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phenylpropanolamine (Dristan SR / Histabid / Dexatrim)

✓ Approved

Lumara Health · 小分子 · 小分子

什么是 phenylpropanolamine？

phenylpropanolamine 是一种小分子，由Lumara Health研发。该药已获批，用于治疗相关适应症，给药途径：Oral (PO)。

药物档案

商品名Dristan SR, Histabid, Dexatrim
公司Lumara Health
药物类别小分子
给药途径Oral (PO)
状态Approved
来源： ClinicalTrials.gov, Lumara Health

治疗适应症

phenylpropanolamine 针对 1 个适应症，涉及 1 个治疗领域。

治疗领域疾病/病症分期
Respiratory, thoracic and mediastinal disordersCough✓ Approved

相关研究文献

PubMedNature communications2026-06-13

Multiscale structural engineering enables superior energy storage in tetragonal tungsten bronze relaxor ferroelectrics.

Wang Saifei S, Huang Juntao J, Li Guangyao G, Yang Tao T et al.

Lead-free relaxor ferroelectric ceramics are promising for pulsed-power systems due to their ultrafast discharge and high-power density, yet their practical use remains limited by low breakdown strength and insufficient energy-storage density. Here, we report Ba2La1-xBixTi2Nb3O15 ceramics with a tetragonal tungsten bronze structure, which achieve a recoverable energy density of 14.39 J/cm3 and an efficiency of 87.69% under an ultrahigh field of 1400 kV/cm-one of the highest recoverable energy density values reported for bulk tetragonal tungsten bronze structured ceramics. By combining experiments, first-principles calculations, and finite-element simulations, we unravel a multiscale structural optimization mechanism. Bi3+ incorporation induces oxygen-octahedral distortion that disrupts long-range order and enhances relaxation behavior. Concurrent grain refinement and band gap widening substantially raise the breakdown strength, leading to superior energy-storage properties. Moreover, the material exhibits excellent stability against variations in temperature, frequency, and fatigue cycles. This work establishes a generally applicable multiscale structural-engineering strategy for tetragonal-tungsten-bronze dielectrics with high energy storage performance.

PMID 42285935
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PubMedJournal of dairy science2026-06-13

Impact of pulsed electric field technology on whey protein isolate.

Ryan Elizabeth L EL, McDougal Owen M OM

A commercially available pulsed electric field (PEF) system has been used to treat a 23% total solids solution of whey protein isolate (WPI) before spray drying. The 3 trials conducted for this study used PEF parameters within the range of 17-21 kV/cm for field strength and 8-15 kJ/L for specific energy. PEF treatment led to a decrease in solution viscosity by as much as 32.8% within 24 h., increased the solubility of spray-dried powder up to 12.2%, and increased the emulsifying activity index (EAI) and emulsion stability index (ESI) by 6.5 times and 250%, respectively, as compared with the non-PEF control. Assessment of protein structure was conducted by gel electrophoresis, circular dichroism (CD), fluorescence spectroscopy, and differential scanning calorimetry (DSC) with only a minor effect on β-strand by CD with the highest PEF treatment, medium and high PEF treatments affected fluorescence intensity, and increased enthalpy associated with denaturation by DSC. These minor changes may explain the changes in physical and functional properties for the PEF treated WPI. This study provides physical and functional property data for the first instance of commercially relevant concentrated WPI being treated through a PEF flow cell at a rate of 170 L/hr.

PMID 42285489
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PubMedBMC oral health2026-06-13

Balancing radiopacity and artifact generation: a quantitative evaluation of CBCT artifacts induced by resin-based restorative materials.

Pehlivan İkbal Esra İE, Kaya Sema S, Koç Alaettin A

While metal-induced artifacts in cone-beam computed tomography (CBCT) are well documented, quantitative data regarding the artifact intensity and spatial distribution of modern injectable composites compared with conventional resin-based materials are sparse. This in vitro study quantitatively evaluated and compared beam-hardening and blooming artifacts generated by various resin-based restorative materials, specifically investigating whether modern injectable composites produce different artifact profiles than conventional resins in CBCT imaging. Ninety 3D-printed mandibular canine models with standardized distal cavities were restored using six different materials (n = 15 per group): G-ænial Anterior (GA), EQUIA Forte HT Fil (EQF), G-ænial Universal Injectable (GUI), Vittra APS Unique (VAU), Charisma Diamond ONE (CHR), and OMNICHROMA (OMN). All samples were scanned using a CS 9600 CBCT unit under identical exposure parameters (120 kV, 4.0 mA, 0.15 mm voxel size) to eliminate motion artifacts and ensure standardization. Grayscale values (GV) were measured on mesial, distal, buccal, and lingual surfaces using standardized regions of interest (ROIs) positioned adjacent to the restoration. Statistical analyses were performed using one-way ANOVA and Kruskal-Wallis tests with post-hoc corrections (α = 0.05). Significant differences in GV were observed on the mesial (p < 0.001), distal (p < 0.001), and buccal (p = 0.004) surfaces, whereas no significant difference was found on the lingual surface (p = 0.053). The GUI and GA groups showed the highest GV, while CHR exhibited the lowest GV across all surfaces. The highest GV were recorded on the mesial surface, not on the distal surface where the restoration was placed (p < 0.001). Different resin-based restorative materials produced different grayscale values and artifact patterns under standardized CBCT conditions. The high-filler injectable composite showed artifact characteristics comparable to those of high-viscosity resin-based materials, particularly on the surface opposite to the restoration. These findings suggest that material-related factors may influence CBCT artifact expression; however, because no direct chemical or elemental analysis was performed, these interpretations should be made cautiously. In clinical situations where CBCT imaging is anticipated, clinicians should consider the potential effect of restorative material radiopacity on image interpretation while balancing the diagnostic need for radiopaque restorations in conventional radiography.

PMID 42286615
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PubMedSensors (Basel, Switzerland)2026-06-12

A Field Emission X-Ray Source Array for Stationary Digital Chest Tomosynthesis Applications.

Tang Huaping H, Zhang Fengyan F, Li Guoyu G, Wang Biao B et al.

Digital chest tomosynthesis (DCT) has been clinically validated to offer significant advantages in diagnostic efficiency for pulmonary diseases and radiation dose reduction. Emerging stationary DCT (sDCT) systems can further shorten acquisition time and eliminate motion artifacts caused by X-ray source movement and patient respiration. This work focuses on the development of a multi-beam X-ray source for mobile sDCT systems by specification definition, source design, and experimental validation. The developed X-ray tube integrates 63 focal spots arranged linearly over a length of 816 mm. X-rays are emitted through seven segmented windows, achieving an angular span of 36° at a source image distance (SID) of 120 cm, with full coverage of a detector area of 35.6 cm × 43.2 cm. The tube operates at a maximum anode voltage of 140 kV, maximum anode current of 20 mA, and 24 mAs per scan, with a focal spot size of IEC 0.6. The developed multi-beam X-ray source achieves multiple key performance breakthroughs and provides an alternative source architecture for future sDCT implementation, with the potential to facilitate further system performance optimization and engineering development.

PMID 42281105
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PubMedInternational journal of molecular sciences2026-06-12

Murine Model of Radiation Dermatitis with Experimental Wound and Effects of Genistein.

Phillips Ernest O N EON, Alzahrani Amal A, Rittase W Bradley WB, Slaven John E JE et al.

Cutaneous Radiation Injuries (CRIs) and wounds within an area of radiation exposure (combined injury, CI) are a significant concern for nuclear accidents and radiation combat/terrorist events. CRIs and CI present unique clinical challenges, and effective countermeasures are urgently needed. Here we describe a murine model of CRI and CI in C57BL/6 mice using 16.9 Gy thoracic X-ray irradiation (5.3 Gy/min, 160 kV) ± experimental wound administered immediately. Wound repair and radiation-induced dermatitis were assessed after irradiation. Our previous studies showed that genistein (200 mg/kg, s.c.), administered 24 h prior to irradiation prevented radiation injuries in two murine models. We investigated the effects of genistein in the CI model. Macroscopic and histological analyses showed that radiation significantly delayed wound closure, although wounds did not significantly alter the progression of radiation dermatitis. Genistein improved the early rate of wound closure and significantly reduced dermatitis in mice. Histological analysis showed that genistein improved skin structure and reduced inflammation and fibrosis. Immunohistochemistry showed that genistein attenuated radiation-induced cyclin-dependent kinase inhibitor 1 (p21/waf1) and α-smooth muscle actin and preserved K15 positive skin adult stem cells. These findings suggest that genistein may be an effective prophylactic against CRIs and CI.

PMID 42278543
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PubMedMaterials (Basel, Switzerland)2026-06-12

Synergistic Defect and Phase Boundary Engineering for Large Strain and Superior Low-Field Energy Storage in Bi0.5Na0.5TiO3-Based Relaxors.

Li Hui H, Shang Zhongfeng Z, Ren Xiaojun X, Li Wenfang W et al.

The advancement of microelectromechanical systems (MEMS) drives the demand for multifunctional ferroelectrics that synergistically combine substantial strain with competitive energy storage capabilities. In this work, the simultaneous enhancement of electromechanical strain and energy storage properties is achieved in (1-x)(Bi0.5Na0.5)0.94Ba0.06(Ti0.98Mn0.02)O3-xSrTiO3 (0 ≤ x ≤ 0.3) ceramics by synergistically employing A-site defect engineering and the nonergodic/ergodic relaxor (NR/ER) phase boundary design. The incorporation of Sr2+ plays a dual role: it induces cationic disorder that expands the polarization difference (ΔP = Pmax - Pr), thereby effectively boosting the recoverable energy density (Wrec). Concurrently, it stabilizes a critical NR/ER phase ratio near room temperature, which maximizes the strain while minimizing the strain hysteresis. Consequently, when x = 0.15, the optimized system delivers a large strain of 0.45% (d33* = 562 pm/V) with low hysteresis (H = 10.8%). In addition, the x = 0.25 composition exhibits an enhanced Wrec of 1.06 J/cm3, a competitive energy-storage potential (Wrec/E) of 0.013 mC/cm2, and a high efficiency (η) of 81% under 80 kV/cm. This work provides an effective strategy for developing multifunctional lead-free materials for integrated actuators and energy storage devices.

PMID 42279981
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