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Fluosol-DA (Fluosol)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · 小分子 · 小分子

什么是 Fluosol-DA？

Fluosol-DA 是一种小分子，由Mitsubishi Tanabe Pharma Corporation研发。该药已获批，用于治疗相关适应症，给药途径：Unknown。

药物档案

商品名Fluosol
公司Mitsubishi Tanabe Pharma Corporation
药物类别小分子
给药途径Unknown
状态Approved
来源： ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

治疗适应症

Fluosol-DA 针对 2 个适应症，涉及 2 个治疗领域。

治疗领域疾病/病症分期
Blood and lymphatic system disordersAnaemia✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Neoplasm malignant✓ Approved

相关研究文献

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Comparison of 90-Day Complications Between Direct Anterior and Postero-Lateral Total Hip Arthroplasty in Morbidly Obese Patients.

Bauer Jordan A JA, Birbara Brooke B, Grosso Matthew J MJ

Morbidly obese (MO) patients undergoing total hip arthroplasty (THA) are at increased risk of postoperative complications. The effect of surgical approach on outcomes in this population remains unclear. This study compared perioperative outcomes and 90-day complications between direct anterior (DA) and postero-lateral (PL) approaches in MO and non-MO patients. We retrospectively reviewed 5,933 primary THAs between January 2017 and March 2022. The surgeons included had performed at least 50 DA cases. Among 365 MO patients (body mass index [BMI] ≥ 40), 238 underwent DA and 127 underwent PL. Demographics, operative characteristics, and 90-day complications were analyzed. Multivariable logistic regressions adjusted for age, sex, BMI, American Society of Anesthesiology (ASA) class, and operative time; rare events were evaluated using penalized logistic regression. Propensity score-based sensitivity analyses were performed to account for confounders. In MO patients, operative times were significantly shorter with DA (71 ± 18 versus 92 ± 26 minutes, P < 0.001). On penalized multivariable analysis, there was a reduced risk of periprosthetic fracture for the DA group (OR [odds ratio] 0.08, 95% CI [confidence interval] 0.01 to 0.89); however, interpretation is limited by higher rates of cementation in the DA group. In sensitivity analysis, the risk of revision surgery remained significantly lower with DA (OR 0.31, 95% CI 0.11 to 0.85). Complication rates were otherwise statistically similar between approaches on adjusted analysis. Compared to non-MO patients, MO patients had longer operative times and higher overall complication rates, regardless of approach. In MO patients undergoing THA, the DA approach was associated with shorter operative times. After multivariate adjustment, overall complication risks were similar between approaches across two analytical frameworks. These findings suggest that both DA and PL can be safely utilized in MO patients undergoing THA, without an increased 90-day complication profile attributable to either approach.

PMID 42570733
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PubMedColloids and surfaces. B, Biointerfaces2026-08-09

Ratiometric "on/off"-type fluorescence sensors based on nitrogen and silicon co-doped graphene quantum dots for identification and semi-quantitative visualized detection of dopamine, epinephrine, and norepinephrine.

Hu Yingying Y, Li Jiahui J, Liao Zengboya Z, Yu Xiaoxiao X et al.

Catecholamines (CAs) play pivotal physiological in the human body, and the aberrant levels of them are closely associated with various diseases. Therefore, developing a rapid, simple, and accurate method for CAs determination is of considerable clinical importance for precise disease diagnosis. In this work, a turn-off fluorescence sensor based on nitrogen and silicon co-doped graphene quantum dots (N,Si-GQDs) was first established for the detection of total CAs, leveraging the inner filter effect (IFE). To achieve the selective identification and separate quantification of dopamine (DA), epinephrine (EP), and norepinephrine (NEP), resorcinol (RS) and ethylenediamine (EDA) were subsequently introduced. Taking advantage of the differential reactivity of DA/EP/NEP toward RS/EDA, three distinct fluorescent adducts were generated: DA-RS (λem=460 nm), EP-EDA (λem=510 nm), and NEP-EDA (λem=492 nm). Therefore, two ratiometric "on/off"-type fluorescence sensors, N,Si-GQDs/RS and N,Si-GQDs/EDA, were successfully constructed for identification and on-site semi-quantitative visual detection of DA (F460/F380), EP (F510/F380), and NEP (F492/F380), respectively. Under the optimal conditions, the detection limits of DA, EP, and NEP were respectively as low as 15.9, 14.1, and 6.3 nM. Furthermore, upon irradiation with a 365 nm UV lamp, the color differences observed at different times can be utilized to distinguish DA, EP and NEP, and conduct their rapid, semi-quantitative, on-site visual detection.

PMID 42570434
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PubMedEcotoxicology and environmental safety2026-08-09

Unmasking aminated graphene quantum dots neurotoxicity in freshwater planarian: Dopaminergic disruption and reversible motor dysfunction at sublethal doses.

Gu Xuanyu X, Li Yujun Y, Zhang Xiaoran X, Zeng Yan Y et al.

Despite their favorable biocompatibility profile, the neurotoxic potential of aminated graphene quantum dots (A-GQDs) remains poorly characterized, especially concerning their environmental impact. Utilizing the planarian Dugesia japonica, a freshwater invertebrate model with a vertebrate-like, highly conserved central nervous system (CNS) and regenerative capacity, we systematically evaluated A-GQDs neurotoxicity. The results demonstrated that sublethal doses (≤80 µg/mL) of A-GQDs selectively accumulated within cephalic ganglia and ventral nerve cords, inducing pronounced, dose- and time-dependent locomotor deficits. Crucially, this neurobehavioral toxicity was reversible upon A-GQDs removal. Mechanistically, A-GQDs exposure significantly disrupted neurotransmitter homeostasis, decreasing dopamine (DA) and 5-hydroxytryptamine (5-HT) levels and suppressing acetylcholinesterase (AChE) activity. Exogenous DA supplementation uniquely rescued locomotor impairment, implicating dopaminergic dysfunction as a primary mechanism. Transcriptional analysis revealed consistent downregulation of synaptic genes (synapsin, Djsyt) alongside upregulation of DA synthesis (Djth) and adhesion (Djdscam) genes. Whole-mount immunofluorescence confirmed dose-dependent neural damage, evidenced by diminished SYNAPSIN signal intensity and structural clarity. Neoblast marker piwiA upregulation indicated triggering regenerative responses post-exposure. To our knowledge, this is the first study to provide comprehensive in vivo evidence of A-GQDs-induced neurotoxicity in a freshwater planarian model, highlighting significant sublethal risks to aquatic ecosystems upon its environmental discharge. These findings revealed that A-GQDs, as "low-toxicity" nanomaterials, despite perceived safety, provoked significant sublethal neurotoxic risks via dopaminergic disruption and synaptic impairment, challenging their unqualified use in biomedical applications and underling the urgent need to regulate their environmental discharge to protect aquatic ecosystems.

PMID 42570585
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PubMedAnnals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft2026-08-09

Horse Anatomy and Art: Carlo Ruini.

Merighi Adalberto A

Carlo Ruini's Dell'Anotomia et dell'infirmità del cavallo (1598) is widely regarded as the first scientific treatise on veterinary anatomy. This paper reviews the historical circumstances of its composition and printing history, the structure and scientific content of its five anatomical books, the long-standing controversy over Ruini's authorship - including the plagiarisms it subsequently suffered - and the disputed attribution of its woodcut illustrations to artists such as Leonardo da Vinci, Titian and Agostino Carracci. Ruini's description of the pulmonary circulation is situated within a comparative chronology running from Vesalius (1543) to Harvey (1628), and a terminological table cross-references Ruini's descriptive language with current veterinary anatomical nomenclature. The paper further considers the nineteenth-century rehabilitation of Ruini's reputation, chiefly through the efforts of Giovan Battista Ercolani, against the background of the broader institutionalization of veterinary medicine in Europe. The analysis situates Ruini's contribution within the broader history of comparative anatomy and of the discovery of blood circulation. It highlights the artistic value of the treatise's iconography alongside its scientific merit.

PMID 42570853
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PubMedFood science & nutrition2026-08-09

Comparative Analysis of Chemical Composition and Bioactivities of Volatile Oils From Wurfbainia villosa Fruit and Stem.

Gu Yuancong Y, Lv Bangyu B, Nian Xingrui X, Xie Xinrui X et al.

This study extracted volatile oils from the fruit and stem of Wurfbainia villosa Lour. (W. villosa) using steam distillation. Their chemical compositions were comparatively analyzed using gas chromatography-mass spectrometry (GC-MS). Their biological activities were evaluated through antioxidant (DPPH, ABTS radical scavenging, and total antioxidant capacity), hypoglycemic (α-glucosidase and α-amylase inhibition), and antibacterial (agar diffusion) assays. The extraction yields were 1.87% for the fruit volatile oil and 0.13% for the stem volatile oil. GC-MS analysis identified 46 compounds in the fruit volatile oil and 59 compounds in the stem volatile oil. The fruit volatile oil was primarily composed of (+)-α-pinene (17.45%), camphene (14.53%), (-)-β-pinene (14.93%), D-limonene (14.66%), borneol (16.18%), and bornyl acetate (3.57%). In contrast, the stem volatile oil was dominated by γ-terpinene (17.78%), p-cymene (17.29%), (+)-4-carene (13.46%), (-)-4-terpineol (9.53%), (-)-β-pinene (9.60%), β-phellandrene (7.25%), and D-limonene (5.31%). The two volatile oils shared 27 common components, of which 19 were unique to the fruit and 32 were unique to the stem. Orthogonal partial least squares-discriminant analysis (OPLS-DA) identified key differential markers, including γ-terpinene, borneol, p-cymene, (+)-4-carene, D-limonene, (-)-4-terpineol, β-phellandrene, and (-)-β-pinene. The fruit volatile oil demonstrated substantially stronger antioxidant activity (based on the DPPH and ABTS radical scavenging and total antioxidant capacity assays) and higher inhibitory activity against α-glucosidase and α-amylase than did the stem volatile oil. Conversely, the stem volatile oil showed substantially greater antibacterial efficacy against Escherichia coli and Staphylococcus aureus. Exploratory correlation analysis suggested that these bioactivity differences might be associated with the distribution profiles of characteristic chemical components. This study revealed substantial differences in the chemical composition and bioactivity of volatile oils from the fruit and stem of W. villosa. The findings provide a scientific basis for the targeted development of these volatile oils as natural antioxidants, hypoglycemics agents, or antibacterials agents, depending on the plant part.

PMID 42571375
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PubMedOpen life sciences2026-08-08

Darutoside ameliorates adjuvant-induced arthritis in mice by repolarizing M1/M2 macrophages through inhibition of JAK2-STAT3-p65 signaling pathway.

Wang Jun J, Gao Shiya S, Meng Mingsong M, Zhang Zilin Z et al.

Darutoside (DA), a diterpenoid compound derived from Herba Siegesbeckiae, possesses notable anti-inflammatory properties. This study evaluated the effectiveness of DA in treating rheumatoid arthritis (RA) symptoms and elucidated the relevant mechanisms. The anti-RA efficacy of DA was investigated in a Complete Freund's Adjuvant (CFA)-induced arthritis mouse model, while RAW264.7 macrophages were used to examine DA's impact on macrophage polarization in vitro. Targets of DA for RA were predicted through protein-protein interaction networks and pathway enrichment analysis. Subsequently, mechanisms were verified through in vitro assays. The results showed that DA alleviated the symptoms in the CFA mouse model, as evidenced by reduced clinical scores, attenuated paw swelling, and decreased inflammatory response. Moreover, DA induced repolarization of M1/M2 macrophages in both the CFA model mice and RAW264.7 cells. Network pharmacology analysis suggested that DA may exert its anti-RA effects by modulating the JAK-STAT signaling pathway. Western blotting confirmed that DA inhibited the JAK2-STAT3-p65 pathway, thereby suppressing M1 macrophage polarization. Furthermore, the repolarization effect of DA on macrophages was counteracted in JAK2-silenced cells. These findings indicate that DA attenuates arthritis symptoms in CFA mice, and this effect may be attributed to its regulation of macrophage M1/M2 polarization through suppression of the JAK2-STAT3 pathway and downstream p65 activation.

PMID 42569178
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