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Fluosol-DA (Fluosol)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · 小分子 · 小分子

什么是 Fluosol-DA？

Fluosol-DA 是一种小分子，由Mitsubishi Tanabe Pharma Corporation研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Fluosol
公司Mitsubishi Tanabe Pharma Corporation
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

治疗适应症

Fluosol-DA 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Blood and lymphatic system disordersAnaemia✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Neoplasm malignant✓ Approved

相关研究文献

PubMedJournal of biophotonics2026-06-13

Evaluating Coronavirus Stability: Insights From Raman Spectroscopy and Multivariate Analysis.

Issmer Ali Haneen AH, Guerrero-Amelin Carolina C, Mateos-Gomez Pedro Antonio PA, Montalvo Gemma G et al.

This study aimed to evaluate viral stability by probing molecular and structural changes in human coronavirus HCoV-229E under different conditions using Raman spectroscopy coupled with multivariate analysis. Wild-type and GFP-tagged HCoV-229E samples were stored at -20°C for 24, 168, and 504 h, and subjected to thermal treatments at 37°C for 120 min and 95°C for 10 min. Multivariate analyses, including principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA), enabled clear discrimination between virus types, concentrations, and environmental conditions. The observed spectral variations reflect underlying molecular alterations associated with environmental stress. The OPLS-DA models demonstrated strong performance, explaining up to 97% of the variance (R2Y) with a predictive capacity of up to 95% (Q2). These findings highlight the potential of Raman spectroscopy combined with multivariate analysis as a rapid and non-destructive tool for investigating stability-related molecular changes in coronaviruses under varying conditions.

PMID 42285904
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PubMedEnvironmental pollution (Barking, Essex : 1987)2026-06-13

Impact of sublethal concentrations of monosodium methylarsonate (MSMA) on zebrafish: Insights from embryotoxicity assessment and NMR-based metabolomics.

Porto Viviane A VA, Júnior Edmilson R R ERR, da Silveira Felipe F C L FFCL, Neto João H S JHS et al.

Organic arsenicals such as monosodium methylarsonate (MSMA) remain widely used, yet their mechanistic toxicity in aquatic systems is poorly understood. Here, we integrated fish embryo toxicity (FET) assays with 1H NMR-based metabolomics to characterize the effects of acute MSMA exposure in zebrafish (Danio rerio) embryos. The 96-h LC50 was 74 mg L-1, and embryos were exposed to sublethal concentrations (10, 30, and 60 mg L-1). Exposure induced concentration-dependent embryotoxicity, with severe phenotypic alterations at 60 mg L-1, including reduced survival (p = 0.0316), delayed hatching (p = 0.0331), tachycardia (p < 0.0001), and a reduction in some morphometric parameters, when compared with the control group. Total arsenic analysis confirmed significant bioaccumulation in larvae, reaching 1.34 ± 0.06, 6.51 ± 0.01, and 11.08 ± 0.22 mg kg-1 across increasing concentrations. Metabolomic profiling revealed marked metabolic reprogramming, and multivariate analyses (PCA, PLS-DA, and OPLS-DA) demonstrated clear separation between the control and exposed groups. Perturbations in energy metabolism were evidenced by decreased levels of lactate, glucose, and oxaloacetate, and increased levels of acetate, suggesting impaired glycolysis, mitochondrial dysfunction, and reduced fatty acid oxidation, while elevated glutathione levels indicated activation of antioxidant defenses. Pathway analysis highlighted disruptions in glycolysis/gluconeogenesis, glutathione metabolism, purine metabolism, and aminoacyl-tRNA biosynthesis. Four metabolites (xanthine, lactate, acetoacetate, and L-tryptophan) consistently discriminated between exposed groups, with high predictive performance (AUC = 0.967) supported by cross-validation and permutation testing (p = 0.001). Overall, these findings provide mechanistic insight into MSMA-induced toxicity and demonstrate the potential of metabolomics-derived biomarkers for environmental risk assessment, supporting more sensitive and integrative strategies for evaluating arsenical contamination in aquatic ecosystems and contributing to the development of improved environmental monitoring and regulatory frameworks for arsenical pollutants.

PMID 42285206
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PubMedBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2026-06-13

[Association between umbilical cord blood proteome and early infant neurodevelopmental risk].

Mo Jingxian J, Wang Haijun H, Liu Jue J, Li Qin Q et al.

To systematically investigate the associations between umbilical cord blood protein expression profiles and early infant neurodevelopment using a prospective birth cohort, to identify potential early biomarkers through high-throughput proteomics, and to explore underlying biological mechanisms, thereby providing scientific evidence for early identification of neurodevelopmental risks and understanding the molecular basis of neurodevelopmental deviations in general populations. Based on the Peking University Birth Cohort in Tongzhou, this study enrolled 96 children who completed ages and stages questionnaires, third edition (ASQ-3) assessments at 1 and 3 years of age. Participants were classified into an abnormal group (n=42) and a control group (n=54) according to ASQ-3 screening results. Non-targeted quantitative proteomics was performed on cryopreserved umbilical cord blood plasma samples collected at birth. Differential expression analysis, principal component analysis (PCA), orthogonal partial least squares discriminant analysis (OPLS-DA), and weighted gene co-expression network analysis (WGCNA) were conducted to identify differentially expressed proteins, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses. The fold change (FC) was calculated. Independent samples t-test was used for statistical comparison, with Benjamini-Hochberg method applied to calculate false discovery rate (FDR) for multiple testing correction. Proteomic analysis identified 8 214 common proteins, among which 385 proteins were differentially expressed (P < 0.05, |log2FC| >0.585), including 189 proteins upregulated and 196 proteins downregulated in the abnormal group. PCA and OPLS-DA revealed systematic differences in protein expression patterns between the two groups. WGCN A identified 10 co-expression modules, with the yellow module showing significant negative correlation with ASQ-3 abnormal grouping (r=-0.233, P=0.024) and the pink module positively correlating with communication domain scores (r=0.342, P=0.003). Enrichment analyses demonstrated that differential proteins and key modules were primarily enriched in two functional categories: (1) genetic information processing pathways, including ribosome, spliceosome, and mRNA processing; and (2) cytoskeleton organization and Wnt signaling pathways. These pathways held significant biological relevance in the pathogenesis of neurodevelopmental disorders. Perturbations in proteins associated with genetic information processing and cytoskeleton/Wnt signaling pathways in umbilical cord blood may represent important molecular characteristics of early neurodevelopmental screening abnormalities in infants. This study provides potential peripheral blood biomarker combinations for early identification of neurodevelopmental risks in general populations and offers novel insights into the biological mechanisms underlying neurodevelopmental deviations. Future research should validate these findings in larger-scale cohorts and elucidate specific functional mechanisms of key proteins through experimental studies.

PMID 42287041
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PubMedJournal of the science of food and agriculture2026-06-13

Enhancement of biological activity and volatile organic compounds of sunflower bee pollen via mixed Lactobacillus fermentation.

Ma Tianchen T, An Xin X, Jin Kai K, Zheng Oujie O et al.

Lactobacillus fermentation represents an efficient approach for enhancing the nutritional, bioactive, and sensory properties of bee pollen. However, the biological activities and volatile organic compounds (VOCs) of Lactobacillus-fermented sunflower bee pollen (FSBP) remain unclear. In this study, we employed mixed fermentation with Lactiplantibacillus plantarum and Lacticaseibacillus casei, optimizing the process using single factor and orthogonal experiments. We then characterized the physicochemical properties, biological activities, and VOCs of unfermented sunflower bee pollen (USBP) and FSBP. Compared to USBP, FSBP exhibited 9.68% and 54.57% increases in total phenolic and flavonoid contents. Additionally, FSBP exhibited 26.08% and 17.59% increases in α-glucosidase inhibitory activity (GIA) and tyrosinase inhibitory activity. Notably, antioxidant and anti-inflammatory activities were significantly improved in FSBP. Headspace-solid-phase microextraction-gas chromatography-mass spectrometry analysis identified 52 VOCs. The orthogonal partial least squares discriminant analysis (OPLS-DA) revealed 16 key VOC markers distinguishing USBP and FSBP, including (1S)-(-)-α-pinene, camphene, α-pinene, ethyl butanoate, ethyl caprate, cis-chrysanthenol, butanoic acid, pentanoic acid, octanoic acid, hexanoic acid, isobutyl methyl ketone, acetophenone, nonanal, tridecane, selina-5,11-diene, and p-cymene. In summary, Lactobacillus fermentation not only improves bioactivity but also modulates flavor, making bee pollen more suitable for food applications. © 2026 Society of Chemical Industry.

PMID 42285775
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PubMedBiotechnology and applied biochemistry2026-06-13

Optimization and Characterization of Poly-γ-Glutamic Acid Production From a Locally Isolated Bacillus cereus ARM24.

Al-Wahili Mohammed Jabbar Hafiz MJH, Al-Manhel Alaa Jabbar Abd AJA, Al-Ali Rawdah Mahmood RM, Tlay Rawaa H RH et al.

For identification of this new local poly-γ-glutamic acid (γ-PGA) bacteria and partial purification of γ-PGA, the bacterium was studied and identified as Bacillus cereus. Sixty isolates of Bacillus spp. were collected from 28 sources (agricultural soil, local market vegetables, and fruits). Preliminary screening was performed on selective plates; 37 strains were selected on the basis of their ability to form a slimy mucoid colony. All isolates were studied for morphological and microscopic characters and identified by biochemical tests; a test for the production of γ-PGA was conducted with spectrophotometric determination of the polymer concentration at 216 nm. The best local strain B3, causing 2.54 g/mL of polymer, was chosen. Isolated strain was designated ARM24 and was published elsewhere with 99% identity as B. cereus ARM24 under the GenBank accession number. Optimization studies indicated that the optimum conditions for γ-PGA production were 37°C, pH 7, inoculum size 2 mL, shaking speed 200 rpm, and fermentation time 48 h using grape pomace juice as carbon source and soybean meal with salting out as nitrogen source. The polymer was precipitated from cold 99% ethanol with a recovery rate of 3:1, purified by dialysis bags (10,000 Da), and characterized by Fourier transform infrared (FT-IR), thin-layer chromatography (TLC), 1H-NMR, and high-performance liquid chromatography (HPLC).

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PubMedMolecular pharmacology2026-06-13

Structural and molecular determinants of glutamate transporter allosteric modulators.

Reeb Katelyn L KL, Saha Satyaki S, Bogetti Xiaowei X, Poli Adi N R ANR et al.

Excitatory amino acid transporters (EAATs) are critical regulators of synaptic glutamate levels in the central nervous system. Dysregulated central nervous system glutamatergic homeostasis is implicated in many neurological diseases, highlighting the key role of EAATs in neurological health. We previously identified a library of small compounds that function as either positive allosteric modulators (PAMs) or negative allosteric modulators of EAATs, with diverse selectivity for subtypes EAAT1, EAAT2, and EAAT3, including astrocytic EAAT1 and EAAT2 and neuronal EAAT3. In this work, we characterized compounds from our library using molecular modeling, mutagenesis, and pharmacologic approaches. We focused on 3 representative compounds: NA-014, an EAAT2-selective PAM, DA-038, an EAAT1-3 PAM, and NA-010, an EAAT2-selective negative allosteric modulators. Binding studies demonstrated that these compounds do not interact with the orthosteric glutamate-binding site, confirming an allosteric action. Docking studies suggested several potential binding poses of NA-014 between the scaffold and transport domains of EAAT2, which we then studied with mutagenesis approaches. We identified potential binding sites of representative compounds in transmembrane domains 1, 5, 8, and hairpin 2 and demonstrated that these are necessary for their activity. Ten key amino acid residues within a subdomain of EAAT2 substituted into EAAT1 conferred EAAT2-selective PAM activity, demonstrating these residues are required and sufficient to enable selective PAM function. Collectively, these studies identified crucial subdomains and key amino acids linked to PAM activity, advancing our understanding of how to modulate EAAT activity. This knowledge can be integrated into future studies to develop EAAT allosteric modulators for neurological disorders. SIGNIFICANCE STATEMENT: We identified modulators of glutamate transporters, key regulators of central nervous system excitability and neuronal health. Using molecular modeling, mutagenesis, and pharmacology, we mapped their allosteric binding sites and identified ten residues that confer selective transport enhancement. This mechanism of transporter activation may guide development of therapies for disorders involving glutamatergic dysregulation, including stroke, neuropathic pain, and substance use disorders.

PMID 42284891
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