showed chronic calcifications consistent with prior neurocysticercosis, while magnetic resonance imaging revealed bilateral frontal and left insular cortical hyperintensities without thalamic involvement. Cerebrospinal fluid analysis conducted 9 days after his cognitive decline showed elevated protein without pleocytosis, and infectious and autoimmune panels were negative. Despite empiric antibiotics and supportive care, his condition deteriorated to coma, requiring intubation. Serologic testing later confirmed recent JEV infection with positive Immunoglobulin G (IgG) and low-titer Immunoglobulin M (IgM). After multidisciplinary discussions, comfort care was initiated, and he died in inpatient hospice. This case illustrates the diagnostic challenge of acute encephalopathy in immunocompromised travelers. Myeloma-related immune dysfunction, as suggested by his lack of pleocytosis, likely contributed to impaired viral clearance, leading to rapid progression. The absence of typical thalamic lesions and the presence of frontal and insular involvement represent an uncommon neuroimaging pattern in JE. Pre-existing neurocysticercosis may have further worsened neurologic outcomes, as prior studies suggest JEV co-infection can lead to worse prognosis. Our case highlights the importance of having a broad differential in an undifferentiated patient and the value of investigating a patient's history holistically. Imported JE should be considered in travelers returning from endemic regions, particularly those who are immunocompromised. A detailed travel history, broad infectious workup, and recognition of atypical imaging findings are key to diagnosis. Vaccination and mosquito precautions remain the most effective preventive measures against this often-fatal disease.
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